2E8 binds to the high affinity I-domain in a metal ion-dependent manner: A second generation monoclonal antibody selectively targeting activated LFA-1

Journal of Biological Chemistry

Volumn 285, Issue 43, 2010, Pages 32860-32868

  Carreño, Roberto ^a   Brown, Wells S ^a   Li, Dan ^a   Hernandez, Jessica A ^a   Wang, Yang ^a   Kim, Tae Kon ^b   Craft Jr , John W ^c   Komanduri, Krishna V ^b   Radvanyi, Laszlo G ^a   Hwu, Patrick ^a   Molldrem, Jeffrey J ^a   Legge, Glen B ^c   McIntyre, Bradley W ^a   Ma, Qing ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF MIAMI   (United States)

^c University of Houston   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESION SITES; AFFINITY STATE; CONFORMATION CHANGE; DISSOCIATION CONSTANT; DISULFIDE BONDS; HIGH AFFINITY; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; IMMUNE RESPONSE; JURKAT CELL; LIGAND BINDING; PARALLEL PLATES; RECOGNITION SITE; SECOND GENERATION; SURFACE PLASMONS; T CELL ACTIVATION; T CELLS;

ADHESION; CELL ADHESION; DISSOCIATION; ENDOTHELIAL CELLS; FLOW CYTOMETRY; MANGANESE; MANGANESE COMPOUNDS; METAL IONS; MONOCLONAL ANTIBODIES; PLASMONS;

SURFACE PLASMON RESONANCE;

CALCIUM ION; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MAGNESIUM ION; MANGANESE; METAL ION; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 2E8; OKT 3; UNCLASSIFIED DRUG;

ANTIGEN BINDING; ANTIGEN EXPRESSION; ARTICLE; BINDING AFFINITY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL ADHESION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOLYSIS; DISSOCIATION CONSTANT; DISULFIDE BOND; ENDOTHELIUM CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNIZATION; LYMPHOCYTE PROLIFERATION; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; SURFACE PLASMON RESONANCE; T LYMPHOCYTE ACTIVATION; UMBILICAL VEIN;

ANIMALS; ANTIBODIES, MONOCLONAL; CATIONS, DIVALENT; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL ADHESION; DISULFIDES; ENDOTHELIAL CELLS; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMANS; IMMUNITY, CELLULAR; INTERCELLULAR ADHESION MOLECULE-1; JURKAT CELLS; K562 CELLS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; METALS; MICE; MICE, INBRED BALB C; MUROMONAB-CD3; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; SURFACE PLASMON RESONANCE; UMBILICAL VEINS;

EID: 77958461226     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.111591     Document Type: Article

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