The transcobalamin 776C>G polymorphism may be a modifiable genetic risk factor for Alzheimer's disease [2]

International Psychogeriatrics

Volumn 17, Issue 2, 2005, Pages 329-331

  Zetterberg, Henrik ^a,b   Nexö, Ebba ^c   Minthon, Lennart ^d   Boson, Roberta ^d   Regland, Björn ^a   Mccaddon, Andrew ^e   Blennow, K A J ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^b HARVARD MEDICAL SCHOOL   (United States)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

^d LUND UNIVERSITY HOSPITAL   (Sweden)

^e GLYNDWR UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYANOCOBALAMIN; TRANSCOBALAMIN;

ADULT; AGED; ALLELE; ALZHEIMER DISEASE; CEREBROSPINAL FLUID LEVEL; CLINICAL ARTICLE; CLINICAL EXAMINATION; COGNITIVE DEFECT; CONTROLLED STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FEMALE; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE; HETEROZYGOTE DETECTION; HOMOZYGOSITY; HUMAN; LETTER; LONG TERM CARE; MALE; VITAMIN SUPPLEMENTATION;

AGING; ALZHEIMER DISEASE; FEMALE; GENOTYPE; HUMANS; MALE; POLYMORPHISM, GENETIC; PSYCHIATRIC STATUS RATING SCALES; RISK FACTORS; TRANSCOBALAMINS; VITAMIN B 12;

EID: 23044457687     PISSN: 10416102     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1041610205222068     Document Type: Letter

References (5)

1. McCaddon, A. et al. (2004). Transcobalamin polymorphism and serum holo-transcobalamin in relation to Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 17, 215-221.
2. 12 deficiency. Clinical Chemistry, 48, 561-562.
3. Refsum, H. and Smith, A. D. (2003). Low vitamin B-12 status in confirmed Alzheimer's disease as revealed by serum holotranscobalamin. Journal of Neurology, Neurosurgery and Psychiatry, 74, 959-961.
4. Zetterberg, H., Palmér, M., Borestrom, C., Rymo, L. and Blennow, K. (2003a). The transcobalamin codon 259 polymorphism should be designated 776C>G, not 775G>C. Blood, 101: 3749-3750.
5. Zetterberg, H. et al. (2003b). The transcobalamin (TC) codon 259 genetic polymorphism influences holo-TC concentration in cerebrospinal fluid from patients with Alzheimer's disease. Clinical Chemistry, 49: 1195-1198.