Investigation of PEG crystallization in frozen PEG-sucrose-water solutions. I. characterization of the nonequilibrium behavior during freeze-thawing

Journal of Pharmaceutical Sciences

Volumn 99, Issue 6, 2010, Pages 2609-2619

  Bhatnagar, Bakul S ^a   Martin, Susan M ^b   Teagarden, Dirk L ^b   Shalaev, Evgenyi Y ^c   Suryanarayanan, Raj ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b PFIZER INC   (United States)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Cryoprotectant; Crystallization; Eutectic melting; Freeze concentration; Freeze drying; Freeze thawing; Low temperature XRD; Lyophilization; PEG; Phase separation; Sucrose; Ternary phase diagram

Indexed keywords

MACROGOL; SUCROSE;

ARTICLE; CONTROLLED STUDY; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; FREEZE THAWING; LOW TEMPERATURE; PHASE SEPARATION; TEMPERATURE SENSITIVITY; X RAY DIFFRACTION;

EID: 77951560954     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22040     Document Type: Article

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