Sulfonamide derivatives of styrylheterocycles as a potent inhibitor of COX-2-mediated prostaglandin E2 production

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 23, 2010, Pages 6938-6941

  Lim, Chaemin ^a   Lee, Minhee ^a   Park, Eun Jung ^b   Cho, Ran ^a   Park, Hyen Joo ^a   Lee, Seong Jin ^c   Cho, Heeyeong ^c   Lee, Sang Kook ^a   Kim, Sanghee ^a  

^a Seoul National University   (South Korea)

^b Ewha Womans University   (South Korea)

^c Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

COX 2 inhibitors; PGE2 production; Structure activity relationships; Styrylheterocycles

Indexed keywords

4 [2 (THIOPHEN 3 YL)VINYL]BENZENESULFONAMIDE; BENZENESULFONAMIDE DERIVATIVE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; HETEROCYCLIC COMPOUND; LIPOPOLYSACCHARIDE; MESSENGER RNA; PROSTAGLANDIN E2; STYRENE DERIVATIVE; SULFONAMIDE; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG; VINYL DERIVATIVE;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; DRUG POTENCY; DRUG SCREENING; ENZYME INHIBITION; GENE EXPRESSION; MACROPHAGE; MOUSE; NONHUMAN; PROSTAGLANDIN SYNTHESIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELL LINE; CYCLOOXYGENASE 2; DINOPROSTONE; HETEROCYCLIC COMPOUNDS; INHIBITORY CONCENTRATION 50; MACROPHAGES; MICE; RNA, MESSENGER; SULFONAMIDES;

MURINAE;

EID: 78149285493     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.09.136     Document Type: Article

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