Role of adenosine in the regulation of coronary blood flow in swine at rest and during treadmill exercise

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 275, Issue 5 44-5, 1998, Pages

  Duncker, Dirk J ^a,b   Stubenitsky, René ^a   Verdouw, Pieter D ^a  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Coronary circulation; Myocardial oxygen consumption; Myocardial oxygen extraction; Pulmonary circulation; Systemic circulation

Indexed keywords

ADENOSINE; ADENOSINE DEAMINASE; ISOPRENALINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL TONE; CATABOLISM; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY BLOOD VESSEL; ENZYME ACTIVITY; HEART MUSCLE OXYGEN CONSUMPTION; LUNG CIRCULATION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BLOCKING; REST; SWINE; TREADMILL EXERCISE; VASCULAR RESISTANCE;

EID: 33750724183     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1998.275.5.h1663     Document Type: Article

References (40)

1. Bacchus, A. N., S. W. Ely, R. M. Knabb, R. Rubio, and R. M. Berne. Adenosine and coronary blood flow in conscious dogs during normal physiological stimuli. Am. J. Physiol. 243 (Heart Circ. Physiol. 12): H628-H633, 1982.
2. Bache, R. J., S. Z. Dai, J. S. Schwartz, and D. C. Homans. Role of adenosine in coronary vasodilation during exercise. Circ. Res. 62: 846-853, 1988.
3. Barnes, P. J., and S. F. Liu. Regulation of pulmonary vascular tone. Pharmacol. Rev. 47: 87-131, 1995.
4. Berne, R. M., and R. Rubio. Regulation of coronary blood flow. Adv. Cardiol. 12: 303-317, 1974.
5. Breisch, E. A., F. C. White, L. E. Nimmo, M. D. McKirnan, and C. M. Bloor. Exercise-induced cardiac hypertrophy: a correlation of blood flow and microvasculature. J. Appl. Physiol. 60: 1259-1267, 1979.
6. Canty, J. M., Jr., and T. P. Smith. Adenosine-recruitable flow reserve is absent during myocardial ischemia in unanesthetized dogs studied in the basal state. Circ. Res. 76: 1079-1087, 1995.
7. Dewitt, D. F., R. D. Wangler, C. I. Thompson, and H. V. Sparks, Jr. Phasic release of adenosine during steady state metabolic stimulation in the isolated guinea pig heart. Circ. Res. 53: 636-643, 1983.
8. Duncker, D. J., D. B. Haitsma, I. E. J. Van Der Geest, R. Stubenitsky, J. R. van Meegen, A. J. Man in 't Veld, and P. D. Verdouw. Systemic, pulmonary and coronary haemodynamic actions of the novel dopamine receptor agonist Z1046 in awake pigs at rest and during treadmill exercise. Br. J. Pharmacol. 120: 1101-1113, 1997.
9. Duncker, D. J., C. Klassen, S. K. Herrlinger, T. J. Pavek, and R. J. Bache. Effects of temperature on myocardial infarction in swine. Am. J. Physiol. 270 (Heart Circ. Physiol. 39): H1189-H1199, 1996.
10. Duncker, D. J., R. Stubenitsky, and P. D. Verdouw. Autonomic control of vasomotion in the porcine coronary circulation during treadmill exercise: evidence for feed-forward β-adrenergic control. Circ. Res. 82: 1312-1322, 1998.
11. + channels and adenosine in regulation of coronary blood flow during exercise with normal and restricted coronary blood flow. J. Clin. Invest. 97: 996-1009, 1996.
12. Edlund, A., T. Conradsson, and A. Sollevi. A role for adenosine in coronary vasoregulation in man. Effects of theophylline and enprofylline. Clin. Physiol. 15: 623-636, 1995.
13. Edlund, A., and A. Sollevi. Theophylline increases coronary vascular tone in humans: evidence for a role of endogenous adenosine in flow regulation. Acta Physiol. Scand. 155: 303-311, 1995.
14. Edlund, A., A. Sollevi, and A. Wennmalm. The role of adenosine and prostacyclin in coronary flow regulation in healthy man. Acta Physiol. Scand. 135: 39-46, 1989.
15. Ely, S. W., R. M. Knabb, A. N. Bacchus, R. Rubio, and R. M. Berne. Measurements of coronary plasma and pericardial infusate adenosine concentrations during exercise in conscious dogs: relationship to myocardial oxygen consumption and coronary blood flow. J. Mol. Cell. Cardiol. 15: 173-183, 1983.
16. Fan, D., L. K. Soei, R. Stubenitsky, E. Boersma, D. J. Duncker, P. D. Verdouw, and R. Krams. Contribution of asynchrony and nonunifofmity to mechanical interaction in normal and stunned myocardium. Am. J. Physiol. 273 (Heart Circ. Physiol. 42): H2146-H2154, 1997.
17. Feigl, E. O. Coronary physiology. Physiol. Rev. 63: 1-205, 1983.
18. Gewirtz, H., R. A. Olsson, D. L. Brautigan, P. R. Brown, and A. S. Most. Adenosine's role in regulating basal coronary arteriolar tone. Am. J. Physiol. 250 (Heart Circ. Physiol. 19): H1030-H1036, 1986.
19. Gewirtz, H., R. A. Olsson, and A. S. Most. Role of adenosine in mediating myocardial blood flow response to isoproterenol: observations in closed chest, sedated, domestic swine. Cardiovasc. Res. 20: 504-511, 1986.
20. Giles, R. W., and D. E. L. Wilcken. Reactive hyperaemia in the dog heart: interrelationships between adenosine, ATP, and aminophylline and the effect of indomethacin. Cardiovasc. Res. 11: 113-121, 1977.
21. 1-purinoceptor antagonist. Eur. J. Pharmacol. 75: 61-64, 1981.
22. Hall, J. L., D. G. L. Van Wylen, R. D. Pizzuro, C. D. Hamilton, C. M. Reiling, and W. C. Stanley. Myocardial interstitial purine metabolites and lactate with increased work in swine. Cardiovasc. Res. 30: 351-356, 1995.
23. Hanley, F. L., M. T. Grattan, M. B. Stevens, and J. I. E. Hoffman. Role of adenosine in coronary autoregulation. Am. J. Physiol. 250 (Heart Circ. Physiol. 19): H558-H566, 1986.
24. Ishida, T., R. M. Lewis, C. J. Hartley, M. L. Entman, and J. B. Field. Comparison of hepatic extraction of insulin and glucagon in conscious and anesthetized dogs. Endocrinology 112: 1098-1109, 1983.
25. Kroll, K., and E. O. Feigl. Adenosine is unimportant in controlling coronary blood flow in unstressed dog hearts. Am. J. Physiol. 249 (Heart Circ. Physiol. 18): H1176-H1187, 1985.
26. Laughlin, M. H., R. E. Klabunde, M. D. Delp, and R. B. Armstrong. Effects of dipyridamole on muscle blood flow in exercising miniature swine. Am. J. Physiol. 257 (Heart Circ. Physiol. 26): H1507-H1515, 1989.
27. Laughlin, M. H., R. Korthuis, D. J. Duncker, and R. J. Bache. Regulation of blood flow to cardiac and skeletal muscle during exercise. In: Handbook of Physiology. Exercise: Regulation and Integration of Multiple Systems. Bethesda, MD: Am. Physiol. Soc., 1996, sect. 12, chapt. 16, p. 705-769.
28. Martin, S. E., W. C. Tidmore, and R. E. Patterson. Adenosine receptor blockade with 8-sulfophenyltheophylline aggravates coronary constriction. Am. J. Physiol. 260 (Heart Circ. Physiol. 29): H1753-H1759, 1991.
29. McKenzie, J. E., R. P. Steffen, and F. J. Haddy. Relationship between adenosine and coronary resistance in conscious exercising dogs. Am. J. Physiol. 242 (Heart Circ. Physiol. 11): H24-H29, 1982.
30. Merrill, G. F., F. J. Haddy, and J. M. Dabney. Adenosine, theophylline, and perfusate pH in the isolated, perfused guinea pig heart. Circ. Res. 42: 225-229, 1978.
31. Olsson, R. A., R. Bunger, and J. A. E. Spaan. Coronary circulation. In: The Heart and Cardiovascular System, edited by H. A. Fozzard, E. Haber, R. B. Jennings, A. M. Katz, and H. E. Morgan. New York: Raven, 1992, p. 1393-1426.
32. Randall, M. D. The involvement of ATP-sensitive potassium channels and adenosine in the regulation of coronary flow in the isolated perfused rat heart. Br. J. Pharmacol. 116: 3068-3074, 1995.
33. Rossen, J. D., H. Oskarsson, R. L. Minor, C. L. Talman, and M. D. Winniford. Effect of adenosine antagonism on metabolically mediated coronary vasodilation in humans. J. Am. Coll. Cardiol. 23: 1421-1426, 1994.
34. Saito, D., C. R. Steinhart, D. G. Nixon, and R. A. Olsson. Intracoronary adenosine deaminase reduces canine myocardial reactive hyperemia. Circ. Res. 49: 1262-1267, 1981.
35. Schutz, W., M. Zipfer, and G. Raberger. Effect of aminophylline on coronary reactive hyperaemia following brief and long occlusion periods. Cardiovasc. Res. 11: 507-511, 1977.
36. Schwartz, L. M., and J. E. McKenzie. Adenosine and active hyperemia in soleus and gracilis muscle of cats. Am. J. Physiol. 259 (Heart Circ. Physiol. 28): H1295-H1304, 1990.
37. Sparks, H. V., Jr., and H. Bardenheuer. Regulation of adenosine formation by the heart. Circ. Res. 58: 193-201, 1986.
38. 2+-sensitizer EMD 57033 in chronically instrumented pigs at rest and during exercise. Br. J. Pharmacol. 122: 1257-1270, 1997.
39. 2 delivery and utilization in swine during treadmill exercise. Cardiovasc. Res. 39: 459-474, 1998.
40. Watkinson, W. P., D. H. Foley, R. Rubio, and R. M. Berne. Myocardial adenosine formation with increased cardiac performance in the dog. Am. J. Physiol. 236 (Heart Circ. Physiol. 5): H13-H21, 1979.