Eicosapentaenoic acid and docosahexaenoic acid reduce interleukin-1β-mediated cartilage degradation

Arthritis Research and Therapy

Volumn 12, Issue 6, 2010, Pages

  Wann, Angus K T ^a   Mistry, Jiten ^a   Blain, Emma J ^b   Michael Titus, Adina T ^a   Knight, Martin M ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DOCOSAHEXAENOIC ACID; GLYCOSAMINOGLYCAN; ICOSAPENTAENOIC ACID; INTERLEUKIN 1BETA; ANTIINFLAMMATORY AGENT;

ANIMAL TISSUE; ARTICLE; CARTILAGE CELL; CARTILAGE DEGENERATION; CELL CULTURE; CELL VIABILITY; CONCENTRATION (PARAMETERS); FLUORESCENCE MICROSCOPY; IN VITRO STUDY; NONHUMAN; TREATMENT RESPONSE; ANIMAL; ARTICULAR CARTILAGE; CATTLE; CELL SURVIVAL; CHONDROPATHY; DRUG EFFECT; IMMUNOLOGY; MALE; PATHOLOGY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CARTILAGE DISEASES; CARTILAGE, ARTICULAR; CATTLE; CELL SURVIVAL; CHONDROCYTES; DOCOSAHEXAENOIC ACIDS; EICOSAPENTAENOIC ACID; INTERLEUKIN-1BETA; MALE;

EID: 78049482396     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar3183     Document Type: Article

References (35)

1. Huang K, Wu LD. Aggrecanase and aggrecan degradation in osteoarthritis: a review. J Int Med Res 2008, 36:1149-1160.
2. Caterson B, Flannery CR, Hughes CE, Little CB. Mechanisms involved in cartilage proteoglycan catabolism. Matrix Biol 2000, 19:333-344. 10.1016/S0945-053X(00)00078-0, 10963994.
3. Lohmander LS, Ionescu M, Jugessur H, Poole AR. Changes in joint cartilage aggrecan after knee injury and in osteoarthritis. Arthritis Rheum 1999, 42:534-544. 10.1002/1529-0131(199904)42:3<534::AID-ANR19>3.0.CO;2-J, 10088777.
4. Struglics A, Larsson S, Pratta MA, Kumar S, Lark MW, Lohmander LS. Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragments. Osteoarthritis Cartilage 2006, 14:101-113. 10.1016/j.joca.2005.07.018, 16188468.
5. Pearle AD, Scanzello CR, George S, Mandl LA, DiCarlo EF, Peterson M, Sculco TP, Crow MK. Elevated high-sensitivity C-reactive protein levels are associated with local inflammatory findings in patients with osteoarthritis. Osteoarthritis Cartilage 2007, 15:516-523. 10.1016/j.joca.2006.10.010, 17157039.
6. Goldring MB, Otero M, Tsuchimochi K, Ijiri K, Li Y. Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism. Ann Rheum Dis 2008, 67(Suppl 3):iii75-iii82. 10.1136/ard.2008.098764, 19022820.
7. Caterson B, Flannery CR, Hughes CE, Little CB. Mechanisms of proteoglycan metabolism that lead to cartilage destruction in the pathogenesis of arthritis. Drugs Today (Barc) 1999, 35:397-402.
8. Amin AR. Regulation of tumor necrosis factor-α and tumor necrosis factor converting enzyme in human osteoarthritis. Osteoarthritis Cartilage 1999, 7:392-394. 10.1053/joca.1998.0221, 10419777.
9. Lotz M. Cytokines in cartilage injury and repair. Clin Orthop Relat Res 2001, 391(Suppl):S108-S115. 10.1097/00003086-200110001-00011, 11603695.
10. Vincenti MP, Brinckerhoff CE. Early response genes induced in chondrocytes stimulated with the inflammatory cytokine interleukin-1β. Arthritis Res 2001, 3:381-388. 10.1186/ar331, 64850, 11714393.
11. Little CB, Flannery CR, Hughes CE, Goodship A, Caterson B. Cytokine induced metalloproteinase expression and activity does not correlate with focal susceptibility of articular cartilage to degeneration. Osteoarthritis Cartilage 2005, 13:162-170. 10.1016/j.joca.2004.10.014, 15694578.
12. Little CB, Mittaz L, Belluoccio D, Rogerson FM, Campbell IK, Meeker CT, Bateman JF, Pritchard MA, Fosang AJ. ADAMTS-1-knockout mice do not exhibit abnormalities in aggrecan turnover in vitro or in vivo. Arthritis Rheum 2005, 52:1461-1472. 10.1002/art.21022, 15880348.
13. Zainal Z, Longman AJ, Hurst S, Duggan K, Caterson B, Hughes CE, Harwood JL. Relative efficacies of omega-3 polyunsaturated fatty acids in reducing expression of key proteins in a model system for studying osteoarthritis. Osteoarthritis Cartilage 2009, 17:896-905. 10.1016/j.joca.2008.12.009, 19217322.
14. Watanabe Y, Namba A, Honda K, Aida Y, Matsumura H, Shimizu O, Suzuki N, Tanabe N, Maeno M. IL-1β stimulates the expression of prostaglandin receptor EP4 in human chondrocytes by increasing production of prostaglandin E2. Connect Tissue Res 2009, 50:186-193. 10.1080/03008200802588451, 19444759.
15. Burr G, Burr M. On the nature and role of fatty acids essential in nutrition. J Biol Chem 1930, 86:587-621.
16. Das UN. Beneficial effect(s) of n-3 fatty acids in cardiovascular diseases: but, why and how?. Prostaglandins Leukot Essent Fatty Acids 2000, 63:351-362. 10.1054/plef.2000.0226, 11133172.
17. Simopoulos AP. Omega-3 fatty acids in health and disease and in growth and development. Am J Clin Nutr 1991, 54:438-463.
18. Michael-Titus AT. Omega-3 fatty acids and neurological injury. Prostaglandins Leukot Essent Fatty Acids 2007, 77:295-300. 10.1016/j.plefa.2007.10.021, 18036801.
19. Wang C, Harris WS, Chung M, Lichtenstein AH, Balk EM, Kupelnick B, Jordan HS, Lau J. n-3 Fatty acids from fish or fish-oil supplements, but not α-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review. Am J Clin Nutr 2006, 84:5-17.
20. Cleland LG, James MJ. Fish oil and rheumatoid arthritis: antiinflammatory and collateral health benefits. J Rheumatol 2000, 27:2305-2307.
21. Roush JK, Dodd CE, Fritsch DA, Allen TA, Jewell DE, Schoenherr WD, Richardson DC, Leventhal PS, Hahn KA. Multicenter veterinary practice assessment of the effects of omega-3 fatty acids on osteoarthritis in dogs. J Am Vet Med Assoc 2010, 236:59-66. 10.2460/javma.236.1.59, 20043800.
22. Hankenson KD, Watkins BA, Schoenlein IA, Allen KG, Turek JJ. Omega-3 fatty acids enhance ligament fibroblast collagen formation in association with changes in interleukin-6 production. Proc Soc Exp Biol Med 2000, 223:88-95. 10.1046/j.1525-1373.2000.22312.x, 10632966.
23. Flower RJ, Perretti M. Controlling inflammation: a fat chance?. J Exp Med 2005, 201:671-674. 10.1084/jem.20050222, 2212824, 15753201.
24. Bloomer RJ, Larson DE, Fisher-Wellman KH, Galpin AJ, Schilling BK. Effect of eicosapentaenoic and docosahexaenoic acid on resting and exercise-induced inflammatory and oxidative stress biomarkers: a randomized, placebo controlled, cross-over study. Lipids Health Dis 2009, 8:36. 10.1186/1476-511X-8-36, 2735747, 19691834.
25. Farndale RW, Sayers CA, Barrett AJ. A direct spectrophotometric microassay for sulfated glycosaminoglycans in cartilage cultures. Connect Tissue Res 1982, 9:247-248. 10.3109/03008208209160269, 6215207.
26. Clutterbuck AL, Mobasheri A, Shakibaei M, Allaway D, Harris P. Interleukin-1β-induced extracellular matrix degradation and glycosaminoglycan release is inhibited by curcumin in an explant model of cartilage inflammation. Ann NY Acad Sci 2009, 1171:428-435. 10.1111/j.1749-6632.2009.04687.x, 19723086.
27. Kojima F, Naraba H, Miyamoto S, Beppu M, Aoki H, Kawai S. Membrane-associated prostaglandin E synthase-1 is upregulated by proinflammatory cytokines in chondrocytes from patients with osteoarthritis. Arthritis Res Ther 2004, 6:R355-365. 10.1186/ar1195, 464891, 15225371.
28. Chowdhury TT, Arghandawi S, Brand J, Akanji OO, Bader DL, Salter DM, Lee DA. Dynamic compression counteracts IL-1β induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs. Arthritis Res Ther 2008, 10:R35. 10.1186/ar2389, 2453754, 18348730.
29. Arner EC, Hughes CE, Decicco CP, Caterson B, Tortorella MD. Cytokine-induced cartilage proteoglycan degradation is mediated by aggrecanase. Osteoarthritis Cartilage 1998, 6:214-228. 10.1053/joca.1998.0114, 9682788.
30. Zhao TZ, Xia YZ, Li L, Li J, Zhu G, Chen S, Feng H, Lin JK. Bovine serum albumin promotes IL-1β and TNF-α secretion by N9 microglial cells. Neurol Sci 2009, 30:379-383. 10.1007/s10072-009-0123-x, 19696964.
31. Barham JB, Edens MB, Fonteh AN, Johnson MM, Easter L, Chilton FH. Addition of eicosapentaenoic acid to gamma-linolenic acid-supplemented diets prevents serum arachidonic acid accumulation in humans. J Nutr 2000, 130:1925-1931.
32. Sethi S. Inhibition of leukocyte-endothelial interactions by oxidized omega-3 fatty acids: a novel mechanism for the anti-inflammatory effects of omega-3 fatty acids in fish oil. Redox Rep 2002, 7:369-378. 10.1179/135100002125001144, 12625944.
33. Arita M, Bianchini F, Aliberti J, Sher A, Chiang N, Hong S, Yang R, Petasis NA, Serhan CN. Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1. J Exp Med 2005, 201:713-722. 10.1084/jem.20042031, 2212834, 15753205.
34. Schwab JM, Chiang N, Arita M, Serhan CN. Resolvin E1 and protectin D1 activate inflammation-resolution programmes. Nature 2007, 447:869-874. 10.1038/nature05877, 2757086, 17568749.
35. Blain EJ, Ali AY, Duance VC. Boswellia frereana (frankincense) suppresses cytokine-induced matrix metalloproteinase expression and production of pro-inflammatory molecules in articular cartilage. Phytother Res 2010, 24:905-912.