Characterization of the promoter of human extracellular matrix metalloproteinase inducer (EMMPRIN)

Gene

Volumn 282, Issue 1-2, 2002, Pages 75-86

  Liang, Liang ^a   Major, Terry ^a   Bocan, Thomas ^a  

^a PFIZER INC   (United States)

Author keywords

Macrophage; Matrix metalloprotein; Sp1; Sp3; Transcriptional regulation

Indexed keywords

DNA FRAGMENT; ENZYME INDUCING AGENT; LUCIFERASE; MATRIX METALLOPROTEINASE; MEMBRANE PROTEIN; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR SP1;

ANIMAL CELL; ARTICLE; BINDING SITE; CONSENSUS SEQUENCE; CONTROLLED STUDY; DELETION MUTANT; DNA FLANKING REGION; DNA TRANSCRIPTION; DNA TRANSFECTION; DNA VECTOR; DROSOPHILA MELANOGASTER; ELECTROPHORETIC MOBILITY; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; GENETIC CODE; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MACROPHAGE; MOLECULAR CLONING; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; REPORTER GENE; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD147; ANTIGENS, NEOPLASM; BASE SEQUENCE; BINDING SITES; CELL LINE; CHO CELLS; CRICETINAE; DNA; DNA-BINDING PROTEINS; GENE EXPRESSION; HUMANS; LUCIFERASES; MEMBRANE GLYCOPROTEINS; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; RECOMBINANT FUSION PROTEINS; SEQUENCE DELETION; SP1 TRANSCRIPTION FACTOR; SP3 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTORS; TRANSCRIPTION INITIATION SITE; TUMOR CELLS, CULTURED;

INSECTA; ORYCTOLAGUS CUNICULUS;

EID: 0037045423     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(01)00847-2     Document Type: Article

References (27)

1. Interactions of monocytic cells with human endothelial cells stimulate monocytic metalloproteinase production
2. Casein kinase II-mediated phosphorylation of the C terminus of Sp1 decreases its DNA binding activity
3. The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily
4. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
5. An inhibitor domain in Sp3 regulates its glutamine-rich activation domains
6. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques
7. Macrophage foam cells from experimental atheroma constitutively produce matrix-degrading proteinases
8. Sp1 and Sp3 physically interact and co-operate with GABP for the activation of the utrophin promoter
9. Stimulation of matrix metalloproteinase production by recombinant extracellular matrix metalloproteinase inducer from transfected Chinese hamster ovary cells
10. Characterization of the gene for human EMMPRIN, a tumor cell surface inducer of matrix metalloproteinases
11. Sp1-mediated transcriptional activation is repressed by Sp3
12. O-glycosylation of eukaryotic transcription factors: Implications for mechanisms of transcriptional regulation
13. Studies on the pathogenesis of atherosclerosis. I. Adhesion and emigration of mononuclear cells in the aorta of hypercholesterolemic rats
14. Tumor cell-derived collagenase-stimulatory factor increases expression of interstitial collagenase, stromelysin, and 72-kDa gelatinase
15. Transcription factors Sp1 and AP-2 mediate induction of acid sphingomyelinase during monocytic differentiation
16. Atherosclerotic plaque caps are locally weakened when macrophages density is increased
17. Novel elements located at -504 to -399 bp of the promoter region regulated the expression of the human macrophage scavenger receptor gene in murine macrophages
18. The role of macrophages in atherogenesis
19. Sp3 is a bifunctional transcription regulator with modular independent activation and repression domains
20. EMMPRIN (extracellular matrix metalloproteinase inducer), a human tumor-cell-derived protein, is induced upon monocyte differentiation and is expressed in human atheroma
21. Coordinate increase in collagenase mRNA and enzyme levels in human fibroblasts treated with the tumor cell factor, TCSF
22. Atherosclerosis - An inflammatory disease
23. Developmental expression of Sp1 in the mouse
24. Glioma cell extracellular matrix metalloproteinase inducer (EMMPRIN) (CD147) stimulates production of membrane-type matrix metalloproteinases and activated gelatinase A in co-cultures with brain-derived fibroblasts
25. Regulation of MMP-1 and MMP-2 production through CD147/extracellular matrix metalloproteinase inducer interactions
26. The Sp-family of transcription factors
27. Domains of transcription factor Sp1 required for synergistic activation with sterol regulatory element binding protein 1 of low density lipoprotein receptor promoter