How does podocyte damage result in tubular damage?

Kidney and Blood Pressure Research

Volumn 22, Issue 1-2, 1999, Pages 26-36

  Kriz, Wilhelm ^a   Elger, M ^a   Hosser, H ^a   Hahnel B ^a   Provoost, A ^b   Kranzlin B ^c   Gretz, N ^c  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Focal segmental glomerulosclerosis; Glomerular tuft adhesion; Misdirected filtration; Podocyte detachment; Tubulointerstitial fibrosis

Indexed keywords

ADHESION; ARTICLE; CAPILLARY; CELL DAMAGE; FIBROBLAST; FOCAL GLOMERULOSCLEROSIS; GLOMERULUS BASEMENT MEMBRANE; GLOMERULUS FILTRATION; HISTOPATHOLOGY; KIDNEY INTERSTITIUM; KIDNEY TUBULE DAMAGE; PODOCYTE; PRIORITY JOURNAL;

ADHESIONS; ANIMALS; EPITHELIAL CELLS; FIBROSIS; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; HUMANS; KIDNEY DISEASES; KIDNEY GLOMERULUS; KIDNEY TUBULES;

EID: 0032979626     PISSN: 14204096     EISSN: None     Source Type: Journal    
DOI: 10.1159/000025906     Document Type: Article

References (33)

1. Kriz W, Gretz N, Lemley KV: Progression of glomerular diseases: Is the podocyte the culprit? Kidney Int 1998;54:687-697.
2. Ong ACM, Fine LG: Loss of glomerular function and tubulointerstitial fibrosis: Cause or effect? Kidney Int 1994;45:345-351.
3. Border WA, Noble NA: TGF-β in kidney fibrosis: A target for gene therapy. Kidney Int 1997;51:1388-1396.
4. Johnson RJ, Schreiner GF: Hypothesis: The role of acquired tubulointerstitial disease in the pathogenesis of salt-dependent hypertension. Kidney Int 1997;52:1169-1179.
5. Bohle A, Strutz F, Müller GA: On the pathogenesis of chronic renal failure in primary glomerulopathies. A view from the interstitium. Exp Nephrol 1994;2:205-210.
6. Gandhi M, Olson JL, Meyer TW: Contribution of tubular injury to loss of remnant kidney function. Kidney Int 1998;54:1157-1165.
7. Burton C, Harris KPG: The role of proteinuria in the progression of chronic renal failure. Am J Kidney Dis 1996;27:765-775.
8. Benigni A, Remuzzi G: Mechanism of progression of renal disease: growth factors and related mechanisms. J Hypertens 1998;16 (suppl):S9-S12.
9. Abbate M, Zoja C, Corna D, Capitanio M, Bertani T, Remuzzi G: In progressive nephropaties, overload to tubular cells with filtered proteins translates glomerular permeability dysfunction into cellular signals of interstitial inflammation. J Am Soc Nephrol 1998; 9:1213-1224.
10. Remuzzi G, Bertani T: Pathophysiology of progressive nephropathies. N Engl J Med 1998;339:1448-1456.
11. Rennke HG: How does glomerular epithelial cell injury contribute to progressive glomerular damage? Kidney Int 1994;45(suppl 45): S58-S63.
12. d'Agati V, Suh JI, Carbone L, Cheng JT, Appel G: Pathology of HIV-associated nephropathy: A detailed morphologic and comparative study. Kidney Int 1989;35:1358-1370.
13. Detwiler RK, Falk RJ, Hogan SL, Jennette JC: Collapsing glomerulopathy: A clinically and pathologically distinct variant of focal segmental glomerulosclerosis. Kidney Int 1994; 45:1416-1424.
14. Valeri A, Barisoni L, Appel GB, Seigle R, d'Agati V: Idiopathic collapsing focal segmental glomerulosclerosis: a clinicopathologic study. Kidney Int 1996;50:1734-1746.
15. Barisoni L, Kriz W, Mundel P, d'Agati V: The dysregulated podocyte phenotype: A novel concept in the pathogenesis of collapsing idiopathic focal segmental glomerulosclerosis and HIV-associated nephropathy. J Am Soc Nephrol 1999;10:51-61.
16. Kretzler M, Koeppen-Hagemann I, Kriz W: Podocyte damage is a critical step in the development of glomerulosclerosis in the uninephrectomized desoxycorticosterone rat. Virchows Arch [A] 1994;425:181-193.
17. Nagata M, Kriz W: Glomerular damage after uninephrectomy in young rats. II. Mechanical stress on podocytes as a pathway to sclerosis. Kidney Int 1992;42:148-160.
18. Shirato I, Hosser H, Kimura K, Sakai T, Tomino Y, Kriz W: The development of focal segmental glomerulosclerosis in Masugi nephritis is based on progressive podocyte damage. Virchows Arch 1996;429:255-273.
19. Kriz W, Hosser H, Hähnel B, Simons JL, Provoost AP: Development of vascular pole associated glomerulosclerosis in the Fawn-hooded rat. J Am Soc Nephrol 1998;9:381-396.
20. Floege J, Hackmann B, Kliem V, Kriz W, Alpers CE, Johnson RJ, Kuhn KW, Koch KM, Brunkhorst R: Age-related glomerulosclerosis and interstital fibrosis in Milan normotensive rats: A podocyte disease. Kidney Int 1997;51: 230-243.
21. Deppe M: Altersabhängige morphologische Veränderungen der Glomeruli bei Mailänder Ratten: Diplomarbeit Biologie, Med Hochschule Hannover, 1983.
22. Kriz W, Hosser H, Hähnel B, Gretz N, Provoost AP: From segmental glomerulosclerosis to total nephron degeneration and interstitial fibrosis: A histopathological study in rat models and human glomerulopathies. Nephrol Dial Transplant 1998;13:2781-2798.
23. Nagata M, Yamaguchi Y, Ito K: Loss of mitotic activity and the expression of vimentin in glomerular epithelial cells of developing human kidneys. Anat Embryol 1993;187:275-279.
24. Kriz W, Hähnel B, Rösener S, Elger M: Long-term treatment of rats with FGF-2 results in focal segmental glomerulosclerosis. Kidney Int 1995;48:1435-1450.
25. Fries JW, Sandstrom DJ, Meyer TW, Rennke HG: Glomerular hypertrophy and epithelial cell injury modulate progressive glomerulosclerosis in the rat. Lab Invest 1989;60:205-218.
26. Olson JL, Uradaneta AG, Heptinstall RH: Glomerular hyalinosis and its relation to hyperfiltration. Lab Invest 1985;52:387.
27. Rennke HG, Anderson S, Brenner BM: The progression of renal disease: structural and functional correlations: in Tisher CC, Brenner BM (eds): Renal Pathology, Philadelphia, Lippincott, 1994, pp 116-139.
28. Miller K, Michael AF: Immunopathology of renal extracellular membranes in diabetes mellitus. Specificity of tubular basement membrane immunofluorescence. Diabetes 1976;25: 701-708.
29. Diamond JR, Anderson S: Irreversible tubulointerstitial damage associated with chronic aminonucleoside nephrosis. Am J Pathol 1990; 137:1323-1332.
30. Hyman LR, Burkholder PM: Focal sclerosing glomerulopathy with segmental hyalinosis. A clinicopathologic analysis. Lab Invest 1973; 28:533-544.
31. Olson JL, Schwartz MM: The nephrotic syndrome: Minimal change, focal segmental glomerulosclerosis, and miscellanous causes; in Jenette JC, Olson JL, Schwartz MM, Silva FG (eds): Heptinstall's Pathology of the Kidney. Philadelphia, Lippincott-Raven, 1998, pp 187-257.
32. Kriz W, Hosser H, Hähnel B, Provoost AP: Misdirected filtration from segmentally injured glomeruli contributes to progression of chronic renal disease (abstract). J Am Soc Nephrol 1998;9:614a.
33. Whiteside C, Prutis K, Cameron R, Thompson J: Glomerular epithelial detachment, not reduced charge density, correlates with proteinuria in adriamycin and puromycin nephrosis. Lab Invest 1989;61:650-660.