Cutting edge: Complement (C3d)-linked antigens break B cell anergy

Journal of Immunology

Volumn 179, Issue 5, 2007, Pages 2695-2699

  Lyubchenko, Taras ^a   Dal Porto, Joseph M ^a   Holers, V Michael ^a   Cambier, John C ^a,b  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C3D; COMPLEMENT COMPONENT C3D RECEPTOR; CROSS REACTING ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; ANTIGEN; AUTOANTIBODY; CALCIUM; COMPLEMENT C3D,G; COMPLEMENT COMPONENT C3B; PEPTIDE FRAGMENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CLONAL ANERGY; CONTROLLED STUDY; CROSS LINKING; ENZYME LINKED IMMUNOSPOT ASSAY; IMMUNE RESPONSE; IMMUNIZATION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; C57BL MOUSE; CROSS REACTION; DRUG EFFECT; DRUG POTENTIATION; IMMUNOLOGY; METABOLISM;

ANIMALS; ANTIGENS; AUTOANTIBODIES; B-LYMPHOCYTES; CALCIUM; CLONAL ANERGY; COMPLEMENT C3B; CROSS REACTIONS; MICE; MICE, INBRED C57BL; PEPTIDE FRAGMENTS; RECEPTORS, ANTIGEN, B-CELL; RECEPTORS, COMPLEMENT 3D;

EID: 37549071968     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.179.5.2695     Document Type: Article

References (31)

1. Jankovic, M., R. Casellas, N. Yannoutsos, H. Wardemann, and M. C. Nussenzweig. 2004. RAGs and regulation of autoantibodies. Annu. Rev. Immunol. 22: 485-501.
2. Wardemann, H., S. Yurasov, A. Schaefer, J. W. Young, E. Meffre, and M. C. Nussenzweig. 2003. Predominant autoantibody production by early human B cell precursors. Science 301: 1374-1377.
3. Nemazee, D., and K. A. Hogquist. 2003. Antigen receptor selection by editing or downregulation of V(D)J recombination. Curr. Opin. Immunol. 15: 182-189.
4. Halverson, R., R. M. Torres, and R. Pelanda. 2004. Receptor editing is the main mechanism of B cell tolerance toward membrane antigens. Nat Immunol. 5: 645-650.
5. Casellas, R., T. A. Shih, M. Kleinewietfeld, J. Rakonjac, D. Nemazee, K. Rajewsky, and M. C. Nussenzweig. 2001. Contribution of receptor editing to the antibody repertoire. Science 291: 1541-1544.
6. Goodnow, C. C., R. Glynne, S. Akkaraju, J. Rayner, D. Mack, J. I. Healy, S. Chaudhry, L. Miosge, L. Wilson, P. Papathanasiou, and A. Loy. 2001. Autoimmunity, self-tolerance and immune homeostasis: from whole animal phenotypes to molecular pathways. Adv. Exp. Med. Biol. 490: 33-40.
7. Gauld, S. B., K. T. Merrell, and J. C. Cambier. 2006. Silencing of autoreactive B cells by anergy: a fresh perspective. Curr. Opin. Immunol. 18: 292-297.
8. Merrell, K. T., R. J. Benschop, S. B. Gauld, K. Aviszus, D. Decote-Ricardo, L. J. Wysocki, and J. C. Cambier. 2006. Identification of anergic B cells within a wild-type repertoire. Immunity 25: 864-967.
9. + cytotoxic T cells during Theiler's murine encephalomyelitis virus infection: implications for autoimmunity. J. Virol. 76: 12834-12844.
10. + T cells: a mechanism for suppression of autoimmunity during BCG infection. J. Autoimmun. 24: 93-100.
11. Fearon, D. T., and M. C. Carroll. 2000. Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex. Annu. Rev. Immunol. 18: 393-422.
12. Lyubchenko, T., J. Dal Porto, J. C. Cambier, and V. M. Holers. 2005. Coligation of the B cell receptor with complement receptor type 2 (CR2/CD21) using its natural ligand C3dg: activation without engagement of an inhibitory signaling pathway. J. Immunol. 174: 3264-3272.
13. Del Nagro, C. J., R. V. Kolla, and R. C. Rickert. 2005. A critical role for complement C3d and the B cell coreceptor (CD19/CD21) complex in the initiation of inflammatory arthritis. J. Immunol. 175: 5379-5389.
14. Benschop, R. J., K. Aviszus, X. Zhang, T. Manser, J. C. Cambier, and L. J. Wysocki. 2001. Activation and anergy in bone marrow B cells of a novel immunoglobulin transgenic mouse that is both hapten specific and autoreactive. Immunity 14: 33-43.
15. Goodnow, C. C., J. Crosbie, S. Adelstein, T. B. Lavoie, S. J. Smith-Gill, R. A. Brink, H. Pritchard-Briscoe, J. S. Wotherspoon, R. H. Loblay, K. Raphael, et al. 1988. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature 334: 676-682.
16. Cambier, J. C., Gauld, S. B., Merrell, K. T., and Vilen, B. J. 2007. Understanding B-cell anergy: from transgenic models to naturally occurring anergic B cells? Nat. Immunol. In press.
17. Wysocki, L. J., and V. L. Sato. 1981. The strain A anti-p- azophenylarsonate major cross-reactive idiotypic family includes members with no reactivity toward p-azophenylarsonate. Eur. J. Immunol. 11: 832-839.
18. Dal Porto, J. M., K. Burke, and J. C. Cambier. 2004. Regulation of BCR signal transduction in B-1 cells requires the expression of the Src family kinase Lck. Immunity 21: 443-453.
19. Gauld, S. B., R. J. Benschop, K. T. Merrell, and J. C. Cambier. 2005. Maintenance of B cell anergy requires constant antigen receptor occupancy and signaling. Nat. Immunol. 6: 1160-1167.
20. Henson, S. E., D. Smith, S. A. Boackle, V. M. Holers, and D. R. Karp. 2001. Generation of recombinant human C3dg tetramers for the analysis of CD21 binding and function. J. Immunol. Methods. 258: 97-109.
21. Rush, J. S., and P. D. Hodgkin. 2001. B cells activated via CD40 and IL-4 undergo a division burst but require continued stimulation to maintain division, survival and differentiation. Eur. J. Immunol. 31: 1150-1159.
22. Christensen, S. R., J. Shupe, K. Nickerson, M. Kashgarian, R. A. Flavell, and M. J. Shlomchik. 2006. Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity 25: 417-428.
23. Brauweiler, A. M., I. Tamir, and J. C. Cambier. 2000. Bilevel control of B-cell activation by the inositol 5-phosphatase SHIP. Immunol. Rev. 176: 69-74.
24. Scharenberg, A. M., and J. P. Kinet. 1998. PtdIns-3,4,5-P3: a regulatory nexus between tyrosine kinases and sustained calcium signals. Cell 94: 5-8.
25. Anzelon, A. N., H. Wu, and R. C. Rickert. 2003. Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function. Nat. Immunol. 4: 287-294.
26. +. Eur. J. Immunol. 30: 1576-1586.
27. Cornall, R. J., J. G. Cyster, M. L. Hibbs, A. R. Dunn, K. L. Otipoby, E. A. Clark, and C. C. Goodnow. 1998. Polygenic autoimmune traits: Lyn. CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection. Immunity 8: 497-508.
28. Fujimoto, M., A. P. Bradney, J. C. Poe, D. A. Steeber, and T. F. Tedder. 1999. Modulation of B lymphocyte antigen receptor signal transduction by a CD19/CD22 regulatory loop. Immunity 11: 191-200.
29. + T cells. J. Exp. Med. 179: 1539-1549.
30. Kozono, Y., R. Abe, H. Kozono, R. G. Kelly, T. Azuma, and V. M. Holers. 1998. Cross-linking CD21/CD35 or CD19 increases both B7-1 and B7-2 expression on murine splenic B cells. J. Immunol. 160: 1565-1572.
31. Prodeus, A. P., S. Goerg, L. M. Shen, O. O. Pozdnyakova, L. Chu, E. M. Alicot, C. C. Goodnow, and M. C. Carroll. 1998. A critical role for complement in maintenance of self-tolerance. Immunity 9: 721-731.