Natural flavone kaempferol suppresses chemokines expression in human monocyte THP-1 cells through MAPK pathways

Journal of Food Science

Volumn 75, Issue 8, 2010, Pages

  Huang, Ching Hua ^a   Jan, Ren Long ^b   Kuo, Chang Hung ^c,e,f   Chu, Yu Te ^d,e   Wang, Wei Li ^c,e   Lee, Min Sheng ^d,e   Chen, Huan Nan ^e   Hung, Chih Hsing ^c,d,e,f  

^a YUAN'S GENERAL HOSPITAL   (Taiwan)

^b CHI MEI MEDICAL CENTER   (Taiwan)

^c KAOHSIUNG MUNICIPAL TA TUNG HOSPITAL   (Taiwan)

^d KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^e KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^f KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Chemokines; Kaempferol; Mitogen activated protein kinase; Monocytes

Indexed keywords

ALPHA CHEMOKINE; CCL22 PROTEIN, HUMAN; CHEMOKINE; IL8 PROTEIN, HUMAN; INTERLEUKIN 8; ISOPROTEIN; KAEMPFEROL; KAEMPFEROL DERIVATIVE; LIPOPOLYSACCHARIDE; MACROPHAGE DERIVED CHEMOKINE; MITOGEN ACTIVATED PROTEIN KINASE P38; NONSTEROID ANTIINFLAMMATORY AGENT; PROTEIN KINASE INHIBITOR;

ARTICLE; CELL LINE; DOWN REGULATION; DRUG ANTAGONISM; DRUG EFFECT; HELPER CELL; HUMAN; HYPERSENSITIVITY; IMMUNOLOGY; METABOLISM; MONOCYTE; NEUTROPHIL; OSMOLARITY; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE; CHEMOKINE CCL22; CHEMOKINES; CHEMOKINES, CXC; DOWN-REGULATION; HUMANS; HYPERSENSITIVITY; INTERLEUKIN-8; KAEMPFEROLS; LIPOPOLYSACCHARIDES; MAP KINASE SIGNALING SYSTEM; MONOCYTES; NEUTROPHILS; OSMOLAR CONCENTRATION; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN ISOFORMS; PROTEIN KINASE INHIBITORS; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 77958518145     PISSN: 00221147     EISSN: 17503841     Source Type: Journal    
DOI: 10.1111/j.1750-3841.2010.01812.x     Document Type: Article

References (36)

1. Barrington R, Williamson G, Bennett RN, Davis BD, Brodbelt JS, Kroon PA. 2009. Absorption, conjugation and efflux of the flavonoids, kaempferol and galangin, using the intestinal CACO- 2/TC7 cell model. J Funct Foods 1:74-87.
2. Barton GM, Medzhitov R. 2003. Toll-like receptor signaling pathways. Science 300:1524-5.
3. Beutler B. 2000. Tlr4: Central component of the sole mammalian LPS sensor. Curr Opin Immunol 12:20-6.
4. Beutler B, Du X, Poltorak A. 2001. Identification of toll-like receptor 4 (Tlr4) as the sole conduit for LPS signal transduction: Genetic and evolutionary studies. J Endotoxin Res 7:277-80.
5. Broaddus VC, Boylan AM, Hoeffel JM, Kim KJ, Sadick M, Chuntharapai A, Hebert CA. 1994. Neutralization of IL-8 inhibits neutrophil influx in a rabbit model of endotoxin-induced pleurisy. J Immunol 152:2960-7.
6. Chalmers GW, MacLeod KJ, Thomson L, Little SA, McSharry C, Thomson NC. 2001. Smoking and airway inflammation in patients with mild asthma. Chest 120:1917-22.
7. Chen CC, Chow MP, Huang WC, Lin YC, Chang YJ. 2004. Flavonoids inhibit tumor necrosis factor-alpha-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respi- ratory epithelial cells through activator protein-1 and nuclear factor-kappaB: Structure-activity relationships. Mol Pharmacol 66:683-93.
8. Comalada M, Ballester I, Bailon E, Sierra S, Xaus J, Galvez J, de Medina FS, Zarzuelo A. 2006. Inhibition of pro-inflammatory markers in primary bone marrow-derived mouse macrophages by naturally occurring flavonoids: Analysis of the structure-activity relationship. Biochem Pharmacol 72:1010-21.
9. Cortes JR, Perez GM, Rivas MD, Zamorano J. 2007. Kaempferol inhibits IL-4-induced STAT6 activation by specifically targeting JAK3. J Immunol 179:3881-7.
10. Crozier A, Jaganath IB, Clifford MN. 2009. Dietary phenolics: Chemistry, bioavailability and effects on health. Nat Prod Rep 26:1001-43.
11. DuPont MS, Day AJ, Bennett RN, Mellon FA, Kroon PA. 2004. Absorption of kaempferol from endive, a source of kaempferol-3-glucuronide, in humans. Eur J Clin Nutr 58:947-54.
12. Garcia-Mediavilla V, Crespo I, Collado PS, Esteller A, Sanchez-Campos S, Tunon MJ, Gonzalez- Gallego J. 2007. The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down- regulation of the nuclear factor kappaB pathway in Chang Liver cells. Eur J Pharmacol 557:221-9.
13. Herath HM, Takano-Ishikawa Y, Yamaki K. 2003. Inhibitory effect of some flavonoids on tumor necrosis factor-alpha production in lipopolysaccharide-stimulated mouse macrophage cell line J774.1. J Med Food 6:365-70.
14. Huang CH, Kuo PL, Hsu YL, Chang TT, Tseng HI, Chu YT, Kuo CH, Chen HN, Hung CH. The natural flavonoid apigenin suppresses Th1- and Th2-related chemokine production by human monocyte THP-1 cells through mitogen-activated protein kinase pathways. J Med Food 13:391-8.
15. Hung CH, Suen JL, Hua YM, Chiang W, Chang HC, Chen CN, Jong YJ. 2007. Suppressive effects of ketotifen on Th1- and Th2-related chemokines of monocytes. Pediatr Allergy Immunol 18:378-84.
16. Kang BY, Kim S, Lee KH, Lee YS, Hong I, Lee MO, Min D, Chang I, Hwang JS, Park JS, Kim DH, Kim BG. 2008. Transcriptional profiling in human HaCaT keratinocytes in response to kaempferol and identification of potential transcription factors for regulating differential gene expression. Exp Mol Med 40:208-19.
17. Kawaguchi M, Kokubu F, Matsukura S, Ieki K, Odaka M, WatanabeS, SuzukiS, Adachi M, Huang SK. 2003. Induction of C-X-C chemokines, growth-related oncogene alpha expression, and epithelial cell-derived neutrophil-activating protein-78 by ML-1 (interleukin- 17F) involves activation of Raf1-mitogen-activated protein kinase kinase-extracellular signal- regulated kinase 1/2 pathway. J Pharmacol Exp Ther 307:1213-20.
18. Kawai M, Hirano T, Higa S, Arimitsu J, Maruta M, Kuwahara Y, Ohkawara T, Hagihara K, Yamadori T, Shima Y, Ogata A, Kawase I, Tanaka T. 2007. Flavonoids and related compounds as anti-allergic substances. Allergol Int 56:113-23.
19. Kempuraj D, Madhappan B, Christodoulou S, Boucher W, Cao J, Papadopoulou N, Cetrulo CL, Theoharides TC. 2005. Flavonols inhibit proinflammatory mediator release, intracellular calcium ion levels and protein kinase C theta phosphorylation in human mast cells. Br J Pharmacol 145:934-44.
20. Kim SK, Kim HJ, Choi SE, Park KH, Choi HK, Lee MW. 2008. Anti-oxidative and inhibitory activities on nitric oxide (NO) and prostaglandin E2 (COX-2) production of flavonoids from seeds of Prunus tomentosa Thunberg. Arch Pharm Res 31:424-8.
21. Knekt P, Kumpulainen J, Jarvinen R, Rissanen H, Heliovaara M, Reunanen A, Hakulinen T, Aromaa A. 2002. Flavonoid intake and risk of chronic diseases. Am J Clin Nutr 76:560-8.
22. Leung TF, Wong GW, Ko FW, Lam CW, Fok TF. 2004. Increased macrophage-derived chemokine in exhaled breath condensate and plasma from children with asthma. Clin Exp Allergy 34:786-91.
23. Luster AD. 1998. Chemokines-chemotactic cytokines that mediate inflammation. N Engl J Med 338:436-45.
24. Matsukawa A, Yoshimura T, Maeda T, Takahashi T, Ohkawara S, Yoshinaga M. 1998. Analysis of the cytokine network among tumor necrosis factor alpha, interleukin-1beta, interleukin-8, and interleukin-1 receptor antagonist in monosodium urate crystal-induced rabbit arthritis. Lab Invest 78:559-69.
25. Middleton E Jr, Drzewiecki G. 1984. Flavonoid inhibition of human basophil histamine release stimulated by various agents. Biochem Pharmacol 33:3333-8.
26. Min YD, Choi CH, Bark H, Son HY, Park HH, Lee S, Park JW, Park EK, Shin HI, Kim SH. 2007. Quercetin inhibits expression of inflammatory cytokines through attenuation of NF-kappaB and p38 MAPK in HMC-1 human mast cell line. Inflamm Res 56:210-5.
27. Nakazato J, Kishida M, Kuroiwa R, Fujiwara J, Shimoda M, Shinomiya N. 2008. Serum levels of Th2 chemokines, CCL17, CCL22, and CCL27, were the important markers of severity in infantile atopic dermatitis. Pediatr Allergy Immunol 19:605-13.
28. Park HH, Lee S, Son HY, Park SB, Kim MS, Choi EJ, Singh TS, Ha JH, Lee MG, Kim JE, Hyun MC, Kwon TK, Kim YH, Kim SH. 2008. Flavonoids inhibit histamine release and expression of proinflammatory cytokines in mast cells. Arch Pharm Res 31:1303-11.
29. Rot A, von Andrian UH. 2004. Chemokines in innate and adaptive host defense: Basic chemoki- nese grammar for immune cells. Annu Rev Immunol 22:891-928.
30. Shannon J, Ernst P, Yamauchi Y, Olivenstein R, Lemiere C, Foley S, Cicora L, Ludwig M, Hamid Q, Martin JG. 2008. Differences in airway cytokine profile in severe asthma compared to moderate asthma. Chest 133:420-6.
31. Simpson JL, Powell H, Boyle MJ, Scott RJ, Gibson PG. 2008. Clarithromycin targets neutrophilic airway inflammation in refractory asthma. Am J Respir Crit Care Med 177:148-55.
32. Takano-Ishikawa Y, Goto M, Yamaki K. 2003. Inhibitory effects of several flavonoids on E- selectin expression on human umbilical vein endothelial cells stimulated by tumor necrosis factor-alpha. Phytother Res 17:1224-7.
33. Tsai YC, Chang HW, Chang TT, Lee MS, Chu YT, Hung CH. 2008. Effects of all-trans retinoic acid on Th1- and Th2-related chemokines production in monocytes. Inflammation 31:428-33.
34. Wark PA, Bucchieri F, Johnston SL, Gibson PG, Hamilton L, Mimica J, Zummo G, Holgate ST, Attia J, Thakkinstian A, Davies DE. 2007. IFN-gamma-induced protein 10 is a novel biomarker of rhinovirus-induced asthma exacerbations. J Allergy Clin Immunol 120:586- 93.
35. Xiao CW. 2008. Health effects of soy protein and isoflavones in humans. J Nutr 138:1244S-9S.
36. Ying B, Yang T, Song X, Hu X, Fan H, Lu X, Chen L, Cheng D, Wang T, Liu D, Xu D, Wei Y, Wen F. 2009. Quercetin inhibits IL-1 beta-induced ICAM-1 expression in pulmonary epithelial cell line A549 through the MAPK pathways. Mol Biol Rep 36:1825-32.