Knockin mice with Leu9′Ser α4-nicotinic receptors: Substantia nigra dopaminergic neurons are hypersensitive to agonist and lost postnatally

Physiological Genomics

Volumn 18, Issue , 2004, Pages 299-307

  Orb, Sabine ^a   Wieacker, Johannes ^a   Labarca, Cesar ^b   Fonck, Carlos ^b   Lester, Henry A ^b   Schwarz, Johannes ^a,b,c  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^c NONE   (Germany)

Author keywords

Cholinergic excitotoxicity; Mouse

Indexed keywords

AMPHETAMINE; CHOLINERGIC RECEPTOR; LEUCINE; NICOTINE; NICOTINIC RECEPTOR; SERINE;

ANIMAL TISSUE; ARTICLE; BEHAVIOR; CELL DEATH; CELL LOSS; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; ELECTROPHYSIOLOGY; EXCITATION AND STIMULATION; FEMALE; INNERVATION; LOCOMOTION; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PRESYNAPTIC MEMBRANE; PRIORITY JOURNAL; RECEPTOR SENSITIVITY; SPIKE; SUBSTANTIA NIGRA; WILD TYPE;

ANIMALS; ANIMALS, NEWBORN; CELL DEATH; DOPAMINE AGONISTS; FEMALE; HETEROZYGOTE; IMMUNOHISTOCHEMISTRY; MALE; MESENCEPHALON; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MOTOR ACTIVITY; MUTATION; NEURONS; PATCH-CLAMP TECHNIQUES; RECEPTORS, DOPAMINE; RECEPTORS, NICOTINIC; SUBSTANTIA NIGRA; TYROSINE 3-MONOOXYGENASE;

ANIMALIA;

EID: 4844227016     PISSN: 15312267     EISSN: None     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00012.2004     Document Type: Article

References (35)

1. Abercrombie M. Estimation of nuclear population from microtome sections. Anat Rec 94: 239-347, 1946.
2. Arroyo-Jiminez MM, Bourgeois JP, Marubio LM, Le Sourd AM, Ottersen OP, Rinvik E, Fairen A, and Changeux JP. Ultrastructural localization of the α4 subunit of the neuronal acetylcholine nicotinic receptor in the rat substantia nigra. J Neurosci 19: 6475-6487, 1999.
3. 3H]nicotine binding in human postmortem brain. J Pharmacol Exp Ther 282: 7-13, 1997.
4. 2 agonist N-0923 in MPTP-induced chronic hemiparkinsonian monkeys. Exp Neurol 158: 414-421, 1999.
5. Flores CM, Rogers SW, Pabreza LA, Wolfe BB, and Kellar KJ. A subtype of nicotinic cholinergic receptor in rat-brain is composed of α4 subunit and β2 subunit and is up-regulated by chronic nicotine treatment. Mol Pharmacol 41: 31-37, 1992.
6. Fonck C, Nashmi R, Deshpande P, Damaj MI, Marks MJ, Riedel A, Schwarz J, Collins AC, Labarca C, and Lester HA. Increased sensitivity to agonist-induced seizures, straub tail, and hippocampal theta rhythm in knock-in mice carrying hypersensitive α4 nicotinic receptors. J Neurosci 23: 2582-2590, 2003.
7. Fonck C, Nashmi R, Deshpande P, Damaj MI, Marks MJ, Riedel A, Schwarz J, Collins AC, Labarca C, and Lester HA. Increased sensitivity to agonist-induced seizures, straub tail, and hippocampal theta rhythm in knock-in mice carrying hypersensitive alpha 4 nicotinic receptors. J Neurosci 23: 2582-2590, 2003.
8. Fung YK and Lau YS. Effect of nicotine pretreatment on striatal dopaminergic system in rats. Pharmacol Biochem Behav 32: 221-226, 1989.
9. Futami T, Takakusaki K, and Kitai ST. Glutamatergic and cholinergic inputs from the pedunculopontine tegmental nucleus to dopamine neurons in the substantia nigra pars compacta. Neurosci Res 21: 331-342, 1995.
10. Gao ZG, Cui WY, Zhang HT, and Liu CG. Effects of nicotine on 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine-induced depression of striatal dopamine content and spontaneous locomotor activity in C57 black mice. Pharmacol Res 38: 101-106, 1998.
11. Gorell JM, Rybicki BA, Johnson CC, and Peterson EL. Smoking and Parkinson's disease: a dose-response relationship. Neurology 52: 115-119, 1999.
12. Grenhoff J, Janson AM, Svensson TH, and Fuxe K. Chronic continuous nicotine treatment causes decreased burst firing of nigral dopamine neurons in rats partially hemitransected at the meso-diencephalic junction. Brain Res 562: 347-351, 1991.
13. Hellenbrand VV, Seidler A, Robra BP, Vieregge P, Oertel WH, Joerg J, Nischan P, Schneider E, and Ulm G. Smoking and Parkinson's disease: a case-control study in Germany. Int J Epidemiol 26: 328-339, 1997.
14. Iribe Y, Moore K, Pang KC, and Tepper JM. Subthalamic stimulation-induced synaptic responses in substantia nigra pars compacta dopaminergic neurons in vitro. J Neurophysiol 82: 925-933, 1999.
15. Janson A and Moller A. Chronic nicotine treatment counteracts nigral cell loss induced by a partial mesodiencephalic hemitransection: an analysis of the total number and mean volume of neurons and glia in substantia nigra of the male rat. Neuroscience 57: 931-941, 1993.
16. Klink R, de Kerchove d'Exaerde A, Zoli M, and Changeux JP. Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei. J Neurosci 21: 1452-1463, 2001.
17. Labarca C, Schwarz J, Deshpande P, Schwarz SC, Nowak MW, Fonck C, Naashmi R, Kofuji P, Dang H, Shi W, Fidan M, Khakh BS, Chen Z, Bowers BJ, Boulter J, Wehner JM, and Lester HA. Point mutant mice with hypersensitive α4 nicotinic receptors show dopaminergic deficits and increased anxiety. Proc Natl Acad Sci USA 98: 2786-2791, 2001.
18. Langsten JW. Epidemiology versus genetics in Parkinson's disease: progress in resolving an age-old debate. Ann Neurol 44: S45-52, 1998.
19. Lester H, Fonck C, Tapper A, McKinney S, Damaj M, Balogh S, Owens J, Wehner J, Collins A, and Labarca C. Hypersensitive knock-in mouse strains identify receptors and pathways for nicotine action. Curr Opin Drug Dev 6: 633-639, 2003.
20. Luo S, Kulak J, Cartier G, Jacobsen R, Yoshikami D, Olivera B, and McIntosh J. Alpha-conotoxin AuIB selectively blocks α3β4 nicotinic acetylcholine receptors and nicotine-evoked norepinephrine release. J Neurosci 18: 8571-8579, 1998.
21. Mansvelder HD and McGehee DS. Cellular and synaptic mechanisms of nicotine addiction. J Neurobiol 53: 606-617, 2002.
22. Masliah E, Rockenstein E, Veinbergs I, Mallory M, Hashimoto M, Takeda A, Sagara Y, Sisk A, and Mucke L. Dopaminergic loss and inclusion body formation in α-synuclein mice: implications for neurodegenerative disorders. Science 287: 1265-1269, 2000.
23. Miettinen RA, Kalesnykas G, and Koivisto EH. Estimation of the total number of cholinergic neurons containing estrogen receptor-alpha in the rat basal forebrain. J Histochem Cytochem 50: 891-902, 2002.
24. Nisell M, Nomikos GG, Hertel P, Panagis G, and Svensson TH. Condition-independent sensitization of locomotor stimulation and mesocortical dopamine release following chronic nicotine treatment in the rat. Synapse 22: 369-381, 1996.
25. Orr-Urtreger A, Broide RS, Kasten MR, Dang H, Dani JA, Beaudet AL, and Patrick JW. Mice homozygous for the L250T mutation in the α7 nicotinic acetylcholine receptor show increased neuronal apoptosis and die within 1 day of birth. J Neurochem 74: 2154-2166, 2000.
26. Pidoplichko V, DeBiasi M, Williams J, and Dani J. Nicotine activates and desensitizes midbrain dopamine neurons. Nature 390: 401-404, 1997.
27. Sauer H and Oertel WH. Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: a combined retrograde tracing and immunocytochemical study in the rat. Neuroscience 59: 401-415, 1994.
28. 3H] acetylcholine recognition sites in brain by nicotinic cholinergic drugs. J Neurochem 45: 427-433, 1985.
29. Takada M, Matsumura M, Kojima J, Yamaji Y, Inase M, Tokuno H, Nambu A, and Imai H. Protection against dopaminergic nigrostriatal cell death by excitatory input ablation. Eur J Neurosci 12: 1771-1780, 2000.
30. Takaki T. Chronic treatment with nicotine enhances the sensitivity of dopamine autoreceptors that modulate dopamine release from the rat striatum [in Japanese, English summary]. Nihon Shinkei Seishin Yakurigaku Zasshi 15: 335-344, 1995.
31. Tanner CM, Goldman SM, Aston DA, Ottman R, Ellenberg J, Mayeux R, and Langston JW. Smoking and Parkinson's disease in twins. Neurology 58: 581-588, 2002.
32. Triarhou LC, Norton J, and Ghetti B. Mesencephalic dopamine cell deficit involves areas A8, A9 and A10 in weaver mutant mice. Exp Brain Res 70: 256-265, 1988.
33. Washio H, Takigachi-Hayashi K, and Konishi S. Early postnatal development of substantia nigra neurons in rat midbrain slices: hyperpolarization-activated inward current and dopamine-activated current. Neurosci Res 34: 91-101, 1999.
34. West MJ and Gundersen HJ. Unbiased stereological estimation of the number of neurons in the human hippocampus. J Comp Neurol 296: 1-22, 1990.
35. West MJ, Slomianka L, and Gundersen HJ. Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anat Rec 231: 482-497, 1991.