3-Hydroxy-2-methylene-3-(4-nitrophenylpropanenitrile): A new highly active compound against epimastigote and trypomastigote form of Trypanosoma cruzi

Bioorganic Chemistry

Volumn 38, Issue 5, 2010, Pages 190-195

  Sandes, Jana M ^a   Borges, Andrezza R ^a   Junior, Cláudio G L ^b   Silva, Fábio P L ^b   Carvalho, Gabriel A U ^b   Rocha, Gerd B ^b   Vasconcellos, Mário L A A ^b   Figueiredo, Regina C B Q ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b FEDERAL UNIVERSITY OF PARAÍBA   (Brazil)

Author keywords

Anti Trypanosoma cruzi activity; Morita Baylis Hillman adducts

Indexed keywords

3 HYDROXY 2 METHYLENE 3 (4 NITROPHENYLPROPANENITRILE); ANTIPARASITIC AGENT; FARNESYL TRANS TRANSFERASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL DEATH; CELL STRUCTURE; CELL VOLUME; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; EPIMASTIGOTE; IC 50; MOLECULAR DOCKING; NONHUMAN; OBSERVATION; PRIORITY JOURNAL; STRUCTURE ANALYSIS; TRYPANOSOMA CRUZI; TRYPOMASTIGOTE;

ACRYLONITRILE; BENZYL ALCOHOLS; CHAGAS DISEASE; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

TRYPANOSOMA CRUZI;

EID: 77955550210     PISSN: 00452068     EISSN: 10902120     Source Type: Journal    
DOI: 10.1016/j.bioorg.2010.06.003     Document Type: Article

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