Spiroimidazolidinone NPC1L1 inhibitors. 1: Discovery by 3D-similarity-based virtual screening

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 11, 2009, Pages 2965-2968

  McMasters, Daniel R ^a   Garcia Calvo, Margarita ^a   Maiorov, Vladimir ^a   McCann, Margaret E ^a   Meurer, Roger D ^a   Bull, Herbert G ^a   Lisnock, JeanMarie ^a   Howell, Kobporn L ^a   DeVita, Robert J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Cholesterol absorption inhibitors; Molecular modeling; NPC1L1 inhibitors; Superposition; Virtual screening

Indexed keywords

IMIDAZOLE DERIVATIVE; PROTEIN INHIBITOR;

ARTICLE; BINDING ASSAY; IC 50; SCREENING; THREE DIMENSIONAL IMAGING;

ANIMALS; ANTICHOLESTEREMIC AGENTS; CRICETINAE; DOGS; DRUG DESIGN; GUINEA PIGS; HUMANS; IMIDAZOLIDINES; MACACA MULATTA; MEMBRANE PROTEINS; MODELS, CHEMICAL; MOLECULAR CONFORMATION; RATS; SOFTWARE; SPIRO COMPOUNDS; SWINE;

EID: 65149099897     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.04.031     Document Type: Article

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