The improved dissolution and prevention of ampoule breakage attained by the introduction of pretreatment into the production process of the lyophilized formulation of recombinant human Interleukin-11 (rhIL-11)

International Journal of Pharmaceutics

Volumn 286, Issue 1-2, 2004, Pages 53-67

  Hirakura, Yutaka ^a   Kojima, Seiki ^a   Okada, Akira ^a   Yokohama, Shigeharu ^a   Yokota, Shoji ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Aluminum; Lyophilization; Pretreatment; Protein; Reconstitution; Sodium phosphate

Indexed keywords

ALUMINUM; DISODIUM HYDROGEN PHOSPHATE; GLYCINE; ICE; RECOMBINANT INTERLEUKIN 11; SODIUM DIHYDROGEN PHOSPHATE;

AMPOULE; ARTICLE; COOLING; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; DRUG SOLUBILITY; FREEZING; LOW TEMPERATURE PROCEDURES; PRIORITY JOURNAL; TEMPERATURE; THERMAL ANALYSIS; X RAY POWDER DIFFRACTION;

CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; DIFFERENTIAL THERMAL ANALYSIS; DOSAGE FORMS; DRUG PACKAGING; DRUG STABILITY; FREEZE DRYING; GLASS; GLYCINE; HUMANS; INJECTIONS; INTERLEUKIN-11; JAPAN; PHOSPHATES; PROPYLENE GLYCOLS; SOLUBILITY; SURFACE PROPERTIES; SURFACE-ACTIVE AGENTS; TEMPERATURE; THERMOGENESIS; TIME FACTORS; X-RAY DIFFRACTION;

EID: 6944253945     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2004.07.030     Document Type: Article

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