The emergence of networks in human genome epidemiology: Challenges and opportunities

Epidemiology

Volumn 18, Issue 1, 2007, Pages 1-8

  Seminara, Daniela ^a   Khoury, Muin J ^b   O'Brien, Thomas R ^a   Manolio, Teri ^c   Gwinn, Marta L ^b   Little, Julian ^d   Higgins, Julian P T ^e,f   Bernstein, Jonine L ^g   Boffetta, Paolo ^h   Bondy, Melissa ⁱ   Bray, Molly S ⁱ   Brenchley, Paul E ^j   Buffler, Patricia A ^k   Casas, Juan Pablo ^l   Chokkalingam, Anand P ^e   Danesh, John ^m   Smith, George Davey ⁿ   Dolan, Siobhan ^o   Duncan, Ross ^p   Gruis, Nelleke A ^q   Hashibe, Mia ^h   Hunter, David ^q   Jarvelin, Marjo Riitta ^r,s   Malmer, Beatrice ^t   Maraganore, Demetrius M ^u   Newton Bishop, Julia A ^v   Riboli, Elio ^h   Salanti, Georgia ^e   Taioli, Emanuela ^w   Timpson, Nic ^m   Uitterlinden, André G ^x   Vineis, Paolo ^r,y   Wareham, Nick ^z   Winn, Deborah M ^a   Zimmern, Ron ^f   Ioannidis, John P A ^aa,ab   more..

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL CENTER ON BIRTH DEFECTS AND DEVELOPMENTAL DISABILITIES   (United States)

^c NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF OTTAWA   (Canada)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^f UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^g MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^h INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

ⁱ UNIVERSITY OF TEXAS   (United States)

^j MANCHESTER ROYAL INFIRMARY   (United Kingdom)

^k UNIVERSITY OF CALIFORNIA   (United States)

^l LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^m UNIVERSITY OF BRISTOL   (United Kingdom)

ⁿ ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^o WORLD HEALTH ORGANIZATION   (Switzerland)

^p LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^q HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^r IMPERIAL COLLEGE LONDON   (United Kingdom)

^s UNIVERSITY OF OULU   (Finland)

^t UMEÅ UNIVERSITY HOSPITAL   (Sweden)

^u MAYO CLINIC   (United States)

^v CR UK Clinical Centre   (United Kingdom)

^w UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^x ERASMUS MEDICAL CENTER   (Netherlands)

^y ISI FOUNDATION   (Italy)

^z MRC EPIDEMIOLOGY UNIT   (United Kingdom)

^aa INSTITUTE OF COMPUTER SCIENCE   (Greece)

^ab TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CLINICAL GENETICS; CONFERENCE PAPER; GENE INTERACTION; GENE REPLICATION; GENETIC ASSOCIATION; GENETIC EPIDEMIOLOGY; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GENOTYPE PHENOTYPE CORRELATION; HUMAN GENOME; LARGE SCALE PRODUCTION; MEDICAL RESEARCH; POPULATION SIZE; PRACTICE GUIDELINE; PRIORITY JOURNAL; SAMPLE SIZE; SCIENTIST;

EPIDEMIOLOGIC METHODS; GENOME, HUMAN; HUMANS; INFORMATION SERVICES; INTERNET;

EID: 33845721725     PISSN: 10443983     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ede.0000249540.17855.b7     Document Type: Conference Paper

References (54)

1. Large Scale Biomedical Science: Exploring Strategies for Future Research; Committee on Large Scale Science and Cancer Research. IOM Report; 2003.
2. Seminara D, Obrams GI. Genetic epidemiology of cancer: a multidisciplinary approach. Genet Epidemiol. 1994;11:235-254.
3. Relationship of blood pressure, serum cholesterol, smoking habit, relative weight and ECG abnormalities to incidence of major coronary events: final report of the pooling project. The Pooling Project Research Group. J Chronic Dis. 1978;4:201-306.
4. Kreeger K. Consortia 'big science': part of a paradigm shift for genetic epidemiology. J Natl Cancer Inst. 2003;95:640-641.
5. Khoury MJ. The case for a global human genome epidemiology initiative. Nat Genet. 2004;36:1027-1028.
6. Collins FS. The case for a US prospective cohort study of genes and environment. Nature. 2004;429:475-477.
7. Ioannidis JPA, Trikalinos TA, Khoury MJ. Implications of small effect sizes of individual genetic variants on the design and interpretation of genetic association studies of complex diseases. Am J Epidemiol. In press.
8. Hirschhorn JN, Daly MJ. Genome-wide association studies for common diseases and complex traits. Nat Rev Genet. 2005;6:95-108.
9. Thomas DC, Haile RW, Duggan D. Recent developments in genomewide association scans: a workshop summary and review. Am J Hum Genet. 2005;77:337-345.
10. Caporaso NE. Why have we failed to find the low penetrance genetic constituents of common cancers? Cancer Epidemiol Biomarkers Prev. 2002;11:1544-1549.
11. Timpson NJ, Lawlor DA, Harbord RM, et al. C-reactive protein and its role in metabolic syndrome: mendelian randomisation study. Lancet. 2005;366:1954-1959.
12. Rogers S, Dowling E, Valle C, et al. The Trends and Development in Consortia as a Tool for Genetic Research in Epidemiology. Proceedings of AACR Frontiers in Cancer Prevention and Research; 2005;C79:
13. Ioannidis JPA Bernstein J, Bofetta P, et al. A network of investigator networks in human genome epidemiology. Am J Epidemiol. 2005;162:302-304.
14. Human Genome Epidemiology web sites. Available at: www.hugenet.org.uk/ networks/list.html (Cambridge) and www.dhe.med.uoi.gr/hugenet.htm (Ioannina). Accessed July 10, 2006.
15. Wacholder S, Chanock S, Garcia-Closas M, et al. Assessing the probability that a positive report is false: an approach for molecular epidemiology studies. J Natl Cancer Inst. 2004;96:434-442.
16. Colhoun HM, McKeigue PM, Davey Smith G. Problems of reporting genetic associations with complex outcomes. Lancet. 2003;361:865-872.
17. Ioannidis JPA. Why most published research findings are false. PLOS Medicine. 2005;2:e124.
18. Taioli E. International collaborative study on genetic susceptibility to environmental carcinogens. Cancer Epidemiol Biomarkers Prev. 1999;8:727-728.
19. Bernstein JL, Teraoka S, Haile RW, et al. WECARE Study Collaborative Group Designing and implementing quality control for multi-center screening of mutations in the ATM gene among women with breast cancer. Hum Mutat. 2003;21:542-550.
20. Maraganore DM, de Andrade M, Lesnick TG, et al. High-resolution whole-genome association study of Parkinson disease. Am J Hum Genet. 2005;77:685-693.
21. Hunter DJ, Riboli E, Haiman CA, et al. National Cancer Institute Breast and Prostate Cancer Cohort Consortium. A candidate gene approach to searching for low-penetrance breast and prostate cancer genes. Nat Rev Cancer. 2005;5:977-985.
22. NIH Guide for Grants and Contracts web site. Available at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-06-071.html. Accessed June 30, 2006.
23. Thomas DC. Are we ready for genome-wide association studies? Cancer Epidemiol Biomarkers Prev. 2006;15:595-598.
24. Raimondi S, Taioli E. APIKIDS: registry of children born after assisted reproductive technologies. Paediat Perinatal Epidemiol. In press.
25. John EM, Hopper JL, Beck JC, et al. The Breast Cancer Family Registry: an infrastructure for cooperative multinational, interdisciplinary and translational studies of the genetic epidemiology of breast cancer. Breast Cancer Res. 2004;6:R375-389.
26. NCI web site. Available at: www.cancer.gov/newscenter/pressreleases/ cohortconsortium. Accessed June 30, 2006.
27. Ioannidis JP, Gwinn M, Little J, et al. A road map for efficient and reliable human genome epidemiology. Nat Genet. 2006;38:3-5.
28. NCI web site. Available at: http://epi.grants.cancer.gov/initiatives. html. Accessed June 30, 2006.
29. GENOMOS web site. Available at: www.genomos.org. Accessed June 30, 2006.
30. Uitterlinden AG, Ralston SH, Brandi ML et al. Large-scale analysis of association between common vitamin D receptor gene variations and osteoporosis: the GENOMOS Study. Ann Intern Med. In press.
31. Ioannidis JP, Rosenberg PS, Goedert JJ, et al. International Meta-Analysis of HIV Host Genetics. Effects of CCR5-Delta32, CCR2-64I, and SDF-1 3′A alleles on HIV-1 disease progression: an international meta-analysis of individual-patient data. Ann Intern Med. 2001;135:782-795.
32. IARC web site. Available at: http://inhance.iarc.fr/. Accessed June 30, 2006.
33. GENOMEL web site. Available at: http://www.genomel.org. Accessed June 30, 2006.
34. CFR web site. Available at: http://epi.grants.cancer.gov/CFR/. Accessed June 30, 2006.
35. Pompanon F, Bonin A, Bellemain E, et al. Genotyping errors: causes, consequences and solutions. Nat Rev Genet. 2005;6:847-859.
36. Contopoulos-Ioannidis, Alexiou G, Gouvias T, et al. An empirical evaluation of multifarious outcomes in pharmacogenetics: beta2 adrenoceptor gene polymorphisms in asthma treatment. Pharmacogenetics and Genomics. In press.
37. Lindor NM, Rabe K, Petersen GM, et al. Lower cancer incidence in Amsterdam-I criteria families without mismatch repair deficiency: familial colorectal cancer type X. JAMA. 2005;293:1979-1985.
38. Rothman N, Skibola CF, Wang SS, et al. Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph Consortium. Lancet Oncol. 2006;7:27.
39. Andrulis IL, Anton-Culver H, Beck J, et al. Cooperative Family Registry for Breast Cancer studies. Comparison of DNA- and RNA-based methods for detection of truncating BRCA1 mutations. Hum Mutat. 2002;20:65-73.
40. Yonan AL, Palmer AA, Gilliam TC. Hardy-Weinberg disequilibrium identified genotyping error of the serotonin transporter (SLC6A4) promoter polymorphism. Psychiatr Genet. 2006;16:31-34.
41. http://130.192.70.30/huge/.
42. Dickersin K, Scherer R, Suci ES, et al. Problems with indexing and citation of articles with group authorship. JAMA. 2002;287:2772-2774.
43. NIH multi-P.I. initiative. Available at: http://grants.nih.gov/grants/ multi_pi/. Accessed June 27, 2006.
44. National Institutes for Health. Data Sharing Policy web site, p 17. Available at: http://grants2.nih.gov/grants/policy/data_sharing/. Accessed June 10, 2006.
45. Ioannidis JP. Journals should publish all 'null' results and should sparingly publish 'positive' results. Cancer Epidemiol Biomarkers Prev. 2006;15:186.
46. GAIN initiative. Available at: www.fnih.org/GAIN/GAIN_home.shtml. Accessed June 27, 2006.
47. NIH Roadmap interdisciplinary consortia link, p 18. Available at: http://grants2.nih.gov/grants/guide/notice-files/NOT-RM-05-006.html. Accessed June 27, 2006.
48. European Community Framework. Available at: www.infoexport.gc.ca/science/ eu_7fp-en.htm;jsessionid=IZHW1NF2GMCHICTHNCACFEQ. Accessed June 27, 2006.
49. Daly MB, Offit K, Li F, et al. Participation in the cooperative family registry for breast cancer studies: issues of informed consent. J Natl Cancer Inst. 2000;92:452-456.
50. Betancourt D, Dowling E, Seminara D; International Consortium on Prostate Cancer Genetics. Data sharing and informed consent in genetic epidemiology consortia. Poster presentation, 9th International Meeting on the Psychosocial Aspects of Genetic Testing for Hereditary Cancer, 2005:19.
51. Pan Z, Trikalinos TA, Kavvoura FK, et al. Local literature bias in genetic epidemiology: an empirical evaluation of the Chinese literature. PLoS Med. 2005;2:e334.
52. Ioannidis JP. grading the credibility of molecular evidence for complex diseases. Int J Epidemiol. 2006;35:572-828.
53. De Angelis C, Drazen JM, Frizelle FA, et al. Clinical trial registration: a statement from the International Committee of Medical Journal Editors. N Engl J Med. 2004;351:1250-1251.
54. Embracing risk. Nat Genet. 2006;38:1.