Contribution of Adenosine A2A and A2B Receptors to Ischemic Coronary Dilation: Role of KV and KATP Channels

Microcirculation

Volumn 17, Issue 8, 2010, Pages 600-607

  Berwick, Zachary C ^a   Payne, Gregory A ^a   Lynch, Brandon ^a   Dick, Gregory M ^b   Sturek, Michael ^a   Tune, Johnathan D ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adenosine receptor; Canine; Coronary vasodilation; Potassium channel; Reactive hyperemia

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 4 AMINOPYRIDINE; 5 AMINO 2 (2 FURYL) 7 (2 PHENYLETHYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; ADENOSINE; ADENOSINE A2 RECEPTOR ANTAGONIST; ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; ALLOXAZINE; GLIBENCLAMIDE; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY DILATATION; CORONARY ARTERY PRESSURE; DIASTOLIC BLOOD PRESSURE; DOG; DOSE RESPONSE; HEART MUSCLE ISCHEMIA; HEART RATE; HYPEREMIA; INTRACORONARY INFUSION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SYSTOLIC BLOOD PRESSURE;

4-AMINOPYRIDINE; ADENOSINE; ADENOSINE A2 RECEPTOR AGONISTS; ADENOSINE A2 RECEPTOR ANTAGONISTS; ANIMALS; CORONARY CIRCULATION; DISEASE MODELS, ANIMAL; DOGS; FLAVINS; GLYBURIDE; HYPEREMIA; KATP CHANNELS; MALE; MYOCARDIAL ISCHEMIA; PHENETHYLAMINES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, VOLTAGE-GATED; PYRIMIDINES; RECEPTOR, ADENOSINE A2A; RECEPTOR, ADENOSINE A2B; TRIAZOLES; VASODILATION;

CANIS FAMILIARIS;

EID: 78149253549     PISSN: 10739688     EISSN: 15498719     Source Type: Journal    
DOI: 10.1111/j.1549-8719.2010.00054.x     Document Type: Article

References (51)

1. Aversano T, Ouyang P, Silverman H. Blockade of the ATP-sensitive potassium channel modulates reactive hyperemia in the canine coronary circulation. Circ Res 69: 618-622, 1991.
2. Bache RJ, Dai XZ, Schwartz JS, Homans DC. Role of adenosine in coronary vasodilation during exercise. Circ Res 62: 846-853, 1988.
3. Bender SB, Tune JD, Borbouse L, Long X, Sturek M, Laughlin MH. Altered mechanism of adenosine-induced coronary arteriolar dilation in early-stage metabolic syndrome. Exp Biol Med (Maywood) 234: 683-692, 2009.
4. Berne RM. Cardiac nucleotides in hypoxia: possible role in regulation of coronary blood flow. Am J Physiol 204: 317-322, 1963.
5. Bittar N, Pauly TJ. Role of adenosine in reactive hyperemia of the dog heart. Experientia 27: 153-154, 1971.
6. Borbouse L, Dick GM, Payne GA, Berwick ZC, Neeb ZP, Alloosh M, Bratz IN, Sturek M, Tune JD. Metabolic syndrome reduces the contribution of K+ channels to ischemic coronary vasodilation. Am J Physiol Heart Circ Physiol 298: H1182-H1189, 2010.
7. Clayton FC, Hess TA, Smith MA, Grover GJ. Coronary reactive hyperemia and adenosine-induced vasodilation are mediated partially by a glyburide-sensitive mechanism. Pharmacology 44: 92-100, 1992.
8. Dart C, Standen NB. Adenosine-activated potassium current in smooth muscle cells isolated from the pig coronary artery. J Physiol 471: 767-786, 1993.
9. Davis CA III, Sherman AJ, Yaroshenko Y, Harris KR, Hedjbeli S, Parker MA, Klocke FJ. Coronary vascular responsiveness to adenosine is impaired additively by blockade of nitric oxide synthesis and a sulfonylurea. J Am Coll Cardiol 31: 816-822, 1998.
10. Dick GM, Bratz IN, Borbouse L, Payne GA, Dincer UD, Knudson JD, Rogers PA, Tune JD. Voltage-dependent K+ channels regulate the duration of reactive hyperemia in the canine coronary circulation. Am J Physiol Heart Circ Physiol 294: H2371-H2381, 2008.
11. Duncker DJ, Laxson DD, Lindstrom P, Bache RJ. Endogenous adenosine and coronary vasoconstriction in hypoperfused myocardium during exercise. Cardiovasc Res 27: 1592-1597, 1993.
12. Duncker DJ, Stubenitsky R, Verdouw PD. Role of adenosine in the regulation of coronary blood flow in swine at rest and during treadmill exercise. Am J Physiol 275: H1663-H1672, 1998.
13. Duncker DJ, Van Zon NS, Ishibashi Y, Bache RJ. Role of K+ ATP channels and adenosine in the regulation of coronary blood flow during exercise with normal and restricted coronary blood flow. J Clin Invest 97: 996-1009, 1996.
14. Feigl EO. Adenosine coronary vasodilation during hypoxia depends on adrenergic receptor activation. Adv Exp Med Biol 346: 199-205, 1993.
15. Feigl EO, Neat GW, Huang AH. Interrelations between coronary artery pressure, myocardial metabolism and coronary blood flow. J Mol Cell Cardiol 22: 375-390, 1990.
16. Feoktistov I, Biaggioni I. Adenosine A2B receptors. Pharmacol Rev 49: 381-402, 1997.
17. Flood A, Headrick JP. Functional characterization of coronary vascular adenosine receptors in the mouse. Br J Pharmacol 133: 1063-1072, 2001.
18. Frobert O, Haink G, Simonsen U, Gravholt CH, Levin M, Deussen A. Adenosine concentration in the porcine coronary artery wall and A2A receptor involvement in hypoxia-induced vasodilatation. J Physiol 570: 375-384, 2006.
19. Headrick JP, Peart J, Hack B, Garnham B, Matherne GP. 5'-Adenosine monophosphate and adenosine metabolism, and adenosine responses in mouse, rat and guinea pig heart. Comp Biochem Physiol A Mol Integr Physiol 130: 615-631, 2001.
20. Hein TW, Belardinelli L, Kuo L. Adenosine A(2A) receptors mediate coronary microvascular dilation to adenosine: role of nitric oxide and ATP-sensitive potassium channels. J Pharmacol Exp Ther 291: 655-664, 1999.
21. Hein TW, Kuo L. cAMP-independent dilation of coronary arterioles to adenosine: role of nitric oxide, G-proteins, and K(ATP) channels. Circ Res 85: 634-642, 1999.
22. Hein TW, Wang W, Zoghi B, Muthuchamy M, Kuo L. Functional and molecular characterization of receptor subtypes mediating coronary microvascular dilation to adenosine. J Mol Cell Cardiol 33: 271-282, 2001.
23. Hodgson JM, Dib N, Kern MJ, Bach RG, Barrett RJ. Coronary circulation responses to binodenoson, a selective adenosine A2A receptor agonist. Am J Cardiol 99: 1507-1512, 2007.
24. Ishibashi Y, Duncker DJ, Zhang J, Bache RJ. ATP-sensitive K+ channels, adenosine, and nitric oxide-mediated mechanisms account for coronary vasodilation during exercise. Circ Res 82: 346-359, 1998.
25. Kanatsuka H, Sekiguchi N, Sato K, Akai K, Wang Y, Komaru T, Ashikawa K, Takishima T. Microvascular sites and mechanisms responsible for reactive hyperemia in the coronary circulation of the beating canine heart. Circ Res 71: 912-922, 1992.
26. Kemp BK, Cocks TM. Adenosine mediates relaxation of human small resistance-like coronary arteries via A2B receptors. Br J Pharmacol 126: 1796-1800, 1999.
27. Kleppisch T, Nelson MT. Adenosine activates ATP-sensitive potassium channels in arterial myocytes via A2 receptors and cAMP-dependent protein kinase. Proc Natl Acad Sci USA 92: 12441-12445, 1995.
28. Kuo L, Chancellor JD. Adenosine potentiates flow-induced dilation of coronary arterioles by activating KATP channels in endothelium. Am J Physiol 269: H541-H549, 1995.
29. Laxson DD, Homans DC, Bache RJ. Inhibition of adenosine-mediated coronary vasodilation exacerbates myocardial ischemia during exercise. Am J Physiol 265: H1471-H1477, 1993.
30. Morrison RR, Talukder MA, Ledent C, Mustafa SJ. Cardiac effects of adenosine in A(2A) receptor knockout hearts: uncovering A(2B) receptors. Am J Physiol Heart Circ Physiol 282: H437-H444, 2002.
31. Mustafa SJ, Morrison RR, Teng B, Pelleg A. Adenosine receptors and the heart: role in regulation of coronary blood flow and cardiac electrophysiology. Handb Exp Pharmacol 193: 161-188, 2009.
32. Mutafova-Yambolieva VN, Keef KD. Adenosine-induced hyperpolarization in guinea pig coronary artery involves A2B receptors and KATP channels. Am J Physiol 273: H2687-H2695, 1997.
33. Ongini E, Dionisotti S, Gessi S, Irenius E, Fredholm BB. Comparison of CGS 15943, ZM 241385 and SCH 58261 as antagonists at human adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol 359: 7-10, 1999.
34. Ongini E, Fredholm BB. Pharmacology of adenosine A2A receptors. Trends Pharmacol Sci 17: 364-372, 1996.
35. Ponnoth DS, Sanjani MS, Ledent C, Roush K, Krahn T, Mustafa SJ. Absence of adenosine-mediated aortic relaxation in A2A adenosine receptor knockout mice. Am J Physiol Heart Circ Physiol 297: H1655-H1660, 2009.
36. Rif Hasan AZ, Abebe W, Mustafa SJ. Antagonism of coronary artery relaxation by adenosine A2A-receptor antagonist ZM241385. J Cardiovasc Pharmacol 35: 322-325, 2000.
37. Rivers RJ, Frame MD. Network vascular communication initiated by increases in tissue adenosine. J Vasc Res 36: 193-200, 1999.
38. Rose'Meyer RB. Adenosine receptor interactions alter cardiac contractility in rat heart. Clin Exp Pharmacol Physiol 37: 46-50, 2010.
39. Saito D, Steinhart CR, Nixon DG, Olsson RA. Intracoronary adenosine deaminase reduces canine myocardial reactive hyperemia. Circ Res 49: 1262-1267, 1981.
40. Stepp DW, Kroll K, Feigl EO. K+ATP channels and adenosine are not necessary for coronary autoregulation. Am J Physiol 273: H1299-H1308, 1997.
41. Talukder MA, Morrison RR, Ledent C, Mustafa SJ. Endogenous adenosine increases coronary flow by activation of both A2A and A2B receptors in mice. J Cardiovasc Pharmacol 41: 562-570, 2003.
42. Tawfik HE, Teng B, Morrison RR, Schnermann J, Mustafa SJ. Role of A1 adenosine receptor in the regulation of coronary flow. Am J Physiol Heart Circ Physiol 291: H467-H472, 2006.
43. Trochu JN, Zhao G, Post H, Xu X, Belardinelli L, Belloni FL, Hintze TH. Selective A2A adenosine receptor agonist as a coronary vasodilator in conscious dogs: potential for use in myocardial perfusion imaging. J Cardiovasc Pharmacol 41: 132-139, 2003.
44. Tune JD, Richmond KN, Gorman MW, Olsson RA, Feigl EO. Adenosine is not responsible for local metabolic control of coronary blood flow in dogs during exercise. Am J Physiol Heart Circ Physiol 278: H74-H84, 2000.
45. Van Winkle DM, Chien GL, Wolff RA, Soifer BE, Kuzume K, Davis RF. Cardioprotection provided by adenosine receptor activation is abolished by blockade of the KATP channel. Am J Physiol 266: H829-H839, 1994.
46. Wyatt AW, Steinert JR, Wheeler-Jones CP, Morgan AJ, Sugden D, Pearson JD, Sobrevia L, Mann GE. Early activation of the p42/p44MAPK pathway mediates adenosine-induced nitric oxide production in human endothelial cells: a novel calcium-insensitive mechanism. FASEB J 16: 1584-1594, 2002.
47. Xu X, Tsai TD, Lee KS. A specific activator of the ATP-inhibited K+ channels in guinea pig ventricular cells. J Pharmacol Exp Ther 266: 978-984, 1993.
48. Yada T, Richmond KN, Van Bibber R, Kroll K, Feigl EO. Role of adenosine in local metabolic coronary vasodilation. Am J Physiol 276: H1425-H1433, 1999.
49. Yang M, Soohoo D, Soelaiman S, Kalla R, Zablocki J, Chu N, Leung K, Yao L, Diamond I, Belardinelli L, Shryock JC. Characterization of the potency, selectivity, and pharmacokinetic profile for six adenosine A2A receptor antagonists. Naunyn Schmiedebergs Arch Pharmacol 375: 133-144, 2007.
50. Yao X, Chang AY, Boulpaep EL, Segal AS, Desir GV. Molecular cloning of a glibenclamide-sensitive, voltage-gated potassium channel expressed in rabbit kidney. J Clin Invest 97: 2525-2533, 1996.
51. Zatta AJ, Headrick JP. Mediators of coronary reactive hyperaemia in isolated mouse heart. Br J Pharmacol 144: 576-587, 2005.