Efficient synthesis of 16 aromatic Morita-Baylis-Hillman adducts: Biological evaluation on Leishmania amazonensis and Leishmania chagasi

Bioorganic Chemistry

Volumn 38, Issue 6, 2010, Pages 279-284

  Junior, Cláudio G L ^a   De Assis, Priscila A C ^a   Silva, Fábio P L ^a   Sousa, Suervy C O ^a   De Andrade, Natália G ^a   Barbosa, Ticiano P ^a   Nerís, Patrícia L N ^a   Segundo, Luiz V G ^a   Anjos, Ítalo C ^a   Carvalho, Gabriel A U ^a   Rocha, Gerd B ^a   Oliveira, Márcia R ^a   Vasconcellos, Mário L A A ^a  

^a FEDERAL UNIVERSITY OF PARAÍBA   (Brazil)

Author keywords

Drugs; Leishmania; Morita Baylis Hillman adducts; Structure activity relationship; Temperature effect

Indexed keywords

1,4 DIAZABICYCLO[2.2.2]OCTANE; 2 [HYDROXY(2 NITROPHENYL)METHYL]ACRYLONITRILE; 2 [HYDROXY(2 NITROPHENYL)METHYL]PROPANOATE; 2 [HYDROXY(3 NITROPHENYL)METHYL]ACRYLONITRILE; 2 [HYDROXY(3 NITROPHENYL)METHYL]PROPANOATE; 2 [HYDROXY(4 BROMOPHENYL)METHYL]ACRYLONITRILE; 2 [HYDROXY(4 BROMOPHENYL)METHYL]PROPANOATE; 2 [HYDROXY(4 NITROPHENYL)METHYL]ACRYLONITRILE; 2 [HYDROXY(4 NITROPHENYL)METHYL]PROPANOATE; 2 [HYDROXY(NAPHTH 2 YL)METHYL]ACRYLONITRILE; 2 [HYDROXY(NAPHTH 2 YL)METHYL]PROPANOATE; 2 [HYDROXY(PYRIDIN 2 YL)METHYL]ACRYLONITRILE; 2 [HYDROXY(PYRIDIN 2 YL)METHYL]PROPANOATE; 2 [HYDROXY(PYRIDIN 3 YL)METHYL]ACRYLONITRILE; 2 [HYDROXY(PYRIDIN 3 YL)METHYL]PROPANOATE; 2 [HYDROXY(PYRIDIN 4 YL)METHYL]ACRYLONITRILE; 2 [HYDROXY(PYRIDIN 4 YL)METHYL]PROPANOATE; ACRYLIC ACID METHYL ESTER; ACRYLONITRILE; ALDEHYDE; ANTILEISHMANIAL AGENT; AROMATIC COMPOUND; MEGLUMINE ANTIMONATE; PENTOSTA; UNCLASSIFIED DRUG;

ARTICLE; BAYLIS HILLMAN REACTION; CATALYSIS; DRUG COST; DRUG SYNTHESIS; IC 50; LEISHMANIA CHAGASI; PRIORITY JOURNAL; PROMASTIGOTE; STRUCTURE ACTIVITY RELATION;

ACRYLATES; ALDEHYDES; ANTIPARASITIC AGENTS; CATALYSIS; GREEN CHEMISTRY TECHNOLOGY; HUMANS; HYDROCARBONS, AROMATIC; LEISHMANIA; LEISHMANIASIS; PIPERAZINES;

LEISHMANIA AMAZONENSIS; LEISHMANIA DONOVANI CHAGASI;

EID: 78049306479     PISSN: 00452068     EISSN: 10902120     Source Type: Journal    
DOI: 10.1016/j.bioorg.2010.08.002     Document Type: Article

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