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Volumn 31, Issue 11, 2010, Pages 1956-1963

ATM kinase activity modulates cFLIP protein levels: Potential interplay between DNA damage signalling and TRAIL-induced apoptosis

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ATM PROTEIN; FLICE INHIBITORY PROTEIN; FLUOROURACIL; MUTANT PROTEIN; PROTEIN P53; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR; ZINOSTATIN;

EID: 78149257662     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgq193     Document Type: Article
Times cited : (34)

References (43)
  • 1
    • 13344285339 scopus 로고
    • Identification and characterization of a new member of the TNF family that induces apoptosis
    • Wiley,S.R. et al. (1995) Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity, 3, 673-682.
    • (1995) Immunity , vol.3 , pp. 673-682
    • Wiley, S.R.1
  • 2
    • 0032929520 scopus 로고    scopus 로고
    • Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo
    • Walczak,H. et al. (1999) Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat. Med., 5, 157-163.
    • (1999) Nat. Med. , vol.5 , pp. 157-163
    • Walczak, H.1
  • 3
    • 35348877298 scopus 로고    scopus 로고
    • Barriers to effective TRAIL-targeted therapy of malignancy
    • Dyer,M.J. et al. (2007) Barriers to effective TRAIL-targeted therapy of malignancy. J. Clin. Oncol., 25, 4505-4506.
    • (2007) J. Clin. Oncol. , vol.25 , pp. 4505-4506
    • Dyer, M.J.1
  • 4
    • 45749098451 scopus 로고    scopus 로고
    • To kill a tumor cell: the potential of proapoptotic receptor agonists
    • Ashkenazi,A. et al. (2008) To kill a tumor cell: the potential of proapoptotic receptor agonists. J. Clin. Invest., 118, 1979-1990.
    • (2008) J. Clin. Invest. , vol.118 , pp. 1979-1990
    • Ashkenazi, A.1
  • 5
    • 34447094000 scopus 로고    scopus 로고
    • TRAIL signalling: decisions between life and death
    • Falschlehner,C. et al. (2007) TRAIL signalling: decisions between life and death. Int. J. Biochem. Cell Biol., 39, 1462-1475.
    • (2007) Int. J. Biochem. Cell Biol. , vol.39 , pp. 1462-1475
    • Falschlehner, C.1
  • 6
    • 54249133441 scopus 로고    scopus 로고
    • FLIP and death effector domain family
    • Yu,J.W. et al. (2008) FLIP and death effector domain family. Oncogene, 27, 6216-6227.
    • (2008) Oncogene , vol.27 , pp. 6216-6227
    • Yu, J.W.1
  • 7
    • 2342588619 scopus 로고    scopus 로고
    • Expression of the cellular FLICE-inhibitory protein (c-FLIP) protects Hodgkin's lymphoma cells from autonomous Fasmediated death
    • Dutton,A. et al. (2004) Expression of the cellular FLICE-inhibitory protein (c-FLIP) protects Hodgkin's lymphoma cells from autonomous Fasmediated death. Proc. Natl Acad. Sci. USA, 101, 6611-6616.
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 6611-6616
    • Dutton, A.1
  • 8
    • 2442545178 scopus 로고    scopus 로고
    • c-FLIP mediates resistance of Hodgkin/Reed-Sternberg cells to death receptor-induced apoptosis
    • Mathas,S. et al. (2004) c-FLIP mediates resistance of Hodgkin/Reed-Sternberg cells to death receptor-induced apoptosis. J. Exp. Med., 199, 1041-1052.
    • (2004) J. Exp. Med. , vol.199 , pp. 1041-1052
    • Mathas, S.1
  • 9
    • 4344607589 scopus 로고    scopus 로고
    • Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs
    • Ganten,T.M. et al. (2004) Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs. Cell Death Differ., 11 (suppl. 1), S86-S96.
    • (2004) Cell Death Differ. , vol.11 , Issue.SUPPL. 1
    • Ganten, T.M.1
  • 10
    • 33646393778 scopus 로고    scopus 로고
    • Preclinical differentiation between apparently safe and potentially hepatotoxic applications of TRAIL either alone or in combination with chemotherapeutic drugs
    • Ganten,T.M. et al. (2006) Preclinical differentiation between apparently safe and potentially hepatotoxic applications of TRAIL either alone or in combination with chemotherapeutic drugs. Clin. Cancer Res., 12, 2640-2646.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 2640-2646
    • Ganten, T.M.1
  • 11
    • 0035496099 scopus 로고    scopus 로고
    • Regulation of lymphocyte proliferation and death by FLIP
    • Thome,M. et al. (2001) Regulation of lymphocyte proliferation and death by FLIP. Nat. Rev. Immunol., 1, 50-58.
    • (2001) Nat. Rev. Immunol. , vol.1 , pp. 50-58
    • Thome, M.1
  • 12
    • 0034899716 scopus 로고    scopus 로고
    • Shared pathways; death receptors and cytotoxic drugs in cancer therapy
    • Petak,I. et al. (2001) Shared pathways; death receptors and cytotoxic drugs in cancer therapy. Pathol. Oncol. Res., 7, 96-106.
    • (2001) Pathol. Oncol. Res. , vol.7 , pp. 96-106
    • Petak, I.1
  • 13
    • 39049148397 scopus 로고    scopus 로고
    • Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy
    • Safa,A.R. et al. (2008) Cellular FLICE-like inhibitory protein (C-FLIP): a novel target for cancer therapy. Curr. Cancer Drug Targets, 8, 37-46.
    • (2008) Curr. Cancer Drug Targets , vol.8 , pp. 37-46
    • Safa, A.R.1
  • 14
    • 38349087547 scopus 로고    scopus 로고
    • ATM kinase activity modulates Fas sensitivity through the regulation of FLIP in lymphoid cells
    • Stagni,V. et al. (2008) ATM kinase activity modulates Fas sensitivity through the regulation of FLIP in lymphoid cells. Blood, 111, 829-837.
    • (2008) Blood , vol.111 , pp. 829-837
    • Stagni, V.1
  • 15
    • 33745186920 scopus 로고    scopus 로고
    • Nuclear ataxia-telangiectasia mutated (ATM) mediates the cellular response to DNA double strand breaks in human neuronlike cells
    • Biton,S. et al. (2006) Nuclear ataxia-telangiectasia mutated (ATM) mediates the cellular response to DNA double strand breaks in human neuronlike cells. J. Biol. Chem., 281, 17482-17491.
    • (2006) J. Biol. Chem. , vol.281 , pp. 17482-17491
    • Biton, S.1
  • 16
    • 0037134020 scopus 로고    scopus 로고
    • A system for stable expression of short interfering RNAs in mammalian cells
    • Brummelkamp,T. et al. (2002) A system for stable expression of short interfering RNAs in mammalian cells. Science, 296, 550-553.
    • (2002) Science , vol.296 , pp. 550-553
    • Brummelkamp, T.1
  • 17
    • 0033937208 scopus 로고    scopus 로고
    • Molecular characterization of the thermosensitive E1 ubiquitin-activating enzyme cell mutant A31N-ts20
    • Salvat,C. et al. (2000) Molecular characterization of the thermosensitive E1 ubiquitin-activating enzyme cell mutant A31N-ts20. Eur. J. Biochem., 267, 3712-3722.
    • (2000) Eur. J. Biochem. , vol.267 , pp. 3712-3722
    • Salvat, C.1
  • 18
    • 0037383316 scopus 로고    scopus 로고
    • Caspase-dependent cleavage of c-Abl contributes to apoptosis
    • Barilà,D. et al. (2003) Caspase-dependent cleavage of c-Abl contributes to apoptosis. Mol. Cell. Biol., 23, 2790-2799.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 2790-2799
    • Barilà, D.1
  • 19
    • 17944373682 scopus 로고    scopus 로고
    • Accelerated degradation of cellular FLIP protein through the ubiquitin-proteasome pathway in p53-mediated apoptosis of human cancer cells
    • Fukazawa,T. et al. (2001) Accelerated degradation of cellular FLIP protein through the ubiquitin-proteasome pathway in p53-mediated apoptosis of human cancer cells. Oncogene, 20, 5225-5231.
    • (2001) Oncogene , vol.20 , pp. 5225-5231
    • Fukazawa, T.1
  • 20
    • 30344452318 scopus 로고    scopus 로고
    • Chemotherapy and TRAIL-mediated colon cancer cell death: the roles of p53, TRAIL receptors, and c-FLIP
    • Galligan,L. et al. (2005) Chemotherapy and TRAIL-mediated colon cancer cell death: the roles of p53, TRAIL receptors, and c-FLIP. Mol. Cancer Ther., 4, 2026-2036.
    • (2005) Mol. Cancer Ther. , vol.4 , pp. 2026-2036
    • Galligan, L.1
  • 21
    • 0032508504 scopus 로고    scopus 로고
    • Enhanced phosphorylation of p53 by ATM in response to DNA damage
    • Banin,S. et al. (1998) Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science, 281, 1674-1677.
    • (1998) Science , vol.281 , pp. 1674-1677
    • Banin, S.1
  • 22
    • 0000303499 scopus 로고    scopus 로고
    • ATM associates with and phosphorylates p53: mapping the region of interaction
    • Khanna,K.K. et al. (1998) ATM associates with and phosphorylates p53: mapping the region of interaction. Nat. Genet., 20, 398-400.
    • (1998) Nat. Genet. , vol.20 , pp. 398-400
    • Khanna, K.K.1
  • 23
    • 9744271049 scopus 로고    scopus 로고
    • Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM
    • Hickson,I. et al. (2004) Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res., 64, 9152-9159.
    • (2004) Cancer Res. , vol.64 , pp. 9152-9159
    • Hickson, I.1
  • 24
    • 12744261484 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors potentiate TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in lymphoid malignancies
    • Inoue,S. et al. (2004) Histone deacetylase inhibitors potentiate TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in lymphoid malignancies. Cell Death Differ., 11 (suppl. 2), S193-S206.
    • (2004) Cell Death Differ. , vol.11 , Issue.SUPPL. 2
    • Inoue, S.1
  • 25
    • 40449140444 scopus 로고    scopus 로고
    • Modulation of TRAIL-induced apoptosis by HDAC inhibitors
    • Fulda,S. (2008) Modulation of TRAIL-induced apoptosis by HDAC inhibitors. Curr. Cancer Drug Targets, 8, 132-140.
    • (2008) Curr. Cancer Drug Targets , vol.8 , pp. 132-140
    • Fulda, S.1
  • 26
    • 0038240386 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-341 sensitizes cells to TRAIL-mediated apoptosis by reducing levels of c-FLIP
    • Sayers,T.J. et al. (2003) The proteasome inhibitor PS-341 sensitizes cells to TRAIL-mediated apoptosis by reducing levels of c-FLIP. Blood, 102, 303-310.
    • (2003) Blood , vol.102 , pp. 303-310
    • Sayers, T.J.1
  • 27
    • 24144431555 scopus 로고    scopus 로고
    • A new TRAIL to therapy of hepatocellular carcinoma: blocking the proteasome
    • Anan,A. et al. (2005) A new TRAIL to therapy of hepatocellular carcinoma: blocking the proteasome. Hepatology, 42, 527-529.
    • (2005) Hepatology , vol.42 , pp. 527-529
    • Anan, A.1
  • 28
    • 33947368690 scopus 로고    scopus 로고
    • TRAIL/bortezomib cotreatment is potentially hepatotoxic but induces cancer-specific apoptosis within a therapeutic window
    • Koschny,R. et al. (2007) TRAIL/bortezomib cotreatment is potentially hepatotoxic but induces cancer-specific apoptosis within a therapeutic window. Hepatology, 45, 649-658.
    • (2007) Hepatology , vol.45 , pp. 649-658
    • Koschny, R.1
  • 29
    • 38949181537 scopus 로고    scopus 로고
    • Bortezomib induces caspase-dependent apoptosis in Hodgkin lymphoma cell lines and is associated with reduced c-FLIP expression: a gene expresssion profiling study with implications for potential combination therapies
    • Zhao,X. et al. (2008) Bortezomib induces caspase-dependent apoptosis in Hodgkin lymphoma cell lines and is associated with reduced c-FLIP expression: a gene expresssion profiling study with implications for potential combination therapies. Leuk. Res., 32, 275-285.
    • (2008) Leuk. Res. , vol.32 , pp. 275-285
    • Zhao, X.1
  • 30
    • 65949119339 scopus 로고    scopus 로고
    • Inhibition of Ataxia Telangiectasia Mutated kinase activity enhances TRAIL-mediated apoptosis in human melanoma cells
    • Ivanov,V.N. et al. (2009) Inhibition of Ataxia Telangiectasia Mutated kinase activity enhances TRAIL-mediated apoptosis in human melanoma cells. Cancer Res., 69, 3510-3519.
    • (2009) Cancer Res. , vol.69 , pp. 3510-3519
    • Ivanov, V.N.1
  • 31
    • 49649110459 scopus 로고    scopus 로고
    • Cisplatin induces p53-dependent FLICE-like inhibitory protein ubiquitination in ovarian cancer cells
    • Abedini,M.R. et al. (2008) Cisplatin induces p53-dependent FLICE-like inhibitory protein ubiquitination in ovarian cancer cells. Cancer Res., 68, 4511-4517.
    • (2008) Cancer Res. , vol.68 , pp. 4511-4517
    • Abedini, M.R.1
  • 32
    • 76749170208 scopus 로고    scopus 로고
    • Radiation and anticancer drugs can facilitate mitochondrial bypass by CD95/Fas via c-FLIP downregulation
    • Verbrugge,I. et al. (2010) Radiation and anticancer drugs can facilitate mitochondrial bypass by CD95/Fas via c-FLIP downregulation. Cell Death Differ., 17, 551-561.
    • (2010) Cell Death Differ. , vol.17 , pp. 551-561
    • Verbrugge, I.1
  • 33
    • 32544438637 scopus 로고    scopus 로고
    • c-FLIP inhibits chemotherapy-induced colorectal cancer cell death
    • Longley,D.B. et al. (2006) c-FLIP inhibits chemotherapy-induced colorectal cancer cell death. Oncogene, 25, 838-848.
    • (2006) Oncogene , vol.25 , pp. 838-848
    • Longley, D.B.1
  • 34
    • 34548754443 scopus 로고    scopus 로고
    • Doxorubicin generates a pro-apoptotic phenotype by phosphorylation on EF-2
    • White,S.J. et al. (2007) Doxorubicin generates a pro-apoptotic phenotype by phosphorylation on EF-2. Free Radic. Biol. Med., 43, 1313-1321.
    • (2007) Free Radic. Biol. Med. , vol.43 , pp. 1313-1321
    • White, S.J.1
  • 35
    • 0037182751 scopus 로고    scopus 로고
    • Ubiquitination capabilities in response to neocarzinostatin and H(2)O(2) stress in cell lines from patients with ataxiatelangiectasia
    • Taylor,A. et al. (2002) Ubiquitination capabilities in response to neocarzinostatin and H(2)O(2) stress in cell lines from patients with ataxiatelangiectasia. Oncogene, 21, 4363-4373.
    • (2002) Oncogene , vol.21 , pp. 4363-4373
    • Taylor, A.1
  • 36
    • 34249947699 scopus 로고    scopus 로고
    • ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
    • Matsuoka,S. et al. (2007) ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science, 316, 1160-1166.
    • (2007) Science , vol.316 , pp. 1160-1166
    • Matsuoka, S.1
  • 37
    • 34547107878 scopus 로고    scopus 로고
    • A proteomic analysis of Ataxia Telangiectasiamutated (ATM/ATM-Rad3-related (ATR) substrates identifies the ubiquitin proteasome system as a regulator for DNA damage checkpoints
    • Mu,J.-J. et al. (2007) A proteomic analysis of Ataxia Telangiectasiamutated (ATM/ATM-Rad3-related (ATR) substrates identifies the ubiquitin proteasome system as a regulator for DNA damage checkpoints. J. Biol. Chem., 282, 17330-17334.
    • (2007) J. Biol. Chem. , vol.282 , pp. 17330-17334
    • Mu, J.-J.1
  • 38
    • 33644538632 scopus 로고    scopus 로고
    • Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli
    • Wu,Z.H. et al. (2006) Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli. Science, 311, 1141-1146.
    • (2006) Science , vol.311 , pp. 1141-1146
    • Wu, Z.H.1
  • 39
    • 33748054298 scopus 로고    scopus 로고
    • ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage
    • Dornan,D. et al. (2006) ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage. Science, 313, 1122-1126.
    • (2006) Science , vol.313 , pp. 1122-1126
    • Dornan, D.1
  • 40
    • 0035339357 scopus 로고    scopus 로고
    • ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage
    • Maya,R. et al. (2001) ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. Genes Dev., 15, 1067-1077.
    • (2001) Genes Dev. , vol.15 , pp. 1067-1077
    • Maya, R.1
  • 41
    • 32044447161 scopus 로고    scopus 로고
    • The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover
    • Chang,L. et al. (2006) The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. Cell, 124, 601-613.
    • (2006) Cell , vol.124 , pp. 601-613
    • Chang, L.1
  • 42
    • 23944498161 scopus 로고    scopus 로고
    • Proapoptotic BID is an ATM effector in the DNAdamage response
    • Kamer,I. et al. (2005) Proapoptotic BID is an ATM effector in the DNAdamage response. Cell, 122, 593-603.
    • (2005) Cell , vol.122 , pp. 593-603
    • Kamer, I.1
  • 43
    • 23944445368 scopus 로고    scopus 로고
    • A role for proapoptotic BID in the DNA-damage response
    • Zinkel,S.S. et al. (2005) A role for proapoptotic BID in the DNA-damage response. Cell, 122, 579-591.
    • (2005) Cell , vol.122 , pp. 579-591
    • Zinkel, S.S.1


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