Oncogenic function of the MUC1 receptor subunit in gene regulation

Oncogene

Volumn 29, Issue 42, 2010, Pages 5663-5666

  Kufe, D ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

MUC1; MUC1 C subunit; nuclear localization; p53; transcriptional regulation; Wnt b catenin

Indexed keywords

MUCIN 1;

ANGIOGENESIS; CANCER INVASION; CARCINOGENESIS; GENE CONTROL; GENE FUNCTION; HUMAN; METASTASIS; NOTE; ONCOGENE; PRIORITY JOURNAL; ANIMAL; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NEOPLASM; PHYSIOLOGY;

ANIMALS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MUCIN-1; NEOPLASMS;

EID: 77958499974     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2010.334     Document Type: Note

References (10)

1. Behrens ME, Grandgenett PM, Bailey JM, Singh PK, Yi C-H, Yu F et al. (2010). The reactive tumor microenvironment: MUC1 signaling directly reprograms transcription of CTGF. Oncogene 29: 5667-5677.
2. Deng YZ, Chen PP, Wang Y, Yin D, Koeffler HP, Li B et al. (2007). Connective tissue growth factor is overexpressed in esophageal squamous cell carcinoma and promotes tumorigenicity through beta-catenin-T-cell factor/Lef signaling. J Biol Chem 282: 36571-36581.
3. Huang L, Chen D, Liu D, Yin L, Kharbanda S, Kufe D. (2005). MUC1 oncoprotein blocks GSK3beta-mediated phosphoryla-tion and degradation of beta-catenin. Cancer Res 65: 10413-10422.
4. Khodarev N, Ahmad R, Rajabi H, Pitroda S, Kufe T, McClary C et al. (2010). Cooperativity of the MUC1 oncoprotein and STAT1 pathway in poor prognosis human breast cancer. Oncogene 29: 920-929.
5. Khodarev N, Pitroda S, Beckett M, Mac-Dermed D, Huang L, Kufe D et al. (2009). MUC1-induced transcriptional programs associated with tumorigenesis predict outcome in breast and lung cancer. Cancer Res 69: 2833-2837.
6. Kufe D. (2009). Mucins in cancer: function, prognosis and therapy. Nat Rev Cancer 9: 874-885.
7. Pitroda S, Khodarev N, Beckett M, Kufe D, Weichselbaum R. (2009). MUC1-induced alterations in a lipid metabolic gene network predict response of human breast cancers to tamoxifen treatment. Proc Natl Acad Sci USA 106: 5837-5841.
8. Raina D, Ahmad R, Joshi M, Yin L, Wu Z, Kawano T et al. (2009). Direct targeting of the MUC1 oncoprotein blocks survival and tumorigenicity of human breast carcinoma cells. Cancer Res 69: 5133-5141.
9. Ramasamy S, Duraisamy S, Barbashov S, Kawano T, Kharbanda S, Kufe D. (2007). The MUC1 and galectin-3 oncoproteins function in a microRNA-dependent regulatory loop. Mol Cell 27: 992-1004.
10. Wei X, Xu H, Kufe D. (2005). Human MUC1 oncoprotein regulates p53-respon-sive gene transcription in the genotoxic stress response. Cancer Cell 7: 167-178.