Regulation of HIF by prolyl hydroxylases: Recruitment of the candidate tumor suppressor protein ING4

Cell Cycle

Volumn 4, Issue 9, 2005, Pages 1153-1156

  Ozer, Abdullah ^a   Bruick, Richard K ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

HIF; Hypoxia; ING4; Prolyl hydroxylase; Tumor suppressor

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROTEIN ING 4; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

CELL ACTIVITY; CELL HYPOXIA; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME STABILITY; GENE TARGETING; HUMAN; NONHUMAN; PROTEIN FUNCTION; REVIEW; TRANSCRIPTION INITIATION;

EID: 25444517925     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.4.9.2040     Document Type: Review

References (27)

1. Semenza GL. HIF-1 and human disease: One highly involved factor. Genes and Dev 2000; 14:1983-91.
2. Bruick RK. Oxygen sensing in the hypoxic response pathway: Regulation of the hypoxia-inducible transcription factor. Genes and Dev 2003; 17:2614-23.
3. Kaelin WGJ. Proline hydroxylation and gene expression. Annu Rev Biochem 2005; 74:115-28.
4. Hirsila M, Koivunen P, Gunzler V, Kivirikko KI, Myllyharju J. Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor HIF. J Biol Chem 2003; 278:30772-80.
5. Schroedl C, McClintock DS, Budinger GRS, Chandel NS. Hypoxic but not anoxic stabilization of HIF-1 requires mitochondrial reactive oxygen species. Am J Physiol Lung Cell Mol Physiol 2002; 283:L922-31.
6. Chan DA, Sutphin PD, Denko NC, Giaccia AJ. Role of prolyl hydroxylation in oncogenically stabilized Hypoxia-inducible Factor-1α. J Biol Chem 2002; 277:40112-7.
7. Temes E, Martin-Puig S, Acosta-Iborra B, Castellanos MC, Feijoo-Cuaresma M, Olmos G, Aragones J, Landazuri MO. Activation of HIF-prolyl hydroxylases by R59949, an inhibitor of the diacylglycerol kinase. J Biol Chem 2005; 280:24238-44.
8. Baek JH, Mahon PC, Oh J, Kelly B, Krishnamachary B, Pearson M, Chan DA, Giaccia AJ, Semenza GL. OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha. Mol Cell 2005; 17:503-12.
9. D'Angelo G, Duplan E, Boyer N, Vigne P, Frelin C. Hypoxia up regulates prolyl hydroxylase. A feedback mechanism that limits HIF-1 responses during reoxygenation. J Biol Chem 2003; 278:38183-7.
10. Nakayama K, Frew IJ, Hagensen M, Skals M, Habelhah H, Bhoumik A, Kadoya T, Erdjument-Bromage H, Tempst P, Frappell PB, Bowtell DD, Ronai Z. Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia. Cell 2004; 117:941-52.
11. Ozer A, Wu LC, Bruick RK. The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF). Proc Natl Acad Sci USA 2005; 102:7481-6.
12. Campos EI, Chin MY, Kuo WH, Li G. Biological functions of the ING family tumor suppressors. Cell Mol Life Sci 2004; 61:2597-613.
13. Feng X, Hara Y, Riabowol K. Different HATS of the ING1 gene family. Trends Cell Biol 2002; 12:532-8.
14. Aasland R, Gibson TJ, Stewart AF. The PHD finger: Implications for chromatin-mediated transcriptional regulation. Trends Biochem Sci 1995; 20:56-9.
15. Shiseki M, Nagashima M, Pedeux RM, Kitahama-Shiseki M, Miura K, Okamura S, Onogi H, Higashimoto Y, Appella E, Yokota J, Harris CC. p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity. Cancer Res 2003; 63:2373-8.
16. 2/M cell cycle arrest and enhances the chemosensitivity to DNA-damage agents in HepG2 cells. FEBS Lett 2004; 570:7-12.
17. Garkavtsev I, Kozin SV, Chernova O, Xu L, Winkler F, Brown E, Barnett GH, Jain RK. The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis. Nature 2004; 428:328-32.
18. Kim S, Chin K, Gray JW, Bishop JM. A screen for genes that suppress loss of contact inhibition: Identification of ING4 as a candidate tumor suppressor gene in human cancer. Proc Natl Acad Sci USA 2004; 101:16251-6.
19. Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003; 3:721-32.
20. Metzen E, Berchner-Pfannschmidt U, Stengel P, Marxsen JH, Stolze I, Klinger M, Huang WQ, Wotzlaw C, Hellwig-Burgel T, Jelkmann W, Acker H, Fandrey J. Intracellular localization of human HIF-1 alpha hydroxylases: Implications for oxygen sensing. J Cell Sci 2003; 116:1319-26.
21. Jiang BH, Zheng JZ, Leung SW, Roe R, Semenza GL. Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity. J Biol Chem 1997; 272:19253-60.
22. Pugh CW, O'Rourke JF, Nagao M, Gleadle JM, Ratcliffe PJ. Activation of hypoxia-inducible factor-1; definition of regulatory domains within the alpha subunit. J Biol Chem 1997; 272:11205-14.
23. Doyon Y, Selleck W, Lane WS, Tan S, Cote J. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Mol Cell Biol 2004; 24:1884-96.
24. Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D. Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1). Mol Cell Biol 2002; 22:835-48.
25. Hochachka PW. The metabolic implications of intracellular circulation. Proc Natl Acad Sci USA 1999; 96:12233-9.
26. Kuznetsova AV, Meller J, Schnell PO, Nash JA, Ignacak ML, Sanchez Y, Conaway JW, Conaway RC, Czyzyk-Krzeska MF. von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination. Proc Natl Acad Sci USA 2003; 100:2706-11.
27. Frei C, Edgar BA. Drosophila cyclin D/Cdk4 requires Hif-1 prolyl hydroxylase to drive cell growth. Dev Cell 2004; 6:241-51.