Characterization of CD4 and CD8 T cells producing IFN-γ in human latent and active tuberculosis

Tuberculosis

Volumn 90, Issue 6, 2010, Pages 346-353

  Rueda, Cesar M ^a   Marín, Nancy D ^a   García, Luis F ^a,b   Rojas, Mauricio ^a,b  

^a UNIVERSIDAD DE ANTIOQUIA   (Colombia)

^b CCITB Centro Colombiano de Investigación en Tuberculosis   (Colombia)

Author keywords

CD4; CD8; IFN ; Latency; RD1 antigens; Tuberculosis

Indexed keywords

CD27 ANTIGEN; CD45RO ANTIGEN; CULTURE FILTRATE PROTEIN 10; EARLY SECRETORY ANTIGENIC TARGET 6; GAMMA INTERFERON; MYCOBACTERIUM ANTIGEN;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL COUNT; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUBERCULOSIS;

ADULT; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; FLOW CYTOMETRY; HUMANS; INTERFERON-GAMMA; LYMPHOCYTE ACTIVATION; MALE; MYCOBACTERIUM TUBERCULOSIS; TUBERCULIN; TUBERCULIN TEST; TUBERCULOSIS, PULMONARY;

EID: 78049466661     PISSN: 14729792     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tube.2010.09.003     Document Type: Article

References (67)

1. World Health Organization Global tuberculosis control: epidemilogy, strategy, financing: WHO report 2009 2009 World Health Organization Geneva, Switzerland
2. P. Nunn, B. Williams, K. Floyd, C. Dye, G. Elzinga, and M. Raviglione Tuberculosis control in the era of HIV Nat Rev Immunol 5 2005 819 826
3. P. Andersen Vaccine strategies against latent tuberculosis infection Trends Microbiol 15 2007 7 13
4. P. Salgame Host innate and Th1 responses and the bacterial factors that control Mycobacterium tuberculosis infection Curr Opin Immunol 17 2005 374 380
5. P.L. Lin, and J.L. Flynn Understanding latent tuberculosis: a moving target J Immunol 185 2010 15 22
6. J.L. Flynn Lessons from experimental Mycobacterium tuberculosis infections Microbes Infect 8 2006 1179 1188
7. J. Wang, L.S. Wicker, and P. Santamaria IL-2 and its high-affinity receptor: genetic control of immunoregulation and autoimmunity Sem Immunol 21 2009 363 371
8. H. Mueller, A.K. Detjen, S.D. Schuck, A. Gutschmidt, U. Wahn, and K. Magdorf Mycobacterium tuberculosis-specific CD4+, IFNγ+, and TNFα+ multifunctional memory T cells coexpress GM-CSF Cytokine 43 2008 143 148
9. D. Goletti, O. Butera, F. Bizzoni, R. Casetti, E. Girardi, and F. Poccia Region of difference 1 antigen-specific CD4+ memory T cells correlate with a favorable outcome of tuberculosis J Infect Dis 194 2006 984 992
10. A. Kamath, J.S.M. Woodworth, and S.M. Behar Antigen-specific CD8+ T Cells and the development of central memory during Mycobacterium tuberculosis infection J Immunol 177 2006 6361 6369
11. A.M. Cooper, D.K. Dalton, T.A. Stewart, J.P. Griffin, D.G. Russell, and I.M. Orme Disseminated tuberculosis in interferon gamma gene-disrupted mice J Exp Med 178 1993 2243 2247
12. J.L. Flynn, J. Chan, K.J. Triebold, D.K. Dalton, T.A. Stewart, and B.R. Bloom An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection J Exp Med 178 1993 2249 2254
13. G. Vanham, Z. Toossi, C.S. Hirsch, R.S. Wallis, S.K. Schwander, and E.A. Rich Examining a paradox in the pathogenesis of human pulmonary tuberculosis: immune activation and suppression/anergy Tuber Lung Dis 78 1997 145 158
14. A.M. Caruso, N. Serbina, E. Klein, K. Tribold, B.R. Bloom, and J. Flynn Mice deficient in CD4 T cells have only transiently diminished levels of IFN-γ, yet succumb to tuberculosis J Immunol 162 1999 5407 5416
15. E. Girardi, D. Goletti, G. Antonucci, and G. Ippolito Tuberculosis and HIV: a deadly interaction J Biol Regul Homeost Agents 15 2001 218 223
16. Z.W. Chen Immunology of AIDS virus and mycobacterial co-infection Curr HIV Res 2 2004 351 355
17. J.L. Flynn, M.M. Goldstein, K.J. Triebold, B. Koller, and B.R. Bloom Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection Proc Nat Acad Sci USA 89 1992 12013 12017
18. J.E. Grotzke, and D.M. Lewinsohn Role of CD8+ T lymphocytes in control of Mycobacterium tuberculosis infection Microbes Infect 7 2005 776 788
19. D. Sud, C. Bigbee, J.L. Flynn, and D.E. Kirschner Contribution of CD8+ T cells to control of Mycobacterium tuberculosis infection J Immunol 176 2006 4296 4314
20. A. Lalvani, R. Brookes, R.J. Wilkinson, A.S. Malin, A.A. Pathan, and P. Andersen Human cytolytic and interferon gamma-secreting CD8+ T lymphocytes specific for Mycobacterium tuberculosis Proc Nat Acad Sci USA 95 1998 270 275
21. S.M. Smith, M.R. Klein, A.S. Malin, J. Sillah, K. Huygen, and P. Andersen Human CD8+ T cells specific for Mycobacterium tuberculosis Secreted antigens in tuberculosis patients and healthy BCG-vaccinated controls in The Gambia Infect Immun 68 2000 7144 7148
22. + T cells during Mycobacterium tuberculosis infection J Immunol 167 2001 6991 7000
23. H. Shams, P. Klucar, S.E. Weis, A. Lalvani, P.K. Moonan, and H. Safi Characterization of a Mycobacterium tuberculosis peptide that is recognized by human CD4+ and CD8+ T cells in the context of multiple HLA alleles J Immunol 173 2004 1966 1977
24. F.O. Sánchez, J.I. Rodríguez, G. Agudelo, and L.F. García Immune responsiveness and lymphokine production in patients with tuberculosis and healthy controls Infect Immun 62 1994 5673 5678
25. R. Hussain, A. Kaleen, F. Shahid, M. Dojki, B. Jamil, and H. Mehmood Cytokine profiles using whole-blood assays and discriminate between tuberculosis patients and healthy endemic controls in a BCG-vaccinated population J Immun Meth 264 2002 98 108
26. R. Palazzo, F. Spensieri, M. Massari, G. Fedele, L. Frasca, and S. Carrara Use of whole-blood samples in in-house bulk and single-cell antigen-specific gamma interferon assays for surveillance of Mycobacterium tuberculosis infections Clin Vaccine Immunol 15 2008 327 337
27. T.S.C. Hinks, D.P.S. Dosanjh, J.A. Innes, G. Pasvol, S. Hackforth, and H. Varia Frequencies of region of difference 1 antigen-specific but not purified protein derivative-specific gamma interferon-secreting T cells correlate with the presence of tuberculosis disease but do not distinguish recent from remote latent infections Infect Immun 77 2009 5486 5495
28. A. Sodhi, J. Gong, C. Silva, D. Qian, and P.F. Barnes Clinical correlates of interferon γ production in patients with tuberculosis Clin Infect Dis 25 1997 617 620
29. P. Andersen, T.M. Doherty, M. Pai, and K. Weldingh The prognosis of latent tuberculosis: can disease be predicted? Trends Mol Med 13 2007 175 182
30. H. del Corral, S.C. París, N.D. Marín, D.M. Marín, L. López, and H.M. Henao IFNγ response to Mycobacterium tuberculosis, risk of infection and disease in household contacts of tuberculosis patients in Colombia PLoS One 4 2009 e8257
31. S.T. Cole, R. Brosch, J. Parkhill, T. Garnier, D. Churcher, and D. Harris Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence Nature 393 1998 537 544
32. T. Garnier, K. Eiglmeier, J.C. Camus, N. Medina, H. Mansoorn, and M. Pryor The complete genome sequence of Mycobacterium bovis Proc Nat Acad Sci USA 100 2003 7877 7882
33. J. Mattow, P.R. Jungblut, U.E. Schaible, H.-J. Mollenkopf, S. Lamer, and U. Zimny-Arndt Identification of proteins from Mycobacterium tuberculosis missing in attenuated Mycobacterium bovis BCG strain Electrophoresis 22 2001 2936 2946
34. L.A.H. van Pinxteren, P. Ravn, E.M. Agger, J. Pollock, and P. Andersen Diagnosis of tuberculosis based on the two specific antigens ESAT-6 and CFP10 Clin Diagn Lab Immunol 7 2000 155 160
35. M. Pai, K. Dheda, J. Cunningham, F. Scano, and R. O'Brien T-cell assays for the diagnosis of latent tuberculosis infection: moving the research agenda forward Lancet Infec Dis 7 2007 428 438
36. P.J. Cockle, S.V. Gordon, A. Lalvani, B.M. Buddle, R.G. Hewinson, and H.M. Vordermeier Identification of Novel Mycobacterium tuberculosis antigens with potential as diagnostic reagents or subunit vaccine candidates by comparative genomics Infect Immun 70 2002 6996 7003
37. R. Al-Attiyah, and A.S. Mustafa Characterization of human cellular immune responses to novel Mycobacterium tuberculosis antigens encoded by genomic regions absent in Mycobacterium bovis BCG Infect Immun 76 2008 4190 4198
38. M. Pai, L.W. Riley, and J. Colford Interferon-γ assays in the immunodiagnosis of tuberculosis: a systematic review Lancet Infect Dis 4 2004 761 776
39. J. Chan, and J. Flynn The immunological aspects of latency in tuberculosis Clin Immunol 110 2004 2 12
40. Y. Hu, F. Movahedzadeh, N.G. Stoker, and A.R.M. Coates Deletion of the Mycobacterium tuberculosis α-crystallin-like hspX gene causes increased bacterial growth in vivo Infect Immun 74 2006 861 868
41. R.J. Wilkinson, K.A. Wilkinson, K.A. De Smet, K. Haslov, G. Paslov, and M. Singh Human T- and B-cell reactivity to the 16kDa alpha-crystallin protein of Mycobacterium tuberculosis Scand J Immunol 48 1998 403 409
42. A. Geluk, M.Y. Lin, K.E. van Meijgaarden, E.M. Leyten, K.L. Franken, and T.H. Ottenhoff T-cell recognition of the HspX protein of Mycobacterium tuberculosis correlates with latent M. tuberculosis infection but not with M. bovis BCG vaccination Infect Immun 75 2007 2914 2921
43. A.B. Lyons Analysing cell division in vivo and in v itro using flow cytometric measurement of CFSE dye dilution J Immun Meth 243 2000 147 154
44. F. Sallusto, J. Geginat, and A. Lanzavecchia Central memory and effector memory T cell subsets: function, generation, and maintenance Rev Immunol 22 2004 745 763
45. A. Schiott, M. Lindstedt, B. Johansson-Lindbom, E. Roggen, and C.A. Borrebaeck CD27-CD4+ memory T cells define a differentiated memory population at both functional and transcription levels Immunol 113 2004 363 370
46. T.J. Scriba, B. Kalsdorf, D.A. Abrahams, F. Isaacs, J. Hofmeister, and G. Black Distinct, specific IL-17- and IL-22-producing CD4+ T cell subsets contribute to the human anti-mycobacterial immune response J Immunol 180 2008 1962 1970
47. B. Kalsdorf, T.J. Scriba, K. Wood, C.L. Day, K. Dheda, and R. Dawson HIV-1 infection impairs the bronchoalveolar T-cell response to mycobacteria Am J Respir Crit Care Med 180 2009 1262 1270
48. P. Tapaninen, A. Korhonen, L. Pusa, I. Seppala, and T. Tuuminen Effector memory T-cells dominate immune responses in tuberculosis treatment: antigen or bacteria persistence? Int J Tuberc Lung Dis 14 2010 347 355
49. W.A. Hanekom, H.M. Dockrell, T.H.M. Ottenhoff, T.M. Dpherty, H. Fletcher, and H. McShane Immunological outcomes of new tuberculosis vaccine trials: WHO panel recommendations PLoS Med 5 2008 e145
50. E.M.S. Leyten, S.M. Arend, C. Prins, F.G.J. Cobelens, T.H.M. Ottenhoff, and J.T. van Dissel Discrepancy between Mycobacterium tuberculosis-specific gamma interferon release assays using short and prolonged in vitro incubation Clin Vaccine Immunol 14 2007 880 885
51. + T cells to gamma interferon production in human tuberculosis Infect Immun 69 2001 3497 3501
52. A. Cehovin, J.M. Cliff, P.C. Hill, R.H. Brookes, and H.M. Dockrell Extended culture enhances sensitivity of a gamma interferon assay for latent Mycobacterium tuberculosis infection Clin Vaccine Immunol 14 2007 796 798
53. K.A. Millington, J.A. Innes, S. Hackforth, T.S.C. Hinks, J.J. Deeks, and D.P.S. Dosanjh Dynamic relationship between IFN-γ and IL-2 profile of Mycobacterium tuberculosis-specific T cells and antigen load J Immunol 178 2007 5217 5226
54. V. Guyot-Revol, J.A. Innes, S. Hackforth, T. Hinks, and A. Lalvani Regulatory T cells are expanded in blood and disease sites in patients with tuberculosis Am J Resp Crit Care Med 173 2006 803 810
55. S. Burl, P.C. Hill, D.J. Jeffries, M.J. Holand, A. Fox, and M.D. Lugos FOXP3 gene expression in a tuberculosis case contact study Clin Exp Immunol 149 2007 117 122
56. T. Roberts, N. Beyers, A. Aguirre, and G. Walzl Immunosuppression during active tuberculosis is characterized by decreased interferon-γ production and CD25 expression with elevated Frokhead Box P3, transforming growth factor-β, and interleukin-4 mRNA levels J Infect Dis 195 2007 870 878
57. A.H. Zea, K.S. Culotta, J. Ali, C. Mason, H.-J. Park, and J. Zabaleta Decreased expression of CD3ζ and nuclear transcription factor kappa B in patients with pulmonary tuberculosis: potential mechanisms and reversibility with treatment J Infect Dis 194 2006 1385 1393
58. C.S. Hirsch, Z. Toossi, G. Vanham, J.L. Johnson, P. Peters, and A. Okwera Apoptosis and T cell hyporesponsiveness in pulmonary tuberculosis J Infect Dis 179 1999 945 953
59. C.S. Hirsch, Z. Toossi, J.L. Johnson, H. Luzze, L. Ntambi, and P. Peters Augmentation of apoptosis and interferon-gamma production at sites of active Mycobacterium tuberculosis infection in human tuberculosis J Infect Dis 183 2001 779 788
60. R.A. Seder, P.A. Darrah, and M. Roederer T-cell quality in memory and protection: implications for vaccine design Nat Rev Immunol 8 2008 247 258
61. T. Einarsdottir, E. Lockhart, and J.L. Flynn Cytotoxicity and secretion of gamma interferon are carried out by distinct CD8 T cells during Mycobacterium tuberculosis infection Infect Immun 77 2009 4621 4630
62. S. Bhattacharyya, R. Singla, A.B. Dey, and H.K. Prasad Dichotomy of cytokine profiles in patients and high-risk healthy subjects exposed to tuberculosis Infect Immun 67 1999 5597 5603
63. M.V. Martins, M.C. Lima, N.C. Duppre, H.J. Matos, J.S. Spencer, and P.J. Brennan The level of PPD-specific IFN-γ-producing CD4+ T cells in the blood predicts the in vivo response to PPD Tuberculosis 87 2007 202 211
64. C. Jafari, M. Ernst, A. Strassburg, U. Greinert, B. Kalsdorf, and D. Kirsten Local immunodiagnosis of pulmonary tuberculosis by enzyme-linked immunospot Eur Resp J 31 2008 261 265
65. G.F. Black, B.A. Thiel, M.O. Ota, S.K. Parida, R. Adegbola, and W.H. Boom Immunogenicity of novel DosR regulon-encoded candidate antigens of Mycobacterium tuberculosis in three high-burden populations in Africa Clin Vaccine Immunol 16 2009 1203 1212
66. D.R. Sherman, M. Voskuil, D. Schnappinger, R. Liao, M.I. Harrell, and G.K. Schoolnik Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding alpha-crystallin Proc Nat Acad Sci 98 2001 7534 7539
67. B.J. Rogerson, Y.J. Jung, R. LaCourse, L. Ryan, N. Enright, and R.J. North Expression levels of Mycobacterium tuberculosis antigen-encoding genes versus production levels of antigen-specific T cells during stationary level lung infection in mice Immunol 118 2006 195 201