Fundus autofluorescence and the bisretinoids of retina

Photochemical and Photobiological Sciences

Volumn 9, Issue 11, 2010, Pages 1480-1489

  Sparrow, Janet R ^a,b   Wu, Yalin ^a   Nagasaki, Takayuki ^a   Yoon, Kee Dong ^a   Yamamoto, Kazunori ^a   Zhou, Jilin ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b NewYork Presbyterian Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 78049420760     PISSN: 1474905X     EISSN: 14749092     Source Type: Journal    
DOI: 10.1039/c0pp00207k     Document Type: Article

References (51)

1. A. von Ruckmann F. W. Fitzke A. C. Bird Distribution of fundus autofluorescence with a scanning laser ophthalmoscope Br. J. Ophthalmol. 1995 79 407 412
2. R. F. Spaide, in Atlas of Fundus Autofluorescence Imaging, ed., F. G. Holz, S. Schmitz-Valckenberg, R. F. Spaide, and, A. C. Bird, Springer-Verlag, Berlin, Heidelberg, 2007, pp. 49-54
3. F. C. Delori Spectrophotometer for noninvasive measurement of intrinsic fluorescence and reflectance of the ocular fundus Appl. Opt. 1994 33 7439 7452
4. J. I. Morgan J. J. Hunter B. Masella R. Wolfe D. C. Gray W. H. Merigan F. C. Delori D. R. Williams Light-induced retinal changes observed with high-resolution autofluorescence imaging of the retinal pigment epithelium Invest. Ophthalmol. Visual Sci. 2008 49 3715 3729
5. F. C. Delori C. K. Dorey G. Staurenghi O. Arend D. G. Goger J. J. Weiter In vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristics Invest. Ophthalmol. Visual Sci. 1995 36 718 729
6. A. von Ruckmann F. W. Fitzke A. C. Bird In vivo fundus autofluorescence in macular dystrophies Arch. Ophthalmol. 1997 115 609 615
7. F. C. Delori D. G. Goger C. K. Dorey Age-related accumulation and spatial distribution of lipofuscin in RPE of normal subjects Invest. Ophthalmol. Visual Sci. 2001 42 1855 1866
8. C. A. Parish M. Hashimoto K. Nakanishi J. Dillon J. R. Sparrow Isolation and one-step preparation of A2E and iso-A2E, fluorophores from human retinal pigment epithelium Proc. Natl. Acad. Sci. U. S. A. 1998 95 14609 14613
9. N. Fishkin J. R. Sparrow R. Allikmets K. Nakanishi Isolation and characterization of a retinal pigment epithelial cell fluorophore: an all-trans-retinal dimer conjugate Proc. Natl. Acad. Sci. U. S. A. 2005 102 7091 7096
10. S. R. Kim Y. P. Jang S. Jockusch N. E. Fishkin N. J. Turro J. R. Sparrow The all-trans-retinal dimer series of lipofuscin pigments in retinal pigment epithelial cells in a recessive Stargardt disease model Proc. Natl. Acad. Sci. U. S. A. 2007 104 19273 19278
11. Y. Wu N. E. Fishkin A. Pande J. Pande J. R. Sparrow Novel lipofuscin bisretinoids prominent in human retina and in a model of recessive Stargardt disease J. Biol. Chem. 2009 284 20155 20166
12. B. Lorenz B. Wabbels E. Wegscheider C. P. Hamel W. Drexler M. N. Presing Lack of fundus autofluorescence to 488 nanometers from childhood on in patients with early-onset severe retinal dystrophy associated with mutations in RPE65 Ophthalmology 2004 111 1585 1594
13. R. C. Eagle A. C. Lucier V. B. Bernardino M. Yanoff Retinal pigment epithelial abnormalities in fundus flavimaculatus Ophthalmology 1980 87 1189 1200
14. J. Weng N. L. Mata S. M. Azarian R. T. Tzekov D. G. Birch G. H. Travis Insights into the function of Rim protein in photoreceptors and etiology of Stargardt's disease from the phenotype in abcr knockout mice Cell 1999 98 13 23
15. S. R. Kim N. Fishkin J. Kong K. Nakanishi R. Allikmets J. R. Sparrow The Rpe65 Leu 450 Met variant is associated with reduced levels of the RPE lipofuscin fluorophores A2E and iso-A2E Proc. Natl. Acad. Sci. U. S. A. 2004 101 11668 11672
16. F. C. Delori G. Staurenghi O. Arend C. K. Dorey D. G. Goger J. J. Weiter In vivo measurement of lipofuscin in Stargardt's disease-Fundus flavimaculatus Invest. Ophthalmol. Visual Sci. 1995 36 2327 2331
17. N. Lois G. E. Holder C. V. Bunce F. W. Fitzke A. C. Bird Phenotypic subtypes of Stargardt macular dystrophy-fundus flavimaculatus Arch. Ophthalmol. 2001 119 359 369
18. V. Vasireddy M. M. Jablonski N. W. Khan X. F. Wang P. Sahu J. R. Sparrow R. Ayyagari Elovl4 5-bp deletion knock-in mouse model for Stargardt-like macular degeneration demonstrates accumulation of ELOVL4 and lipofusin Exp. Eye Res. 2009 89 905 912
19. J. E. Chung R. F. Spaide Fundus autofluorescence and vitelliform macular dystrophy Arch. Ophthalmol. 2004 122 1078
20. G. L. Wing G. C. Blanchard J. J. Weiter The topography and age relationship of lipofuscin concentration in the retinal pigment epithelium Invest. Ophthalmol. Visual Sci. 1978 17 601 607
21. R. W. Young Pathophysiology of age-related macular degeneration Surv. Ophthalmol. 1987 31 291 306
22. J. Zhou Y. P. Jang S. R. Kim J. R. Sparrow Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium Proc. Natl. Acad. Sci. U. S. A. 2006 103 16182 16187
23. J. Zhou S. R. Kim B. S. Westlund J. R. Sparrow Complement activation by bisretinoid constituents of RPE lipofuscin Invest. Ophthalmol. Visual Sci. 2009 50 1392 1399
24. F. G. Holz C. Bellman S. Staudt F. Schutt H. E. Volcker Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration Invest. Ophthalmol. Visual Sci. 2001 42 1051 1056
25. A. G. Robson M. Michaelides Z. Saihan A. C. Bird A. R. Webster A. T. Moore F. W. Fitzke G. E. Holder Functional characteristics of patients with retinal dystrophy that manifest abnormal parafoveal annuli of high density fundus autofluorescence: a review and update Doc. Ophthalmol. 2008 116 79 89
26. S. Schmitz-Valckenberg J. Jorzik K. Unnebrink F. G. Holz Analysis of digital scanning laser ophthalmoscopy fundus autofluorescenceimages of geographic atrophy in advanced age-related macular degeneration Graefe's Arch. Clin. Exp. Ophthalmol. 2002 240 73 78
27. J. Liu Y. Itagaki S. Ben-Shabat K. Nakanishi J. R. Sparrow The biosynthesis of A2E, a fluorophore of aging retina, involves the formation of the precursor, A2-PE, in the photoreceptor outer segment membrane J. Biol. Chem. 2000 275 29354 29360
28. N. Sakai J. Decatur K. Nakanishi G. E. Eldred Ocular age pigment "A2E": An unprecedented pyridinium bisretinoid J. Am. Chem. Soc. 1996 118 1559 1560
29. N. Fishkin G. Pescitelli J. R. Sparrow K. Nakanishi N. Berova Absolute configurational determination of an all-trans-retinal dimer isolated from photoreceptor outer segments Chirality 2004 16 637 641
30. F. C. Delori, C. Keilhauer, J. R. Sparrow and G. Staurenghi, in Atlas of Fundus Autofluorescence Imaging, ed., F. G. Holz, S. Schmitz-Valckenberg, R. F. Spaide, and, A. C. Bird, Springer-Verlag, Berlin, Heidelberg, 2007, pp. 17-29
31. J. R. Sparrow C. A. Parish M. Hashimoto K. Nakanishi A2E, a lipofuscin fluorophore, in human retinal pigmented epithelial cells in culture Invest. Ophthalmol. Visual Sci. 1999 40 2988 2995
32. S. R. Kim Y. Jang J. R. Sparrow Photooxidation of RPE Lipofuscin bisretinoids enhanced fluorescence intensity Vision Res. 2010 50 729 736
33. J. R. Sparrow K. Yoon Y. Wu K. Yamamoto Interpretations of fundus autofluorescence from studies of the bisretinoids of retina Invest. Ophthalmol. Visual Sci. 2010 51 4351 4357
34. Y. P. Jang H. Matsuda Y. Itagaki K. Nakanishi J. R. Sparrow Characterization of peroxy-A2E and furan-A2E photooxidation products and detection in human and mouse retinal pigment epithelial cells lipofuscin J. Biol. Chem. 2005 280 39732 39739
35. D. Bok Retinal photoreceptor-pigment epithelium interactions. Friedenwald lecture Invest. Ophthalmol. Visual Sci. 1985 26 1659 1694
36. S. Ben-Shabat C. A. Parish H. R. Vollmer Y. Itagaki N. Fishkin K. Nakanishi J. R. Sparrow Biosynthetic studies of A2E, a major fluorophore of RPE lipofuscin J. Biol. Chem. 2002 277 7183 7190
37. S. R. Kim J. He E. Yanase Y. P. Jang N. Berova J. R. Sparrow K. Nakanishi Characterization of dihydro-A2PE: an Intermediate in the A2E biosynthetic pathway Biochemistry 2007 46 10122 10129
38. J. R. Sparrow S. R. Kim A. M. Cuervo U. Bandhyopadhyayand A2E, a pigment of RPE lipofuscin is generated from the precursor A2PE by a lysosomal enzyme activity Adv. Exp. Med. Biol. 2008 613 393 398
39. S. Ben-Shabat Y. Itagaki S. Jockusch J. R. Sparrow N. J. Turro K. Nakanishi Formation of a nona-oxirane from A2E, a lipofuscin fluorophore related to macular degeneration, and evidence of singlet oxygen involvement Angew. Chem., Int. Ed. 2002 41 814 817
40. S. R. Kim S. Jockusch Y. Itagaki N. J. Turro J. R. Sparrow Mechanisms involved in A2E oxidation Exp. Eye Res. 2008 86 975 982
41. J. R. Sparrow J. Zhou S. Ben-Shabat H. Vollmer Y. Itagaki K. Nakanishi Involvement of oxidative mechanisms in blue light induced damage to A2E-laden RPE Invest. Ophthalmol. Visual Sci. 2002 43 1222 1227
42. M. A. Genead G. A. Fishman M. Lindeman Spectral-domain optical coherence tomography and fundus autofluorescence characteristics in patients with fundus albipunctatus and retinitis punctata albescens Ophthalmic Genet. 2010 31 66 72
43. H. Yamamoto K. Yakushijin S. Kusuhara M. F. Escano A. Nagai A. Negi A novel RDH5 gene mutation in a patient with fundus albipunctatus presenting with macular atrophy and fading white dots Am. J. Ophthalmol. 2003 136 572 574
44. G. Humbert C. Delettre A. Sénéchal C. Bazalgette A. Barakat C. Bazalgette B. Arnaud G. Lenaers C. P. Hamel Homozygous deletion related to Alu repeats in RLBP1 causes retinitis punctata albescens Invest. Ophthalmol. Visual Sci. 2006 47 4719 4724
45. T. M. Redmond S. Yu E. Lee D. Bok D. Hamasaki N. Chen P. Goletz J.-X. Ma R. K. Crouch K. Pfeifer Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle Nat. Genet. 1998 20 344 351
46. S. Alex H. L. Thanh D. Vocelle Studies of the effect of hydrogen bonding on the absorption and fluorescence spectra of all-trans-retinal at room temperature Can. J. Chem. 1992 70 880 887
47. T. Takemura G. Hug P. K. Das R. S. Becker Visual pigments. 9. Fluorescence of dimers of retinals J. Am. Chem. Soc. 1978 100 2631 2634
48. A. Maeda T. Maeda M. Golczak S. Chou A. Desai C. L. Hoppel S. Matsuyama K. Palczewski Involvement of all-trans-retinal in acute light-induced retinopathy of mice J. Biol. Chem. 2009 284 15173 15183
49. S. A. Schadel M. Heck D. Maretzki S. Filipek D. C. Teller K. Palczewski K. P. Hofmann Ligand channeling with a G-protein-coupled receptor: The entry and exit of retinal in native opsin J. Biol. Chem. 2003 278 24896 24903
50. R. E. Anderson M. B. Maude Phospholipids of bovine outer segments Biochemistry 1970 9 3624 3628
51. J. R. Sparrow Y. Wu C. Y. Kim J. Zhou Phospholipid meets all-trans-retinal: the making of RPE bisretinoids J. Lipid Res. 2010 51 247 261