Antiproliferative effect of panaxynol on RASMCs via inhibition of ERK1/2 and CREB

Chemico-Biological Interactions

Volumn 171, Issue 3, 2008, Pages 348-354

  Jiang, Li Ping ^a,b   Lu, Yang ^a   Nie, Bao Ming ^a   Chen, Hong Zhuan ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b NANCHANG UNIVERSITY   (China)

Author keywords

p CREB; p ERK1 2; Panaxynol; Proliferation; Rat aortic vascular smooth muscle cells

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PANAXYNOL;

ANIMAL CELL; ARTICLE; CELL CYCLE; CONTROLLED STUDY; DNA SYNTHESIS; DRUG EFFECT; DRUG STRUCTURE; NONHUMAN; RAT; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

ANIMALS; AORTA; CELL CYCLE; CELL PROLIFERATION; CELLS, CULTURED; CREB-BINDING PROTEIN; DIYNES; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; FATTY ALCOHOLS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MOLECULAR CONFORMATION; MUSCLE, SMOOTH, VASCULAR; PHOSPHORYLATION; RATS; SIGNAL TRANSDUCTION; TIME FACTORS;

APIUM GRAVEOLENS VAR. DULCE; DAUCUS CAROTA; RATTUS;

EID: 38549113570     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2007.11.013     Document Type: Article

References (45)

1. Waller B.F., Pinkerton C.A., Orr C.M., Slack J.D., Van Tassel J.W., and Peters T. Morphological observations late (greater than 30 days) after clinically successful coronary balloon angioplasty. Circulation 83 Suppl. 2 (1991) 28-41
2. Ross R. Mechanisms of atherosclerosis: a review. Adv. Nephrol Necker Hosp. 19 (1990) 79-86
3. Sachinidis A., Locher R., Vetter W., Tatje D., and Hoppe J. Different effects of platelet-derived growth factor isoforms on rat vascular smooth muscle cells. J. Biol. Chem. 265 (1990) 10238-10243
4. Robinson M.J., and Cobb M.H. Mitogen-activated protein kinase pathways. Curr. Opin. Cell Biol. 9 (1997) 180-186
5. Kondo T., Konishi F., Inui H., and Inagami T. Differing signal transductions elicited by three isoforms of platelet-derived growth factor in vascular smooth muscle cells. J. Biol. Chem. 268 (1993) 4458-4464
6. Inui H., Kitami Y., Tani M., Kondo T., and Inagami T. Differences in signal transduction between platelet-derived growth factor alpha and beta receptors in vascular smooth muscle cells. PDGF-BB is a potent mitogen, but PDGF-AA promotes only protein synthesis without activation of DNA synthesis. J. Biol. Chem. 269 (1994) 30546-30552
7. Jiang B., Yamamura S., Nelson P.R., Mureebe L., and Kent K.C. Differential effects of platelet-derived growth factor isotypes on human smooth muscle cell proliferation and migration are mediated by distinct signaling pathways. Surgery 120 (1996) 427-432
8. Kakishita H., and Hattori Y. Vascular smooth muscle cell activation and growth by 4-hydroxynonenal. Life Sci. 69 (2001) 689-697
9. Yamaguchi H., Igarashi M., Hirata A., Susa S., Ohnuma H., Tominaga M., Daimon M., and Kato T. Platelet-derived growth factor BB-induced p38 mitogen-activated protein kinase activation causes cell growth, but not apoptosis, in vascular smooth muscle cells. Endocrinol. J. 48 (2001) 433-442
10. Funakoshi Y., Ichiki T., Takeda K., Tokuno T., Iino N., and Takeshita A. Critical role of cAMP response element-binding protein for angiotensin II-induced hypertrophy of vascular smooth muscle cells. J. Biol. Chem. 277 (2002) 18710-18717
11. Cho H. Molecular mechanism of the antiproliferative effect of ginseng panaxynol on a human malignant melanoma cell line, SK-MEL-1. J. Ginseng Res. 23 (1999) 190-197
12. Takai S., Jin D., Kirimura K., Ikeda J., Sakaguchi M., Baba K., Fujita T., and Miyazaki M. Effects of a liproxygenase inhibitor, panaxynol, on vascular contraction induced by angiotensin II. Jpn. Pharmacol. 80 (1999) 89-92
13. Kwon B.M., Ro S.H., Kim M.K., Nam J.Y., Jung H.J., Lee I.R., Kim Y.K., and Bok S.H. Polyacetylene analogs, isolated from hairy roots of Panax ginseng, inhibit acyl-CoA: cholesterol acyltransferase. Planta Med. 63 (1997) 552-553
14. Wang C.N., Shiao Y.J., Kuo Y.H., Chen C.C., and Lin Y.L. Inducible nitric oxide synthase inhibitors from Saposhnikovia divaricata and Panax quinquefolium. Planta Med. 66 (2000) 644-647
15. 2. Chin. Trad. Herbal Drugs 36 (2005) 72-75
16. Wang H., Wu X., Cui Y., Zhu L., Lu Y., and Chen H. Up-regulation of M1 muscarinic receptors expressed in CHOm1 cells by panaxynol via cAMP pathway. Neurosci. Lett. 383 (2005) 121-126
17. Wang Z., Chen H., and Lu Y. Neurotrophic and neuroprotective effects of panaxynol on PC12 cell. Chin. Pharm. J. 40 (2005) 1073-1076
18. Jiang L., Nie B., Lu H., Gan L., Chen H., and Lu Y. Inhibitory effect of panaxynol on the proliferation of rat aortic smooth muscle cell and its mechanisms. Chin. Pharm. Bull. 21 (2005) 1313-1319
19. Wang Z., Nie B., Chen H., and Lu Y. Panaxynol induces neurite outgrowth in PC12D cells via cAMP- and MAP kinase-dependent mechanisms. Chem.-Biol. Interact. 159 (2006) 58-64
20. Nie B., Yang L., Fu S., Jiang X., Lu P., and Lu Y. Protective effect of panaxydol and panaxynol on sodium nitroprusside-induced apoptosis in cortical neurons. Chem.-Biol. Interact. 160 (2006) 225-231
21. 2. Chin. Pharm. J. 42 (2007) 987-990
22. Lin Q., Zhao X., Lu Y., Chen Z., and Liu P. Study on the lipophilic components of Panax notoginseng. Chin. Trad. Herbal Drugs 33 (2002) 490-492
23. Chamley J.H., Campbell G.R., McConnell J.D., and Groschel-Stewart U. Comparison of vascular smooth muscle cells from adult human, monkey and rabbit in primary culture and in subculture. Cell Tissue Res. 177 (1977) 503-522
24. Kim T.J., Zhang Y.H., Kim Y., Lee C.K., Lee M.K., Hong J.T., and Yun Y.P. Effects of apigenin on the serum- and platelet-derived growth factor-BB-induced proliferation of rat aortic vascular smooth muscle cells. Planta Med. 68 (2002) 605-609
25. Dzau V.J., Braun-Dullaeus R.C., and Sedding D.G. Vascular proliferation and atherosclerosis: new perspectives and therapeutic strategies. Nat. Med. 8 (2002) 1249-1256
26. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362 (1993) 801-809
27. Schwartz S.M. Smooth muscle migration in atherosclerosis and restenosis. J. Clin. Invest. 99 (1997) 2814-2816
28. Schwartz S.M., deBlois D., and O'Brien E.R. The intima: soil for atherosclerosis and restenosis. Circ. Res. 77 (1995) 445-465
29. Kuo Y.C., Lin Y.L., Huang C.P., Shu J.W., and Tsai W.J. A tumor cell growth inhibitor from Saposhnikovae divaricata. Cancer Invest. 20 (2002) 955-964
30. Lewis T.S., Hunt J.B., Aveline L.D., Jonscher K.R., Louie D.F., Yeh J.M., Nahreini T.S., Resing K.A., and Ahn N.G. Identification of novel MAP kinase pathway signaling targets by functional proteomics and mass spectrometry. Mol. Cells 6 (2000) 1343-1354
31. Lee Jr. J.T., and McCubrey J.A. The RAF/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia. Leukemia 16 (2002) 486-507
32. Blenis J. Signal transduction via the MAP kinases: proceed at your own RSK. Proc. Natl. Acad. Sci. 90 (1993) 5889-5892
33. Marshall C.J. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80 (1995) 179-185
34. Zheng C.F., and Guan K.L. Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2. J. Biol. Chem. 268 (1993) 11435-11439
35. Chen K.H., Guo X., Ma D., Guo Y., Li Q., Yang D., Li P., Qiu X., Wen S., Xiao R.P., and Tang J. Dysregulation of HSG triggers vascular proliferative disorders. Nat. Cell Biol. 6 (2004) 872-883
36. 2+ in activation of mitogen-activated protein kinase and DNA synthesis in vascular smooth muscle cells. J. Hypertens. 15 (1997) 1671-1675
37. MacCorkle R.A., and Tan T.-H. Mitogen-activated protein kinases in cell cycle control. Cell Biochem. Biophys. 43 (2005) 451-461
38. Gonzalez G.A., and Montminy M.R. Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell 59 (1989) 675-680
39. Tokunou T., Ichiki T., Takeda K., Funakoshi Y., Iino N., and Takeshita A. cAMP response element-binding protein mediates thrombin-induced proliferation of vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 21 (2001) 1764-1769
40. Funakoshi Y., Ichiki T., Takeda K., Tokuno T., Iino N., and Takeshita A. Critical role of cAMP response element-binding protein for angiotensin II-induced hypertrophy of vascular smooth muscle cells. J. Biol. Chem. 277 (2002) 18710-18719
41. Stevenson A.S., Cartin L., Wellman T.L., Dick M.H., Nelson M.T., and Lounsbury K.M. Membrane depolarization mediates phosphorylation and nuclear translocation of CREB in vascular smooth muscle cells. Exp. Cell Res. 263 (2001) 118-130
42. Cook J.L., Mills S.J., Naquin R., Alam J., and Re R.N. Nuclear accumulation of the AT1 receptor in a rat vascular smooth muscle cell line: effects upon signal transduction and cellular proliferation. J. Mol. Cell. Cardiol. 40 (2006) 696-707
43. Cai J.X., Jin J., and Lu Y. Progress in studies on naturally occurring polyacetylenes. Chin. Trad. Herbal Drugs 38 (2007) 620-623
44. Kobaek-Larsen M., Christensen L.P., Vach W., Ritskes-Hoitinga J., and Brandt K. Inhibitory effects of feeding with carrots or (-)-falcarinol on development of azoxymethane-induced preneoplastic lesions in the rat colon. J. Agric. Food Chem. 53 (2005) 1823-1827
45. Hai J., Lin Q., Lu Y., Zhang H., and Yi J. Induction of apoptosis in rat C6 glioma cells by panaxydol. Cell Biol. Int. 31 (2007) 711-715