Pharmacokinetic investigations in patients from northern angola refractory to melarsoprol treatment

Tropical Medicine and International Health

Volumn 6, Issue 5, 2001, Pages 412-420

  Burri, C ^a   Keiser, J ^a  

^a SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

Author keywords

Angola; Drug levels; Drug resistance; Melarsoprol; Pharmacokinetics; Sleeping sickness; Trypanosomes; Trypanosomiasis

Indexed keywords

MELARSOPROL;

AFRICAN TRYPANOSOMIASIS; ANGOLA; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; FEMALE; GENETIC ANALYSIS; HUMAN; MALE; TREATMENT FAILURE; TREATMENT OUTCOME; TRYPANOSOMIASIS;

ADOLESCENT; ADULT; ANGOLA; ANIMALS; DRUG ADMINISTRATION SCHEDULE; DRUG MONITORING; DRUG RESISTANCE; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MELARSOPROL; MIDDLE AGED; SEROTYPING; SEVERITY OF ILLNESS INDEX; TREATMENT FAILURE; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI GAMBIENSE; TRYPANOSOMIASIS, AFRICAN;

PROTOZOA;

EID: 0034991804     PISSN: 13602276     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3156.2001.00725.x     Document Type: Article

References (22)

1. Discrepancy in plasma melarsoprol concentrations between HPLC and bioassay methods in patients with T. gambiense sleeping sickness indicates that melarsoprol is metabolized
2. Pharmacokinetic properties of the trypanocidal drug melarsoprol
3. Arsenical-resistant trypanosomes lack an unusual adenosine transporter
4. Sexual compatibility among Trypanosoma brucei isolates from an epidemic area in southeastern Uganda
5. Characterisation of melarsen-resistant Trypanosoma brucei brucei with respect to cross-resistance to other drugs and trypanothione metabolism
6. Risk factors for treatment failure after melarsoprol for Trypanosoma brucei gambiense trypanosomiasis in Uganda
7. Therapeutic failure of melarsoprol among patients treated for late stage of T.b. gambiense human African trypanosomiasis in Uganda
8. A card agglutination test with stained trypanosomes (CATT) for the serological diagnosis of T.b. gambiense trypanosomiasis
9. The mechanisms of drug resistance in Trypanosoma brucei spp.
10. A nucleoside transporter from Trypanosoma brucei involved in drug resistance
11. An automated biological assay to determine levels of the trypanocidal drug melarsoprol in biological fluids
12. Pathways involved in environmental sensing in trypanosomatids
13. The treatment of human African trypanosomiasis
14. Follow-up des traitements contre la trypanosomiase expérimenté à Kimpangu (République du Zaire)
15. Human African trypanosomiasis: An emerging public health crisis
16. A miniature kit for the in vitro isolation of Trypanosoma brucei gambiense: A preliminary field assessment on sleeping sickness patients in Cote d'Ivoire
17. Antigenic variation in Trypanosoma brucei analyzed by electrophoretic separation of chomosome-sized DNA molecules
18. Epidemiology and control of African trypanosomiasis
19. Control and surveillance of African trypanosomiasis
20. Amplification of the inosinate dehydrogenase gene in Trypanosoma brucei gambiense due to an increase in chromosome copy number