Multiple strategies for the preparation of a sulfur-35 labeled NPC1L1 radioligand

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 17, 2009, Pages 5033-5036

  Simeone, Joseph P ^a   Braun, Matthew P ^a   Leone, Joseph F ^a   Lin, Peter ^a   DeVita, Robert J ^a   Garcia Calvo, Margarita ^a   Bull, Herb G ^a   Lisnock, JeanMarie ^a   Dean, Dennis C ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

NPC1L1; Radioligand; Sulfur 35; Synthesis

Indexed keywords

EZETIMIBE; GLUCURONIDE; NIEMANN PICK C1 LIKE 1 PROTEIN; PROTEIN; RADIOLIGAND; SULFUR 35; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHOLESTEROL TRANSPORT; CONJUGATE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG GLUCURONIDATION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; HUMAN; HUMAN CELL; IC 50; INTESTINE BRUSH BORDER; LIGAND BINDING; LIVER MICROSOME; NONHUMAN; RAT; RECEPTOR AFFINITY; SONOGASHIRA REACTION;

ANIMALS; ANTICHOLESTEREMIC AGENTS; AZETIDINES; CELL LINE; GLUCURONIDES; HUMANS; LIGANDS; MEMBRANE PROTEINS; MICE; PROTEIN BINDING; RATS; RECOMBINANT PROTEINS; SULFUR RADIOISOTOPES;

EID: 68349127059     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.07.051     Document Type: Article

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