Polymorphisms in the Toll-like Receptor 2 subfamily and risk of asthma: A case-control analysis in a chinese population

Journal of Investigational Allergology and Clinical Immunology

Volumn 20, Issue 4, 2010, Pages 340-346

  Qian, F H ^a   Zhang, Q ^b   Zhou, L F ^b   Jin, G F ^b   Bai, J L ^b   Yin, K S ^b  

^a JIANGSU UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Allergic rhinitis; Asthma; Single nucleotide polymorphism; SNpstream; Toll like receptors

Indexed keywords

TOLL LIKE RECEPTOR 10; TOLL LIKE RECEPTOR 2; TLR10 PROTEIN, HUMAN; TLR6 PROTEIN, HUMAN; TOLL LIKE RECEPTOR 6;

ADOLESCENT; ADULT; AGED; ALLELE; ALLERGIC RHINITIS; ARTICLE; ASTHMA; CASE CONTROL STUDY; CHINESE; CONTROLLED STUDY; EOSINOPHIL COUNT; ETHNICITY; FEMALE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; GENE INTERACTION; GENE LOCUS; GENE MUTATION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; PROTEIN POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM; CHINA; GENETIC PREDISPOSITION; GENETICS; HAY FEVER; IMMUNOLOGY; METABOLISM; MIDDLE AGED; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PERENNIAL RHINITIS;

ADOLESCENT; ADULT; AGED; ASTHMA; CHINA; DNA MUTATIONAL ANALYSIS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RHINITIS, ALLERGIC, PERENNIAL; RHINITIS, ALLERGIC, SEASONAL; TOLL-LIKE RECEPTOR 10; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 6;

EID: 78049431319     PISSN: 10189068     EISSN: 16980808     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Umetsu DT, Dekruyff RH. The regulation of allergy and asthma. Immunol Rev. 2006;212:238-55.
2. Horner AA. Toll-like receptor ligands and atopy: a coin with at least two sides. J Allergy Clin Immunol. 2006;117:1133-40.
3. O'Neill LA, Bowie AG. The family of five: TIR-domain-containing adaptors in Toll-like receptor signaling. Nat Rev Immunol. 2007;7:353-64.
4. Akira S, Takeda K, Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol. 2001;2:675-80.
5. Cohn L, Tepper JS, Bottomly K. IL-4-independent induction of airway hyperresponsiveness by Th2, but not Th1, cells. J Immunol. 1998;161:3813-6.
6. Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell. 2006;124:783-801.
7. Tapping RI, Omueti KO, Johnson CM. Genetic polymorphisms within the human Toll-like receptor 2 subfamily. Biochem Soc Trans. 2007;35:1445-8.
8. Chaudhary PM, Ferguson C, Nguyen V, Nguyen O, Massa HF, Eby M, Jasmin A, Trask BJ, Hood L, Nelson PS. Cloning and characterization of two Toll/interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans. Blood. 1998;91:4020-7.
9. Chuang T, Ulevitch RJ. Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells. Biochim Biophys Acta. 2001;1518:157-61.
10. Kawai T, Akira S. TLR signaling. Semin Immunol. 2007;19:24-32.
11. Lazarus R, Vercelli D, Palmer LJ, Klimecki WJ, Silverman EK, Richter B, Riva A, Ramoni M, Martinez FD, Weiss ST, Kwiatkowski DJ. Single nucleotide polymorphisms in innate immunity genes: abundant variation and potential role in complex human disease. Immunol Rev. 2002;190:9-25.
12. Qiu YY, Zhang XL, Yin KS. Association between beta2-adrenergic receptor genetic polymorphisms and total serum IgE in asthmatic patients of Chinese Han nationality. Respiration. 2006;73:180-4.
13. Hoffjan S, Stemmler S, Parwez Q, Petrasch-Parwez E, Arinir U, Rohde G, Reinitz-Rademacher K, Schultze-Werninghaus G, Bufe A, Epplen JT. Evaluation of the toll-like receptor 6 Ser249Pro polymorphism in patients with asthma, atopic dermatitis and chronic obstructive pulmonary disease. BMC Med Genet. 2005;6:34.
14. Puthothu B, Heinzmann A. Is toll-like receptor 6 or toll-like receptor 10 involved in asthma genetics or both? Allergy. 2006;61:649-50.
15. Eder W, Klimecki W, Yu L, von Mutius E, Riedler J, Braun-Fahrländer C, Nowak D, Martinez FD, ALEX Study Team. Toll-like receptor 2 as a major gene for asthma in children of European farmers. J Allergy Clin Immunol. 2004;113:482-8.
16. Tantisira K, Klimecki WT, Lazarus R, Palmer LJ, Raby BA, Kwiatkowski DJ, Silverman E, Vercelli D, Martinez FD, Weiss ST. Toll-like receptor 6 gene (TLR6): single-nucleotide polymorphism frequencies and preliminary association with the diagnosis of asthma. Genes Immun. 2004;5:343-6.
17. Lazarus R, Raby BA, Lange C, Silverman EK, Kwiatkowski DJ, Vercelli D, Klimecki WJ, Martinez FD, Weiss ST. Toll-like receptor 10 genetic variation is associated with asthma in two independent samples. Am J Respir Crit Care Med. 2004;170:594-600.
18. Noguchi E, Nishimura F, Fukai H, Kim J, Ichikawa K, Shibasaki M, Arinami T. An association study of asthma and total serum immunoglobin E levels for Toll-like receptor polymorphisms in a Japanese population. Clin Exp Allergy. 2004;34:177-83.
19. Smit LA, Bongers SI, Ruven HJ, Rijkers GT, Wouters IM, Heederik D, Omland Ø, Sigsgaard T. Atopy and new-onset asthma in young Danish farmers and CD14, TLR2, and TLR4 genetic polymorphisms: a nested case-control study. Clin Exp Allergy. 2007;37:1602-8.
20. Kormann MS, Depner M, Hartl D, Klopp N, Illig T, Adamski J, Vogelberg C, Weiland SK, Mutius E, Kabesch M. Toll-like receptor heterodimer variants protect from childhood asthma. J Allergy Clin Immunol. 2008;122:86-92.
21. National Institutes of Health, National Heart, Lung and Blood Institute: GINA workshop report, Global strategy for asthma management and prevention (2005 Update). [cited Jan 16, 2006]. Available from: www.ginasthma.com.
22. Wu X, Gu J, Grossman HB, Amos CI, Etzel C, Huang M, Zhang Q, Millikan RE, Lerner S, Dinney CP, Spitz MR. Bladder cancer predisposition: a multigenic approach to DNA-repair and cellcycle- control genes. Am J Hum Genet. 2006;78:464-79.
23. Qian FH, Zhang Q, Zhou LF, Liu H, Huang M, Zhang XL, Yin KS. High sensitivity C-reactive protein: a predicative marker in severe asthma. Respirology. 2008;15:664-9.
24. Denomme GA, Van Oene M. High-throughput multiplex singlenucleotide polymorphism analysis for red cell and platelet antigen genotypes. Transfusion. 2005;45:660-6.
25. Olson JE, Ma CX, Pelleymounter LL, Schaid DJ, Pankratz VS, Vierkant RA, Fredericksen ZS, Ingle JN, Wu Y, Couch F, Sellers TA, Weinshilboum RM, Vachon CM. A comprehensive examination of CYP19 variation and risk of breast cancer using two haplotypetagging approaches. Cancer Epidemiol Biomarkers Prev. 2007;16:623-5.
26. Lancaster GI, Khan Q, Drysdale P, Wallace F, Jeukendrup AE, Drayson MT, Gleeson M. The physiological regulation of Tolllike receptor expression and function in humans. J Physiol. 2005;563:945-55.
27. Cristofaro P, Opal SM. Role of Toll-like receptors in infection and immunity: clinical implications. Drugs. 2006;66:15-29.
28. Redecke V, Hacker H, Datta SK, Fermin A, Pitha PM, Broide DH, Raz E. Cutting edge: activation of Toll-like receptor 2 induces a Th2 immune response and promotes experimental asthma. J Immunol. 2004;172:2739-43.
29. Medzhitov R. Toll-like receptors and innate immunity. Nat Rev Immunol. 2001;1:135-45.
30. Magnan A, Meunier JP, Saugnac C, Gasteau J, Neukirch F. Frequency and impact of allergic rhinitis in asthma patients in everyday general medical practice: a French observational crosssectional study. Allergy. 2007; 63:292-8.