Altered mechanism of adenosine-induced coronary arteriolar dilation in early-stage metabolic syndrome

Experimental Biology and Medicine

Volumn 234, Issue 6, 2009, Pages 683-692

  Bender, Shawn B ^a   Tune, Johnathan D ^b   Borbouse, Lena ^b   Long, Xin ^b   Sturek, Michael ^b   Laughlin, M Harold ^a  

^a UNIVERSITY OF MISSOURI   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adenosine receptor; Coronary blood flow; Diabetes; Obesity; Ossabaw miniature swine; Potassium channel

Indexed keywords

2 CHLOROADENOSINE; ADENOSINE; ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; POTASSIUM CHANNEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIOLE; ARTERY CATHETERIZATION; ARTICLE; ATHEROMA; CHOLESTEROL DIET; CONTROLLED STUDY; CORONARY ARTERY DILATATION; IN VITRO STUDY; IN VIVO STUDY; INTRAVASCULAR ULTRASOUND; ISOLATED ARTERY; LIPID DIET; MALE; METABOLIC SYNDROME X; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR BLOCKING;

ADENOSINE; ANIMALS; ARTERIOLES; CARDIOVASCULAR DISEASES; CHOLESTEROL; CORONARY CIRCULATION; DIETARY FATS; MALE; METABOLIC SYNDROME X; POTASSIUM CHANNELS, VOLTAGE-GATED; RECEPTOR, ADENOSINE A2A; RISK FACTORS; SWINE; SWINE, MINIATURE; VASODILATION; VASODILATOR AGENTS;

SUIDAE;

EID: 66449135104     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.3181/0812-RM-350     Document Type: Article

References (55)

1. Malik S, Wong ND, Franklin SS, Kamath TV, L'Italien GJ, Pio JR, Williams GR. Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults. Circulation 110:1245-1250, 2004. (Pubitemid 39202340)
2. Knudson JD, Dincer UD, Bratz IN, Sturek M, Dick GM, Tune JD. Mechanisms of coronary dysfunction in obesity and insulin resistance. Microcirculation 14:317-338, 2007. (Pubitemid 47050025)
3. Tune JD, Gorman MW, Feigl EO. Matching coronary blood flow to myocardial oxygen consumption. J Appl Physiol 97:404-415, 2004. (Pubitemid 38802544)
4. Duncker DJ, Bache RJ. Regulation of coronary blood flow during exercise. Physiol Rev 88:1009-1086, 2008.
5. Pirat B, Bozbas H, Simsek V, Yildirir A, Sade LE, Gursoy Y, Altin C, Atar I, Muderrisoglu H. Impaired coronary flow reserve in patients with metabolic syndrome. Atherosclerosis 201:112-116, 2008.
6. Hein TW, Wang W, Zoghi B, Muthuchamy M, Kuo L. Functional and molecular characterization of receptor subtypes mediating coronary microvascular dilation to adenosine. J Mol Cell Cardiol 33:271-282, 2001. (Pubitemid 32537926)
7. Kemp BK, Cocks TM. Adenosine mediates relaxation of human small resistance-like coronary arteries via A2B receptors. Br J Pharmacol 126:1796-1800, 1999. (Pubitemid 29213097)
8. Talukder MA, Morrison RR, Mustafa SJ. Comparison of the vascular effects of adenosine in isolated mouse heart and aorta. Am J Physiol Heart Circ Physiol 282:H49-H57, 2002. (Pubitemid 34654133)
9. Hein TW, Kuo L. cAMP-independent dilation of coronary arterioles to adenosine : role of nitric oxide, G proteins, and K(ATP) channels. Circ Res 85:634-642, 1999.
10. Heaps CL, Bowles DK. Gender-specific K(+)-channel contribution to adenosine-induced relaxation in coronary arterioles. J Appl Physiol 92:550-558, 2002.
11. Dick GM, Bratz IN, Borbouse L, Payne GA, Dincer UD, Knudson JD, Rogers PA, Tune JD. Voltage-dependent K+ channels regulate the duration of reactive hyperemia in the canine coronary circulation. Am J Physiol Heart Circ Physiol 294:H2371-H2381, 2008.
12. Mokelke EA, Dietz NJ, Eckman DM, Nelson MT, Sturek M. Diabetic dyslipidemia and exercise affect coronary tone and differential regulation of conduit and microvessel K+ current. Am J Physiol Heart Circ Physiol 288:H1233-H1241, 2005. (Pubitemid 40270029)
13. Heaps CL, Tharp DL, Bowles DK. Hypercholesterolemia abolishes voltage-dependent K+ channel contribution to adenosine-mediated relaxation in porcine coronary arterioles. Am J Physiol Heart Circ Physiol 288:H568-H576, 2005. (Pubitemid 40139639)
14. Miura H, Wachtel RE, Loberiza FR Jr, Saito T, Miura M, Nicolosi AC, Gutterman DD. Diabetes mellitus impairs vasodilation to hypoxia in human coronary arterioles: reduced activity of ATP-sensitive potassium channels. Circ Res 92:151-158, 2003. (Pubitemid 36254271)
15. Bubolz AH, Li H, Wu Q, Liu Y. Enhanced oxidative stress impairs cAMP-mediated dilation by reducing Kv channel function in small coronary arteries of diabetic rats. Am J Physiol Heart Circ Physiol 289:H1873-H1880, 2005. (Pubitemid 41507335)
16. Liu Y, Terata K, Rusch NJ, Gutterman DD. High glucose impairs voltage-gated K(+) channel current in rat small coronary arteries. Circ Res 89:146-152, 2001. (Pubitemid 34135822)
17. Dyson MC, Alloosh M, Vuchetich JP, Mokelke EA, Sturek M. Components of metabolic syndrome and coronary artery disease in female Ossabaw swine fed excess atherogenic diet. Comparative medicine 56:35-45, 2006.
18. Lee DL, Wamhoff BR, Katwa LC, Reddy HK, Voelker DJ, Dixon JL, Sturek M. Increased endothelin-induced Ca2+ signaling, tyrosine phosphorylation, and coronary artery disease in diabetic dyslipidemic Swine are prevented by atorvastatin. J Pharmacol Exp Ther 306:132-140, 2003. (Pubitemid 36734366)
19. Hodgson JM, Reddy KG, Suneja R, Nair RN, Lesnefsky EJ, Sheehan HM. Intracoronary ultrasound imaging: correlation of plaque morphology with angiography, clinical syndrome and procedural results in patients undergoing coronary angioplasty. J Am Coll Cardiol 21:35-44, 1993. (Pubitemid 23031293)
20. Mintz GS, Nissen SE, Anderson WD, Bailey SR, Erbel R, Fitzgerald PJ, Pinto FJ, Rosenfield K, Siegel RJ, Tuzcu EM, Yock PG. American College of Cardiology Clinical Expert Consensus Document on Standards for Acquisition, Measurement and Reporting of Intravascular Ultrasound Studies (IVUS). A report of the American College of Cardiology Task Force on Clinical Expert Consensus Documents. J Am Coll Cardiol 37:1478-1492, 2001.
21. Wong CB, Porter TR, Xie F, Deligonul U. Segmental analysis of coronary arteries with equivalent plaque burden by intravascular ultrasound in patients with and without angiographically significant coronary artery disease. Am J Cardiol 76:598-601, 1995.
22. Henderson KK, Turk JR, Rush JW, Laughlin MH. Endothelial function in coronary arterioles from pigs with early-stage coronary disease induced by high-fat, high-cholesterol diet: effect of exercise. J Appl Physiol 97:1159-1168, 2004. (Pubitemid 39121447)
23. Munoz G, San Martin R, Farias M, Cea L, Vecchiola A, Casanello P, Sobrevia L. Insulin restores glucose inhibition of adenosine transport by increasing the expression and activity of the equilibrative nucleoside transporter 2 in human umbilical vein endothelium. J Cell Physiol 209:826-835, 2006. (Pubitemid 44665704)
24. Leung GP, Man RY, Tse CM. D-Glucose upregulates adenosine transport in cultured human aortic smooth muscle cells. Am J Physiol Heart Circ Physiol 288:H2756-H2762, 2005. (Pubitemid 40720655)
25. Rubin LJ, Johnson LR, Dodam JR, Dhalla AK, Magliola L, Laughlin MH, Jones AW. Selective transport of adenosine into porcine coronary smooth muscle. Am J Physiol Heart Circ Physiol 279:H1397-H1410, 2000.
26. Wang J, Whitt SP, Rubin LJ, Huxley VH. Differential coronary microvascular exchange responses to adenosine: roles of receptor and microvessel subtypes. Microcirculation 12:313-326, 2005. (Pubitemid 40872924)
27. Puffinbarger NK, Hansen KR, Resta R, Laurent AB, Knudsen TB, Madara JL, Thompson LF. Production and characterization of multiple antigenic peptide antibodies to the adenosine A2b receptor. Mol Pharmacol 47:1126-1132, 1995.
28. Olanrewaju HA, Qin W, Feoktistov I, Scemama JL, Mustafa SJ. Adenosine A(2A) and A(2B) receptors in cultured human and porcine coronary artery endothelial cells. Am J Physiol Heart Circ Physiol 279:H650-H656, 2000.
29. Sato A, Terata K, Miura H, Toyama K, Loberiza FR Jr, Hatoum OA, Saito T, Sakuma I, Gutterman DD. Mechanism of vasodilation to adenosine in coronary arterioles from patients with heart disease. Am J Physiol Heart Circ Physiol 288:H1633-H1640, 2005. (Pubitemid 40417986)
30. Hinschen AK, Rose'Meyer RB, Headrick JP. Adenosine receptor subtypes mediating coronary vasodilation in rat hearts. J Cardiovasc Pharmacol 41:73-80, 2003. (Pubitemid 36015058)
31. Grden M, Podgorska M, Szutowicz A, Pawelczyk T. Altered expression of adenosine receptors in heart of diabetic rat. J Physiol Pharmacol 56:587-597, 2005. (Pubitemid 43127555)
32. Duarte JM, Oliveira CR, Ambrosio AF, Cunha RA. Modification of adenosine A1 and A2A receptor density in the hippocampus of streptozotocin-induced diabetic rats. Neurochem Int 48:144-150, 2006. (Pubitemid 41832450)
33. Grden M, Podgorska M, Szutowicz A, Pawelczyk T. Diabetes-induced alterations of adenosine receptors expression level in rat liver. Exp Mol Pathol 83:392-398, 2007. (Pubitemid 350087017)
34. Pawelczyk T, Grden M, Rzepko R, Sakowicz M, Szutowicz A. Region-specific alterations of adenosine receptors expression level in kidney of diabetic rat. Am J Pathol 167:315-325, 2005. (Pubitemid 43026089)
35. Pelleg A, Hurt CM. Effects of N6-endonorbornan-2-yl-9-methyladenine, N0861, on negative chronotropic and vasodilatory actions of adenosine in the canine heart in vivo. Can J Physiol Pharmacol 70:1450-1456, 1992.
36. Tawfik HE, Teng B, Morrison RR, Schnermann J, Mustafa SJ. Role of A1 adenosine receptor in the regulation of coronary flow. Am J Physiol Heart Circ Physiol 291:H467-H472, 2006.
37. Yada T, Hiramatsu O, Tachibana H, Toyota E, Kajiya F. Role of NO and K(+)(ATP) channels in adenosine-induced vasodilation on in vivo canine subendocardial arterioles. Am J Physiol 277:H1931-H1939, 1999.
38. Farouque HM, Worthley SG, Meredith IT, Skyrme-Jones RA, Zhang MJ. Effect of ATP-sensitive potassium channel inhibition on resting coronary vascular responses in humans. Circ Res 90:231-236, 2002. (Pubitemid 34627093)
39. Zimmermann PA, Knot HJ, Stevenson AS, Nelson MT. Increased myogenic tone and diminished responsiveness to ATP-sensitive K+ channel openers in cerebral arteries from diabetic rats. Circ Res 81:996-1004, 1997. (Pubitemid 27514949)
40. Kamata K, Miyata N, Kasuya Y. Functional changes in potassium channels in aortas from rats with streptozotocin-induced diabetes. Eur J Pharmacol 166:319-323, 1989. (Pubitemid 19186772)
41. Hodnett BL, Xiang L, Dearman JA, Carter CB, Hester RL. K(ATP)-mediated vasodilation is impaired in obese Zucker rats. Microcirculation 15:485-494, 2008.
42. Kersten JR, Brooks LA, Dellsperger KC. Impaired microvascular response to graded coronary occlusion in diabetic and hyperglycemic dogs. Am J Physiol 268:H1667-H1674, 1995.
43. Tune JD, Yeh C, Setty S, Downey HF. ATP-dependent K(+) channels contribute to local metabolic coronary vasodilation in experimental diabetes. Diabetes 51:1201-1207, 2002.
44. Hussain T, Mustafa SJ. Regulation of adenosine receptor system in coronary artery: functional studies and cAMP. Am J Physiol 264:H441-H447, 1993. (Pubitemid 23081116)
45. Matsumoto T, Wakabayashi K, Kobayashi T, Kamata K. Functional changes in adenylyl cyclases and associated decreases in relaxation responses in mesenteric arteries from diabetic rats. Am J Physiol Heart Circ Physiol 289:H2234-H2243, 2005. (Pubitemid 41507378)
46. Matsumoto T, Wakabayashi K, Kobayashi T, Kamata K. Diabetes-related changes in cAMP-dependent protein kinase activity and decrease in relaxation response in rat mesenteric artery. Am J Physiol Heart Circ Physiol 287:H1064-H1071, 2004. (Pubitemid 39096651)
47. Cole WC, Clement-Chomienne O, Aiello EA. Regulation of 4-aminopyridine-sensitive, delayed rectifier K+ channels in vascular smooth muscle by phosphorylation. Biochem Cell Biol 74:439-447, 1996. (Pubitemid 126734106)
48. Hein TW, Belardinelli L, Kuo L. Adenosine A(2A) receptors mediate coronary microvascular dilation to adenosine: role of nitric oxide and ATP-sensitive potassium channels. J Pharmacol Exp Ther 291:655-664, 1999. (Pubitemid 29503538)
49. Ji XD, Jacobson KA. Use of the triazolotriazine [3H]ZM 241385 as a radioligand at recombinant human A2B adenosine receptors. Drug Des Discov 16:217-226, 1999.
50. Poucher SM, Keddie JR, Singh P, Stoggall SM, Caulkett PW, Jones G, Coll MG. The in vitro pharmacology of ZM 241385, a potent, non-xanthine A2a selective adenosine receptor antagonist. Br J Pharmacol 115:1096-1102, 1995.
51. Bruns RF, Lu GH, Pugsley TA. Characterization of the A2 adenosine receptor labeled by [3H]NECA in rat striatal membranes. Mol Pharmacol 29:331-346, 1986.
52. Swan JW, Walton C, Godsland IF, Crook D, Oliver MF, Stevenson JC. Insulin resistance syndrome as a feature of cardiological syndrome X in non-obese men. Br Heart J 71:41-44, 1994. (Pubitemid 2011318)
53. Jadhav ST, Ferrell WR, Petrie JR, Scherbakova O, Greer IA, Cobbe SM, Sattar N. Microvascular function, metabolic syndrome, and novel risk factor status in women with cardiac syndrome X. Am J Cardiol 97:1727-1731, 2006. (Pubitemid 43817858)
54. Cheng TO. Cardiac syndrome X versus metabolic syndrome X. Int J Cardiol 119:137-138, 2007. (Pubitemid 46818505)
55. Buhr C, Gossl M, Erbel R, Eggebrecht H. Regadenoson in the detection of coronary artery disease. Vasc Health Risk Manag 4:337-340, 2008.