메뉴 건너뛰기




Volumn 33, Issue 9, 2010, Pages 975-982

Lovastatin inhibits T-cell proliferation while preserving the cytolytic function of EBV, CMV, and MART-1-specific CTLs

Author keywords

cytolytic T lymphocytes (CTLs); cytotoxicity; proliferation; statin; tumorinfiltrating lymphocytes (TILs)

Indexed keywords

CYTOMEGALOVIRUS ANTIGEN PP65; GAMMA INTERFERON; INTERLEUKIN 2; LATENT MEMBRANE PROTEIN 2; MELAN A; MEVINOLIN; PRAVASTATIN; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

EID: 78149282617     PISSN: 15249557     EISSN: None     Source Type: Journal    
DOI: 10.1097/CJI.0b013e3181fb0486     Document Type: Article
Times cited : (10)

References (34)
  • 1
    • 0035902174 scopus 로고    scopus 로고
    • Haematopoietic cell transplantation as immunotherapy
    • Appelbaum FR. Haematopoietic cell transplantation as immunotherapy. Nature. 2001;411:385-389.
    • (2001) Nature , vol.411 , pp. 385-389
    • Appelbaum, F.R.1
  • 2
    • 29844445435 scopus 로고    scopus 로고
    • Pathology of hemato-poietic cell transplantation
    • Blume KG, Forman SJ, Appelbaum FR, eds, Boston, MA: Blackwell Scientific Publications
    • Sale GE, Shulman HM, Hackman RC. Pathology of hemato-poietic cell transplantation. In: Blume KG, Forman SJ, Appelbaum FR, eds. Thomas's Hematopoietic Cell Transplantation. Boston, MA: Blackwell Scientific Publications; 2004:286-299.
    • (2004) Thomas's Hematopoietic Cell. Transplantation , pp. 286-299
    • Sale, G.E.1    Shulman, H.M.2    Hackman, R.C.3
  • 3
    • 28344436790 scopus 로고    scopus 로고
    • The pathophysiology of graft-versus-host disease
    • Ferrara JLM, Cooke KR, Deeg HJ, eds, New York, NY: Marcel Dekker
    • Ferrara JLM, Cooke KR, Teshima T. The pathophysiology of graft-versus-host disease. In: Ferrara JLM, Cooke KR, Deeg HJ, eds. Graft-Versus-Host-Disease. New York, NY: Marcel Dekker; 2005:1-34.
    • (2005) Graft-Versus-Host-Disease , pp. 1-34
    • Ferrara, J.L.M.1    Cooke, K.R.2    Teshima, T.3
  • 4
    • 4644305627 scopus 로고    scopus 로고
    • Murine models for graft-versus-host disease
    • Blume KG, Forman SJ, Appelbaum FR, eds, Boston, MA: Blackwell Scientific Publications
    • Korngold R, Friedman TM. Murine models for graft-versus-host disease. In: Blume KG, Forman SJ, Appelbaum FR, eds. Thomas's Hematopoietic Cell Transplantation. Boston, MA: Blackwell Scientific Publications; 2004:353-368.
    • (2004) Thomas's Hematopoietic Cell. Transplantation , pp. 353-368
    • Korngold, R.1    Friedman, T.M.2
  • 5
    • 0025100777 scopus 로고
    • Graft-versus-leukemia reactions after bone marrow transplantation
    • Horowitz MM, Gale RP, Sondel PM, et al. Graft-versus-leukemia reactions after bone marrow transplantation. Blood. 1990;75:555-562.
    • (1990) Blood , vol.75 , pp. 555-562
    • Horowitz, M.M.1    Gale, R.P.2    Sondel, P.M.3
  • 6
    • 73349118783 scopus 로고    scopus 로고
    • Acute graft-versus-host disease: From the bench to the bedside
    • Socie G, Blazar BR. Acute graft-versus-host disease: from the bench to the bedside. Blood. 2009;114:4327-4336.
    • (2009) Blood , vol.114 , pp. 4327-4336
    • Socie, G.1    Blazar, B.R.2
  • 7
    • 34247573902 scopus 로고    scopus 로고
    • Graft-versus-host disease
    • Shlomchik WD. Graft-versus-host disease. Nat Rev Immunol. 2007;7:340-352.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 340-352
    • Shlomchik, W.D.1
  • 8
    • 39649089195 scopus 로고    scopus 로고
    • Preemptive HMG-CoA reductase inhibition provides graft-versus-host disease protection by Th-2 polarization while sparing graft-versus-leukemia activity
    • Zeiser R, Youssef S, Baker J, et al. Preemptive HMG-CoA reductase inhibition provides graft-versus-host disease protection by Th-2 polarization while sparing graft-versus-leukemia activity. Blood. 2007;110:4588-4598.
    • (2007) Blood , vol.110 , pp. 4588-4598
    • Zeiser, R.1    Youssef, S.2    Baker, J.3
  • 9
    • 70350571793 scopus 로고    scopus 로고
    • Blocking LFA-1 activation with lovastatin prevents graft-versus-host disease in mouse bone marrow transplantation
    • Wang Y, Li D, Jones D, et al. Blocking LFA-1 activation with lovastatin prevents graft-versus-host disease in mouse bone marrow transplantation. Biol Blood Marrow Transplant. 2009;15:1513-1522.
    • (2009) Biol. Blood Marrow Transplant , vol.15 , pp. 1513-1522
    • Wang, Y.1    Li, D.2    Jones, D.3
  • 10
    • 77949500938 scopus 로고    scopus 로고
    • Donor statin treatment protects against severe acute graft-versus-host disease after related allogeneic hematopoietic cell transplantation
    • Rotta M, Storer BE, Storb RF, et al. Donor statin treatment protects against severe acute graft-versus-host disease after related allogeneic hematopoietic cell transplantation. Blood. 2010;115:1288-1295.
    • (2010) Blood , vol.115 , pp. 1288-1295
    • Rotta, M.1    Storer, B.E.2    Storb, R.F.3
  • 11
    • 0035902080 scopus 로고    scopus 로고
    • Progress in human tumour immunology and immunotherapy
    • Rosenberg SA. Progress in human tumour immunology and immunotherapy. Nature. 2001;411:380-384.
    • (2001) Nature , vol.411 , pp. 380-384
    • Rosenberg, S.A.1
  • 12
    • 0036593490 scopus 로고    scopus 로고
    • Modulating T-cell immunity to tumours: New strategies for monitoring T-cell responses
    • Yee C, Greenberg P. Modulating T-cell immunity to tumours: new strategies for monitoring T-cell responses. Nat Rev Cancer. 2002;2:409-419.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 409-419
    • Yee, C.1    Greenberg, P.2
  • 13
    • 0036805674 scopus 로고    scopus 로고
    • Statins as anti-inflammatory agents
    • Weitz-Schmidt G. Statins as anti-inflammatory agents. Trends Pharmacol Sci. 2002;23:482-486.
    • (2002) Trends Pharmacol. Sci. , vol.23 , pp. 482-486
    • Weitz-Schmidt, G.1
  • 14
    • 0035829849 scopus 로고    scopus 로고
    • Locking a leukocyte integrin with statins
    • Frenette PS. Locking a leukocyte integrin with statins. N Engl J Med. 2001;345:1419-1421.
    • (2001) N. Engl. J. Med. , vol.345 , pp. 1419-1421
    • Frenette, P.S.1
  • 15
    • 55549106484 scopus 로고    scopus 로고
    • Graft-versus-host disease: Suppression by statins
    • Broady R, Levings MK. Graft-versus-host disease: suppression by statins. Nat Med. 2008;14:1155-1156.
    • (2008) Nat. Med. , vol.14 , pp. 1155-1156
    • Broady, R.1    Levings, M.K.2
  • 16
    • 0034948339 scopus 로고    scopus 로고
    • Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site
    • Weitz-Schmidt G, Welzenbach K, Brinkmann V, et al. Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site. Nat Med. 2001;7:687-692.
    • (2001) Nat. Med. , vol.7 , pp. 687-692
    • Weitz-Schmidt, G.1    Welzenbach, K.2    Brinkmann, V.3
  • 17
    • 18244370299 scopus 로고    scopus 로고
    • Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immuno-regulatory epitope to a small molecule
    • Gadek TR, Burdick DJ, McDowell RS, et al. Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immuno-regulatory epitope to a small molecule. Science. 2002;295:1086-1089.
    • (2002) Science , vol.295 , pp. 1086-1089
    • Gadek, T.R.1    Burdick, D.J.2    McDowell, R.S.3
  • 18
    • 0027982876 scopus 로고
    • Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
    • Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell. 1994;76:301-314.
    • (1994) Cell. , vol.76 , pp. 301-314
    • Springer, T.A.1
  • 19
    • 0038240981 scopus 로고    scopus 로고
    • Coordination of T-cell activation and migration through formation of the immunological synapse
    • Dustin ML. Coordination of T-cell activation and migration through formation of the immunological synapse. Ann N y Acad Sci. 2003;987:51-59.
    • (2003) Ann. N. Y Acad. Sci. , vol.987 , pp. 51-59
    • Dustin, M.L.1
  • 21
    • 0038079490 scopus 로고    scopus 로고
    • Structural biology. Changing partners
    • Hynes RO. Structural biology. Changing partners. Science. 2003;300:755-756.
    • (2003) Science , vol.300 , pp. 755-756
    • Hynes, R.O.1
  • 22
    • 0037155910 scopus 로고    scopus 로고
    • Activation-induced conformational changes in the I domain region of lymphocyte function-associated antigen 1
    • Ma Q, Shimaoka M, Lu C, et al. Activation-induced conformational changes in the I domain region of lymphocyte function-associated antigen 1. J Biol Chem. 2002;277:10638-10641.
    • (2002) J. Biol. Chem. , vol.277 , pp. 10638-10641
    • Ma, Q.1    Shimaoka, M.2    Lu, C.3
  • 23
    • 67649814709 scopus 로고    scopus 로고
    • LFA-1 affinity regulation is necessary for the activation and proliferation of naive T cells
    • Wang Y, Li D, Nurieva R, et al. LFA-1 affinity regulation is necessary for the activation and proliferation of naive T cells. J Biol Chem. 2009;284:12645-12653.
    • (2009) J. Biol. Chem. , vol.284 , pp. 12645-12653
    • Wang, Y.1    Li, D.2    Nurieva, R.3
  • 24
    • 68949085309 scopus 로고    scopus 로고
    • +T-cell activation via T-cell receptor-mediated and LFA-1-mediated Erk1/2 signal pathways
    • +T-cell activation via T-cell receptor-mediated and LFA-1-mediated Erk1/2 signal pathways. J Biol Chem. 2009;284:21001-21010.
    • (2009) J. Biol. Chem. , vol.284 , pp. 21001-21010
    • Li, D.1    Molldrem, J.J.2    Ma, Q.3
  • 25
    • 71249109305 scopus 로고    scopus 로고
    • Co-engagement of alpha (4) beta (1) integrin (VLA-4) and CD4 or CD8 is necessary to induce maximal Erk1/2 phosphorylation and cytokine production in human T cells
    • Kim TK, Billard MJ, Wieder ED, et al. Co-engagement of alpha (4) beta (1) integrin (VLA-4) and CD4 or CD8 is necessary to induce maximal Erk1/2 phosphorylation and cytokine production in human T cells. Hum Immunol. 2010;71 23-28.
    • (2010) Hum. Immunol. , vol.71 , pp. 23-28
    • Kim, T.K.1    Billard, M.J.2    Wieder, E.D.3
  • 26
    • 33749514632 scopus 로고    scopus 로고
    • Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals
    • Leen AM, Myers GD, Sili U, et al. Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals. Nat Med. 2006;12:1160-1166.
    • (2006) Nat. Med. , vol.12 , pp. 1160-1166
    • Leen, A.M.1    Myers, G.D.2    Sili, U.3
  • 27
    • 35549008976 scopus 로고    scopus 로고
    • Complete responses of relapsed lymphoma following genetic modification of tumor-antigen presenting cells and T-lymphocyte transfer
    • Bollard CM, Gottschalk S, Leen AM, et al. Complete responses of relapsed lymphoma following genetic modification of tumor-antigen presenting cells and T-lymphocyte transfer. Blood. 2007;110:2838-2845.
    • (2007) Blood , vol.110 , pp. 2838-2845
    • Bollard, C.M.1    Gottschalk, S.2    Leen, A.M.3
  • 28
    • 24344469675 scopus 로고    scopus 로고
    • A sensitive flow cytometry-based cytotoxic T-lymphocyte assay through detection of cleaved caspase 3 in target cells
    • He L, Hakimi J, Salha D, et al. A sensitive flow cytometry-based cytotoxic T-lymphocyte assay through detection of cleaved caspase 3 in target cells. J Immunol Methods. 2005;304:43-59.
    • (2005) J. Immunol. Methods , vol.304 , pp. 43-59
    • He, L.1    Hakimi, J.2    Salha, D.3
  • 29
    • 73949086540 scopus 로고    scopus 로고
    • MART-1-specific melanoma tumor-infiltrating lymphocytes maintaining CD28 expression have improved survival and expansion capability following antigenic restimulation in vitro
    • Li Y, Liu S, Hernandez J, et al. MART-1-specific melanoma tumor-infiltrating lymphocytes maintaining CD28 expression have improved survival and expansion capability following antigenic restimulation in vitro. J Immunol. 2010;184:452-465.
    • (2010) J. Immunol. , vol.184 , pp. 452-465
    • Li, Y.1    Liu, S.2    Hernandez, J.3
  • 30
    • 0034606276 scopus 로고    scopus 로고
    • Melanocyte destruction after antigen-specific immunotherapy of melanoma: Direct evidence of T-cell-mediated vitiligo
    • Yee C, Thompson JA, Roche P, et al. Melanocyte destruction after antigen-specific immunotherapy of melanoma: direct evidence of T-cell-mediated vitiligo. J Exp Med. 2000;192:1637-1644.
    • (2000) J. Exp. Med. , vol.192 , pp. 1637-1644
    • Yee, C.1    Thompson, J.A.2    Roche, P.3
  • 32
    • 0030963722 scopus 로고    scopus 로고
    • T-cell therapy of human CMV and EBV infection in immunocompromised hosts
    • Riddell SR, Greenberg PD. T-cell therapy of human CMV and EBV infection in immunocompromised hosts. Rev Med Virol. 1997;7:181-192.
    • (1997) Rev. Med. Virol. , vol.7 , pp. 181-192
    • Riddell, S.R.1    Greenberg, P.D.2
  • 33
    • 43549086236 scopus 로고    scopus 로고
    • The impact of HMG-CoA reductase inhibition on the incidence and severity of graft-versus-host disease in patients with acute leukemia undergoing allogeneic transplantation
    • Hamadani M, Awan FT, Devine SM. The impact of HMG-CoA reductase inhibition on the incidence and severity of graft-versus-host disease in patients with acute leukemia undergoing allogeneic transplantation. Blood. 2008;111:3901-3902.
    • (2008) Blood , vol.111 , pp. 3901-3902
    • Hamadani, M.1    Awan, F.T.2    Devine, S.M.3
  • 34
    • 51649096724 scopus 로고    scopus 로고
    • Statins inhibit human APC function: Implications for the treatment of GVHD
    • Shimabukuro-Vornhagen A, Liebig T, von Bergwelt-Baildon M. Statins inhibit human APC function: implications for the treatment of GVHD. Blood. 2008;112:1544-1545.
    • (2008) Blood , vol.112 , pp. 1544-1545
    • Shimabukuro-Vornhagen, A.1    Liebig, T.2    Von Bergwelt-Baildon, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.