Immortalization and transformation are associated with specific alterations in choline metabolism

Cancer Research

Volumn 56, Issue 20, 1996, Pages 4630-4635

  Bhakoo, Kishore K ^a   Williams, Stephen R ^a   Florian, Catarina L ^a   Land, Hartmut ^b   Noble, Mark D ^c  

^a ROYAL COLLEGE OF SURGEONS OF ENGLAND   (United Kingdom)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^c UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; CANCER; CANCER CELL; CARCINOGENESIS; CELL IMMORTALIZATION; CELL TRANSFORMATION; NONHUMAN; PRIORITY JOURNAL; RAT; SCHWANN CELL;

ANIMALS; ANTIGENS, VIRAL, TUMOR; CELL DIVISION; CELL LINE, TRANSFORMED; CHOLINE; GLIOBLASTOMA; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MENINGIOMA; NEOPLASMS; NEUROBLASTOMA; PHOSPHORYLCHOLINE; RAS PROTEINS; RATS; SCHWANN CELLS; TUMOR CELLS, CULTURED;

EID: 0029815158     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Urenjak, J., Williams, S R., Gadian, D. G., and Noble, M. Proton nuclear magnetic resonance spectroscopy unambiguously identifies different neural cell types. J Neurosci., 13: 981-989, 1993
2. Bhakoo, K. K , Williams, I T , Williams, S R., Gadian, D. G , and Noble, M. D. Proton nuclear magnetic resonance spectroscopy of primary cells derived from nervous tissue. J Neurochem., 66: 1254-1263, 1996
3. Flonan, C L., Preece, N E , Bhakoo, K K , Williams, S R , and Noble, M D. Cell type-specific fingerprinting of meningioma and meningeal cells by proton nuclear magnetic resonance spectroscopy Cancer Res., 55: 420-427, 1995
4. 3EP MRS of experimental tumours NMR Biomed , 6: 345-365, 1993
5. Daly, P F., and Cohen, J. S Magnetic resonance spectroscopy of tumors and potential in vivo clinical applications: a review. Cancer Res., 49: 770-779, 1989.
6. 1H-MR spectroscopy in vivo: initial experience in patients with cerebral tumours. Radiology, 172: 541-548, 1989
7. Gill, S. S., Thomas, D G. T., van Bruggen, N., Gadian, G. D., Peden, C J., Bell, J. D., Cox, J. I., Menon, D. K., Iles, R. A., and Coutts, G. A Proton NMR spectroscopy of intracranial tumours: in vivo and in vitro studies. J. Comput Assist. Tomogr , 14: 497-504, 1990
8. Langkowski, J H., Wieland, J., Bomsdorf, H , Leibfritz, D., Westphal, M., Offermann, W., and Maas, R. Pre-operative localized in vivo spectroscopy in cerebral tumors at 4.0 Tesla: first results. Magn. Reson. Imaging, 7, 555-574, 1989
9. 1H-NMR spectroscopy in vivo and in vitro. J. Neurochem., 63: 1538-1543, 1994.
10. 31P-NMR. Biochim. Biophys. Acta., 1135: 27-34, 1992
11. 1H NMR analysis at 4.7 and 14.1 Tesla. J. Magn. Reson., 67: 443-450, 1986
12. 31P NMR study. FEBS Lett , 176: 88-92, 1984.
13. 31P NMR spectroscopy. J Biol. Chem., 262: 14875-14878, 1987.
14. 31P NMR analyses of phosphocholine metabolism in rat glioma cells. Magn. Reson. Med , 32: 310-318, 1994.
15. Ridley, A. J., Paterson, H. F., Noble, M., and Land, H. Ras-mediated cell cycle arrest is altered by nuclear oncogenes to induce Schwann cell transformation. EMBO J., 7: 1635-1645, 1988.
16. Brockes, J P , Fields, K. L., and Raff, M. C Studies on cultured rat Schwann cells. I. Establishment of purified populations from cultures of peripheral nerve. Brain Res , 165: 105-118, 1979.
17. Lake, P., Clark, E. A., Khorshidi, M , and Sunshine, G. H. Production and characterization of cytotoxic Thy-1 antibody-secreting hybrid cell lines. Detection of T-cell subsets. Eur. J. Immunol., 9 875-886, 1979.
18. Florian, C L , Williams, S. R , Bhakoo, K. K , and Noble, M. D. Characteristic metabolite profiles revealed by proton nuclear magnetic resonance spectroscopy of human brain and nervous system tumours. NMR Biomed., 8: 253-264, 1996
19. Cadoux-Hudson, T A D , Blackledge, M. J , Rajagopalan, B., Taylor, D. J., and Radda, G. K. Human primary brain-tumour metabolism in vivo: a phosphorus magnetic resonance spectroscopy study. Br. J Cancer, 60: 430-436, 1989.
20. 31P MRS study Br. J. Cancer, 67: 1145-1153, 1993.
21. Negendank, W. Studies of human tumours by MRS a review. NMR Biomed , 5, 303-324, 1992.
22. Smith, T. A. D , Eccles, S , Ormerod, M. G., Tombs, A. J , Titley, J C , and Leach, M. O. The effects of oestrogen ablation on the phospholipid metabolite content of primary and transplanted rat mammary tumours. NMR Biomed., 6: 209-214, 1993.
23. Carnero, A., Cuadrado, A , del Peso, L., and Lacal, J C. Activation of type D phospholipase by serum stimulation and ras-induced transformation in NIH3T3 cells Oncogene, 9: 1387-1395, 1994.
24. Cuadrado, A , Carnero, A., Dolfi, F., Jimenez, B., and Lacal, J. C. Phosphorylcholine: a novel second messenger essential for mitogenic activity of growth factors. Oncogene, 8: 2959-2968, 1993.
25. Murphy-Boesch, J., Stoyanova, R., Srinivasan, R., Willard, T , Vigneron, D., Nelson, S , Taylor, J. S., and Brown, T Proton-decoupled P-31 chemical-shift imaging of the human brain in normal volunteers. NMR Biomed., 6: 173-180, 1993
26. Compere, S. J., Baldacci, P , Sharpe, A H., Thompson, T., Land, H., and Jaenisch, R. The ras and myc oncogenes cooperate in tumor induction in many tissues when introduced into mid-gestation mouse embryos by retroviral vectors Proc Natl. Acad Sci. USA, 86: 2224-2228, 1989.