The neem limonoids azadirachtin and nimbolide inhibit hamster cheek pouch carcinogenesis by modulating xenobiotic-metabolizing enzymes, DNA damage, antioxidants, invasion and angiogenesis

Free Radical Research

Volumn 43, Issue 5, 2009, Pages 492-504

  Priyadarsini, Ramamurthi Vidya ^a   Manikandan, Palrasu ^a   Kumar, Gurram Harish ^a   Nagini, Siddavaram ^a  

^a ANNAMALAI UNIVERSITY   (India)

Author keywords

Angiogenesis; Antioxidants; Azadirachtin; DMBA; Invasion; Neem; Nimbolide; Xenobiotic metabolizing enzymes

Indexed keywords

ASCORBIC ACID; AZADIRACHTIN; BETA ACTIN; CARCINOGEN; CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; CYTOCHROME B5; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; DIMETHYLBENZ[A]ANTHRACENE; DNA; ETHOXYRESORUFIN DEETHYLASE; FREE RADICAL; GAMMA GLUTAMYLTRANSFERASE; GELATINASE A; GELATINASE B; GLUTATHIONE TRANSFERASE; LIMONOID; MANGANESE SUPEROXIDE DISMUTASE; NIMBOLIDE; PENTOXYRESORUFIN DEALKYLASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SUPEROXIDE DISMUTASE; TISSUE INHIBITOR OF METALLOPROTEINASE 2; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; XENOBIOTIC AGENT; 7,12 DIMETHYLBENZ[A]ANTHRACENE; ANTINEOPLASTIC AGENT; ANTIOXIDANT; ENZYME; PRIMER DNA; SCAVENGER;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; AZADIRACHTA INDICA; CANCER INHIBITION; CANCER INVASION; CARCINOGENESIS; CHEEK POUCH; CONTROLLED STUDY; DETOXIFICATION; DNA DAMAGE; DRUG POTENCY; DRUG STRUCTURE; HAMSTER; IN VITRO STUDY; IN VIVO STUDY; MALE; MEDICAL RESEARCH; MOUTH CANCER; NONHUMAN; OXIDATIVE STRESS; POLYACRYLAMIDE GEL ELECTROPHORESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING; ANIMAL; CHEEK; COMPARATIVE STUDY; DRUG EFFECT; EXPERIMENTAL NEOPLASM; GENETICS; METABOLISM; MOUTH MUCOSA; NEOVASCULARIZATION (PATHOLOGY); NUCLEOTIDE SEQUENCE; PATHOLOGY; SYRIAN HAMSTER;

AZADIRACHTA INDICA; CRICETINAE;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; ANTICARCINOGENIC AGENTS; ANTIOXIDANTS; BASE SEQUENCE; CHEEK; CRICETINAE; DNA DAMAGE; DNA PRIMERS; ENZYMES; FREE RADICAL SCAVENGERS; LIMONINS; MALE; MESOCRICETUS; MOUTH MUCOSA; NEOPLASM INVASIVENESS; NEOPLASMS, EXPERIMENTAL; NEOVASCULARIZATION, PATHOLOGIC; XENOBIOTICS;

EID: 67650104057     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.1080/10715760902870637     Document Type: Article

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