QKI-7 regulates expression of interferon-related genes in human astrocyte glioma cells

PLoS ONE

Volumn 5, Issue 9, 2010, Pages

  Jiang, Lin ^a   Saetre, Peter ^a,b   Radomska, Katarzyna J ^a   Jazin, Elena ^a   Carlström, Eva Lindholm ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON INDUCIBLE GUANYLATE BINDING PROTEIN 1; GUANINE NUCLEOTIDE BINDING PROTEIN; HALOPERIDOL; INTERFERON; INTERFERON STIMULATED GENE 54; INTERFERON STIMULATED GENE 56; MELANOMA DIFFERENTIATION ASSOCIATED GENE 5; QUAKING I 5; QUAKING I 6; QUAKING I 7; RNA BINDING PROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR G1P2; TRANSCRIPTION FACTOR G1P3; TRANSCRIPTION FACTOR MX1; TRANSCRIPTION FACTOR MX2; UNCLASSIFIED DRUG;

ARTICLE; ASTROCYTE; BINDING SITE; CANCER CELL CULTURE; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION REGULATION; GENE SILENCING; GLIOMA CELL; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; UPREGULATION;

ASTROCYTES; CELL LINE; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOMA; HUMANS; INTERFERONS; PROTEIN BINDING; RNA-BINDING PROTEINS;

EID: 77958531624     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0013079     Document Type: Article

References (47)

1. Ebersole TA, Chen Q, Justice MJ, Artzt K (1996) The quaking gene product necessary in embryogenesis and myelination combines features of RNA binding and signal transduction proteins. Nat Genet 12: 260-265.
2. Chen T, Damaj BB, Herrera C, Lasko P, Richard S (1997) Self-association of the single-KH-domain family members Sam68, GRP33, GLD-1, and Qk1: role of the KH domain. Mol Cell Biol 17: 5707-5718.
3. Larocque D, Richard S (2005) QUAKING KH domain proteins as regulators of glial cell fate and myelination. RNA Biol 2: 37-40.
4. Galarneau A, Richard S (2005) Target RNA motif and target mRNAs of the Quaking STAR protein. Nat Struct Mol Biol 12: 691-698.
5. Lindholm E, Ekholm B, Shaw S, Jalonen P, Johansson G, et al. (2001) A schizophrenia-susceptibility locus at 6q25, in one of the world's largest reported pedigrees. Am J Hum Genet 69: 96-105.
6. Aberg K, Saetre P, Jareborg N, Jazin E (2006) Human QKI, a potential regulator of mRNA expression of human oligodendrocyte-related genes involved in schizophrenia. Proc Natl Acad Sci U S A 103: 7482-7487.
7. Haroutunian V, Katsel P, Dracheva S, Davis KL (2006) The human homolog of the QKI gene affected in the severe dysmyelination "quaking" mouse phenotype: downregulated in multiple brain regions in schizophrenia. Am J Psychiatry 163: 1834-1837.
8. McCullumsmith RE, Gupta D, Beneyto M, Kreger E, Haroutunian V, et al. (2007) Expression of transcripts for myelination-related genes in the anterior cingulate cortex in schizophrenia. Schizophr Res 90: 15-27.
9. Karoutzou G, Emrich HM, Dietrich DE (2007) The myelin-pathogenesis puzzle in schizophrenia: a literature review. Mol Psychiatry 13: 245-260.
10. McInnes LA, Lauriat TL (2006) RNA metabolism and dysmyelination in schizophrenia. Neurosci Biobehav Rev 30: 551-561.
11. Segal D, Koschnick JR, Slegers LH, Hof PR (2007) Oligodendrocyte pathophysiology: a new view of schizophrenia. Int J Neuropsychopharmacol 10: 503-511.
12. Walterfang M, Wood SJ, Velakoulis D, Pantelis C (2006) Neuropathological, neurogenetic and neuroimaging evidence for white matter pathology in schizophrenia. Neurosci Biobehav Rev 30: 918-948.
13. Chen Y, Tian D, Ku L, Osterhout DJ, Feng Y (2007) The selective RNAbinding protein quaking I (QKI) is necessary and sufficient for promoting oligodendroglia differentiation. J Biol Chem 282: 23553-23560.
14. Hardy RJ, Loushin CL, Friedrich VL Jr., Chen Q, Ebersole TA, et al. (1996) Neural cell type-specific expression of QKI proteins is altered in quakingviable mutant mice. J Neurosci 16: 7941-7949.
15. Wolf F, Kirchhoff F (2008) Neuroscience. Imaging astrocyte activity. Science 320: 1597-1599.
16. Bernstein HG, Steiner J, Bogerts B (2009) Glial cells in schizophrenia: pathophysiological significance and possible consequences for therapy. Expert Rev Neurother 9: 1059-1071.
17. Muller N, Myint AM, Schwarz MJ (2009) The impact of neuroimmune dysregulation on neuroprotection and neurotoxicity in psychiatric disorders- relation to drug treatment. Dialogues Clin Neurosci 11: 319-332.
18. Bilbo SD, Schwarz JM (2009) Early-life programming of later-life brain and behavior: a critical role for the immune system. Front Behav Neurosci 3: 14.
19. Barley K, Dracheva S, Byne W (2009) Subcortical oligodendrocyte- and astrocyte-associated gene expression in subjects with schizophrenia, major depression and bipolar disorder. Schizophr Res 112: 54-64.
20. Kolomeets NS, Uranova N (2009) Ultrastructural abnormalities of astrocytes in the hippocampus in schizophrenia and duration of illness: A postortem morphometric study. World J Biol Psychiatry. pp 1-11.
21. Jiang L, Saetre P, Jazin E, Carlstrom EL (2009) Haloperidol changes mRNA expression of a QKI splice variant in human astrocytoma cells. BMC Pharmacol 9: 6.
22. De Keyser J, Mostert JP, Koch MW (2008) Dysfunctional astrocytes as key players in the pathogenesis of central nervous system disorders. J Neurol Sci 267: 3-16.
23. Post GR, Dawson G (1992) Characterization of a cell line derived from a human oligodendroglioma. Mol Chem Neuropathol 16: 303-317.
24. Jiang L, Saetre P, Jazin E, Carlstrom EL (2009) Haloperidol changes mRNA expression of a QKI splice variant in human astrocytoma cells. BMC Pharmacol 9: 1-6.
25. Buka SL, Cannon TD, Torrey EF, Yolken RH (2007) Maternal Exposure to Herpes Simplex Virus and Risk of Psychosis Among Adult Offspring. Biol Psychiatry 63: 809-815.
26. Wu JI, Reed RB, Grabowski PJ, Artzt K (2002) Function of quaking in myelination: regulation of alternative splicing. Proc Natl Acad Sci U S A 99: 4233-4238.
27. Wacher C, Muller M, Hofer MJ, Getts DR, Zabaras R, et al. (2007) Coordinated regulation and widespread cellular expression of interferonstimulated genes (ISG) ISG-49, ISG-54, and ISG-56 in the central nervous system after infection with distinct viruses. J Virol 81: 860-871.
28. Delhaye S, Paul S, Blakqori G, Minet M, Weber F, et al. (2006) Neurons produce type I interferon during viral encephalitis. Proc Natl Acad Sci U S A 103: 7835-7840.
29. Haller O, Staeheli P, Kochs G (2007) Interferon-induced Mx proteins in antiviral host defense. Biochimie 89: 812-818.
30. Ritchie KJ, Hahn CS, Kim KI, Yan M, Rosario D, et al. (2004) Role of ISG15 protease UBP43 (USP18) in innate immunity to viral infection. Nat Med 10: 1374-1378.
31. Herberts CA, van Gaans-van den Brink J, van der Heeft E, van Wijk M, Hoekman J, et al. (2003) Autoreactivity against induced or upregulated abundant self-peptides in HLA-A*0201 following measles virus infection. Hum Immunol 64: 44-55.
32. Guenzi E, Topolt K, Lubeseder-Martellato C, Jorg A, Naschberger E, et al. (2003) The guanylate binding protein-1 GTPase controls the invasive and angiogenic capability of endothelial cells through inhibition of MMP-1 expression. Embo J 22: 3772-3782.
33. Naschberger E, Lubeseder-Martellato C, Meyer N, Gessner R, Kremmer E, et al. (2006) Human guanylate binding protein-1 is a secreted GTPase present in increased concentrations in the cerebrospinal fluid of patients with bacterial meningitis. Am J Pathol 169: 1088-1099.
34. Malathi K, Dong B, Gale M Jr., Silverman RH (2007) Small self-RNA generated by RNase L amplifies antiviral innate immunity. Nature 448: 816-819.
35. Dong Y, Benveniste EN (2001) Immune function of astrocytes. Glia 36: 180-190.
36. Farina C, Aloisi F, Meinl E (2007) Astrocytes are active players in cerebral innate immunity. Trends Immunol 28: 138-145.
37. Hakak Y, Walker JR, Li C, Wong WH, Davis KL, et al. (2001) Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia. Proc Natl Acad Sci U S A 98: 4746-4751.
38. Sugai T, Kawamura M, Iritani S, Araki K, Makifuchi T, et al. (2004) Prefrontal abnormality of schizophrenia revealed by DNA microarray: impact on glial and neurotrophic gene expression. Ann N Y Acad Sci 1025: 84-91.
39. Foster R, Kandanearatchi A, Beasley C, Williams B, Khan N, et al. (2006) Calprotectin in microglia from frontal cortex is up-regulated in schizophrenia: evidence for an inflammatory process? Eur J Neurosci 24: 3561-3566.
40. Hanson DR, Gottesman II (2005) Theories of schizophrenia: a geneticinflammatory- vascular synthesis. BMC Med Genet 6: 1-17.
41. Monji A, Kato T, Kanba S (2009) Cytokines and schizophrenia: Microglia hypothesis of schizophrenia. Psychiatry Clin Neurosci 63: 257-265.
42. Potvin S, Stip E, Sepehry AA, Gendron A, Bah R, et al. (2008) Inflammatory cytokine alterations in schizophrenia: a systematic quantitative review. Biol Psychiatry 63: 801-808.
43. Saetre P, Emilsson L, Axelsson E, Kreuger J, Lindholm E, et al. (2007) Inflammation-related genes up-regulated in schizophrenia brains. BMC Psychiatry 7: 1-10.
44. Westermark B, Ponten J, Hugosson R (1973) Determinants for the establishment of permanent tissue culture lines from human gliomas. Acta Pathol Microbiol Scand A 81: 791-805.
45. Dennis G, Jr., Sherman BT, Hosack DA, Yang J, Gao W, et al. (2003) DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol 4: P3.
46. Lenhard B, Wasserman WW (2002) TFBS: Computational framework for transcription factor binding site analysis. Bioinformatics 18: 1135-1136.
47. Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65: 55-63.