ING4 induces cell growth inhibition in human lung adenocarcinoma A549 cells by means of Wnt-1/β-catenin signaling pathway

Anatomical Record

Volumn 291, Issue 5, 2008, Pages 593-600

  Li, Xiaomei ^a   Cai, Limin ^b   Liang, Meihua ^a   Wang, Yandong ^c   Yang, Jing ^d   Zhao, Yulan ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b INSTITUTE OF DERMATOLOGY   (China)

^c Daqing Longnan Hospital   (China)

^d Heilongjiang Province Hospital   (China)

Author keywords

ING4; Lung adenocarcinoma; Proliferation; Wnt 1 catenin signaling

Indexed keywords

BETA CATENIN; CYCLIN D1; CYCLOOXYGENASE 2; INHIBITOR OF GROWTH 4 PROTEIN; PLASMID DNA; PROTEIN P27; S PHASE KINASE ASSOCIATED PROTEIN 2; TUMOR SUPPRESSOR PROTEIN; WNT1 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CHEMOTHERAPY; CANCER INHIBITION; CANCER RADIOTHERAPY; CELL GROWTH; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; LUNG ADENOCARCINOMA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUPPRESSOR GENE; UPREGULATION; WESTERN BLOTTING;

ADENOCARCINOMA; BETA CATENIN; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; CLONING, MOLECULAR; CYCLIN D1; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLOOXYGENASE 2; DNA, COMPLEMENTARY; GENE EXPRESSION; HOMEODOMAIN PROTEINS; HUMANS; LUNG NEOPLASMS; PLASMIDS; S-PHASE KINASE-ASSOCIATED PROTEINS; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS; WNT PROTEINS;

EID: 43149122240     PISSN: 19328486     EISSN: 19328494     Source Type: Journal    
DOI: 10.1002/ar.20685     Document Type: Article

References (19)

1. Campos EI, Chin MY, Kuo WH, Li G. 2004. Biological functions of the ING family tumor suppressors. Cell Mol Life Sci 61:2597-2613.
2. Castelo-Branco G, Wagner J, Rodriguez FJ, Kele J, Sousa K, Rawal N, Pasolli HA, Fuchs E, Kitajewski J, Arenas E. 2003. Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a. Proc Natl Acad Sci U S A 100:12747-12752.
3. Castro DS, Hermanson E, Joseph B, Wallen A, Aarnisalo P, Heller A, Perlmann T. 2001. Induction of cell cycle arrest and morphological differentiation by Nurr1 and retinoids in dopamine MN9D cells. J Biol Chem 276:43277-43284.
4. Chen G, Shukeir N, Potti A, Sircar K, Aprikian A, Goltzman D, Rabbani SA. 2004. Up-regulation of Wnt-1 and beta-catenin production in patients with advanced metastatic prostate carcinoma: potential pathogenetic and prognostic implications. Cancer 101:1345-1356.
5. Coats S, Flanagan WM, Nourse J, Roberts JM. 1996. Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle. Science 272:877-880.
6. Feng X, Hara Y, Riabowol K. 2002. Different HATS of the ING1 gene family. Trends Cell Biol 12:532-538.
7. Garkavtsev I, Kozin SV, Chernova O, Xu L, Winkler F, Brown E, Barnett GH, Jain RK. 2004. The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis. Nature 428:328-332.
8. Gunduz M, Nagatsuka H, Demircan K, Gunduz E, Cengiz B, Ouchida M, Tsujigiwa H, Yamachika E, Fukushima K, Beder L, Hirohata S, Ninomiya Y, Nishizaki K, Shimizu K, Nagai N. 2005. Frequent deletion and down-regulation of ING4, a candidate tumor suppressor gene at 12p13, in head and neck squamous cell carcinomas. Gene 356:109-117.
9. Howe LR, Subbaramaiah K, Chung WJ, Dannenberg AJ, Brown AM. 1999. Transcriptional activation of cyclooxygenase-2 in Wnt-1-transformed mouse mammary epithelial cells. Cancer Res 59:1572-1577.
10. Hulit J, Lee RJ, Li Z, Wang C, Katiyar S, Yang J, Quong AA, Wu K, Albanese C, Russell R, Di Vizio D, Koff A, Thummala S, Zhang H, Harrell J, Sun H, Muller WJ, Inghirami G, Lisanti MP, Pestell RG. 2006. p27Kip1 repression of ErbB2-induced mammary tumor growth in transgenic mice involves Skp2 and Wnt/{beta}-catenin signaling. Cancer Res 66:8529-8541.
11. Kim S, Chin K, Gray JW, Bishop JM. 2004. A screen for genes that suppress loss of contact inhibition: identification of ING4 as a candidate tumor suppressor gene in human cancer. Proc Natl Acad Sci U S A 101:16251-16256.
12. Möbius C, Stein HJ, Spiess C, Becker I, Feith M, Theisen J, Gais P, Jutting U, Siewert JR. 2005. COX2 expression, angiogenesis, proliferation and survival in Barrett's cancer. Eur J Surg Oncol 31:755-759.
13. Nagashima M, Shiseki M, Miura K, Hagiwara K, Linke SP, Pedeux R, Wang XW, Yokota J, Riabowol K, Harris CC. 2001. DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53. Proc Natl Acad Sci U S A 98:9671-9676.
14. Nagashima M, Shiseki M, Pedeux RM, Okamura S, Kitahama-Shiseki M, Miura K, Yokota J, Harris CC. 2003. A novel PHD-finger motif protein, p47ING3, modulates p53-mediated transcription, cell cycle control, and apoptosis. Oncogene 22:343-350.
15. Shiseki M, Nagashima M, Pedeux RM, Kitahama-Shiseki M, Miura K, Okamura S, Onogi H, Higashimoto Y, Appella E, Yokota J, Harris CC. 2003. p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity. Cancer Res 63:2373-2378.
16. Tzankov A, Heiss S, Ebner S, Sterlacci W, Schaefer G, Augustin F, Fiegl M, Dirnhofer S. 2007. Angiogenesis in nodal B cell lymphomas: a high throughput study. J Clin Pathol 60:476-482.
17. Weinberg RA. 1995. The retinoblastoma protein and cell cycle control. Cell 81:323-330.
18. Wong SC, Lo SF, Lee KC, Yam JW, Chan JK, Wendy Hsiao WL. 2002. Expression of frizzled-related protein and Wnt-signaling molecules in invasive human breast tumours. J Pathol 196:145-153.
19. Zhang X, Xu LS, Wang ZQ, Wang KS, Li N, Cheng ZH, Huang SZ, Wei DZ, Han ZG. 2004. ING4 induces G2/M cell cycle arrest and enhances the chemosensitivity to DNA-damage agents in HepG2 cells. FEBS Lett 570:7-12.