Clindamycin-induced enrichment and long-term persistence of resistant Bacteroides spp. and resistance genes

Journal of Antimicrobial Chemotherapy

Volumn 58, Issue 6, 2006, Pages 1160-1167

  Löfmark, Sonja ^a   Jernberg, Cecilia ^a,b   Jansson, Janet K ^c   Edlund, Charlotta ^a,d  

^a KAROLINSKA INSTITUTE   (Sweden)

^b SÖDERTÖRN UNIVERSITY   (Sweden)

^c SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^d MEDICAL PRODUCTS AGENCY   (Sweden)

Author keywords

Antimicrobial resistance; Clindamycin; Intestinal microflora

Indexed keywords

AMPICILLIN; CLINDAMYCIN; DOXYCYCLINE; PENICILLIN DERIVATIVE; TETRACYCLINE;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIUM CULTURE; BACTERIUM IDENTIFICATION; BACTERIUM ISOLATE; BACTEROIDES; BACTEROIDES THETAIOTAOMICRON; DRUG CAPSULE; DRUG SENSITIVITY; GENOTYPE; HUMAN; HUMAN EXPERIMENT; INTESTINE FLORA; MINIMUM INHIBITORY CONCENTRATION; NORMAL HUMAN; PHENOTYPE; REAL TIME POLYMERASE CHAIN REACTION; SPECIES DIVERSITY; STRAIN DIFFERENCE;

ADULT; ANTI-BACTERIAL AGENTS; BACTERIAL TYPING TECHNIQUES; BACTEROIDES; BACTEROIDES INFECTIONS; CLINDAMYCIN; DNA, BACTERIAL; DRUG RESISTANCE, BACTERIAL; ECOSYSTEM; FECES; FEMALE; GENOTYPE; HUMANS; INTESTINES; MALE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; POLYMERASE CHAIN REACTION;

EID: 33845349674     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkl420     Document Type: Article

References (30)

1. Salyers AA, Gupta A, Wang Y. Human intestinal bacteria as reservoirs for antibiotic resistance genes. Trends Microbiol 2004; 12: 412-16.
2. Sullivan A, Barkholt L, Nord CE. Lactobacillus acidophilus, Bifidobacterium lactis and Lactobacillus F19 prevent antibiotic associated ecological disturbances of Bacteroides fragilis in the intestine. J Antimicrob Chemother 2003; 52: 308-11.
3. Leigh DA, Simmons K. Effect of clindamycin and lincomycin therapy on faecal flora. J Clin Pathol 1978; 31: 439-43.
4. Jemberg C, Sullivan A, Edlund C et al. Monitoring of antibiotic induced alterations in the human intestinal microflora and detection of probiotic strains by use of terminal restriction fragment length polymorphism. Appl Environ Microbiol 2005; 71: 501-6.
5. Franks AH, Harmsen HJ, Raangs GC et al. Variations of bacterial populations in human feces measured by fluorescent in situ hybridization with group-specific 16S rRNA-targeted oligonucleotide probes. Appl Environ Microbiol 1998; 64: 3336-45.
6. Hedberg M, Nord CE. Antimicrobial susceptibility of Bacteroides fragilis group isolates in Europe. Clin Microbiol Infect 2003; 9: 475-88.
7. Aldridge KE, Ashcraft D, Cambre K et al. Multicenter survey of the changing in vitro antimicrobial susceptibilities of clinical isolates of Bacteroides fragilis group, Prevotella, Fusobacterum, Porphyromonas, and Peptostreptococcus species. Antimicrob Agents Chemother 2001; 45: 1238-43.
8. Shoemaker NB, Vlamakis H, Hayes K et al. Evidence for extensive resistance gene transfer among Bacteroides spp. and among Bacteroides and other genera in the human colon. Appl Environ Microbiol 2001; 67: 561-8.
9. Roberts MC. Resistance to macrolide, lincosamide, streptogramin, ketolide, and oxazolidinone antibiotics. Mol Biotechnol 2004; 28: 47-62.
10. Whittle G, Shoemaker NB, Salyers AA. The role of Bacteroides conjugative transposons in the dissemination of antibiotic resistance genes. Cell Mol Life Sci 2002; 59: 2044-54.
11. Salyers AA, Amabile-Cuevas CF. Why are antibiotic resistance genes so resistant to elimination? Antimicrob Agents Chemother 1997; 41: 2321-5.
12. Vedantam G, Hecht DW. Antibiotics and anaerobes of gut origin. Curr Opin Microbiol 2003; 6: 457-61.
13. Phillips I, King A, Nord CE et al. Antibiotic sensitivity of the Bacteroides fragilis group in Europe. European Study Group. Eur J Clin Microbiol Infect Dis 1992; 11: 292-304.
14. Hecht DW. Prevalence of antibiotic resistance in anaerobic bacteria: worrisome developments. Clin Infect Dis 2004; 39: 92-7.
15. Ulger (Toprak) N, Celik C, Cakici O et al. Antimicrobial susceptibilities of Bacteroides fragilis and Bacteroides thetaiotaomicron strains isolated from clinical specimens and human intestinal microbiota. Anaerobe 2004; 10: 255-9.
16. Roberts MC. Update on acquired tetracycline resistance genes. FEMS Microbiol Lett 2005; 245: 195-203.
17. Paula GR, Falcao LS, Antunes EN et al. Determinants of resistance in Bacteroides fragilis strains according to recent Brazilian profiles of antimicrobial susceptibility. Int J Antimicrob Agents 2004; 24: 53-8.
18. Rasmussen BA, Bush K, Tally FP. Antimicrobial resistance in anaerobes. Clin infect Dis 1997; 24 Suppl 1: S110-20.
19. Morgan JR, Liu PY, Smith JA. Semi-microtechnique for the biochemical characterization of anaerobic bacteria. J Clin Microbiol 1976; 4: 315-8.
20. Jouisimies-Somer HR, Summanen P, Citron D et al. Wadsworth KTL Anaerobic Bacteriology Manual. 6th edn. Belmont, CA: Star publishing company, 2002.
21. Moraes SR, Goncalves RB, Mouton C et al. Use of rep-PCR to define genetic relatedness among Bacteroides fragilis strains. J Med Microbiol 2000; 49: 279-84.
22. National Committee for Clinical Laboratory Standards. Methods for Antimicrobial Susceptibility Testing of Anaerobic Bacteria Sixth Edition: Approved Standards M11-A6 NCCLS, Wayne, PA, USA, 2004.
23. Duerden BI. The isolation and identification of Bacteroides spp. from the normal human faecal flora. J Med Microbiol 1980; 13: 69-78.
24. Job ML, Jacobs NF, Jr. Drug-induced Clostridium difficile-associated disease. Drug Saf 1997; 17: 37-46.
25. Sullivan A, Edlund C, Nord CE. Effect of antimicrobial agents on the ecological balance of human microflora. Lancet Infect Dis 2001; 1: 101-14.
26. Lautenbach E, LaRosa LA, Marr AM et al. Changes in the prevalence of vancomycin-resistant enterococci in response to antimicrobial formulary interventions: Impact of progressive restrictions on use of vancomycin and third-generation cephalosporins. Chn Infect Dis 2003; 36: 440-6.
27. Nord CE, Heimdahl A. Impact of different antimicrobial agents on the colonisation resistance in the intestinal tract with special reference to doxycycline. Scand J Infect Dis Suppl 1988; 53: 50-8.
28. Edlund C, Nord CE. Ecological impact of antimicrobial agents on human intestinal microflora. Alpe Adria Microbiology J 1993; 3: 137-64.
29. Arthur M, Molinas C, Mabilat C et al. Detection of erythromycin resistance by the polymerase chain reaction using primers in conserved regions of erm rRNA methylase genes. Antimicrob Agents Chemother 1990; 34: 2024-6.
30. Ono T, Shiota S, Hirota K et al. Susceptibilities of oral and nasal isolates of Streptococcus mitis and Streptococcus oralis to macrolides and PCR detection of resistance genes. Antimicrob Agents Chemother 2000; 44: 1078-80.