Promoter hypomethylation up-regulates CD147 expression through increasing Sp1 binding and associates with poor prognosis in human hepatocellular carcinoma

Journal of Cellular and Molecular Medicine

Volumn 15, Issue 6, 2011, Pages 1415-1428

  Kong, Ling Min ^a   Liao, Cheng Gong ^a   Chen, Liang ^a   Yang, Hu Shan ^b   Zhang, Si He ^a   Zhang, Zheng ^a   Bian, Hui Jie ^a   Xing, Jin Liang ^a   Chen, Zhi Nan ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

CD147; Hepatocellular carcinoma; Hypomethylation; Prognosis; Sp1

Indexed keywords

BSG PROTEIN, HUMAN; CD147 ANTIGEN; MESSENGER RNA; TRANSCRIPTION FACTOR SP1; TUMOR PROTEIN;

AGED; ARTICLE; DNA METHYLATION; DOWN REGULATION; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; LIVER TUMOR; MALE; METABOLISM; MIDDLE AGED; MOLECULAR GENETICS; MORTALITY; NUCLEOTIDE SEQUENCE; PATHOLOGY; PROGNOSIS; PROMOTER REGION; PROTEIN BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SURVIVAL; TUMOR CELL LINE; UPREGULATION; WESTERN BLOTTING;

AGED; ANTIGENS, CD147; BASE SEQUENCE; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; DNA METHYLATION; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; PROGNOSIS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SP1 TRANSCRIPTION FACTOR; SURVIVAL ANALYSIS; UP-REGULATION;

EID: 77958592863     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2010.01124.x     Document Type: Article

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