The paradoxical association of common polymorphisms of the renin-angiotensin system genes with risk of myocardial infarction

European Journal of Preventive Cardiology

Volumn 11, Issue 6, 2004, Pages 477-483

  Andrikopoulos, George K ^a   Richter, Dimitri J ^b   Needham, Edward W ^c   Tzeis, Stylianos E ^a   Zairis, Michalis N ^d   Gialafos, Elias J ^e   Vogiatzi, Paraskeui G ^e   Papasteriadis, Evaggelos G ^f   Kardaras, Fotios G ^a   Foussas, Stefanos G ^d   Gialafos, John E ^g   Stefanadis, Christodoulos I ^g   Toutouzas, Pavlos K ^g   Mattu, Raj K ^c  

^a EVANGELISMOS HOSPITAL   (Greece)

^b Athens Euroclinic   (Greece)

^c UNIVERSITY OF WARWICK   (United Kingdom)

^d TZANEIO GENERAL HOSPITAL OF PIRAEUS   (Greece)

^e LAIKO GENERAL HOSPITAL   (Greece)

^f Cardiology Department   (Greece)

^g UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

A1166C polymorphism; angiotensin converting enzyme gene; angiotensin II AT1 receptor gene; insertion deletion polymorphism; myocardial infarction

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE;

ACE GENE; ADULT; AGED; ARTICLE; ATR1 GENE; CASE CONTROL STUDY; CORONARY RISK; FAMILY HISTORY; FEMALE; GENE; GENE DELETION; GENE INSERTION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE PHENOTYPE CORRELATION; HEART INFARCTION; HIGH RISK POPULATION; HUMAN; HYPERCHOLESTEROLEMIA; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PATHOGENESIS; PRIORITY JOURNAL; RECEPTOR GENE; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RISK ASSESSMENT;

CASE-CONTROL STUDIES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GREECE; HUMANS; HYPERCHOLESTEROLEMIA; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; MYOCARDIAL INFARCTION; PEPTIDYL-DIPEPTIDASE A; POLYMORPHISM, GENETIC; RECEPTOR, ANGIOTENSIN, TYPE 1; RISK FACTORS;

EID: 19944426133     PISSN: 20474873     EISSN: 20474881     Source Type: Journal    
DOI: 10.1097/01.hjr.0000152240.05585.da     Document Type: Article

References (26)

1. Rigat B, Hubert C, Corvol P, Soubrier F. PCR detection of the insertion/ deletion polymorphism of the human angiotensin converting enzyme gene. Nucleic Acids Res 1992; 20: 1433.
2. Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F. An insertion/deletion polymorphismin the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 1990; 86: 1343–1346.
3. Tiret L, Bonnardeaux A, Poirier O, Ricard S, Marques Vidal P, Evans A, et al. Synergistic effects of angiotensin-converting enzyme and angiotensin-II type 1 receptor gene polymorphisms on risk of myocardial infarction. Lancet 1994; 344: 910–913.
4. Cambien F, Poirier O, Lecerf L, Evans A, Cambou JP, Arveiler D, et al. Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction. Nature 1992; 359: 641–644.
5. Beohar N, Damaraju S, Prather A, Yu QT, Raizner A, Kleiman NS, et al. Angiotensin-I converting enzyme genotype DD is a risk factor for coronary artery disease. J Invest Med 1995; 43: 275–280.
6. Schuster H, Wienker TF, Stremmler U, Noll B, Steinmetz A, Luft FC. An angiotensin-converting enzyme gene variant is associated with acute myocardial infarction in women but not in men. Am J Cardiol 1995; 76: 601–603.
7. Wang XL, McCredie RM, Wilcken DE. Genotype distribution of angiotensin-converting enzyme polymorphism in Australian healthy and coronary populations and relevance to myocardial infarction and coronary artery disease. Arterioscler Thromb Vasc Biol 1996; 16: 115–119.
8. Keavney B, McKenzie C, Parish S, Palmer A, Clark S, Youngman L, et al. Large-scale test of hypothesised associations between the angiotensin-converting-enzyme insertion/deletion polymorphism and myocardial infarction in about 5000 cases and 6000 controls. International Studies of Infarct Survival (ISIS) Collaborators. Lancet 2000; 355: 434–442.
9. Lindpaintner K, Pfeffer MA, Kreutz R, Stampfer MJ, Grodstein F, LaMotte F, et al. A prospective evaluation of an angiotensin-converting-enzyme gene polymorphism and the risk of ischaemic heart disease. N Engl J Med 1995; 332: 706–711.
10. Sans S, Kesteloot H, Kromhout D. The burden of cardiovascular diseases mortality in Europe. Task Force of the European Society of Cardiology on Cardiovascular Mortality and Morbidity Statistics in Europe. Eur Heart J 1997; 18: 1231–1248.
11. Panagiotakos DB, Pitsavos C, Chrysohoou C, Stefanadis C, Toutouzas P. Risk stratification of coronary heart disease through established and emerging lifestyle factors in a Mediterranean population: CARDIO2000 epidemiological study. J Cardiovasc Risk 2001; 8: 329–335.
12. Moulopoulos SD, Adamopoulos PN, Diamantopoulos EI, Nanas SN, Anthopoulos LN, Iliadi-Alexandrou M. Coronary heart disease risk factors in a random sample of Athenian adults. The Athens Study. Am J Epidemiol 1987; 126: 882–892.
13. Panagiotakos DB, Pitsavos C, Chrysohoou C, Stefanadis C, Toutouzas P. Risk stratification of coronary heart disease in Greece: final results from the CARDIO2000 Epidemiological Study. Prev Med 2002; 35: 548–556.
14. Lifestyle and risk factor management and use of drug therapies in coronary patients from 15 countries; principal results from EUROASPIRE II Euro Heart Survey Programme. Eur Heart J 2001; 22: 554–572.
15. Andrikopoulos GK, Richter DJ, Dilaveris PE, Pipilis A, Zaharoulis A, Gialafos JE, et al. In-hospital mortality of habitual cigarette smokers after acute myocardial infarction. The smoker's paradox in a countrywide study. Eur Heart J 2001; 22: 776–784.
16. Bohn M, Berge KE, Bakken A, Erikssen J, Berg K. Insertion/deletion (I/D) polymorphism at the locus for angiotensin-I converting enzyme and myocardial infarction. Clin Gen 1993; 44: 292–297.
17. Samani NJ, O'Toole L, Martin D, Rai H, Fletcher S, Lodwick D, et al. Insertion/deletion polymorphism in the angiotensin-converting enzyme gene and risk of and prognosis after myocardial infarction. J Am Coll Cardiol 1996; 28: 338–344.
18. Barley J, Blackwood A, Carter ND, Crews DE, Cruickshank JK, Jeffery S, et al. Angiotensin converting enzyme insertion/deletion polymorphism: association with ethnic origin. J Hypertens 1994; 12: 955–957.
19. Staessen JA, Ginocchio G, Wang JG, Saavedra AP, Soubrier F, Vlietinck R, et al. Genetic variability in the renin-angiotensin system: prevalence of alleles and genotypes. J Cardiovasc Risk 1997; 4: 401–422.
20. Gardemann A, Nguyen QD, Humme J, Stricker J, Katz N, Tillmanns H, et al. Angiotensin II type I receptor A1166C gene polymorphism. Absence of an association with the risk of coronary artery disease and myocardial infarction and of a synergistic effect with angiotensin-converting enzyme gene polymorphism on the risk of these diseases. Eur Heart J 1998; 19: 1657–1665.
21. Fatini C, Abbate R, Pepe G, Battaglini B, Gensini F, Ruggiano G, et al. Searching for a better assessment of the individual coronary risk profile. The role of angiotensin-converting enzyme, angiotensin-II type-I receptor and angiotensinogen gene polymorphisms. Eur Heart J 2000; 21: 633–638.
22. Uemura K, Nakura J, Kohara K, Miki T. Association of ACE I/D polymorphism with cardiovascular risk factors. Hum Genet 2000; 107: 239–242.
23. Suzuki T, Yokota H, Yamazaki T, Kitamura K, Yamaoki K, Nagai R, et al. Angiotensin converting enzyme polymorphism is associated with severity of coronary heart disease and serum lipids (total cholesterol and triglycerides levels) in Japanese patients. Coron Artery Dis 1996; 7: 371–375.
24. Oren I, Brook JG, Gershoni-Baruch R, Kepten I, Tamir A, Linn S, et al. The D allele of the angiotensin-converting enzyme gene contributes towards blood LDL-cholesterol levels and the presence of hypertension. Atherosclerosis 1999; 145: 267–271.
25. Marian AJ, Safavi F, Ferlic L, Dunn JK, Gotto AM, Ballantyne CM. Interactions between angiotensin-I converting enzyme insertion/deletion polymorphism and response of plasma lipids and coronary atherosclerosis to treatment with fluvastatin: the lipoprotein and coronary atherosclerosis study. J Am Coll Cardiol 2000; 35: 89–95.
26. Bosse Y, Vohl MC, Dumont M, Brochu M, Bergeron J, Despres JP, et al. Influence of the angiotensin-converting enzyme gene insertion/deletion polymorphism on lipoprotein/lipid response to gemfibrozil. Clin Genet 2002; 62: 45–52.