Synthesis and inhibitory effects of pinosylvin derivatives on prostaglandin E 2 production in lipopolysaccharide-induced mouse macrophage cells

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 23, 2004, Pages 5895-5898

  Park, Eun Jung ^a   Min, Hye Young ^a   Ahn, Yong Hyun ^b   Bae, Cheol Man ^b   Pyee, Jae Ho ^b   Lee, Sang Kook ^a  

^a Ewha Womans University   (South Korea)

^b Dankook University   (South Korea)

Author keywords

Cancer chemoprevention; COX 2; PGE2; Pinosylvin

Indexed keywords

3 HYDROXY 5 BENZYLOXYSTILBENE; 3,5 DIMETHOXYSTILBENE; LIPOPOLYSACCHARIDE; PINOSYLVIN; PINOSYLVIN DERIVATIVE; PROSTAGLANDIN E2; RESVERATROL; STILBENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENCY; DRUG SYNTHESIS; MACROPHAGE; MOUSE; NONHUMAN; PROSTAGLANDIN SYNTHESIS INHIBITION;

ANIMALS; CELL LINE; DINOPROSTONE; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; STILBENES;

EID: 7044262352     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.09.022     Document Type: Article

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24. 2 level of vehicle treated-control)] × 100
25. 2 dishes for 24 h. Then, compound 1, or 7 was treated with 1 μg/mL of LPS for 6 h. After washing with PBS, total RNA was isolated from the cells. Briefly, cells were lysed by Tri-reagent and separated into three phases by chloroform. The aqueous phase was transferred to a fresh tube, and added the same amount of isopropanol to precipitate RNA pellet. RNA pellet was washed with 75% ethanol and dissolved in nuclease free water. The concentration of RNA was determined by absorbance at 260 nm. RNA (1 μg) was performed reverse transcription (RT) using avian myeloblastosis virus (AMV) reverse transcriptase. The cDNA products of RT were amplified by PCR using Taq DNA polymerase. The sense and antisense primers for COX-2 were 5′-GGAGAGACTATCA-AGATAGTGATC-3′ and 5′- ATGGTCAGTAGAC-TTTTACAGCTA-3′, respectively. The sense and antisense primers for β-actin were 5′-TGTGATGG-TGGGAATGGGTCAG-3′ and 5′-TTTGATGTCA-CGCACGATTTCC-3′, respectively. The PCR products were run on a 2% agarose gel and visualized by SYBR Gold staining