Haloperidol changes mRNA expression of a QKI splice variant in human astrocytoma cells

BMC Pharmacology

Volumn 9, Issue , 2009, Pages

  Jiang, Lin ^a   Saetre, Peter ^a,b   Jazin, Elena ^a   Carlström, Eva Lindholm ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ARIPIPRAZOLE; CLOZAPINE; HALOPERIDOL; MESSENGER RNA; OLANZAPINE; QUAKING HOMOLOG KH DOMAIN RNA BINDING PROTEIN; RISPERIDONE; RNA BINDING PROTEIN; UNCLASSIFIED DRUG; BENZODIAZEPINE DERIVATIVE; DOPAMINE 2 RECEPTOR; NEUROLEPTIC AGENT; PIPERAZINE DERIVATIVE; QKI PROTEIN, HUMAN; QUINOLONE DERIVATIVE;

ARTICLE; ASTROCYTOMA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; OLIGODENDROGLIOMA; PREFRONTAL CORTEX; REAL TIME POLYMERASE CHAIN REACTION; RNA SPLICING; ALTERNATIVE RNA SPLICING; DOSE RESPONSE; DRUG EFFECT; GENETICS; METABOLISM; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TIME; TUMOR CELL LINE;

ALTERNATIVE SPLICING; ANTIPSYCHOTIC AGENTS; ASTROCYTOMA; BENZODIAZEPINES; CELL LINE, TUMOR; CLOZAPINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, NEOPLASTIC; HALOPERIDOL; HUMANS; PIPERAZINES; QUINOLONES; RECEPTORS, DOPAMINE D2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RISPERIDONE; RNA, MESSENGER; RNA-BINDING PROTEINS; TIME FACTORS;

EID: 65749084217     PISSN: None     EISSN: 14712210     Source Type: Journal    
DOI: 10.1186/1471-2210-9-6     Document Type: Article

References (15)

1. Aberg K Saetre P Jareborg N Jazin E Human QKI, a potential regulator of mRNA expression of human oligodendrocyte-related genes involved in schizophrenia Proc Natl Acad Sci USA 2006, 103(19):7482-7487 1464365 16641098 10.1073/pnas.0601213103
2. Aberg K Saetre P Lindholm E Ekholm B Pettersson U Adolfsson R Jazin E Human QKI, a new candidate gene for schizophrenia involved in myelination Am J Med Genet B Neuropsychiatr Genet 2006, 141B(1):84-90 10.1002/ajmg.b.30243 16342280
3. Lindholm E Ekholm B Shaw S Jalonen P Johansson G Pettersson U Sherrington R Adolfsson R Jazin E A schizophrenia-susceptibility locus at 6q25, in one of the world's largest reported pedigrees Am J Hum Genet 2001, 69(1):96-105 1226052 11389481 10.1086/321288
4. Hardy RJ Molecular defects in the dysmyelinating mutant quaking J Neurosci Res 1998, 51(4):417-422 10.1002/ (SICI)1097-4547(19980215)51:4<417::AID-JNR1>3.0.CO;2-F 9514195
5. Tkachev D Mimmack ML Ryan MM Wayland M Freeman T Jones PB Starkey M Webster MJ Yolken RH Bahn S Oligodendrocyte dysfunction in schizophrenia and bipolar disorder Lancet 2003, 362(9386):798-805 10.1016/ S0140-6736(03)14289-4 13678875
6. Chen Y Tian D Ku L Osterhout DJ Feng Y The selective RNA-binding protein quaking I (QKI) is necessary and sufficient for promoting oligodendroglia differentiation J Biol Chem 2007, 282(32):23553-23560 10.1074/jbc.M702045200 17575274
7. Ishibashi T Dakin KA Stevens B Lee PR Kozlov SV Stewart CL Fields RD Astrocytes promote myelination in response to electrical impulses Neuron 2006, 49(6):823-832 1474838 16543131 10.1016/j.neuron.2006.02.006
8. De Keyser J Mostert JP Koch MW Dysfunctional astrocytes as key players in the pathogenesis of central nervous system disorders J Neurol Sci 2008, 267(1-2):3-16 10.1016/j.jns.2007.08.044 17935736
9. Baumann P Hiemke C Ulrich S Eckermann G Gaertner I Gerlach M Kuss H-J Laux G Muller-Oerlinghausen B Rao ML et al The AGNP-TDM expert group consensus guidelines: Therapeutic drug monitoring in psychiatry Pharmacopsychiatry 2004, 37(6):243-265 10.1055/s-2004-832687 15551191
10. Ohara K Tanabu S Yoshida K Ishibashi K Ikemoto K Shibuya H Effects of smoking and cytochrome P450 2D6*10 allele on the plasma haloperidol concentration/dose ratio Prog Neuropsychopharmacol Biol Psychiatry 2003, 27(6):945-949 10.1016/S0278-5846(03)00154-4 14499311
11. Oosterhuis M Kraats Van De G Tenback D Safety of aripiprazole: High serum levels in a CYP2D6 mutated patient Am J Psychiatry 2007, 164(1):175 10.1176/appi.ajp.164.1.175 17202571
12. Spina E Avenoso A Facciola G Scordo MG Ancione M Madia AG Ventimiglia A Perucca E Relationship between plasma concentrations of clozapine and norclozapine and therapeutic response in patients with schizophrenia resistant to conventional neuroleptics Psychopharmacology (Berl) 2000, 148(1):83-89 10.1007/s002130050028 10663421
13. Narayan S Kass KE Thomas EA Chronic haloperidol treatment results in a decrease in the expression of myelin/oligodendrocyte-related genes in the mouse brain J Neurosci Res 2007, 85(4):757-765 10.1002/jnr.21161 17177202
14. Li A Guo H Luo X Sheng J Yang S Yin Y Zhou J Apomorphine-induced activation of dopamine receptors modulates FGF-2 expression in astrocytic cultures and promotes survival of dopaminergic neurons FASEB J 2006, 20(8):1263-1265 10.1096/fj.05-5510fje 16636101
15. Castensson A Emilsson L Preece P Jazin EE High-resolution quantification of specific mRNA levels in human brain autopsies and biopsies Genome Res 2000, 10(8):1219-1229 310892 10958640 10.1101/gr.10.8.1219