Novel naphthalene-based inhibitors of Trypanosoma brucei RNA editing ligase 1

PLoS Neglected Tropical Diseases

Volumn 4, Issue 8, 2010, Pages

  Durrant, Jacob D ^a   Hall, Laurence ^b   Swift, Robert V ^c   Landon, Melissa ^d,f   Schnaufer, Achim ^b   Amaro, Rommie E ^c,e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d BRANDEIS UNIVERSITY   (United States)

^e Irvine   (United States)

^f CUBIST PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 NAPHTHOIC ACID; 2 NITRONAPHTHALENE; ANTITRYPANOSOMAL AGENT; NAPHTHALENE DERIVATIVE; NAPSYLIC ACID; PROTOZOAL PROTEIN; RNA EDITING LIGASE 1; UNCLASSIFIED DRUG; ENZYME INHIBITOR; LIGASE; MITOCHONDRIAL PROTEIN; REL1 RNA LIGASE, TRYPANOSOMA BRUCEI;

AFRICAN TRYPANOSOMIASIS; ANTIPROTOZOAL ACTIVITY; ARTICLE; CLUSTER ANALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG SCREENING; DRUG SPECIFICITY; DRUG STRUCTURE; HYDROPHOBICITY; LIGAND BINDING; MOLECULAR DOCKING; MOLECULAR DYNAMICS; NONHUMAN; PROTEIN CONFORMATION; TRYPANOSOMA BRUCEI; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; ENZYMOLOGY; METHODOLOGY; PROTEIN BINDING;

CARBON-OXYGEN LIGASES; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; MITOCHONDRIAL PROTEINS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NAPHTHALENES; PROTEIN BINDING; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI;

EID: 78149265785     PISSN: None     EISSN: None     Source Type: Journal    
DOI: 10.1371/journal.pntd.0000803     Document Type: Article

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