A1166C genetic variation of the angiotensin II type I receptor gene and susceptibility to coronary heart disease: Collaborative of 53 studies with 20,435 cases and 23,674 controls

Atherosclerosis

Volumn 213, Issue 1, 2010, Pages 191-199

  Xu, Mingqing ^a,b,c,d,e   Sham, Pak ^f   Ye, Zheng ^g   Lindpaintner, Klaus ^h   He, Lin ^c,d,e  

^a HARVARD UNIVERSITY   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c SHANGHAI JIAO TONG UNIVERSITY   (China)

^d FUDAN UNIVERSITY   (China)

^e INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^f UNIVERSITY OF HONG KONG   (Hong Kong)

^g UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^h F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Angiotensin II type I receptor gene; Coronary heart disease; Genetic polymorphism

Indexed keywords

ANGIOTENSIN 1 RECEPTOR;

ADULT; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; CORONARY ARTERY DISEASE; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; HEART INFARCTION; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; META ANALYSIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECEPTOR GENE;

EID: 77958496161     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2010.07.046     Document Type: Article

References (97)

1. Hsueh W.A. Effect of the renin-angiotensin system in the vascular disease of type II diabetes mellitus. Am J Med 1992, 92:13S-19S.
2. Wang J.G., Staessen J.A. Genetic polymorphism in the renin-angiotensin system: relevance for susceptibility to cardiovascular disease. Eur J Pharmacol 2000, 410:289-302.
3. Harrap S.B. Cardiovascular disease and genetics of the renin-angiotensin system. Heart 1996, 76:13-17.
4. Xu M.Q., Ye Z., Hu F.B., He L. Quantitative assessment of the effect of angiotensinogen gene polymorphisms on the risk of coronary heart disease. Circulation 2007, 116:1356-1366.
5. Kim S., Iwao H. Molecular and cellular mechanisms of angiotensin II-mediated cardiovascular and renal diseases. Pharmacol Rev 2000, 52:11-34.
6. Tiret L., Bonnardeaux A., Poirier O., et al. Synergistic effects of angiotensin-converting enzyme and angiotensin-II type 1 receptor gene polymorphisms on risk of myocardial infarction. Lancet 1994, 344:910-913.
7. Nakauchi Y., Suehiro T., Yamamoto M., et al. Significance of angiotensin I-converting enzyme and angiotensin II type 1 receptor gene polymorphisms as risk factors for coronary heart disease. Atherosclerosis 1996, 125:161-169.
8. Berge K.E., Bakken A., Bohn M., Erikssen J., Berg K. A DNA polymorphism at the angiotensin II type 1 receptor (AT1R) locus and myocardial infarction. Clin Genet 1997, 52:71-76.
9. Poirier O., Georges J.L., Ricard S., et al. New polymorphisms of the angiotensin II type 1 receptor gene and their associations with myocardial infarction and blood pressure: the ECTIM study. Etude Cas-Temoin de l'Infarctus du Myocarde. J Hypertens 1998, 16:1443-1447.
10. Bogaty P., Robitaille N.M., Solymoss S., et al. Atherogenic, hemostatic, and other potential risk markers in subjects with previous isolated myocardial infarction compared with long-standing uncomplicated stable angina. Am Heart J 1998, 136:884-893.
11. Gardemann A., Nguyen Q.D., Humme J., et al. Angiotensin II type 1 receptor A1166C gene polymorphism. Absence of an association with the risk of coronary artery disease and myocardial infarction and of a synergistic effect with angiotensin-converting enzyme gene polymorphism on the risk of these diseases. Eur Heart J 1998, 19:1657-1665.
12. Alvarez R., Reguero J.R., Batalla A., et al. Angiotensin-converting enzyme and angiotensin II receptor 1 polymorphisms: association with early coronary disease. Cardiovasc Res 1998, 40:375-379.
13. Rice G.I., Foy C.A., Grant P.J. Angiotensin converting enzyme and angiotensin II type 1-receptor gene polymorphisms and risk of ischaemic heart disease. Cardiovasc Res 1999, 41:746-753.
14. Karjalainen J., Kujala U.M., Stolt A., et al. Angiotensinogen gene M235T polymorphism predicts left ventricular hypertrophy in endurance athletes. J Am Coll Cardiol 1999, 34:494-499.
15. Fernandez-Arcas N., Dieguez-Lucena J.L., Munoz-Moran E., et al. The genotype interactions of methylenetetrahydrofolate reductase and renin-angiotensin system genes are associated with myocardial infarction. Atherosclerosis 1999, 145:293-300.
16. Olivieri O., Trabetti E., Grazioli S., et al. Genetic polymorphisms of the renin-angiotensin system and atheromatous renal artery stenosis. Hypertension 1999, 34:1097-1100.
17. Keavney B., McKenzie C., Parish S., et al. Large-scale test of hypothesised associations between the angiotensin-converting-enzyme insertion/deletion polymorphism and myocardial infarction in about 5000 cases and 6000 controls. International Studies of Infarct Survival (ISIS) Collaborators. Lancet 2000, 355:434-442.
18. Canavy I., Henry M., Morange P.E., et al. Genetic polymorphisms and coronary artery disease in the south of France. Thromb Haemost 2000, 83:212-216.
19. Zhong Y., Ha D. The relationship between angiotensin II type 1 receptor gene polymorphism and Chinese essential hypertension. Acta Academiae Medicinae Hubei 2000, 21:124-127.
20. Fatini C., Abbate R., Pepe G., et al. Searching for a better assessment of the individual coronary risk profile. The role of angiotensin-converting enzyme, angiotensin II type 1 receptor and angiotensinogen gene polymorphisms. Eur Heart J 2000, 21:633-638.
21. Stangl K., Cascorbi I., Stangl V., et al. A1166C polymorphism of the angiotensin II type 1 receptor gene and risk of adverse events after coronary catheter interventions. Am Heart J 2000, 140:170-175.
22. Surber R., Sigusch H.H., Lehmann M.H., et al. Angiotensin II type 1 receptor gene polymorphism is associated with the severity but not prevalence of coronary artery disease. Clin Genet 2000, 58:237-238.
23. Kee F., Morrison C., Poirier O., et al. Angiotensin II type-I receptor and ACE polymorphisms and risk of myocardial infarction in men and women. Eur J Clin Invest 2000, 30:1076-1082.
24. Batalla A., Alvarez R., Reguero J.R., et al. Synergistic effect between apolipoprotein E and angiotensinogen gene polymorphisms in the risk for early myocardial infarction. Clin Chem 2000, 46:1910-1915.
25. Steeds R.P., Wardle A., Smith P.D., et al. Analysis of the postulated interaction between the angiotensin II sub-type 1 receptor gene A1166C polymorphism and the insertion/deletion polymorphism of the angiotensin converting enzyme gene on risk of myocardial infarction. Atherosclerosis 2001, 154:123-128.
26. van Geel P.P., Pinto Y.M., Zwinderman A.H., et al. Increased risk for ischaemic events is related to combined RAS polymorphism. Heart 2001, 85:458-462.
27. Petrovic D., Zorc M., Kanic V., Peterlin B. Interaction between gene polymorphisms of renin-angiotensin system and metabolic risk factors in premature myocardial infarction. Angiology 2001, 52:247-252.
28. Olivieri O., Stranieri C., Girelli D., et al. Homozygosity for angiotensinogen 235T variant increases the risk of myocardial infarction in patients with multi-vessel coronary artery disease. J Hypertens 2001, 19:879-884.
29. Aoki S., Mukae S., Itoh S., et al. Genetic background in patients with acute myocardial infarction. Jpn Heart J 2001, 42:15-28.
30. Fernandez-Arcas N., Dieguez-Lucena J.L., Munoz-Moran E., et al. Both alleles of the M235T polymorphism of the angiotensinogen gene can be a risk factor for myocardial infarction. Clin Genet 2001, 60:52-57.
31. Deng Y.L., Yu H.Z., Yang Q., Cheng M., Huang D.J. Relation between coronary artery disease and polymorphism of type 1 angiotensin II receptor gene. South China J Cardiovasc Dis 2001, 7:258-260.
32. Liu R., Cheng Y.C., Bai H., et al. Association between angiotensin II type 1 receptor A1166C polymorphism and coronary heart disease in Chinese. J WCUMS 2002, 33:533-535.
33. Peng J., Peng S., Gong W.X. Association between early-onset coronary heart disease and angiotensin II type 1 receptor gene polymorphism. Natl Med J China 2002, 82:471-473.
34. Hooper W.C., Dowling N.F., Wenger N.K., et al. Relationship of venous thromboembolism and myocardial infarction with the renin-angiotensin system in African-Americans. Am J Hematol 2002, 70:1-8.
35. Nakai K., Habano W., Fujita T., et al. Highly multiplexed genotyping of coronary artery disease-associated SNPs using MALDI-TOF mass spectrometry. Hum Mutat 2002, 20:133-138.
36. Ermis C., Tsai M.Y., Hanson N.Q., Akar N., Aras O. Angiotensin I converting enzyme, angiotensin II type 1 receptor and angiotensinogen polymorphisms and early myocardial infarction in Turkish population. Thromb Haemost 2002, 88:693-694.
37. Hindorff L.A., Heckbert S.R., Tracy R., et al. Angiotensin II type 1 receptor polymorphisms in the cardiovascular health study: relation to blood pressure, ethnicity, and cardiovascular events. Am J Hypertens 2002, 15:1050-1056.
38. Buraczynska M., Pijanowski Z., Spasiewicz D., et al. Renin-angiotensin system gene polymorphisms: assessment of the risk of coronary heart disease. Kardiol Pol 2003, 58:1-9.
39. Jones A., Dhamrait S.S., Payne J.R., et al. Genetic variants of angiotensin II receptors and cardiovascular risk in hypertension. Hypertension 2003, 42:500-506.
40. Guan L.X., Zhang Y.Z., Wang J.X., et al. Association between the type 1 angiotensin II receptor (AT1R) gene A1166C polymorphism and insulin resistance in patients with type 2 diabetes. Chin J Birth Health Hered 2003, 11:30-32.
41. Jin W., Liu Y., Sheng H.H., et al. Single nucleotide polymorphisms in promoter of angiotensin II type 1 receptor gene associated with essential hypertension and coronary heart disease in Chinese population. Acta Pharmacol Sin 2003, 24:1083-1088.
42. Zhang R.Z., Wang S.Y., Dai Y., Zhai L.H., Xu H. Association between angiotensin II type 1 receptor gene polymorphism and hypertension with coronary artery disease. China J Mod Med 2004, 14:38-40.
43. Ranjith N., Pegoraro R.J., Rom L., Lanning P.A., Naidoo D.P. Renin-angiotensin system and associated gene polymorphisms in myocardial infarction in young South African Indians. Cardiovasc J S Afr 2004, 15:22-26.
44. Fan X.H., Li L., Qiu C.G., Liu R.Y., Huang Z.W. Analysis of the relationship between angiotensin II type 1 receptor gene polymorphism and the severity of coronary artery disease. J Zhengzhou Univ (Med Sci) 2004, 39:584-586.
45. Zhu T.N., Pan J.Q., Shen Z.J., Zhao Y.Q., Shen T. Gene polymorphisms of renin-angiotensin system and coronary artery thrombosis disease. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2004, 12:674-679.
46. Andrikopoulos G.K., Richter D.J., Needham E.W., et al. The paradoxical association of common polymorphisms of the renin-angiotensin system genes with risk of myocardial infarction. Eur J Cardiovasc Prev Rehabil 2004, 11:477-483.
47. Berdeli A., Sekuri C., Sirri Cam F., et al. Association between the eNOS (Glu298Asp) and the RAS genes polymorphisms and premature coronary artery disease in a Turkish population. Clin Chim Acta 2005, 351:87-94.
48. Sekuri C., Cam F.S., Ercan E., et al. Renin-angiotensin system gene polymorphisms and premature coronary heart disease. J Renin Angiotensin Aldosterone Syst 2005, 6:38-42. (contact author).
49. Ozisik K., Misirlioglu M., Ulus T.A., et al. Renin-angiotensin system polymorphisms and coronary artery surgery patients. Asian Cardiovasc Thorac Ann 2005, 13:153-156.
50. Zhang K.X., Liu T.B., Xu Q.X., Zhu D.L., Huang W. Association of angiotensin II receptor type 1 gene single nucleotide polymorphism with Chinese essential hypertension complicated with coronary heart disease. Chin J Cardiol 2005, 33:720-723.
51. Araujo M.A., Goulart L.R., Cordeiro E.R., et al. Genotypic interactions of renin-angiotensin system genes in myocardial infarction. Int J Cardiol 2005, 103:27-32.
52. Jia Y.P., Ren J., Lu J.Y., Guo X.H. The relationship between coronary heart disease and polymorphism of angiotensiongen and angiotensin II type 1 receptor genes. Chin J Cardiovasc Rev 2005, 3:816-819.
53. Methot J., Hamelin B.A., Bogaty P., et al. ACE-DD genotype is associated with the occurrence of acute coronary syndrome in postmenopausal women. Int J Cardiol 2005, 105:308-314.
54. Ding Y.P. Analysis on angiotensin receptor polymorphism in high-risk population with primary hypertension and coronary heart disease. J Henan Univ Sci Tech (Med Sci) 2006, 24:86-88.
55. Jia Y.P., Guo X.H., Lu J.Y., et al. Relationship between angiotensin II type 1 receptor gene A1166/C polymorphism and coronary heart disease. Chin J Integr Med Cardio-Cerebrovasc Dis 2006, 4:568-570.
56. Lin X.F., Xia X.M., Ceng L.R., Jin L.Z., Li J. Relationship between angiotensin system gene polymorphisms and premature coronary artery disease. Clin Med China 2006, 22:971-974.
57. Tsai C.T., Hwang J.J., Ritchie M.D., et al. Renin-angiotensin system gene polymorphisms and coronary artery disease in a large angiographic cohort: detection of high order gene-gene interaction. Atherosclerosis 2007, 195:172-180.
58. Morgan T.M., Krumholz H.M., Lifton R.P., Spertus J.A. Nonvalidation of reported genetic risk factors for acute coronary syndrome in a large-scale replication study. JAMA 2007, 297:1551-1561.
59. Franco E., Palumbo L., Crobu F., et al. Renin-angiotensin-aldosterone system polymorphisms: a role or a hole in occurrence and long-term prognosis of acute myocardial infarction at young age. BMC Med Genet 2007, 8:27.
60. Schelleman H., Klungel O.H., Witteman J.C., et al. Pharmacogenetic interactions of three candidate gene polymorphisms with ACE-inhibitors or beta-blockers and the risk of atherosclerosis. Br J Clin Pharmacol 2007, 64:57-66.
61. Moher D., Cook D.J., Eastwood S., et al. Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement. Quality of Reporting of Meta-analyses. Lancet 1999, 354:1896-1900.
62. Stroup D.F., Berlin J.A., Morton S.C., et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA 2000, 283:2008-2012.
63. DerSimonian R., Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986, 7:177-188.
64. Higgins J.P., Thompson S.G., Deeks J.J., Altman D.G. Measuring inconsistency in meta-analyses. BMJ 2003, 327:557-560.
65. Thompson S.G., Sharp S.J. Explaining heterogeneity in meta-analysis: a comparison of methods. Stat Med 1999, 18:2693-2708.
66. Begg C.B., Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics 1994, 50:1088-1101.
67. Duval S., Tweedie R. A nonparametric "trim and fill" method of accounting for publication bias in meta-analysis. J Am Stat Assoc 2000, 95:89-98.
68. Lau J., Ioannidis J.P., Terrin N., Schmid C.H., Olkin I. The case of the misleading funnel plot. BMJ 2006 Sep 16, 333:597-600.
69. Egger M., Davey Smith G., Schneider M., Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997, 315:629-634.
70. Jeffrey D.S. Publication Bias: The "File-Drawer Problem" in Scientific Inference. J Sci Exploration 2000, 14:94-106.
71. Shiffman D., Ellis S.G., Rowland C.M., et al. Identification of four gene variants associated with myocardial infarction. Am J Hum Genet 2005, 77:596-605.
72. Ozaki K., Tanaka T. Genome-wide association study to identify single-nucleotide polymorphisms conferring risk of myocardial infarction. Methods Mol Med 2006, 128:173-180.
73. Wellcome Trust Case Control Consortium Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007, 447:661-678.
74. McPherson R., Pertsemlidis A., Kavaslar N., et al. A common allele on chromosome 9 associated with coronary heart disease. Science 2007, 316:1488-1491.
75. Samani N.J., Erdmann J., Hall A.S., et al. Genomewide association analysis of coronary artery disease. N Engl J Med 2007, 357:443-453.
76. Larson M.G., Atwood L.D., Benjamin E.J., et al. Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes. BMC Med Genet 2007, 8(Suppl. 1):S5.
77. Lohmueller K.E., Pearce C.L., Pike M., Lander E.S., Hirschhorn J.N. Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet 2003, 33:177-182.
78. Morgan T.M., Coffey C.S., Krumholz H.M. Overestimation of genetic risks owing to small sample sizes in cardiovascular studies. Clin Genet 2003, 64:7-17.
79. Colhoun H.M., McKeigue P.M., Davey Smith G. Problems of reporting genetic associations with complex outcomes. Lancet 2003, 361:865-872.
80. Hirschhorn J.N., Lohmueller K.E., Byrne E., Hirschhorn K. A comprehensive review of genetic association studies. Genet Med 2002, 4:45-61.
81. Ionnidis J.P.A., Trikalinos T.A., Ntzani E.E., Contopoulos-Ioannidis D.G. Genetic associations in large versus small studies: an empirical assessment. Lancet 2003, 361:567-571.
82. Ioannidis J.P., Gwinn M., Little J., et al. A road map for efficient and reliable human genome epidemiology. Nat Genet 2006, 38:3-5.
83. Seminara D., Khoury M.J., O'Brien T.R., et al. The emergence of networks in human genome epidemiology: challenges and opportunities. Epidemiology 2007, 18:1-8.
84. Kavvoura F.K., Ioannidis J.P. Methods for meta-analysis in genetic association studies: a review of their potential and pitfalls. Hum Genet 2008, 123:1-14.
85. Kavvoura F.K., McQueen M.B., Khoury M.J., et al. Evaluation of the potential excess of statistically significant findings in published genetic association studies: application to Alzheimer's disease. Am J Epidemiol 2008, 168:855-865.
86. Allen N.C., Bagade S., McQueen M.B., et al. Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat Genet 2008, 40:827-834.
87. Bagade S, Allen NC, Tanzi R, Bertram L. The PDGene Database. Alzheimer Research Forum. Available at: Accessed [date of access]. http://www.pdgene.org/.
88. Evangelou E., Maraganore D.M., Ioannidis J.P. Meta-analysis in genome-wide association datasets: strategies and application in Parkinson disease. PLoS ONE 2007, 2:e196.
89. Baum A.E., Hamshere M., Green E., et al. Meta-analysis of two genome-wide association studies of bipolar disorder reveals important points of agreement. Mol Psychiatry 2008, 13:466-467.
90. Zeggini E., Scott L.J., Saxena R., et al. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 2008, 40:638-645.
91. Cooper J.D., Smyth D.J., Smiles A.M., et al. Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. Nat Genet 2008, 40:1399-1401.
92. Houlston R.S., Webb E., Broderick P., et al. Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. Nat Genet 2008, 40:1426-1435.
93. Li D., Collier D.A., He L. Meta-analysis shows strong positive association of the neuregulin 1 (NRG1) gene with schizophrenia. Hum Mol Genet 2006, 15:1995-2002.
94. Takkouche B., Regueira-Méndez C., Etminan M. Breast cancer and use of nonsteroidal anti-inflammatory drugs: a meta-analysis. J Natl Cancer Inst 2008, 100:1439-1447.
95. Wheeler J.G., Keavney B.D., Watkins H., Collins R., Danesh J. Four paraoxonase gene polymorphisms in 11212 cases of coronary heart disease and 12786 controls: meta-analysis of 43 studies. Lancet 2004, 363:689-695.
96. Ye Z., Liu E.H., Higgins J.P., et al. Seven haemostatic gene polymorphisms in coronary disease: meta-analysis of 66,155 cases and 91,307 controls. Lancet 2006, 367:651-658.
97. Ntzani E.E., Rizos E.C., Ioannidis J.P. Genetic effects versus bias for candidate polymorphisms in myocardial infarction: case study and overview of large-scale evidence. Am J Epidemiol 2007, 165:973-984.