Rapid characterization and quality control of complex cell culture media solutions using Raman spectroscopy and chemometrics

Biotechnology and Bioengineering

Volumn 107, Issue 2, 2010, Pages 290-301

  Li, Boyan ^a   Ryan, Paul W ^a   Ray, Bryan H ^a   Leister, Kirk J ^b   Sirimuthu, Narayana M S ^a   Ryder, Alan G ^a  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^b BRISTOL MYERS SQUIBB COMPANY   (United States)

Author keywords

Cell culture; Chemically defined media; Chemometrics; PCA; Raman spectroscopy; SIMCA

Indexed keywords

BASELINE DRIFT; CELL CULTURE MEDIA; CHEMICALLY DEFINED MEDIA; CHEMOMETRICES; CHEMOMETRICS; CHINESE HAMSTER OVARY CELLS; DILUTE AQUEOUS SOLUTION; INDUSTRIAL CONTEXT; KEY FACTORS; MAMMALIAN CELL CULTURE; MEDIA COMPONENTS; OPTIMUM METHOD; PCA; QUALITY ASSESSMENT; QUALITY EVALUATION; RAMAN SPECTRAL DATA; RAPID IDENTIFICATION; RECOMBINANT PROTEIN; ROBUST METHODS; ROUTINE ANALYSIS; SAMPLE HANDLING; SAMPLE PREPARATION; SIMCA; SOFT INDEPENDENT MODELING OF CLASS ANALOGIES; SPECTRAL DATA;

ANIMAL CELL CULTURE; CELL CULTURE; IDENTIFICATION (CONTROL SYSTEMS); INDEPENDENT COMPONENT ANALYSIS; MAMMALS; PRINCIPAL COMPONENT ANALYSIS; PROTEINS; RAMAN SCATTERING; RAMAN SPECTROSCOPY; SAMPLING; SPECTRUM ANALYSIS;

QUALITY CONTROL;

RECOMBINANT PROTEIN;

ARTICLE; ARTIFACT; CHEMOMETRICS; CHO CELL; CULTURE MEDIUM; INSTRUMENTATION; PRINCIPAL COMPONENT ANALYSIS; QUALITY CONTROL; RAMAN SPECTROMETRY; SOLUTION AND SOLUBILITY; ANIMAL CELL; AQUEOUS SOLUTION; FEMALE; INFRARED SPECTROSCOPY; NEAR INFRARED SPECTROSCOPY; NONHUMAN; PROTEIN SYNTHESIS; ANIMAL; BIOTECHNOLOGY; CHEMICAL ANALYSIS; CHEMISTRY; CRICETULUS; CULTURE TECHNIQUE; HAMSTER; METHODOLOGY; STANDARD;

CRICETULUS GRISEUS; MAMMALIA;

ANIMALS; BIOTECHNOLOGY; CELL CULTURE TECHNIQUES; CHEMISTRY TECHNIQUES, ANALYTICAL; CHO CELLS; CRICETINAE; CRICETULUS; CULTURE MEDIA; QUALITY CONTROL; SPECTRUM ANALYSIS, RAMAN;

EID: 78149237599     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.22813     Document Type: Article

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