Increased expression of low density lipoprotein receptor-related protein/α2-macroglobulin receptor in human malignant astrocytomas

Cancer Research

Volumn 57, Issue 13, 1997, Pages 2799-2805

  Yamamoto, Masaaki ^a   Ikeda, Kohichi ^a   Ohshima, Kohichi ^a   Tsugu, Hitoshi ^a   Kimura, Hideo ^a   Tomonaga, Masamichi ^a  

^a FUKUOKA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOPROTEIN RECEPTOR; MESSENGER RNA; UROKINASE;

ARTICLE; ASTROCYTOMA; CANCER INVASION; CONTROLLED STUDY; ENZYME REGULATION; GLIOBLASTOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LIPOPROTEIN SYNTHESIS; NEOVASCULARIZATION (PATHOLOGY); PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION;

ADENOCARCINOMA; ASTROCYTOMA; BRAIN NEOPLASMS; GLIOBLASTOMA; HUMANS; IMMUNOHISTOCHEMISTRY; LDL-RECEPTOR RELATED PROTEIN 1; LUNG NEOPLASMS; NEOPLASM INVASIVENESS; PLASMINOGEN ACTIVATORS; RECEPTORS, CELL SURFACE; RECEPTORS, IMMUNOLOGIC; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 0030837448     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Liotta, L. A., Steeg, P. S., and Stetler-Stevenson, W. G. Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell, 64: 327-336, 1991.
2. Blasi, F. Urokinase and urokinase receptor: a paracrine/autocrine system regulating cell migration and invasiveness. BioEssays, 15: 105-111, 1993.
3. r receptor protein for urokinase-type plasminogen activator: identification in human tumor cell lines and partial purification. J. Biol. Chem., 263: 2358-2363, 1988.
4. Pöllänen, J., Stephens, R. W., and Vaheri, A. Directed plasminogen activation at the surface of normal and malignant cells. Adv. Cancer Res., 57: 273-328, 1991.
5. Yamamoto, M., Sawaya, R., Mohanam, S., Bindal, A. K., Bruner, J. M., Oka, K., Rao, V. H., Tomonaga, M., Nicolson, G. L., and Rao, J. S. Expression and localization of urokinase-type plasminogen activator in human astrocytomas in vivo. Cancer Res., 54: 3656-3661, 1994.
6. Yamamoto, M., Sawaya, R., Mohanam, S., Loskutoff, D. J., Bruner, J. M., Rao, V. H., Oka, K., Tomonaga, M., Nicolson, G. L., and Rao, J. S. Expression and cellular localization of messenger RNA for plasminogen activator inhibitor type 1 in human astrocytomas in vivo. Cancer Res., 54: 3329-3332, 1994.
7. Yamamoto, M., Sawaya, R., Mohanam, S., Rao, V. H., Bruner, J. M., Nicolson, G. L., and Rao, J. S. Expression and localization of urokinase-type plasminogen activator receptor in human gliomas. Cancer Res., 54: 5016-5020, 1994.
8. Mohanam, S., Sawaya, R., Yamamoto, M., Bruner, J. M., Nicholson, G. L., and Rao, J. S. Proteolysis and invasiveness of brain tumors: role for urokinase-type plasminogen activator receptor. J. Neuro-oncol., 22: 153-160, 1994.
9. Andreasen, P. A., Sottrup-Jensen, L., Kjøller, L., Nakjær, A., Moestrup, S. K., Petersen, C. M., and Gliemann, J. Receptor-mediated endocytosis of plasminogen activators and activator/inhibitor complexes. FEBS Lett., 338: 239-245, 1994.
10. Herz, J., Clouthier, D. E., and Hammer, R. E. LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation. Cell, 71: 411-421, 1992.
11. Herz, J., Hamann, U., Rogne, S., Myklebost, O., Gausepohl, H., and Stanley, K. K. Surface location and high affinity for calcium of a 500-kD liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor. EMBO J., 7: 4119-4127, 1988.
12. Strickland, D. K., Kounnas, M. Z., Williams, S. E., and Argraves, W. S. LDL receptor-related protein (LRP): a multiligand receptor. Fibrinolysis, 8 (Suppl. 1): 204-215, 1994.
13. Kowal, R. C., Herz, J., Goldstein, J. L., Esser, V., and Brown, M. S. Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins. Proc. Natl. Acad. Sci. USA, 86: 5810-5814, 1989.
14. Kounnas, M. Z., Morris, R. E., Thompson, M. R., FitzGerald, D. J., Strickland, D. K., and Saelinger, C. B. The α2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A. J. Biol. Chem., 267: 12420-12423, 1992.
15. Strickland, D. K., Ashcom, J. D., Williams, S., Battery, P., Behre, E., McTigue, K., Battery, J. F., and Argraves, W. S. Primary structure of α-macroglobulin receptor-associated protein: human homologue of a heyman nephritis antigen. J. Biol. Chem., 266: 13364-13369, 1991.
16. Strickland, D. K., Ashcom, J. D., Williams, S., Burgess, W. H., Migliorini, M., and Argraves, W. S. Sequence identity between the α2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor. J. Biol. Chem., 265: 17401-17404, 1990.
17. Bu, G., Williams, S., Strickland, D. K., and Schwanz, A. L. Low density lipoprotein receptor-related protein/α2-macroglobulin receptor is an hepatic receptor for tissue-type plasminogen activator. Proc. Natl. Acad. Sci. USA, 89: 7427-7431, 1992.
18. Nykjær, A., Peterson, C. M., Møller, B., Jensen, P. H., Moestrup. S. K., Holtet, T., Etzerodt, M., Thøgersen, H. C., Munch, M., Andreasen, P. A., and Gliemann, J. Purified α2-macroglobulin receptor/LDL receptor-related protein binds urokinase-plasminogen activator inhibitor type-1 complex: evidence that the α2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes. J. Biol. Chem., 267: 14543-14546, 1992
19. Orth, K., Madison, E. L., Gething, M-J., Sambrook, J. F., and Herz, J. Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized by means of the low density lipoprotein receptor-related protein/α2-macroglobulin receptor. Proc. Natl. Acad. Sci. USA., 89: 7422-7426, 1992.
20. de Vries, T. J., Verheijen, J. H., de Bart, A. C. W., Weidle, U. H., and Ruiter, D. J., van Muijen, G. N. P. Decreased expression of both the low-density lipoprotein receptor-related protein/α2-macroglobulin receptor and its receptor-associated protein in late stages of cutaneous melanocytic tumor progression. Cancer Res., 56: 1432-1439, 1996.
21. Bu, G., Maksymoviteh, E. A., Nerbonne, J. M. and Schwartz, A. L. Expression and function of the low density lipoprotein receptor-related protein (LRP) in mammalian central neurons. J. Biol. Chem., 269: 18521-18528, 1994.
22. Moestrup, S. K., Gliemann, J., and Pallesen, G. Distribution of the α2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues. Cell Tissue Res., 269: 375-382, 1992.
23. Rebeck, G. W., Reiter, J. S., Strickland, D. K., and Hyman, B. T. Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions. Neuron, 11: 575-580, 1993.
24. Wolf, B. B., Lopes, M. B. S., VandenBerg, S. R., and Gonias, S. L. Characterization and immunohisiochemical localization of α2-macroglobulin receptor (low-density lipoprotein receptor-related protein) in human brain. Am. J. Pathol., 141: 37-42, 1992.
25. Saksela, O., Wahström, T., Lehtovirta, P., Seppälä, M., and Vaheri, A. Presence of α2-macroglobulin in normal but not in malignant syncytiotrophoblasts. Cancer Res., 41: 2507-2513, 1981.
26. Van Leuven, F., Cassiman, J-J., and Van den Berghe, H. Demonstration of an α2-macroglobulin receptor in human fibroblasts, absent in tumor-derived cell lines. J. Biol. Chem., 254: 5155-5160, 1979.
27. Bu, G., Maksymovitch, E. A., Geuze, H., and Schwartz, A. L. Subcellular localization and endocytic function of low density lipoprotein receptor-related protein in human glioblastoma cells. J. Biol. Chem., 269: 29874-29882, 1994.
28. Kleihues, P., Burger, P. C., and Scheithauer, B. W. Histological Typing of Tumors of the Central Nervous System, Ed. 2, pp. 11-20. Berlin: Springer-Verlag, 1993.
29. 1 arrest in vitro. J. Cell. Physiol., 99: 43-54, 1079.
30. Giard, D. J., Aaronson, S. A., Todaro, G. J., Arnstein, P., Kersey, J. H., Dosik, H., and Parks, W. P. In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors. J. Natl. Cancer Inst., 51: 1417-1423, 1973.
31. Yamamoto, M., Mohanam, S., Sawaya, R., Fuller, G. N., Seiki, M., Sato, H., Gokaslan, Z. L., Liotta, L. A., Nicolson, G. L., and Rao, J. S, Differential expression of membrane-type matrix metalloproteinase and its correlation with gelatinase A activation in human malignant brain tumor in vivo and in vitro. Cancer Res., 56: 384-392, 1996.
32. Roldan, A. L., Cubellis, M. V., Masucci, M. T., Behrendt, N., Lund, L. R., Danø, K., Appella, E., and Blasi, F. Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis. EMBO J., 9: 467-474, 1990.
33. Pyke, C., Eriksen, J., Solberg, H., Nielsen, B. S., Kristensen, P., Lund, L. R., and Danø, K. An alternatively spliced variant of mRNA for the human receptor for urokinase plasminogen activator. FEBS Lett., 326: 69-74, 1993.
34. Lopes, M. B. S., Bogaev, C. A., Gonias, S. L., and VandenBerg, S. R. Expression of α2-macroglobulin receptor/low density lipoprotein receptor-related protein is increased in reactive and neoplastic glial cells. FEBS Lett., 338: 301-305, 1994.
35. Grobmyer, S. R., Kuo, A., Orishimo, M., Okada, S. S., Cines, D. B., and Barnathan, E. S. Determinants of binding and internalization of tissue-type plasminogen activator by human vascular smooth muscle and endothelial cells. J. Biol. Chem., 268: 13291-13300, 1993.
36. Camani, C., and Kruithof, E. K. O. Clearance receptors for tissue-type plasminogen activator. Int. J. Hematol., 60: 97-109, 1994.
37. Kancha, R. K., Stearns, M. E., and Hussain, M. M. Decreased expression of the low density lipoprotein receptor-related protein/α2-macroglobulin receptor in invasive cell clones derived from human prostate and breast tumor cells. Oncol. Res., 6: 365-372, 1994.
38. Moestrup, S. K. CD91 (α2MR/LRP) Cluster Workshop Report: Leukocyte Typing V. pp. 971-975. Oxford, England: Oxford University Press, 1995.
39. Gonias, S. L., LaMarre, J., Crookston, K. P., Webb, D. J., Wolf, B. B., Lopes, M. B. S., Moses, H. L., and Hayes, M. A. α 2-macroglobulin and the α 2-macroglobulin receptor/LRP: a growth regulatory axis. Ann. NY Acad. Sci., 737: 273-290, 1994.
40. Giese, A., and Westphal, M. Glioma invasion in the central nervous system. Neurosurgery (Baltimore), 39: 235-252, 1996.
41. Heegaard, C. W., Simonsen, A. C. W., Oka, K., Kjoller, L., Christensen, A., Madsen, B., Ellgaard, L., Chan, L., and Andreasen, P. A. Very low density lipoprotein receptor binds and mediates endocytosis of urokinase-type plasminogen activator-type 1 plasminogen activator inhibitor complex. J. Biol. Chem., 270: 20855-20861, 1995.
42. Narita, M., Bu, G., Herz, J., and Schwarz, A. L. Two receptor systems are involved in the plasma clearance of tissue-type plasminogen activator (t-PA) in vivo. J. Clin. Invest., 96: 1164-1168, 1995.
43. Pepper, M. S., Vassalli, J-D., Montesano, R., and Orci, L. Urokinase-type plasminogen activator is induced in migrating capillary endothelial cells. J. Cell Biol., 105: 2535-2541, 1987.