Nuclear localization signal of ING4 plays a key role in its binding to p53

Biochemical and Biophysical Research Communications

Volumn 331, Issue 4, 2005, Pages 1032-1038

  Zhang, Xin ^a,b   Wang, Ke Sheng ^b   Wang, Zhi Qin ^b   Xu, Lu Sheng ^b   Wang, Qing Wan ^b   Chen, Fei ^b   Wei, Dong Zhi ^a   Han, Ze Guang ^b  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b CHINESE NATIONAL HUMAN GENOME CENTER AT SHANGHAI   (China)

Author keywords

ING4; Nuclear localization signal; p21; p53; Protein protein interaction; Subcellular localization; Transcriptional activity

Indexed keywords

GLUTATHIONE TRANSFERASE; INHIBITOR OF GROWTH 4 PROTEIN; PROTEIN INHIBITOR; PROTEIN P21; PROTEIN P53; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GENE DELETION; GENE MUTATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION;

AMINO ACID SEQUENCE; CELL CYCLE PROTEINS; CELL LINE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HOMEODOMAIN PROTEINS; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEAR LOCALIZATION SIGNALS; PROTEIN BINDING; SEQUENCE HOMOLOGY, AMINO ACID; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

MINK CELL FOCUS-FORMING VIRUS;

EID: 18844368509     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.04.023     Document Type: Article

References (28)

1. I. Garkavtsev, I.A. Grigorian, V.S. Ossovskaya, M.V. Chernov, P.M. Chumakov, and A.V. Gudkov The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control Nature 391 1998 295 298
2. C.C. Helbing, C. Veillette, K. Riabowol, R.N. Johnston, and I. Garkavtsev A novel candidate tumor suppressor, ING1, is involved in the regulation of apoptosis Cancer Res. 57 1997 1255 1258
3. M. Nagashima, M. Shiseki, K. Miura, K. Hagiwara, S.P. Linke, R. Pedeux, X.W. Wang, J. Yokota, K. Riabowol, and C.C. Harris DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53 Proc. Natl. Acad. Sci. USA 98 2001 9671 9676
4. I. Garkavtsev, A. Kazarov, A. Gudkov, and K. Riabowol Suppression of the novel growth inhibitor p33ING1 promotes neoplastic transformation Nat. Genet. 14 1996 415 420
5. L. Chen, N. Matsubara, T. Yoshino, T. Nagasaka, N. Hoshizima, Y. Shirakawa, Y. Naomoto, H. Isozaki, K. Riabowol, and N. Tanaka Genetic alterations of candidate tumor suppressor ING1 in human esophageal squamous cell cancer Cancer Res. 61 2001 4345 4349
6. T. Toyama, H. Iwase, P. Watson, H. Muzik, E. Saettler, A. Magliocco, L. DiFrancesco, P. Forsyth, I. Garkavtsev, S. Kobayashi, and K. Riabowol Suppression of ING1 expression in sporadic breast cancer Oncogene. 18 1999 5187 5193
7. M. Ohmori, M. Nagai, T. Tasaka, H.P. Koeffler, T. Toyama, K. Riabowol, and J. Takahara Decreased expression of p33ING1 mRNA in lymphoid malignancies Am. J. Hematol. 62 1999 118 119
8. E. Oki, Y. Maehara, E. Tokunaga, Y. Kakeji, and K. Sugimachi Reduced expression of p33(ING1) and the relationship with p53 expression in human gastric cancer Cancer Lett. 147 1999 157 162
9. T. Ohgi, T. Masaki, S. Nakai, A. Morishita, S. Yukimasa, M. Nagai, Y. Miyauchi, T. Funaki, K. Kurokohchi, S. Watanabe, and S. Kuriyama Expression of p33(ING1) in hepatocellular carcinoma: relationships to tumour differentiation and cyclin E kinase activity Scand. J. Gastroenterol. 37 2002 1148 1440
10. M. Gunduz, M. Ouchida, K. Fukushima, H. Hanafusa, T. Etani, S. Nishioka, K. Nishizaki, and K. Shimizu Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas Cancer Res. 60 2000 3143 3146
11. B. Chen, E.I. Campos, R. Crawford, M. Martinka, and G. Li Analyses of the tumour suppressor ING1 expression and gene mutation in human basal cell carcinoma Int. J. Oncol. 22 2003 927 931
12. Y. Hara, Z. Zheng, S.C. Evans, D. Malatjalian, D.C. Riddell, D.L. Guernsey, L.D. Wang, K. Riabowol, and A.G. Casson ING1 and p53 tumor suppressor gene alterations in adenocarcinomas of the esophagogastric junction Cancer Lett. 192 2003 109 116
13. M. Gunduz, M. Ouchida, K. Fukushima, S. Ito, Y. Jitsumori, T. Nakashima, N. Nagai, K. Nishizaki, and K. Shimizu Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers Oncogene 21 2002 4462 4470
14. M. Nagashima, M. Shiseki, Pedeux, S. Okamura, M. Kitahama-Shiseki, K. Miura, J. Yokota, and C.C. Harris A novel PHD-finger motif protein, p47ING3, modulates p53-mediated transcription, cell cycle control, and apoptosis Oncogene 22 2003 343 350
15. R.M. Hu, Z.G. Han, H.D. Song, Y.D. Peng, Q.H. Huang, S.X. Ren, Y.J. Gu, C.H. Huang, Y.B. Li, C.L. Jiang, G. Fu, Q.H. Zhang, B.W. Gu, M. Dai, Y.F. Mao, G.F. Gao, R. Rong, M. Ye, J. Zhou, S.H. Xu, J. Gu, J.X. Shi, W.R. Jin, C.K. Zhang, T.M. Wu, G.Y. Huang, Z. Chen, M.D. Chen, and J.L. Chen Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning Proc. Natl. Acad. Sci. USA 97 2000 9543 9548
16. M. Shiseki, M. Nagashima, R.M. Pedeux, M. Kitahama-Shiseki, K. Miura, S. Okamura, H. Onogi, Y. Higashimoto, E. Appella, J. Yokota, and C.C. Harris p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity Cancer Res. 63 2003 2373 2378
17. X. Zhang, L.S. Xu, Z.Q. Wang., K.S. Wang, N. Li, Z.H. Cheng, S.Z. Huang, D.Z. Wei, and Z.G. Han ING4 induces G2/M cell cycle arrest and enhances the chemosensitivity to DNA-damage agents in HepG2 cells FEBS Lett. 570 2004 7 12
18. I. Garkavtsev, S.V. Kozin, O. Chernova, L. Xu, F. Winkler, E. Brown, G.H. Barnett, and R.K. Jain The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis Nature 428 2004 328 332
19. S. Kim, K. Chin, J.W. Gray, and J.M. Bishop A screen for genes that suppress loss of contact inhibition: identification of ING4 as a candidate tumor suppressor gene in human cancer Proc. Natl. Acad. Sci. USA 101 2004 16251 16256
20. C. Dingwall, and R.A. Laskey Nuclear targeting sequences-a consensus? Trends Biochem. Sci. 16 1991 478 481
21. M.A. Powers, and D.J. Forbes Cytosolic factors in nuclear transport: what's important? Cell 79 1994 931 934
22. P.A. Silver How proteins enter the nucleus Cell 64 1991 489 497
23. E.A. Nigg Nucleocytoplasmic transport: signals, mechanisms and regulation Nature 386 1997 779 787
24. J. Robbins, S.M. Dilworth, R.A. Laskey, and C. Dingwall Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: identification of a class of bipartite nuclear targeting sequence Cell 64 1991 615 623
25. J.P. Makkerh, C. Dingwall, and R.A. Laskey Comparative mutagenesis of nuclear localization signals reveals the importance of neutral and acidic amino acids Curr. Biol. 6 1996 1025 1027
26. M.R. Hodel, A.H. Corbett, and A.E. Hodel Dissection of a nuclear localization signal J. Biol. Chem. 276 2001 1317 1325
27. D. Kalderon, W.D. Richardson, A.F. Markham, and A.E. Smith Sequence requirements for nuclear location of simian virus 40 large-T antigen Nature 311 1984 33 58
28. W.S. el-Deiry, T. Tokino, V.E. Velculescu, D.B. Levy, R. Parsons, J.M. Trent, D. Lin, W.E. Mercer, K.W. Kinzler, and B. Vogelstein WAF1, a potential mediator of p53 tumor suppression Cell 75 1993 817 825