Dichotomy of cytokine profiles in patients and high-risk healthy subjects exposed to tuberculosis

Infection and Immunity

Volumn 67, Issue 11, 1999, Pages 5597-5603

  Bhattacharyya, S ^a   Singla, R ^b   Dey, A B ^a   Prasad, H K ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^b LRS Institute of Tuberculosis and Lung Diseases   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 4;

ADULT; APOPTOSIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; EFFECTOR CELL; HELPER CELL; HIGH RISK PATIENT; HUMAN; IMMUNE RESPONSE; IMMUNOREGULATION; LUNG TUBERCULOSIS; MONONUCLEAR CELL; MYCOBACTERIUM TUBERCULOSIS; PRIORITY JOURNAL;

EID: 0032706006     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.67.11.5597-5603.1999     Document Type: Article

References (53)

1. Abbas, A. K., K. M. Murphy, and A. Sher. 1996. Functional diversity of helper T lymphocytes. Nature 383:787-793.
2. Appleberg, R., A. G. Castro, J. Pedrosa, R. A. Silva, I. M. Orme, and P. Minoprio. 1994. Role of IFN-γ and TNF alpha during T-cell-independent and -dependent phases of Mycobacterium avium infection. Infect. Immun. 62:3962-3971.
3. Bhattacharyya, S., S. N. Das, A. B. Dey, K. Nagarkar, J. Lobo, S. K. Kapoor, and H. K. Prasad. 1997. Flow cytometric assessment of intracellular interferon-γ production in human CD4+ve T cells on mycobacterial antigen stimulation. J. Biosci. 22:99-109.
4. Bose, M., A. Gupta, J. N. Banavalikar, and K. Saha. 1995. Dysregulation of homeostasis of blood T-lymphocyte subpopulations persists in chronic multibacillary pulmonary tuberculosis patients refractory to treatment. Tubercle Lung Dis. 76:59-64.
5. Boyum, A. 1968. Isolation of mononuclear cells and granulocytes from human blood. Scand. J. Clin. Lab. Invest. 21(Suppl. 97):77-89.
6. Chase, M. W. 1945. The cellular transfer of cutaneous hypersensitivity to tuberculin. Proc. Soc. Exp. Biol. Med. 59:134-135.
7. Choong, M. L., S. H. Ton, and S. K. Cheong. 1995. Influence of race, age and sex on the lymphocyte subsets in peripheral blood of healthy Malaysian adults. Ann. Clin. Biochem. 32(Pt. 6):532-539.
8. Cohen, J. J. 1995. Exponential growth in apoptosis. Immunol. Today 16:346-348.
9. Condos, R., W. N. Rom, and N. W. Schluger. 1997. Treatment of multi-drug-resistant pulmonary tuberculosis with interferon-gamma via aerosol. Lancet 349:1513-1515.
10. Cooper, A. M., D. K. Dalton, T. A. Stewart, J. P. Griffin, D. G. Russell, and I. M. Orme. 1993. Disseminated tuberculosis in interferon γ gene-disrupted mice. J. Exp. Med. 178:2243-2247.
11. Das, G., H. Vohra, B. Saha, J. N. Agrewala, and G. C. Mishra. 1999. Apoptosis of Th1 like cells in experimental tuberculosis (TB). Clin. Exp. Immunol. 115:324-328.
12. Denis, M. 1991. Killing of Mycobacterium tuberculosis within human monocytes: activation by cytokines and calcitriol. Clin. Exp. Immunol. 84:200-206.
13. Douvas, G. S., L. L. Looker, A. E. Vatter, and A. J. Crowle. 1985. Gamma interferon activates human macrophages to become tumoricidal and leishmanicidal but enhances replication of macrophage associated bacteria. Infect. Immun. 50:1-8.
14. Ellner, J. J. 1997. Regulation of the human immune response during tuberculosis. J. Lab. Clin. Med. 130:469-475.
15. Eremeev, V. V., V. G. Audlenko, I. V. Bocharove, S. M. Liashenko, and A. M. Moroz. 1995. Modulation of the course of experimental tuberculosis in mice by in vivo administration of monoclonal antibodies to interleukin-2, gamma-interferon and interleukin-4. Vestn. Ross. Akad. Med. Nauk. 7:38-41.
16. Flesch, I., and S. H. E. Kaufmann. 1987. Mycobacterial growth inhibition by interferon-γ-activated bone marrow macrophages and differential susceptibility among strains of Mycobacterium tuberculosis. J. Immunol. 138:4408-4413.
17. Flynn, J. L., J. Chan, K. J. Triebold, D. K. Dalton, T. A. Stewart, and B. R. Bloom. 1993. An essential role for IFN-γ in resistance to Mycobacterium tuberculosis infection. J. Exp. Med. 178:2249-2254.
18. Frucht, D. M., and S. M. Holland. 1996. Defective monocyte costimulation for IFN-γ production in familial disseminated Mycobacterium avium complex infection. J Immunol. 157:411-416.
19. Gros, L. G., S. Z. Ben-Sasson, R. Seder, F. D. Finkelman, and W. E. Paul. 1990. Generation of interleukin-4 (IL-4)-producing cells in-vivo and in-vitro are required for in vitro generation of IL-4-producing cells. J. Exp. Med. 172:921-929.
20. Jung, T., U. Schauer, C. Heusser, C. Neumann, and C. Rieger. 1993. Detection of intracellular cytokines by flowcytometry. J. Immunol. Methods 159: 197-207.
21. Kamijo, R., J. Le, D. Shapiro, E. A. Havell, S. Huang, M. Auget, M. Bosland, and J. Vilcek. 1993. Mice that lack the interferon-γ receptor have profoundly altered responses to infection with bacillus Calmette-Guerin and subsequent challenge with lipopolysaccharide. J. Exp. Med. 178:1435-1440.
22. Kelso, A. 1995. Th1 and Th2 subsets: paradigm lost? Immunol. Today 16: 374-379.
23. Kochi, A., B. Vareldzis, and K. Styblo. 1993. Multi-drug-resistant tuberculosis and its control. Res. Microbiol. 144:104-110.
24. Krause, A. K. A few observations on immunity to tuberculosis. 1922. Am. Rev. Respir. Dis. 19:306-308.
25. Ladel, C. H., S. Daugelet, and S. H. Kaufmann. 1995. Immune response to Mycobacterium bovis Bacille Calmette Guerin infection in major histocompatibility complex class I and class II deficient knock-out mice: contribution of CD4 and CDST cells to acquired resistance. Eur. J. Immunol. 25:377-384.
26. Lurie, M. B. 1942. Studies on the mechanism of immunity in tuberculosis. The fate of tubercle bacilli ingested by mononuclear phagocytes derived from normal and immunised animals. J. Exp. Med. 75:247-268.
27. + T-cell counts have impaired Th1 responses. J. Immunol. 158:492-500.
28. Modlin, R. L. 1994. Th1-Th2 paradigm: insights from leprosy. J. Investig. Dermatol. 102:828-832.
29. Mosmann, T. R., and R. L. Coffman. 1989. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145-173.
30. Murray, C. J. L., K. Styblo, and A. Rouillon. 1990. Tuberculosis in developing countries: burden, intervention and cost. Bull. Int. Union Tubercle Lung Dis. 65:6-24.
31. Narain, J. P., M. C. Raviglione, and A. Kochi. 1992. HIV-associated tuberculosis in developing countries: epidemiology and strategies for prevention. Tubercle Lung Dis. 73:311-321.
32. Orme, I. M., and F. M. Collind. 1983. Protection against Mycobacterium tuberculosis infection by adoptive immunotherapy. Requirement for T-cell-deficient recipients. J. Exp. Med. 158:74-83.
33. Robinson, D. S., Q. Hamid, S. Ying, A. Tsicopoulous, J. Barkans, A. M. Bently, C. Corrigan, S. R. Durham, and A. B. Kay. 1992. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. New. Engl. J. Med. 326:298-304.
34. Romagnani, S. 1994. Lymphokine production by human T cells in disease states. Annu. Rev. Immunol. 12:227-257.
35. Rook, G. A. W., J. Steele, M. Ainsworth, and B. R. Champion. 1986. Activation of macrophages to inhibit proliferation of Mycobacterium tuberculosis: comparison of the effects of recombinant gamma-interferon on human monocytes and murine peritoneal macrophages. Immunology 59:333-338.
36. Sanchez, F. O., J. I. Rodriguez, G. Agudelo, and L. F. Garcia. 1994. Immune responsiveness and lymphokine production in patients with tuberculosis and healthy controls. Infect. Immun. 62:5673-5678.
37. Sander, B., J. Andersson, and U. Andersson. 1991. Assessment of cytokines by immunofluorescence and the paraformaldehyde-saponin procedure. Immunol. Rev. 119:65-93.
38. Siegel, S. 1956. Non-parametric statistics for the behavioral sciences, international student edition. McGraw-Hill Book Co., Inc., New York, N.Y.
39. + T cells in purified protein derivative positive but not in purified protein derivative negative subjects. J. Immunol. 160:2408-2417.
40. Slutkin, G., J. Leowki, and J. Mann. 1988. The effect of AIDS epidemic on the tuberculosis problem, and on the tuberculosis programme. Bull. Int. Union Tubercle Lung Dis. 63:21-24.
41. Surcel, H. M., M. Troye-Blomberg, S. Paulle, G. Andersson, C. Morreno, G. Pasvol, and J. Ivanyi. 1994. TH1/TH2 profiles in tuberculosis, based on proliferation and cytokine response of blood lymphocytes to mycobacterial antigens. Immunology 81:171-176.
42. Taha, R. A., J. C. Kotsimbos, Y. L. Song, D. Menzies, and Q. Hamid. 1997. IFN-gamma and IL-12 are increased in active compared with inactive tuberculosis. Am. J. Respir. Crit. Care Med. 155:1135-1139.
43. + cytotoxic T cells and relative resistance of alveolar macrophages to lysis. J. Immunol. 159:290-297.
44. Tepper, R. I., D. A. Levinson, B. Z. Stanger, J. Campos-Torres, A. K. Abbas, and P. Leder. 1990. IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice. Cell 62:457-467.
45. Toossi, Z., M. E. Kleinerz, and J. J. Ellner. 1986. Defective interleukin-2 production and responsiveness in human pulmonary tuberculosis. J. Exp. Med. 163:1162-1172.
46. Turcotte, R., Y. Des Ormeaux, and A. F. Borduas. 1976. Partial characterization of a factor extracted from sensitized lymphocytes that inhibits the growth of Mycobacterium tuberculosis within macrophages in vitro. Infect. Immun. 14:337-344.
47. + T-lymphocyte depletion in patients without HIV infection treated for tuberculosis. Chest 105:1335-1337.
48. Varadhachary, A. S., S. N. Perdo, C. Hu, M. Ramanarayanan, and P. Salgame. 1997. Differential ability of T cell subsets to undergo activation-induced cell death. Proc. Natl. Acad. Sci. USA 94:5778-5783.
49. Vithayasai, V., T. Sirisanthana, C. Sakonwasun, and C. Suvanpiyasiri. 1997. Flow cytometric analysis of T-lymphocytes subsets in adult Thais. Asian Pac. J. Allergy Immunol. 15:141-146.
50. Webster, H. K., K. Pattanapanyasat, P. Phanupak, C. Wasi, C. Chuenchitra, L. Ybarra, and L. Buchner. 1996. Lymphocyte immunophenotype reference ranges in healthy Thai adults: implications for management of HIV/AIDS in Thailand. Southeast Asian J, Trop. Med. Public Health 27:418-429.
51. Yamamura, M., K. Uyemura, R. J. Deans, K. Weinberg, T. H. Rea, B. R. Bloom, and R. L. Modlin. 1991. Defining protective response to pathogens: cytokine profiles in leprosy lesions. Science 254:277-279.
52. Zhang, M., Y. Lin, D. V. Iyer, J. Gong, J. S. Abrams, and P. F. Barnes. 1995. T cell cytokine responses in human infection with Mycobacterium tuberculosis. Infect. Immun. 63:3231-3234.
53. Zhang, X., T. Brunner, L. Carter, R. W., Dutton, P. Rogers, L. Bradley, T. Sato, J. C. Reed, D. Green, and S. L. Swain. 1997. Unequal death in T helper cell 1 (Th1) and Th2 effectors: Th1 but not Th2 effectors undergo rapid Fas/FasL-mediated apoptosis. J. Exp. Med. 185:1837-1849.