-
1
-
-
0036561908
-
Modelling the molecular circuitry of cancer
-
Hahn, W.C. et al. (2002) Modelling the molecular circuitry of cancer. Nat. Rev. Cancer, 2, 331-341.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 331-341
-
-
Hahn, W.C.1
-
2
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan, D. et al. (2000) The hallmarks of cancer. Cell, 100, 57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
-
3
-
-
58149171661
-
The ING gene family in the regulation of cell growth and tumorigenesis
-
Coles, A.H. et al. (2009) The ING gene family in the regulation of cell growth and tumorigenesis. J. Cell. Physiol., 218, 45-57.
-
(2009)
J. Cell. Physiol.
, vol.218
, pp. 45-57
-
-
Coles, A.H.1
-
4
-
-
3142642621
-
2/M cell cycle arrest and enhances the chemosensitivity to DNA-damage agents in HepG2 cells
-
2/M cell cycle arrest and enhances the chemosensitivity to DNA-damage agents in HepG2 cells. FEBS Lett., 570, 7-12.
-
(2004)
FEBS Lett.
, vol.570
, pp. 7-12
-
-
Zhang, X.1
-
5
-
-
9244239717
-
A screen for genes that suppress loss of contact inhibition: identification of ING4 as a candidate tumor suppressor gene in human cancer
-
Kim, S. et al. (2004) A screen for genes that suppress loss of contact inhibition: identification of ING4 as a candidate tumor suppressor gene in human cancer. Proc. Natl Acad. Sci. USA, 101, 16251-16256.
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 16251-16256
-
-
Kim, S.1
-
6
-
-
39649104151
-
The new tumor-suppressor gene inhibitor of growth family member 4 (ING4) regulates the production of proangiogenic molecules by myeloma cells and suppresses hypoxia-inducible factor-1 alpha (HIF-1alpha) activity: involvement in myeloma-induced angiogenesis
-
Colla, S. et al. (2007) The new tumor-suppressor gene inhibitor of growth family member 4 (ING4) regulates the production of proangiogenic molecules by myeloma cells and suppresses hypoxia-inducible factor-1 alpha (HIF-1alpha) activity: involvement in myeloma-induced angiogenesis. Blood, 110, 4464-4475.
-
(2007)
Blood
, vol.110
, pp. 4464-4475
-
-
Colla, S.1
-
7
-
-
1642586297
-
The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis
-
Garkavtsev, I. et al. (2004) The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis. Nature, 428, 328-332.
-
(2004)
Nature
, vol.428
, pp. 328-332
-
-
Garkavtsev, I.1
-
8
-
-
43149122240
-
ING4 induces cell growth inhibition in human lung adenocarcinoma A549 cells by means of Wnt-1/B-catenin signaling pathway
-
Li, X. et al. (2008) ING4 induces cell growth inhibition in human lung adenocarcinoma A549 cells by means of Wnt-1/B-catenin signaling pathway. Anat. Rec., 291, 593-600.
-
(2008)
Anat. Rec.
, vol.291
, pp. 593-600
-
-
Li, X.1
-
9
-
-
34047273596
-
Inhibitor of growth 4 suppresses cell spreading and cell migration by interacting with a novel binding partner, liprin alpha1
-
Shen, J.C. et al. (2007) Inhibitor of growth 4 suppresses cell spreading and cell migration by interacting with a novel binding partner, liprin alpha1. Cancer Res., 67, 2552-2558.
-
(2007)
Cancer Res.
, vol.67
, pp. 2552-2558
-
-
Shen, J.C.1
-
10
-
-
25444517925
-
Regulation of HIF by prolyl hydroxylases: recruitment of the candidate tumor suppressor protein ING4
-
Ozer, A. et al. (2005) Regulation of HIF by prolyl hydroxylases: recruitment of the candidate tumor suppressor protein ING4. Cell Cycle, 4, 1153-1156.
-
(2005)
Cell Cycle
, vol.4
, pp. 1153-1156
-
-
Ozer, A.1
-
11
-
-
19644376763
-
The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF)
-
Ozer, A. et al. (2005) The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF). Proc. Natl Acad. Sci. USA, 102, 7481-7486.
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 7481-7486
-
-
Ozer, A.1
-
12
-
-
58649102691
-
ING4 mediates crosstalk between histone H3 K4 trimethylation and H3 acetylation to attenuate cellular transformation
-
Hung, T. et al. (2009) ING4 mediates crosstalk between histone H3 K4 trimethylation and H3 acetylation to attenuate cellular transformation. Mol. Cell, 33, 248-256.
-
(2009)
Mol. Cell.
, vol.33
, pp. 248-256
-
-
Hung, T.1
-
13
-
-
47049087662
-
Molecular basis of histone H3K4me3 recognition by ING4
-
Palacios, A. et al. (2008) Molecular basis of histone H3K4me3 recognition by ING4. J. Biol. Chem., 283, 15956-15964.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 15956-15964
-
-
Palacios, A.1
-
14
-
-
33745818717
-
Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2
-
Pena, P.V. et al. (2006) Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2. Nature, 442, 100-103.
-
(2006)
Nature
, vol.442
, pp. 100-103
-
-
Pena, P.V.1
-
15
-
-
33745868054
-
ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression
-
Shi, X. et al. (2006) ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Nature, 442, 96-99.
-
(2006)
Nature
, vol.442
, pp. 96-99
-
-
Shi, X.1
-
16
-
-
29544444195
-
ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation
-
Doyon, Y. et al. (2006) ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Mol. Cell, 21, 51-64.
-
(2006)
Mol. Cell.
, vol.21
, pp. 51-64
-
-
Doyon, Y.1
-
17
-
-
55449102824
-
The ING4 tumor suppressor attenuates NF-kappaB activity at the promoters of target genes
-
Nozell, S. et al. (2008) The ING4 tumor suppressor attenuates NF-kappaB activity at the promoters of target genes. Mol. Cell. Biol., 28, 6632-6645.
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 6632-6645
-
-
Nozell, S.1
-
18
-
-
37549064391
-
Hbo1 Links p53-dependent stress signaling to DNA replication licensing
-
Iizuka, M. et al. (2008) Hbo1 Links p53-dependent stress signaling to DNA replication licensing. Mol. Cell. Biol., 28, 140-153.
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 140-153
-
-
Iizuka, M.1
-
19
-
-
0038520190
-
p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity
-
Shiseki, M. et al. (2003) p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity. Cancer Res., 63, 2373-2378.
-
(2003)
Cancer Res.
, vol.63
, pp. 2373-2378
-
-
Shiseki, M.1
-
20
-
-
18844368509
-
Nuclear localization signal of ING4 plays a key role in its binding to p53
-
Zhang, X. (2005) Nuclear localization signal of ING4 plays a key role in its binding to p53. Biochem. Biophys. Res. Commun., 331, 1032-1038.
-
(2005)
Biochem. Biophys. Res. Commun.
, vol.331
, pp. 1032-1038
-
-
Zhang, X.1
-
21
-
-
23844441255
-
Frequent deletion and down-regulation of ING4, a candidate tumor suppresor gene at 12p13, in head and neck squamous cell carcinomas
-
Gunduz, M. et al. (2005) Frequent deletion and down-regulation of ING4, a candidate tumor suppresor gene at 12p13, in head and neck squamous cell carcinomas. Gene, 356, 109-117.
-
(2005)
Gene
, vol.356
, pp. 109-117
-
-
Gunduz, M.1
-
22
-
-
34547790389
-
Detection of novel mRNA splice variants of human ING4 tumor suppressor gene
-
Raho, G. et al. (2007) Detection of novel mRNA splice variants of human ING4 tumor suppressor gene. Oncogene, 26, 5247-5257.
-
(2007)
Oncogene
, vol.26
, pp. 5247-5257
-
-
Raho, G.1
-
23
-
-
68849123129
-
Reduced expression and novel splice variants of ING4 in human gastric adenocarcinoma
-
Li, M. et al. (2009) Reduced expression and novel splice variants of ING4 in human gastric adenocarcinoma. J. Pathol., 219, 87-95.
-
(2009)
J. Pathol.
, vol.219
, pp. 87-95
-
-
Li, M.1
-
24
-
-
33845938807
-
Novel splice variants of ING4 and their possible roles in the regulation of cell growth and motility
-
Unoki, M. et al. (2006) Novel splice variants of ING4 and their possible roles in the regulation of cell growth and motility. J. Biol. Chem., 281, 34677-34686.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 34677-34686
-
-
Unoki, M.1
-
25
-
-
0034980666
-
Induction of senescence by oncogenic Ras
-
Palmero, I. et al. (2001) Induction of senescence by oncogenic Ras. Methods Enzymol., 333, 247-256.
-
(2001)
Methods Enzymol
, vol.333
, pp. 247-256
-
-
Palmero, I.1
-
26
-
-
11144278644
-
Growth inhibition by the tumor suppressor p33ING1 in immortalized and primary cells: involvement of two silencing domains and effect of Ras
-
Goeman, F. et al. (2005) Growth inhibition by the tumor suppressor p33ING1 in immortalized and primary cells: involvement of two silencing domains and effect of Ras. Mol. Cell. Biol., 25, 422-431.
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 422-431
-
-
Goeman, F.1
-
27
-
-
85047699497
-
Activation of ARF by oncogenic stress in mouse fibroblasts is independent of E2F1 and E2F2
-
Palmero, I. et al. (2002) Activation of ARF by oncogenic stress in mouse fibroblasts is independent of E2F1 and E2F2. Oncogene, 21, 2939-2947.
-
(2002)
Oncogene
, vol.21
, pp. 2939-2947
-
-
Palmero, I.1
-
28
-
-
33747821383
-
A functional link between the tumour suppressors ARF and p33ING1
-
Gonzalez, L. et al. (2006) A functional link between the tumour suppressors ARF and p33ING1. Oncogene, 25, 5173-5179.
-
(2006)
Oncogene
, vol.25
, pp. 5173-5179
-
-
Gonzalez, L.1
-
29
-
-
25444523243
-
HuntING4 new tumor suppressors
-
Kim, S. (2005) HuntING4 new tumor suppressors. Cell Cycle, 4, 516-517.
-
(2005)
Cell Cycle
, vol.4
, pp. 516-517
-
-
Kim, S.1
-
30
-
-
49349105425
-
Role of ING4 in human melanoma cell migration, invasion, and patient survival
-
Li, J. et al. (2008) Role of ING4 in human melanoma cell migration, invasion, and patient survival. Carcinogenesis, 29, 1373-1379.
-
(2008)
Carcinogenesis
, vol.29
, pp. 1373-1379
-
-
Li, J.1
-
31
-
-
53049089584
-
Adenovirus-mediated ING4 expression suppresses lung carcinoma cell growth via induction of cell cycle alteration and apoptosis and inhibition of tumor invasion and angiogenesis
-
Xie, Y. et al. (2008) Adenovirus-mediated ING4 expression suppresses lung carcinoma cell growth via induction of cell cycle alteration and apoptosis and inhibition of tumor invasion and angiogenesis. Cancer Lett., 271, 105-116.
-
(2008)
Cancer Lett.
, vol.271
, pp. 105-116
-
-
Xie, Y.1
-
32
-
-
33845384201
-
Solution structure and NMR characterization of the binding to methylated histone tails of the plant homeodomain finger of the tumour suppressor ING4
-
Palacios, A. et al. (2006) Solution structure and NMR characterization of the binding to methylated histone tails of the plant homeodomain finger of the tumour suppressor ING4. FEBS Lett., 580, 6903-6908.
-
(2006)
FEBS Lett.
, vol.580
, pp. 6903-6908
-
-
Palacios, A.1
-
33
-
-
0038784526
-
The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor
-
Gozani, O. et al. (2003) The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell, 114, 99-111.
-
(2003)
Cell
, vol.114
, pp. 99-111
-
-
Gozani, O.1
-
34
-
-
54849361700
-
Two wobble splicing events affect ING4 protein subnuclear localization and degradation
-
Tsai, K. et al. (2008) Two wobble splicing events affect ING4 protein subnuclear localization and degradation. Exp. Cell Res., 314, 3130-3141.
-
(2008)
Exp. Cell Res.
, vol.314
, pp. 3130-3141
-
-
Tsai, K.1
-
35
-
-
44949115881
-
Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressor
-
Pena, P.V. et al. (2008) Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressor. J. Mol. Biol., 380, 303-312.
-
(2008)
J. Mol. Biol.
, vol.380
, pp. 303-312
-
-
Pena, P.V.1
-
36
-
-
35948930995
-
Phosphorylation of the tumor suppressor p33(ING1b) at Ser-126 influences its protein stability and proliferation of melanoma cells
-
Garate, M. et al. (2007) Phosphorylation of the tumor suppressor p33(ING1b) at Ser-126 influences its protein stability and proliferation of melanoma cells. FASEB J., 21, 3705-3716.
-
(2007)
FASEB J.
, vol.21
, pp. 3705-3716
-
-
Garate, M.1
-
37
-
-
9744281543
-
Mutations of the ING1 tumor suppressor gene detected in human melanoma abrogate nucleotide excision repair
-
Campos, E.I. et al. (2004) Mutations of the ING1 tumor suppressor gene detected in human melanoma abrogate nucleotide excision repair. Int. J. Oncol., 25, 73-80.
-
(2004)
Int. J. Oncol.
, vol.25
, pp. 73-80
-
-
Campos, E.I.1
-
38
-
-
77949423402
-
The tumor suppressor ING3 is degraded by SCF(Skp2)-mediated ubiquitin-proteasome system
-
Chen, G. et al. (2010) The tumor suppressor ING3 is degraded by SCF(Skp2)-mediated ubiquitin-proteasome system. Oncogene, 29, 1498-1508.
-
(2010)
Oncogene
, vol.29
, pp. 1498-1508
-
-
Chen, G.1
-
39
-
-
77954174209
-
HECT ubiquitin ligase Smurf1 targets the tumor suppressor ING2 for ubiquitination and degradation
-
Nie, J. et al. (2010) HECT ubiquitin ligase Smurf1 targets the tumor suppressor ING2 for ubiquitination and degradation. FEBS Lett., 584, 3005-3012.
-
(2010)
FEBS Lett.
, vol.584
, pp. 3005-3012
-
-
Nie, J.1
-
40
-
-
59549089745
-
Inhibitor of growth 4 is involved in melanomagenesis and induces growth suppression and apoptosis in melanoma cell line M14
-
Cai, L. et al. (2009) Inhibitor of growth 4 is involved in melanomagenesis and induces growth suppression and apoptosis in melanoma cell line M14. Melanoma Res., 19, 1-7.
-
(2009)
Melanoma Res.
, vol.19
, pp. 1-7
-
-
Cai, L.1
-
41
-
-
60549094969
-
Decreased expression of inhibitor of growth 4 correlated with poor prognosis of hepatocellular carcinoma
-
Fang, F. et al. (2009) Decreased expression of inhibitor of growth 4 correlated with poor prognosis of hepatocellular carcinoma. Cancer Epidemiol. Biomarkers Prev., 18, 409-416.
-
(2009)
Cancer Epidemiol. Biomarkers Prev.
, vol.18
, pp. 409-416
-
-
Fang, F.1
-
42
-
-
77953766708
-
A dominant mutant allele of the ING4 tumor suppressor found in human cancer cells exacerbates MYC-initiated mouse mammary tumorigenesis
-
Kim, S. et al. (2010) A dominant mutant allele of the ING4 tumor suppressor found in human cancer cells exacerbates MYC-initiated mouse mammary tumorigenesis. Cancer Res., 70, 5155-5162.
-
(2010)
Cancer Res.
, vol.70
, pp. 5155-5162
-
-
Kim, S.1
|