PET with 18F-labelled choline-based tracers for tumour imaging: A review of the literature

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 37, Issue 11, 2010, Pages 2188-2193

  Mertens, Koen ^a   Slaets, Dominique ^a   Lambert, Bieke ^a   Acou, Marjan ^a   De Vos, Filip ^a   Goethals, Ingeborg ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

18F; Choline; Oncology; PET CT

Indexed keywords

CHOLINE C 11; CHOLINE DERIVATIVE; FLUOROCHOLINE F 18; FLUORODEOXYGLUCOSE F 18; FLUOROETHYL LEVO THYROSINE F 18; PROSTATE SPECIFIC ANTIGEN; TRACER; UNCLASSIFIED DRUG;

BRAIN METASTASIS; CANCER DIAGNOSIS; CANCER STAGING; CELL PROLIFERATION; COMPUTER ASSISTED TOMOGRAPHY; DIAGNOSTIC ACCURACY; DIFFERENTIAL DIAGNOSIS; DRUG ACCUMULATION; DRUG UPTAKE; ESOPHAGUS CANCER; FEMALE GENITAL TRACT TUMOR; GLIOBLASTOMA; GLIOMA; HEAD AND NECK CANCER; HUMAN; IMAGE QUALITY; LIVER CELL CARCINOMA; LYMPH NODE METASTASIS; METASTASIS; NEUROIMAGING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PROSTATE CANCER; RADIATION INJURY; RADIATION NECROSIS; REVIEW; TUMOR RECURRENCE;

BRAIN NEOPLASMS; CHOLINE; HUMANS; LIVER NEOPLASMS; MALE; NEOPLASMS; POSITRON-EMISSION TOMOGRAPHY; PROSTATIC NEOPLASMS;

EID: 77958461203     PISSN: 16197070     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00259-010-1496-z     Document Type: Review

References (56)

1. S Vallabhajosula 2007 (18)F-Labeled positron emission tomographic radiopharmaceuticals in oncology: an overview of radiochemistry and mechanisms of tumor localization Semin Nucl Med 37 400 419 10.1053/j.semnuclmed.2007.08.004 17920348
2. JV Swinnen K Brusselmans G Verhoeven 2006 Increased lipogenesis in cancer cells: new players, novel targets Curr Opin Clin Nutr Metab Care 9 358 365 1:CAS:528:DC%2BD28Xot1ahsLw%3D 10.1097/01.mco.0000232894.28674.30 16778563
3. F Podo 1999 Tumour phospholipid metabolism NMR Biomed 12 413 439 1:CAS:528:DC%2BD3cXnt1Gmuw%3D%3D 10.1002/(SICI)1099-1492(199911)12:7<413:: AID-NBM587>3.0.CO;2-U 10654290
4. E Ackerstaff BR Pflug JB Nelson ZM Bhujwalla 2001 Detection of increased choline compounds with proton nuclear magnetic resonance spectroscopy subsequent to malignant transformation of human prostatic epithelial cells Cancer Res 61 3599 3603 1:CAS:528:DC%2BD3MXjsFCgtLY%3D 11325827
5. MG Swanson DB Vigneron ZL Tabatabai RG Males L Schmitt PR Carroll, et al. 2003 Proton HR-MAS spectroscopy and quantitative pathologic analysis of MRI/3D-MRSI-targeted postsurgical prostate tissues Magn Reson Med 50 944 954 1:CAS:528:DC%2BD3sXps1amt70%3D 10.1002/mrm.10614 14587005
6. KK Bhakoo SR Williams CL Florian H Land MD Noble 1996 Immortalization and transformation are associated with specific alterations in choline metabolism Cancer Res 56 4630 4635 1:CAS:528:DyaK28XmsV2isbY%3D 8840976
7. K Nakagami T Uchida S Ohwada Y Koibuchi Y Suda T Sekine, et al. 1999 Increased choline kinase activity and elevated phosphocholine levels in human colon cancer Jpn J Cancer Res 90 419 424 1:CAS:528:DyaK1MXislGrtr0%3D 10363580
8. A Ramirez de Molina A Rodriguez-Gonzalez R Gutierrez L Martinez-Pineiro J Sanchez F Bonilla, et al. 2002 Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers Biochem Biophys Res Commun 296 580 583 1:CAS:528: DC%2BD38XmtFShtb8%3D 10.1016/S0006-291X(02)00920-8 12176020
9. A Roivainen S Forsback T Gronroos P Lehikoinen M Kahkonen E Sutinen, et al. 2000 Blood metabolism of [methyl-11C]choline; implications for in vivo imaging with positron emission tomography Eur J Nucl Med 27 25 32 1:CAS:528:DyaK1MXnvFektro%3D 10.1007/PL00006658 10654143
10. TR DeGrado RE Coleman S Wang SW Baldwin MD Orr CN Robertson, et al. 2001 Synthesis and evaluation of 18F-labeled choline as an oncologic tracer for positron emission tomography: initial findings in prostate cancer Cancer Res 61 110 117 1:CAS:528:DC%2BD3MXlsl2lsA%3D%3D 11196147
11. T Hara N Kosaka H Kishi 2002 Development of (18)F-fluoroethylcholine for cancer imaging with PET: synthesis, biochemistry, and prostate cancer imaging J Nucl Med 43 187 199 1:CAS:528:DC%2BD38XjvFWjtrs%3D 11850483
12. A Bansal W Shuyan T Hara RA Harris TR Degrado 2008 Biodisposition and metabolism of [(18)F]fluorocholine in 9L glioma cells and 9L glioma-bearing fisher rats Eur J Nucl Med Mol Imaging 35 1192 1203 1:CAS:528: DC%2BD1cXlvVClt7o%3D 10.1007/s00259-008-0736-y 18264706
13. SA Kwee TR DeGrado JN Talbot F Gutman MN Coel 2007 Cancer imaging with fluorine-18-labeled choline derivatives Semin Nucl Med 37 420 428 10.1053/j.semnuclmed.2007.07.003 17920349
14. T Hara 2001 18F-fluorocholine: a new oncologic PET tracer J Nucl Med 42 1815 1817 1:STN:280:DC%2BD38%2FgtlOgsA%3D%3D 11752078
15. R Iwata C Pascali A Bogni S Furumoto K Terasaki K Yanai 2002 [18F]Fluoromethyl triflate, a novel and reactive [18F]fluoromethylating agent: preparation and application to the on-column preparation of [18F]fluorocholine Appl Radiat Isot 57 347 352 1:CAS:528:DC%2BD38XltlegtLk%3D 10.1016/S0969- 8043(02)00123-9 12201141
16. D Kryza V Tadino MA Filannino G Villeret L Lemoucheux 2008 Fully automated [18F]fluorocholine synthesis in the TracerLab MX FDG Coincidence synthesizer Nucl Med Biol 35 255 260 1:CAS:528:DC%2BD1cXhsl2hu70%3D 10.1016/j.nucmedbio.2007.11.008 18312837
17. N Takahashi T Inoue J Lee T Yamaguchi K Shizukuishi 2007 The roles of PET and PET/CT in the diagnosis and management of prostate cancer Oncology 72 226 233 10.1159/000112946 18176088
18. HP Beerlage TM de Reijke JJ de la Rosette 1998 Considerations regarding prostate biopsies Eur Urol 34 303 312 1:STN:280:DyaK1cvit1CjtQ%3D%3D 10.1159/000019746 9748677
19. JP Sedelaar PL Vijverberg TM De Reijke JJ de la Rosette PJ Kil JG Braeckman, et al. 2001 Transrectal ultrasound in the diagnosis of prostate cancer: state of the art and perspectives Eur Urol 40 275 284 1:STN:280:DC%2BD3MnhtVahsw%3D%3D 10.1159/000049787 11684843
20. J Crook S Malone G Perry Y Bahadur S Robertson M Abdolell 2000 Postradiotherapy prostate biopsies: what do they really mean? Results for 498 patients Int J Radiat Oncol Biol Phys 48 355 367 1:STN:280: DC%2BD3cvlvVCjsg%3D%3D 10974448
21. D Pucar T Sella H Schoder 2008 The role of imaging in the detection of prostate cancer local recurrence after radiation therapy and surgery Curr Opin Urol 18 87 97 10.1097/MOU.0b013e3282f13ac3 18090496
22. H Hricak PL Choyke SC Eberhardt SA Leibel PT Scardino 2007 Imaging prostate cancer: a multidisciplinary perspective Radiology 243 28 53 10.1148/radiol.2431030580 17392247
23. E Sala SC Eberhardt O Akin CS Moskowitz CN Onyebuchi K Kuroiwa, et al. 2006 Endorectal MR imaging before salvage prostatectomy: tumor localization and staging Radiology 238 176 183 10.1148/radiol.2381052345 16373766
24. MR Hersh EL Knapp J Choi 2004 Newer imaging modalities to assess tumor in the prostate Cancer Control 11 353 357 15625522
25. L Wang H Hricak MW Kattan HN Chen PT Scardino K Kuroiwa 2006 Prediction of organ-confined prostate cancer: incremental value of MR imaging and MR spectroscopic imaging to staging nomograms Radiology 238 597 603 10.1148/radiol.2382041905 16344335
26. J Scheidler H Hricak DB Vigneron KK Yu DL Sokolov LR Huang, et al. 1999 Prostate cancer: localization with three-dimensional proton MR spectroscopic imaging - clinicopathologic study Radiology 213 473 480 1:STN:280: DC%2BD3c%2FhvV2htA%3D%3D 10551229
27. M Chen HD Dang JY Wang C Zhou SY Li WC Wang, et al. 2008 Prostate cancer detection: comparison of T2-weighted imaging, diffusion-weighted imaging, proton magnetic resonance spectroscopic imaging, and the three techniques combined Acta Radiol 49 602 610 1:CAS:528:DC%2BD1cXhtlWiurnM 10.1080/02841850802004983 18568549
28. DT Schmid H John R Zweifel T Cservenyak G Westera GW Goerres, et al. 2005 Fluorocholine PET/CT in patients with prostate cancer: initial experience Radiology 235 623 628 10.1148/radiol.2352040494 15858102
29. SA Kwee MN Coel J Lim JP Ko 2005 Prostate cancer localization with 18fluorine fluorocholine positron emission tomography J Urol 173 252 255 10.1097/01.ju.0000142099.80156.85 15592091
30. SA Kwee H Wei I Sesterhenn D Yun MN Coel 2006 Localization of primary prostate cancer with dual-phase 18F-fluorocholine PET J Nucl Med 47 262 269 16455632
31. I Igerc S Kohlfurst HJ Gallowitsch S Matschnig E Kresnik I Gomez-Segovia, et al. 2008 The value of 18F-choline PET/CT in patients with elevated PSA-level and negative prostate needle biopsy for localisation of prostate cancer Eur J Nucl Med Mol Imaging 35 976 983 1:STN:280:DC%2BD1c3ksVOjuw%3D%3D 10.1007/s00259-007-0686-9 18188560
32. SA Kwee GP Thibault RS Stack MN Coel B Furusato IA Sesterhenn 2008 Use of step-section histopathology to evaluate 18F-fluorocholine PET sextant localization of prostate cancer Mol Imaging 7 12 20 18384719
33. R Tiguert EL Gheiler MV Tefilli P Oskanian M Banerjee DJ Grignon, et al. 1999 Lymph node size does not correlate with the presence of prostate cancer metastasis Urology 53 367 371 1:STN:280:DyaK1M7ivFygtA%3D%3D 10.1016/S0090-4295(98)00518-4 9933056
34. A Häcker S Jeschke K Leeb K Prammer J Ziegerhofer W Sega, et al. 2006 Detection of pelvic lymph node metastases in patients with clinically localized prostate cancer: comparison of [18F]fluorocholine positron emission tomography-computerized tomography and laparoscopic radioisotope guided sentinel lymph node dissection J Urol 176 2014 2018 10.1016/j.juro.2006.07.037 17070241
35. DB Husarik R Miralbell M Dubs H John OT Giger A Gelet, et al. 2008 Evaluation of [(18)F]-choline PET/CT for staging and restaging of prostate cancer Eur J Nucl Med Mol Imaging 35 253 263 10.1007/s00259-007-0552-9 17926036
36. W Langsteger M Heinisch I Fogelman 2006 The role of fluorodeoxyglucose, 18F-dihydroxyphenylalanine, 18F-choline, and 18F-fluoride in bone imaging with emphasis on prostate and breast Semin Nucl Med 36 73 92 10.1053/j.semnuclmed. 2005.09.002 16356797
37. M Heinisch A Dirisamer W Loidl F Stoiber B Gruy S Haim, et al. 2006 Positron emission tomography/computed tomography with F-18-fluorocholine for restaging of prostate cancer patients: meaningful at PSA <5 ng/ml? Mol Imaging Biol 8 43 48 10.1007/s11307-005-0023-2 16315004
38. M Cimitan R Bortolus S Morassut V Canzonieri A Garbeglio T Baresic, et al. 2006 [18F]Fluorocholine PET/CT imaging for the detection of recurrent prostate cancer at PSA relapse: experience in 100 consecutive patients Eur J Nucl Med Mol Imaging 33 1387 1398 10.1007/s00259-006-0150-2 16865395
39. J Mohler RJ Babaian RR Bahnson B Boston A D'Amico JA Eastham, et al. 2007 Prostate cancer. Clinical practice guidelines in oncology J Natl Compr Canc Netw 5 650 683 17692170
40. E Pelosi V Arena A Skanjeti V Pirro A Douroukas A Pupi, et al. 2008 Role of whole-body 18F-choline PET/CT in disease detection in patients with biochemical relapse after radical treatment for prostate cancer Radiol Med 113 895 904 1:STN:280:DC%2BD1cnpt1GntA%3D%3D 10.1007/s11547-008-0263-8 18414809
41. H Vees F Buchegger S Albrecht H Khan D Husarik H Zaidi, et al. 2007 18F-Choline and/or 11C-acetate positron emission tomography: detection of residual or progressive subclinical disease at very low prostate-specific antigen values (<1 ng/mL) after radical prostatectomy BJU Int 99 1415 1420 1:CAS:528:DC%2BD2sXotFansLw%3D 10.1111/j.1464-410X.2007.06772.x 17428249
42. T Hara 2002 11C-Choline and 2-deoxy-2-[18F]fluoro-D-glucose in tumor imaging with positron emission tomography Mol Imaging Biol 4 267 273 10.1016/S1536-1632(02)00015-X 14537115
43. SA Kwee MN Coel J Lim JP Ko 2004 Combined use of F-18 fluorocholine positron emission tomography and magnetic resonance spectroscopy for brain tumor evaluation J Neuroimaging 14 285 289 15228773
44. SA Kwee JP Ko CS Jiang MR Watters MN Coel 2007 Solitary brain lesions enhancing at MR imaging: evaluation with fluorine 18 fluorocholine PET Radiology 244 557 565 10.1148/radiol.2442060898 17581887
45. N Spaeth MT Wyss B Weber S Scheidegger A Lutz J Verwey, et al. 2004 Uptake of 18F-fluorocholine, 18F-fluoroethyl-L-tyrosine, and 18F-FDG in acute cerebral radiation injury in the rat: implications for separation of radiation necrosis from tumor recurrence J Nucl Med 45 1931 1938 1:CAS:528: DC%2BD2cXhtVKnurrO 15534065
46. Y Yamamoto Y Nishiyama R Kameyama K Okano H Kashiwagi A Deguchi, et al. 2008 Detection of hepatocellular carcinoma using 11C-choline PET: comparison with 18F-FDG PET J Nucl Med 49 1245 1248 10.2967/jnumed.108.052639 18632827
47. N Salem Y Kuang F Wang GT Maclennan Z Lee 2009 PET imaging of hepatocellular carcinoma with 2-deoxy-2[18F]fluoro-D-glucose, 6-deoxy-6[18F] fluoro-D-glucose, [1-11C]-acetate and [N-methyl-11C]-choline Q J Nucl Med Mol Imaging 53 144 156 1:STN:280:DC%2BD1M3hvFGjsw%3D%3D 19039303
48. JN Talbot F Gutman L Fartoux JD Grange N Ganne K Kerrou, et al. 2006 PET/CT in patients with hepatocellular carcinoma using [(18)F]fluorocholine: preliminary comparison with [(18)F]FDG PET/CT Eur J Nucl Med Mol Imaging 33 1285 1289 10.1007/s00259-006-0164-9 16802155
49. M Tian H Zhang N Oriuchi T Higuchi K Endo 2004 Comparison of 11C-choline PET and FDG PET for the differential diagnosis of malignant tumors Eur J Nucl Med Mol Imaging 31 1064 1072 1:CAS:528:DC%2BD2cXmtFWks7w%3D 15014903
50. T Hara K Inagaki N Kosaka T Morita 2000 Sensitive detection of mediastinal lymph node metastasis of lung cancer with 11C-choline PET J Nucl Med 41 1507 1513 1:STN:280:DC%2BD3cvksVemsA%3D%3D 10994730
51. RM Pieterman TH Que PH Elsinga J Pruim JW van Putten AT Willemsen, et al. 2002 Comparison of (11)C-choline and (18)F-FDG PET in primary diagnosis and staging of patients with thoracic cancer J Nucl Med 43 167 172 11850480
52. N Khan N Oriuchi H Zhang T Higuchi M Tian T Inoue, et al. 2003 A comparative study of 11C-choline PET and [18F]fluorodeoxyglucose PET in the evaluation of lung cancer Nucl Med Commun 24 359 366 1:CAS:528: DC%2BD3sXisFCqtbo%3D 10.1097/00006231-200304000-00004 12673163
53. PL Jager TH Que W Vaalburg J Pruim P Elsinga JT Plukker 2001 Carbon-11 choline or FDG-PET for staging of oesophageal cancer? Eur J Nucl Med 28 1845 1849 1:CAS:528:DC%2BD3MXosFagu7c%3D 10.1007/s002590100655 11734925
54. N Khan N Oriuchi H Ninomiya T Higuchi H Kamada K Endo 2004 Positron emission tomographic imaging with 11C-choline in differential diagnosis of head and neck tumors: comparison with 18F-FDG PET Ann Nucl Med 18 409 417 10.1007/BF02984484 15462403
55. H Ninomiya N Oriuchi N Kahn T Higuchi K Endo K Takahashi, et al. 2004 Diagnosis of tumor in the nasal cavity and paranasal sinuses with [11C]choline PET: comparative study with 2-[18F]fluoro-2-deoxy-D-glucose (FDG) PET Ann Nucl Med 18 29 34 1:CAS:528:DC%2BD2cXktlKnsbg%3D 10.1007/BF02985611 15072181
56. T Torizuka T Kanno M Futatsubashi H Okada E Yoshikawa F Nakamura, et al. 2003 Imaging of gynecologic tumors: comparison of (11)C-choline PET with (18)F-FDG PET J Nucl Med 44 1051 1056 1:CAS:528:DC%2BD3sXmtF2msLY%3D 12843219