Similar effects of succinic acid dimethyl ester and glucose on islet calcium oscillations and insulin release

Biochemical Pharmacology

Volumn 67, Issue 5, 2004, Pages 981-988

  Mukala Nsengu, André ^a   Fernández Pascual, Sergio ^a   Martín, Francisco ^b   Martín Del Río, Rafael ^c   Tamarit Rodriguez, Jorge ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

^c HOSPITAL RAMÓN Y CAJAL   (Spain)

Author keywords

Cytosolic calcium; Glucose; Insulin release; Islet metabolism; Succinic and malonic acid

Indexed keywords

CALCIUM ION; CARBON MONOXIDE; ESTER DERIVATIVE; GLUCOSE; INSULIN; MALONIC ACID DIMETHYL ESTER; SUCCINIC ACID DIMETHYL ESTER; UNCLASSIFIED DRUG;

AEROBIC METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CELL ACTIVATION; CELL SECRETION; CITRIC ACID CYCLE; CONTROLLED STUDY; ENZYME SUBSTRATE; GLUCOSE UTILIZATION; GLYCOLYSIS; INSULIN RELEASE; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; RAT;

EID: 1042263996     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2003.10.024     Document Type: Article

References (32)

1. Prentki M., Tornheim K., Corkey B.-E. Signal transduction mechanism in nutrient-induced insulin secretion. Diabetologia. 40:1997;S32-S41.
2. Rorsman P. The pancreatic beta-cell as a fuel sensor: an electrophysiologist's viewpoint. Diabetologia. 40:1997;487-495.
3. Dukes I.-D., McIntyre M.-S., Mertz R.-J., Philipson L.H., Roe M.W., Spencer B., Worley J.F. III Dependence on NADH produced during glycolysis for β-cell signaling. J. Biol. Chem. 269:1994;10979-10982.
4. Eto K., Tsubamoto Y., Terauchi Y., Sugiyama T., Kishimoto T., Takahashi N., Yamauchi N., Kubota N., Murayama S., Aizawa T., Akanuma Y., Aizawa S., Kasai H., Yazaki Y., Kadowaki T. Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion. Science. 283:1999;981-985.
5. Mertz R.-J., Worley J.-F. III, Spencer B., Johnson J.-H., Dukes I.-D. Activation of stimulus-secretion coupling in pancreatic β-cell by specific products of glucose metabolism. Evidence for privileged signaling by glycolysis. J. Biol. Chem. 271:1996;4838-4845.
6. Wollheim C.-B. Beta-cell mitochondria in the regulation of insulin secretion: a new culprit in Type II diabetes. Diabetologia. 43:2000;265-277.
7. Maechler P., Kennedy E.-D., Pozzan T., Wollheim C.-B. Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic β-cells. EMBO J. 16:1997;3833-3841.
8. MacDonald M.-J., Fahien L.-A. Glyceraldehyde phosphate and methyl esters of succinic acid. Two "new" potent insulin secretagogues. Diabetes. 37:1988;997-999.
9. MacDonald M.-J., Fahien L.-A. Insulin release in pancreatic islets by a glycolytic and a Krebs cycle intermediate: contrasting patterns of glyceraldehyde phosphate and succinate. Arch Biochem. Biophys. 279:1990;104-108.
10. Malaisse W.-J., Rasschaert J., Villanueva-Peñacarrillo M., Valverde I. Respiratory, ionic, and functional effects of succinate esters in pancreatic islets. Am. J. Physiol. 264:1993;E428-E433.
11. Zawalich W.-S., Zawalich K.-C. Biochemical mechanisms involved in monomethylsuccinate-induced insulin secretion. Endocrinology. 131:1992;649-654.
12. Zawalich W.-S., Zawalich K.-C., Cline G., Shulman G., Rasmussen H. Comparative effects of monomethyl succinate and glucose on insulin secretion from perifused rat islets. Diabetes. 42:1993;843-850.
13. MacDonald M.-J. Metabolism of the insulin secretagogue methyl succinate by pancreatic islets. Arch Biochem. Biophys. 300:1993;201-205.
14. Malaisse W.-J., Sener A. Metabolic effects and fate of succinate esters in pancreatic islets. Am. J. Physiol. 264:1993;E434-E440.
15. Olson M-S. Bioenergetics and oxidative metabolism. In: Devlin T-M, editor. Textbook of biochemistry. With clinical correlations. New York: Wiley-Liss; 1992. p. 237-89.
16. Lacy P.-E., Kostianovsky M. Method for the isolation of intact islets of Langerhans from the rat pancreas. Diabetes. 16:1967;35-39.
17. Ashcroft S.-J.-H., Weerasinghe C.-C., Bassett J.-M., Randle P.-J. The pentose cycle and insulin release in mouse pancreatic islets. Biochem. J. 126:1972;525-532.
18. Vytasek R. A sensitive assay for the determination of DNA. Anal. Biochem. 120:1982;243-248.
19. Martin F., Andreu E., Rovira J.-M.et al. Mechanisms of glucose hypersensitivity in β-cells from normoglycaemic partially depancretectomized mice. Diabetes. 48:1999;1954-1961.
20. i in single rat pancreatic islets and its correlation with simultaneously measured insulin release. J. Mol. Endocrinol. 15:1995;177-185.
21. i oscillations induced by ketoisocaproate in single mouse pancreatic islets. Diabetes. 44:1995;300-305.
22. 2+] oscillations in single mouse pancreatic islets of Langerhans. J. Physiol. 486:1995;361-371.
23. 2+ uptake and metabolism Biochem. Med. 25:1981;366-372.
24. Sener A., Kawazu S., Hutton J.-C., Boschero A.C., Devis G., Somers G., Herchuelz A., Malaisse W.J. The stimulus-secretion coupling of glucose-induced insulin release. Effect of exogenous pyruvate on islet function. Biochem. J. 176:1978;217-232.
25. 2+ channels accounts for first-phase insulin secretion in mouse β-cells. Diabetes. 51(Suppl. 1):2002;S74-S82.
26. Panten U., Biermann J., Graen W. Recognition of insulin-releasing fuels by pancreatic B-cells. α-Ketoisocaproic acid is an appropriate model compound to study the role of B-cell metabolism. Mol. Pharmacol. 20:1981;76-82.
27. MacDonald M.-J., Fahien L.-A., Mertz R.-J., Rana R.-S. Effect of esters of succinic acid and other citric acid cycle intermediates on insulin release and inositol phosphate formation by pancreatic islets. Arch Biochem. Biophys. 269:1989;400-406.
28. Antinozzi P.-A., Ishihara H., Newgard C.-B., Wollheim C.-B. Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell. A survey of four fuel secretagogues. J. Biol. Chem. 277:2002;11746-11755.
29. i oscillations by glucose, α-ketoisocaproic acid, glyceraldehyde and glycolytic intermediates. Biochim. Biophys. Acta. 1523:2000;65-72.
30. MacDonald M.J. Differences between mouse and rat pancreatic islets: succinate responsiveness, malic enzyme, and anaplerosis. Am. J. Physiol. Endocrinol. Metab. 283:2002;E302-E310.
31. McCormack J.-G., Longo E.-A., Corkey B.-E. Glucose-induced activation of pyruvate dehydrogenase in isolated rat pancreatic islets. Biochem. J. 267:1990;527-530.
32. 2+-sensitive 2-ketoglutarate dehydrogenase in the regulation of mitochondrial function. Biochim. Biophys. Acta. 1019:1990;42-50.