Tumour phospholipid metabolism

NMR in Biomedicine

Volumn 12, Issue 7, 1999, Pages 413-439

  Podo, F ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

1H MRS; 31P MRS; Phospholipid metabolism; Tumours

Indexed keywords

GLYCEROPHOSPHOETHANOLAMINE; GLYCEROPHOSPHORYLCHOLINE; PHOSPHOETHANOLAMINE; PHOSPHOLIPID; PHOSPHORYLCHOLINE;

BRAIN TUMOR; BREAST TUMOR; CANCER GROWTH; CARCINOGENESIS; CARCINOGENICITY; HUMAN; LYMPHOMA; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHOLIPID METABOLISM; PHOSPHOLIPID SYNTHESIS; PRIORITY JOURNAL; REVIEW;

ANIMALS; ETHANOLAMINES; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; NEOPLASMS; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLETHANOLAMINES; PHOSPHOLIPIDS; PHOSPHORYLCHOLINE;

MAMMALIA;

EID: 0033371680     PISSN: 09523480     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1492(199911)12:7<413::AID-NBM587>3.0.CO;2-U     Document Type: Review

References (242)

1. Vogelstein, B. and Kinzler, K. W. The multistep nature of cancer. Trends Genet. 9, 138-141 (1993).
2. Bishop, J. M. Cancer: the rise of the gene paradigm. Genes Dev. 9, 1309-1315 (1995).
3. Warburg, O. On the origin of cancer cells. Science 123, 309-314 (1956).
4. Pedersen, P. L. Tumor mitochondria and the bioenergetics of cancer cells. Prog. Exp. Tumor Res. 22, 190-274 (1978).
5. Morton, R., Waite, M., Hartz, J., Cunningham, C. and Morris, H. P. The composition and metabolism of microsomal and mitochondrial membrane lipids in the Morris 7777 hepatoma. Adv. Exp. Med. Biol. 92, 381-403 (1977).
6. Crain, R. C., Clark, R. W. and Harvey, B. E. Role of lipid transfer proteins in the abnormal lipid content of Morris hepatoma mitochondria and microsomes. Cancer Res. 43, 3197-3202 (1983).
7. Nishizuka, Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258, 607-614 (1992).
8. J. D. de Certaines, W. M. M. J. Bovée and F. Podo. In Magnetic Resonance Spectroscopy in Biology and Medicine: Functional and Pathological Tissue Characterization, ed. by J. D. de Certaines, W. M. M. J. Boree and F. Pudo. Pergamon Press, Oxford (1992).
9. Gadian, D. G. NMR and its Applications to Living Systems. Oxford University Press, Oxford (1995).
10. F. Podo and J. D. de Certaines. Proceedings of the Special Symposium on Lipid Metabolism and Function in Cancer. Significance of Magnetic Resonance Spectroscopy (MRS) Measurements in Relation to Biochemical Processes and Cellular Control Anticancer Res. 16, 1305-1594 (1996).
11. Bottomley, P. A. Human in vivo NMR Spectroscopy in diagnostic medicine: clinical tool or research probe? Radiology 170, 1-15 (1989).
12. Aisen, A. M. and Chenevent, T. L. MR Spectroscopy: Clinical perspective. Radiology 173, 593-599 (1989).
13. Daly, P. F. and Cohen, J. S. Magnetic resonance Spectroscopy of tumors and potential in vivo clinical applications: a review. Cancer Res. 49, 770-779 (1989).
14. Glickson, J. D. Clinical NMR Spectroscopy of tumors. Current status and future directions. Invest. Radiol. 24, 1011-1016 (1989).
15. 31P nuclear magnetic resonance spectroscopy in the clinical evaluation of intracranial tumors. Magn. Reson. Q. 5, 152-168 (1989).
16. Radda, G. K., Rajagopalan, B. and Taylor, D. J. Biochemistry in vivo: an appraisal of clinical magnetic resonance spectroscopy. Magn. Reson. Q. 5, 122-151 (1989).
17. 31P nuclear magnetic resonance spectroscopy: a review. Cancer Res. 49, 4075-4085 (1989).
18. Bottomley, P. A. The trouble with spectroscopy papers. J. Magn. Reson. Imag. 2, 1-8 (1992).
19. Ruiz-Cabello, J. and Cohen, J. S. Phospholipid metabolites as indicators of cancer cell function. NMR Biomed. 5, 226-233 (1992).
20. Negendank, W. G. Studies of human tumors by MRS: a review. NMR Biomed. 5, 303-324 (1992).
21. Leach, M. O., Le Moyec, L. and Podo, F. MRS of tumours: basic principles. In Magnetic Resonance Spectroscopy in Biology and Medicine, ed. by J. D. de Certaines, W. M. M. J. Bovée and F. Podo, pp 295-344. Pergamon Press, Oxford (1992).
22. 31P MRS of experimental tumours. NMR Biomed. 6, 345-365 (1993).
23. 31P measurements of response to treatment. NMR Biomed. 11, 314-340 (1998).
24. Sijens, P. E. Phosphorus MR spectroscopy in the treatment of human extremity sarcomas. NMR Biomed. 11, 341-353 (1998).
25. 31P MR spectral alterations in human hepatic tumours. NMR Biomed. 11, 354-359 (1998).
26. 31P-NMR studies of a human tumour in situ. The Lancet i, 1435-1436 (1983).
27. 13C resonances. Biochim. Biophys. Acta 805, 104-116 (1984).
28. 31P nuclear magnetic resonance studies of Ehrlich ascites tumor cells. Proc. Natl Acad. Sci. USA 74, 87-91 (1977).
29. 31P nuclear magnetic resonance studies of HeLa cells. Proc. Natl Acad. Sci. USA 74, 4909-4913 (1977).
30. 31P nuclear magnetic resonance. Proc. Natl Acad. Sci. USA, 75, 891-895 (1978).
31. 31P NMR detection of mobile dog brain phospholipids. Magn. Reson. Med. 3, 432-439 (1986).
32. 31P NMR spectra in vivo. Magn. Reson. Med. 12, 282-289 (1989).
33. 31P signal. Magn. Reson. Med. 12, 145-150 (1989).
34. 31P-NMR study of brain phospholipid structures in vivo. Biochim. Biophys. Acta 1085, 257-264 (1991).
35. 31P NMR spectra of human breast tumours in vivo. NMR Biomed. 5, 37-42 (1992).
36. 31P nuclear magnetic resonance spectroscopic investigation of human neuroblastoma in situ. New Engl. J. Med. 23, 1500-1505 (1985).
37. Luyten, P. R. and den Hollander, J. A. Observation of metabolites in the human brain by MR spectroscopy. Radiology 161, 795-798 (1986).
38. Bruhn, H., Frahm, J., Gyngell, M. L., Merboldt, K. D., Hänicke, W., Sauter, R. and Hamburger, C. Noninvasive differentiation of tumors with use of localized H-1 MR spectroscopy in vivo: initial experience in patients with cerebral tumors. Radiology 172, 541-548 (1989).
39. 1H NMR spectra of human brain in vivo. NMR Biomed. 4, 90-98 (1991).
40. Frahm, J., Bruhn, H., Hänicke, W., Merboldt, K.-D., Mursch, K. and Markakis, E. Localized proton NMR spectroscopy of brain tumors using short-echo time STEAM sequences. J. Comput. Assist. Tomogr. 15, 915-922 (1991).
41. 31P chemical shift imaging of the human brain in normal volunteers. NMR Biomed. 6, 173-180 (1993).
42. Keevil, S. F., Barbiroli, B., Collins, D. J., Danielsen, E. R. Hennig, J., Henriksen, O., Leach, M. O., Longo, R., Lowry, M., Moore, C., Moser, E., Segebarth, C., Bovée, W. M. M. J. and Podo, F. Quality assessment in in vivo NMR spectroscopy: IV. A protocol for quality assessment. Magn. Reson. Imag. 13, 139-157 (1995).
43. De Beer, R., Bachert-Baumann, P., Bovée, W. M. J. J., Cady, E., Chambron, J., Dommisse, R., Van Echteld, C. J. A., Mathur-De Vré, R. and Williams, S. R. Quality assessment in in vivo NMR spectroscopy: VI. Multicentre quantification of MRS test signals. Magn. Reson. Imag. 13, 169-176 (1995).
44. Keevil, S. F., Barbiroli, B., Brooks, J. C. W., Cady, E. B., Canese, R., Carlier, P., Collins, D. J., Gilligan, P., Gobbi, G., Hennig, J., Kügel., H., Leach, M. O., Metzler, D., Mlynárik, V., Moser, E., Newbold, M. C., Payne, G. S., Ring, P., Roberts, J. N., Rowland, I. J., Thiel, T., Tkác, I., Topp, S., Wittsack, H. J., Wylezinska, M., Zaniol, P., Henriksen, O. and Podo, F. Absolute metabolite quantification by in vivo NMR spectroscopy: II. A multicentre trial of protocols for in vivo localized proton studies of human brain. Magn. Reson. Imag. 16, 1093-1106 (1998).
45. Bovée, W., Canese, R., Decorps, M., Forssell-Aronsson, E., Le Fur, Y., Howe, F., Karlsen, O., Knijn, A., Kontaxis, G., Kügel, H., McLean, M., Podo, F., Slotboom, J., Vikhoff, B. and Ziegler, A. Absolute metabolite quantification by in vivo NMR spectroscopy: IV. Multicentre trial on MRSI localisation tests. Magn. Reson. Imag. 16, 1113-1125 (1998).
46. Negendank, W., Sauter, R., Brown, T. R., Evelhoch, J. L., Falini, A., Gotsis, E. D., Heerschap, A., Kamada, K., Lee, B. C. P., Mengeot, M. M., Moser, E., Padavic-Shaller, K. A., Sanders, J. A., Spraggins, T. A., Stillman, A. E., Terwey, B., Vogl, T. J., Wicklow, K. and Zimmerman, R. A. Proton magnetic resonance spectroscopy in patients with glial tumors: a multicenter study. J. Neurosurg. 84, 449-158 (1996).
47. 1H MR spectroscopy in patients with metastatic brain tumors: a multicentre study. Magn. Reson. Med. 33, 818-826 (1995).
48. 31P nuclear magnetic resonance analysis of interferon-induced alterations of phospholipid metabolism in interferon-sensitive and interferon-resistant Friend leukemia cell tumors in mice. Cancer Res. 46, 2849-2857 (1986).
49. Podo, F., Carpinelli, G., Di Vito, M., Giannini, M., Proietti, E., Fiers, W., Gresser, I. and Belardelli, F. Nuclear magnetic resonance analysis of tumor necrosis factor-induced alterations of phospholipid metabolites and pH in Friend leukemia cell tumors and fibrosarcomas in mice. Cancer Res. 47, 6481-6489 (1987).
50. Belardelli, F., Proietti, E., Ciolli, V., Sestili, P., Carpinelli, G., Di Vito, M., Ferretti, A., Woodrow, D., Boraschi, D. and Podo, F. Interleukin-1-β induces tumor necrosis and early morphologic and metabolic changes in transplantable mouse tumors. Similarities with the anti-tumor effects of tumor necrosis factor χ or β Int. J. Cancer 44, 116-123 (1989).
51. Bravo, E., Carpinelli, G., Proietti, E., Belardelli, F., Cantafora, A. and Podo, F. Alterations of lipid composition in Friend leukemia cell tumors in mice treated with tumor necrosis factor. FEBS Lett. 260, 220-224 (1990).
52. 31P MRS of human tumor cells: effects of culture media and conditions on phospholipid metabolite concentrations. Anticancer Res. 16, 1365-1374 (1996).
53. Agris, P. F. and Campbell, I. D. Proton nuclear magnetic resonance of intact Friend leukemia cells: phosphocholine increase during differentiation. Science 216, 1325-1327 (1982).
54. 31P NMR study. FEBS Lett. 176, 88-92 (1984).
55. 1H NMR studies. Israel J. Chem. 32, 47-54 (1992).
56. 31P NMR spectroscopy. J. Biol. Chem. 262, 14875-14878 (1987).
57. 31P NMR in man and animal models. Ann. N.Y. Acad. Sci. 508, 300-308 (1987).
58. Miceli, M. V., Lou-sing Kan and Newsome D.A. Phosphorus-31 nuclear magnetic spectroscopy of human retinoblastoma cells: correlation with metabolic indices. Biochim. Biophys. Acta 970, 262-269 (1988).
59. 13C studies of choline and ethanolamine uptake. Biochim. Biophys. Acta 1095, 5-16 (1991).
60. 31P magnetic resonance studies. J. Biol. Chem. 266, 3688-3694 (1991).
61. Pelech, S. L. and Vance, D. E. Signal transduction via phosphatidylcholine cycles. Trends Biochem. Sci. 14, 28-30 (1989).
62. Kiss, Z. and Anderson, W. B. Phorbol ester stimulates the hydrolysis of phosphatidylethanolamine in leukemic HL-60, NIH 3T3 and baby hamster kidney cells. J. Biol. Chem. 264, 1483-1487, 1989.
63. Fisher, G. J., Henderson, P. A., Voohees, J. J. and Baldassare, J. Epidermal growth factor-induced hydrolysis of phosphatidylcholine by phospholipase D and phospholipase C in human dermal fibroblasts. J. Cell Physiol. 146, 309-317 (1991).
64. Radda, G. K., Dixon, R. M. and Wood C. A. N.m.r. studies on phospholipid metabolism and cell proliferation. Biochem. Soc. Trans. 19, 995-996 (1991).
65. Podo, F. and de Certaines, J. D. Magnetic resonance spectroscopy in cancer: phospholipid, neutral lipid and lipoprotein metabolism and function. Anticancer Res. 16, 1305-1316 (1996).
66. Jackowski, S. Cell cycle regulation of membrane phospholipid metabolism. J. Biol. Chem. 271, 20219-20222 (1996).
67. 31P MRS study. Br. J. Cancer 67, 1145-1153 (1993).
68. Oberhaensli, R. D., Hilton-Jones, D., Bore, P. J., Hands, L. J., Rampling, R. P. and Radda, G. K. Biochemical investigation of human tumours in vivo by phosphorus-31 magnetic resonance spectroscopy. Lancet ii, 8-11 (1986).
69. Sijens, P. E., Wijrdeman, H. K., Moerland, M. A., Bakker, C. J. G., Vermeulen, J. W. A. and Luyten, P. R. Human breast cancer in vivo: H-1 and P-31 spectroscopy at 1.5 T. Radiology 169, 615-620 (1988).
70. 31P NMR spectra from human breast tumours: variations in phospholipid metabolism. Br. J. Cancer 63, 514-516 (1991).
71. Redmond, O. M., Stack, J. P., O'Connor, N. G., Codd, M. B. and Ennis, J. T. In vivo phosphorus-31 magnetic resonance spectroscopy of normal and pathological breast tissues. Br. J. Radiol. 64, 210-216 (1991).
72. Merchant, T. E., Thelissen, G. R. P., de Graaf, P. W., den Otter, W. and Glonek, T. Clinical magnetic resonance spectroscopy of human breast disease. Invest. Radiol. 26, 1053-1059 (1991).
73. Degani, H., Horowitz, A. and Itzchak, I. Breast tumors: evaluation with P-31 MR spectroscopy. Radiology 161, 53-55 (1986).
74. 31P magnetic resonance spectroscopic profiles of neoplastic human breast tissues. Cancer Res. 48, 5112-5118 (1988).
75. Barzilai, A., Horowitz, A., Geier, A. and Degani, H. Phosphate metabolites and steroid hormone receptors of benign and malignant breast tumors. Cancer 67, 2919-2925 (1991).
76. 31P NMR spetroscopy. NMR Biomed. 4, 262-267 (1991).
77. Smith, T. A. D., Bush, C., Jameson, C., Titley, J. C., Leach, M. O., Wilman, D. E. and McCready, V. R. Phospholipid metabolites, prognosis and proliferation in human breast carcinoma. NMR Biomed. 6, 318-323 (1993).
78. 31P MRS in situ. Magn. Reson. Med. 10, 125-134 (1989).
79. 31P magnetic resonance spectroscopy for monitoring treatment response in breast cancer. Lancet, i, 1326-1327 (1989).
80. Redmond, O. M., Stack, J. P., O'Connor, N., Carney, D. N., Dervan, P. A., Hurson B. J., Ennis J. T. P-31 MRS as an early prognostic indicator of patient response to chemotherapy. Magn. Reson. Med. 25, 30-44 (1992).
81. Twelves, C. J., Porter, D. A., Lowry, M., Dobbs, N. A., Graves, P. E., Smith, M. A., Rubens, R. D. and Richards, M. A. Phosphorus-31 metabolism of post-menopausal breast cancer studied in vivo by magnetic resonance spectroscopy. Br. J. Cancer 69, 1151-1156 (1994).
82. 31P-NMR spectroscopy of human cancer cells proliferating in a basement membrane gel. FASEB J. 2, 2596-2604 (1988).
83. Ronen, S. M. and Degani, H. Studies of the metabolism of human breast cancer spheroids. Magn. Reson. Med. 12, 274-281 (1989).
84. 31P nuclear magnetic resonance study. Cancer Res. 50, 552-557 (1990).
85. Ronen, S. A., Stier, A. and Degani, H. NMR studies of the lipid metabolism of T47D human breast cancer spheroids. FEBS Lett. 266, 147-149 (1990).
86. Freyer, J. P., Schor, P. L., Jarrett, K. A., Neeman, M. and Sillerud, L. O. Cellular energetics measured by phosphorous nuclear magnetic resonance spectroscopy are not correlated with chronic nutrient deficiency in multicellular tumor spheroids. Cancer Res. 51, 3831-3837 (1991).
87. Ting, Y.-L.T., Sherr, D. and Degani, H. Variations in the energy and phospholipid metabolism in normal and cancer human mammary epithelial cells. Anticancer Res. 16, 1381-1388 (1996).
88. Aiken, N. R. and Gillies, R. J. Phosphomonoester metabolism as a function of cell proliferative status and exogenous precursors. Anticancer Res. 16, 1393-1397 (1996).
89. 31P MRS studies of phosphomonoester metabolism in human breast cancer cells: tumorigenicity and growth status. 5th Meeting of the International Society for Magnetic Resonance in Medicine, Abstr., p. 1103 (1997).
90. 31P-MRS of human tumor cells: influence of culture medium components on phosphate metabolite profiles. 6th Annual Meeting of the International Society of Magnetic Resonance in Medicine, Abstr., p. 1682 (1998).
91. Neeman, M. and Degani, H. Metabolic studies of estrogen- and tamoxifen-treated human breast cancer cells by nuclear magnetic resonance spectroscopy. Cancer Res. 49, 589-594 (1989).
92. Smith, T. A. D., Eccles, S., Ormerod, M. G., Tombs, A. J., Titley, J. C. and Leach, M. O. The phosphocholine and glycerophosphocholine content of an oestrogen-sensitive rat mammary tumour correlates strongly with growth rate. Br. J. Cancer 64, 821-826 (1991).
93. Mueller-Klieser, W. Multicellular spheroids: a review on cellular aggregates in cancer research. J. Cancer Res. Clin. Oncol. 113, 101-122 (1987).
94. Freyer, J. P., Fink, N. H., Neeman, M., Schor, P. L., Coulter, J. R. and Sillerud, L. O. A system for viably maintaining a stirred suspension of multicellular spheroids during NMR spectroscopy. NMR Biomed. 3, 195-205 (1990).
95. Freyer, J. P., Linford, H., Lovejoy, V. and Moore, G. M. Correlation between alterations in phosphomonoesters and cellular proliferation during recovery from quiescence in a tumour model. 2nd Meeting of the International Society of Magnetic Resonance in Medicine, Abstr., p. 451 (1994).
96. Aiken, N. R., Ting, Y.-L.T., Zhao, M. and Gillies, R. J. Ethanolamine metabolism in human breast cancer cells as a function of metastatic potential: MRS and radiotracer analyses. 6th Annual Meeting of the International Society of Magnetic Resonance in Medicine, Abstr., p. 615 (1998).
97. Smith, T. A. D., Eccles, S., Box, G., Titley, J. C., Leach, M. O. and McCready, V. R. Phosphocholine and choline content of rat sarcoma cells grown in the presence and absence of serum. Anticancer Res. 16, 1389-1392 (1996).
98. 31P NR study in vivo and in vitro. 6th Annual Meeting of the International Society of Magnetic Resonance in Medicine, Abstr., p. 610 (1998).
99. Aboagye, E. O. and Bhujwalla, Z. M. Malignant transformation alters membrane choline phospholipid metabolism of human mammary epithelial cells. Cancer Res. 59, 80-84 (1999).
100. Bhakoo, K. K., Williams, S. R., Florian, C. L., Land, H. and Noble, M. D. Immortalization and transformation are associated with specific alterations in choline metabolism. Cancer Res. 56, 4630-4635 (1996).
101. Mackinnon, W. B., Barry, P. A., Malycha, P. L., Gillet, D. J., Russell, P., Lean, C. L., Doran, S. T., Barraclough, B. H., Bilous, M., Mountford, C. E. Fine-needle biopsy specimens of benign breast lesions distinguished from invasive cancer ex vivo with proton MR spectroscopy. Radiology 204, 661-666 (1997).
102. Preul, M. C., Caramanos, Z., Collins, D. L., Villemure, J.-G., Leblanc, R., Olivier, A., Pokrupa, R. and Arnold, D. L. Accurate, non-invasive diagnosis of human brain tumors by using proton magnetic resonance spectroscopy. Nature Med. 2, 323-325 (1996).
103. 1H NMR spectroscopy in vivo and in vitro. J. Neurochem. 63, 1538-1543 (1994).
104. 1H MRS analysis of human brain tumors. Anticancer Res. 16, 1559-1564 (1996).
105. 31P MRS brain examination. 6th Annual Meeting of the International Society for Magnetic Resonance in Medicine, Abstr., p. 30 (1998).
106. Narayana, P. A., Johnston, D. and Flaming, D. P. In vivo proton magnetic resonance spectroscopy studies of human brain. Magn. Reson. Imag. 9, 303-308 (1991).
107. Hennig, J., Pfister, H., Ernst, T. and Ott, D. Direct absolute quantification of metabolites in the human brain with in vivo localized proton spectroscopy. NMR Biomed. 5, 193-199 (1992).
108. Barker, P. B., Soher, B. J., Blackband, S. J., Chatham, J. C., Mathews, V. P. and Bryan, N. Quantitation of proton NMR spectra of the human brain using tissue water as an internal concentration reference. NMR Biomed. 6, 89-94 (1993).
109. Michaelis, T., Merboldt, K.-D., Bruhn, H., Hänicke, W. and Frahm, J. Absolute concentrations of metabolites in the adult human brain in vivo: quantification of localized proton MR spectra. Radiology 187, 219-227 (1993).
110. 1H-MRS using water as an internal standard. Magn. Reson. Imag. 2, 107-118 (1993).
111. Kreis, R., Ernst, T. and Ross, B. D. Absolute quantitation of water and metabolites in the human brain. II. Metabolite concentrations. J. Magn. Reson. B 102, 9-19 (1993).
112. Tofts, P. B., Christiansen, P., Pryds, O., Lou, H. and Henriksen, O. T1, T2 and concentrations of brain metabolites in neonates and adolescents estimated with H-1 MR spectroscopy. J. Magn. Reson. Imag. 4, 1-5 (1994).
113. Danielsen, E. R. and Henriksen, O. Absolute quantitative proton NMR spectroscopy based on the amplitude of the local water suppression pulse. Quantification of brain water and metabolites. NMR Biomed. 7, 311-318 (1994).
114. Husted, C. A., Dujin, J. H., Matson, G. B., Maudsley, A. A. and Weiner, M. W. Molar quantitation of in vivo proton metabolites in human brain with 3D magnetic resonance spectroscopic imaging. Magn. Reson. Imag. 12, 661-667 (1994).
115. Petroff, O. A. C., Spencer, D. D., Alger, J. R. and Prichard, J. W. High-field proton magnetic resonance spectroscopy of human cerebrum obtained during surgery from epilepsy. Neurology 39, 1197-1202 (1989).
116. 1H-magnetic resonance spectroscopy of pediatric posterior fossa tumors in vitro. J. Neurosurg. 81, 443-448 (1994).
117. Kinoshita, Y and Yokota, A. Absolute concentrations of metabolites in human brain tumors using in vitro proton magnetic resonance spectroscopy. NMR Biomed. 10, 2-12 (1997).
118. 1H NMR spectroscopy studies of extracts of human cerebral neoplasms. Magn. Reson. Med. 24, 123-136 (1992).
119. Gill, S. S., Thomas, D. G. T., van Bruggen, N., Gadian, D. G., Peden, C. J., Bell, J. D., Cox, I. J., Menon, D. K., Iles, D. G., Bolyant, D. J. and Coutts, G. A. Proton MR spectroscopy of intracranial tumours: in vivo and in vitro studies. J. Comput. Assist. Tomogr. 14, 497-504 (1990).
120. Clarke, D. D., Lajtha, A. L. and Maker, H. S. Intermediary metabolism. In Basic Neurochemistry. ed. by G. Siegel, B. Agranoff, R. W. Albers and P. Molinoff, 4th edn, pp. 541-565. Raven, New York (1973).
121. Kinoshita, Y., Yokota, A. and Koga, Y. Phosphorylethanolamine content of human brain tumors. Neurol. Med. Chir. (Tokyo) 34, 803-806 (1994).
122. Perry, T. L., Berry, K., Hansen, S., Diamond, S. and Mok, C. Regional distribution of amino acids in human brain obtained at autopsy. J. Neurochem. 18, 513-519 (1971).
123. Perry, T. L., Hansen, S., Berry, K., Mok, C. and Lesk, D. Free amino acids and related compounds in biopsies of human brain. J. Neurochem. 18, 521-528, 1971.
124. Hubesch, B., Sappey-Marinier, D., Roth K., Meyerhoff, D. J., Matson, G. B., Weiner, M. W. P-31 MR spectroscopy of normal human brain and brain tumors. Radiology 174, 401-409 (1990).
125. Cadoux-Hudson, T. A. D., Blackledge, M. J., Rajagopalan, B., Taylor, D. J. and Radda, G. K. Human primary brain tumour metabolism in vivo: a phosphorus magnetic resonance spectroscopy study. Br. J. Cancer 60, 430-436 (1989).
126. Segebarth, C., Balériaux, D., Arnold, D. L., Lyten, P. R. and den Hollander, J. A. MR image-guided P-31 MR spectroscopy in the evaluation of brain tumor treatment. Radiology 165, 215-219 (1987).
127. 1H NMR spectroscopic imaging. Magn. Reson. Med. 13, 62-76 (1990).
128. Kalra, R., Wade, K. E., Cadoux-Hudson, T. A. D., Parkers, H. G., McDonald, B., Esiri, M. and Radda, G. K. NMR study of phospholipid metabolism of human meningioma. 10th Annual Meeting of the Society of Magnetic Resonance in Medicine, Abstr., p. 628 (1991).
129. Urenjak, J., Williams, S. R., Gadian, D. G. and Noble, M. Proton nuclear magnetic resonance spectroscopy unambiguously identifies different neural cell types. J. Neurosci. 13, 981-985 (1993).
130. 31P NMR analyses of phosphocholine metabolism in rat glioma cells. Magn. Reson. Med. 32, 310-318 (1994).
131. 31P MR spectra from patients with hepatic lymphoma. A possible marker of liver infiltration and response to chemotherapy. Br. J. Cancer 63, 953-958 (1991).
132. Dixon, R. M. NMR studies of phospholipid metabolism in hepatic lymphoma. NMR Biomed. 11, 370-379 (1998).
133. 31P MRS in situ. Int. J. Radiat. Oncol. Biol. Phys. 13, 1545-1551 (1987).
134. Bryant, D. J., Bydder, G. M., Case, H. A., Collins, A. G., Cox, I. J., Makepeace, A. and Pennok, J. M. Use of phosphorus-31 MR spectroscopy to monitor response to chemotherapy in non-Hodgkin lymphoma. J. Comput. Assist. Tomogr. 12, 770-774 (1988).
135. 31P magnetic resonance spectroscopy. Br. J. Cancer 61, 485-490 (1990).
136. 31P magnetic resonance spectroscopy study in non-Hodgkin's lymphoma. Br. J. Radiol 64, 923-928 (1991).
137. Karczmar, G. S., Meyerhoff, D. J., Boska, M. D., Hubesch, B., Poole, J., Matson, G. B., Valone, F. and Weiner, M. W. P-31 spectroscopy study of response of superficial tumours to therapy. Radiology 179, 149-153 (1991).
138. Meyerhoff, D. J., Maudsley, A. A., Schaefer, S. and Weiner, M. W. Phosphorus-31 magnetic reonance metabolite imaging in the human body. Magn. Reson. Imag. 10, 245-256 (1992).
139. Negendank, W. G., Padavic-Shaller, K. A., Li, C.-W., Murphy-Boesch, J. Stoyanova, R., Krigel, R. L., Schilder, R. J., Smith, M. R. and Brown, T. R. Metabolic characterization of human non-Hodgkin's lymphomas in vivo with the use of proton-decoupled phosphorus magnetic resonance spectroscopy. Cancer Res. 55, 3286-3294 (1995).
140. 14C-radiolabelled compounds in vivo. Biochim. Biophys. Acta 1181, 111-121 (1993).
141. 31P magnetic resonance spectroscopy in vivo and in vitro. Br. J. Cancer 69, 633-640 (1994).
142. 13C NMR study. Anticancer Res. 16, 1351-1356 (1996).
143. 31P-NMR spectra of human peripheral blood lymphocytes. Biochim. Biophys. Acta 888, 282-285 (1986).
144. 31P-NMR spectroscopy: in vivo monitoring of the local anti-tumor effects of systemic immune cell transfer. Int. J. Cancer 66, 484-495 (1996).
145. 1H NMR studies of ethanolamine-linked phosphoglycerides metabolism in human T lymphocytes. Cell. Mol. Biol. 37, 705-711 (1991).
146. 31P-NMR study. Biochim. Biophys. Acta 1093, 29-35 (1991).
147. Ishidate, K. 'Chol'ine transport and choline kinase. In Phosphatidylcholine Metabolism, ed. by D. E. Vance, pp. 9-32. CRC Press, Boca Raton, FL (1989).
148. Bligh, J. The level of free choline in plasma. J. Physiol. 117, 234-240 (1952).
149. Appleton, H. D., La Du, B. N., Levy, B. B., Steele, J. M. and Brodie, B. B. A chemical method for the determination of free choline in plasma. J. Biol. Chem. 205, 803-813 (1953).
150. Pomfret, E. A., da Costa, K.-A., Schutman, L. L. and Zeisel, S. H. Measurement of choline and choline metabolite concentrations using high-pressure liquid chromatography and gas chromatography-mass spectrometry. Anal. Biochem. 180, 85-90 (1989).
151. Shiao, Y. J. and Vance, J. E. Evidence for an ethanolamine cycle. Differential recycling of the ethanolamine moiety of phosphatidylethanolamine derived from phospatidylserine and ethanolamine. Biochem. J. 310, 673-679 (1995).
152. Houweling, M., Tijburg, L. B. M., Vaartijes, W. J. and van Golde, L. M. G. Phosphatidylethanolamine metabolism in rat liver after partial hepatectomy. Control of biosynthesis of phosphatidylethanolamine by the availability of ethanolamine. Biochem. J. 283, 55-61 (1992).
153. 31P-NMR. Biochim. Biophys. Acta 1135, 27-34 (1992).
154. Meyerhoff, D. J., Karczmar, G. S., Vaìone, F., Venook, A., Matson, G. B. and Weiner, M. W. Hepatic cancers and their response to chemoembolization therapy. Invest. Radiol. 27, 456-464 (1992).
155. Massarelli, R., Mykita, S., Sorrentino, G. The supply of choline to glial cells. In Astrocytes Vol. 2 Biochemistry, Physiology and Pharmacology of Astrocytes, ed. by S. Fedoroff and A. Vernadakis, pp. 155-178. Academic Press, Orlando (1986).
156. Okumura, N., Otsuki, S. and Kameyama, A. Studies on free amino acids in human brain. J. Biochem. 47, 315-320 (1960).
157. Blustajn, J. K., Lopez Gonzales-Coviello, I., Logue, M., Growdon, J. H., Wurtman, R. J. Levels of phospholipid catabolic intermediates, glycerophosphocholine and glycerophosphoethanolamine, are elevated in brains of Alzheimer's disease but not of Down's syndrome patients. Brain Res. 536, 240-244 (1990).
158. 31P NMR studies during the development of chick embryo nervous system. Seventh Meeting of the Society of Magnetic Resonance in Medicine, Abstr., p. 501 (1988).
159. Cady, E. B., Costello, A. M. de L., Dawson, M. J., Delpy, D. T., Hope, P. L., Reynolds, E. O. R., Tofts, P. S. and Wilkie, D. R. Non-invasive investigation of cerebral metabolism in newborn infants by phosphorus nuclear magnetic resonance spectroscopy. Lancet i, 1059-1062 (1983).
160. Younkin, D. P., Delivoria-Papadopoulos, M., Leonard, J. C., Harihara-Subramanian, V., Eleff, S., Leign, J. S. and Chance, B. Unique aspects of human newborn cerebral metabolism evaluated with phosphorus magnetic resonance spectroscopy. Ann. Neurol. 16, 581-586 (1984).
161. 31P nuclear magnetic resonance studies of phosphoglyceride metabolism in developing and degenerating brain: preliminary observations. J. Neuropath. Exp. Neurol. 46, 419-430 (1987).
162. Peden, C. J., Cowan, F. M., Bryant, D J., Sargentoni, J., Cox, I. J., Menon, D. K., Gadian, D. G., Bell, J. D. and Dubowitz, L. M. Proton MR spectroscopy of the brain in infants. J. Comput. Assist. Tomogr. 14, 886-894 (1990).
163. 1H magnetic resonance spectroscopy of rat brain extracts compared with chromatographic methods. Neurochem. Res. 15, 1009-1016 (1990).
164. van der Knaap, M. S., van der Grond, J., van Rijen, P. C., Faber, J. A. J., Valk, J., Willemse, K. Age dependent changes in localized proton and phosphorus MR spectroscopy of the brain. Radiology, 176, 509-515 (1990).
165. 1H spectroscopy in developing human brain. Pediatr. Res. 30, 574-578 (1991).
166. Kreis R., Ernst, T., Ross, B. D. Development of the human brain: in vivo quantification of metabolite and water content with proton magnetic resonance spectroscopy. Magn. Reson. Med. 30, 424-437 (1993).
167. Carpinelli, G., Granata, F., Iorio, E., Ferretti, A., Podo, F. Alternations in the levels of phosphocholine and phosphoethanolamine during myogenesis. Anticancer Res. 15, 1688 (1995).
168. Bucher, N. L. R. and Malt, R. A. Regeneration of Liver and Kidney. Little, Brown, Boston, MA (1971).
169. Meyerhoff, D. J., Boska, M. D., Thomas, A. M. and Weiner, M. W. Alcoholic liver disease: quantitative image-guided P-31 MR spectroscopy. Radiology 173, 393-400 (1989).
170. 31P nuclear magnetic resonance spectroscopy. Clin. Sci. 78, 33-38 (1990).
171. Oberhaensli, R. D., Rajagopalan, B., Galloway, G. J., Taylor, D. J. and Radda, G. K. Study of human liver disease by P-31 magnetic resonance spectroscopy. Gut 31, 463-467 (1990).
172. Vance, D. E. (ed.) Phosphatidylcholine Metabolism. CRC Press, Boca Raton, FL (1989).
173. Exton, J. H. Signaling through phosphatidylcholine breakdown. Minireview. J. Biol. Chem. 265, 1-4 (1990).
174. Billah, M. M. and Antes, J. C. The regulation and cellular functions of phosphatidylcholine hydrolysis. Review article. Biochem. J. 269, 281-291 (1990).
175. Tronchère, H., Record, M., Tercé, F., Chap, H. Phosphatidylcholine cycle and regulation of phosphatidylcholine biosynthesis by enzyme translocation. Biochim. Biophys. Acta 1212, 137-151 (1994).
176. Exton, J. New developments in phospholipase D. J. Biol. Chem. 272, 15579-15582 (1997).
177. Kennedy, E. P. and Weiss, S. B. The function of cytidine coenzymes in the biosynthesis of phospholipids. J. Biol. Chem. 222, 193-214 (1956).
178. Kennedy, E. P. The biosynthesis of phospholipids. In Lipids and Membranes: Past, Present and Future, ed. by J. A. F. Op denKamp, B. Roclofsen, K. W. A. Wirtz, pp. 171-206. Elsevier Science, Amsterdam (1986).
179. Moreau, P. and Cassagne, C. Phospholipid trafficking and membrane biogenesis. Biochim. Biophys. Acta 1197, 257-290 (1994).
180. Ishidate, K. Choline/ethanolamine kinase from mammalian tissues. Biochim. Biophys. Acta 1348, 70-78 (1997).
181. Cornell, R. Cholinephosphotransferase. In Phosphatidylcholine Metabolism, ed. by D. E. Vance, pp. 47-64. CRC Press, Boca Raton, FL (1989).
182. Vance, D. E. CTP: cholinephosphate cytidylyltransferase. In Phosphatidylcholine Metabolism, ed. by D. E. Vance, pp. 33-45. CRC Press, Boca Raton, FL (1989).
183. Jamil, H., Hatch, G. M. and Vance, D. E. Evidence that binding of CTP:phosphocholine cytidylyltransferase to membranes in rat hepatocytes is modulated by the ratio of bilayer-non-bilayer-forming lipids. Biochem. J. 291, 419-427 (1993).
184. Brindley, D. N. Intracellular translocation of phosphatidate phosphohydrolase and its possible role in the control of glycerolipid synthesis. Prog. Lipid Res. 23, 115-133 (1984).
185. Kanoh, H., Kai, M. and Wada, I. Phosphatidic acid phosphatase from mammalian tissues: discovery of channel-like proteins with unexpected functions, Biochim. Biophys. Acta 1348, 56-62 (1997).
186. Besterman, J. M., Pollenz, R. S., Booker, E. L. and Cuatrecasas, P. Diacylglycerol-induced translocation of diacylglycerol kinase: use of affinity-purified enzyme in a reconstitution system. Proc. Natl Acad. Sci. USA, 83, 9378-9382 (1986).
187. Kanfer, J. N. The base exchange enzymes and phospholipase D of mammalian tissue. Can. J. Biochem. 58, 1370-1380 (1980).
188. Ridgway, N. D. Phosphatidylethanolamine N-methyltransferase. In Phosphatidylcholine Metabolism, ed. by D. E. Vance, pp. 104-120. CRC Press, Boca Raton, FL (1989).
189. Sundler, R. and Åkesson, B. Regulation of phospholipid biosynthesis in isolated rat hepatocytes. J. Biol. Chem. 250, 3359-3367 (1975).
190. Hirata, F. and Axelrod, J. Phospholipid methylation and biological signal transmission. Science 209, 1082-1090 (1980).
191. Berridge, M. J. and Irvine, R. F. Inositol phosphates and cell signalling. Nature 341, 197-205 (1989).
192. Zeisel, S. H. Choline phospholipids: signal transduction and carcinogenesis. FASEB J. 17, 551-557 (1993).
193. Mountford, C. E., Lena, C. L., Mackinnon, W. B., Russell, P. The use of proton MR in cancer pathology. Annual Report on NMR Spectroscopy, ed. by G. A. Webbs, Vol 27, pp. 173-215. Academic Press, New York (1993).
194. Mountford, C. E., Mackinnon, W. E. B., Russell, P., Rutter, A., Delikatny, E. J. Human cancers detected by proton MRS and chemical shift imaging ex vivo. Anticancer Res. 16, 1521-1532 (1996).
195. May, G. L., Wright, L. C., Holmes, K. T., Williams, P. G., Smith, I. C. P., Wright, P. E., Fox, R. M. and Mountford, C. E. Assignment of methylene proton resonances in NMR spectra of embryonic and transformed cells to plasma membrane triglyceride. J. Biol. Chem. 261, 3048-3053 (1986).
196. 1H MR spectrum in murine T-cells and B-cells occurs in G1 phase. Magn. Reson. Med. 16, 1-8 (1990).
197. 1H NMR visible neutral lipids in activated T lymphocytes: relationship to phosphatidylcholine cycle. Biochim. Biophys. Acta 1303, 215-221 (1996).
198. 1H-NMR-detectable mobile lipid in stimulated lymphocytes: relationship to cellular activation, the cell cycle, and phosphatidylcholine-specific phospholipase C. Biochem. Biophys. Res. Commun. 239, 868-874 (1997).
199. 1H NMR-detectable mobile lipid domains in NIH-3T3 fibroblasts Biochim. Biophys. Acta 1438, 329-348 (1999).
200. Hodgkin, M. N., Pettitt, T. R., Martin, A., Michell, R. H., Pemberton, A. J. and Wakelam, J. O. Diacylglycerols and phosphatidates: which molecular species are intracellular messengers? Trends Biochem. Sci. 23, 200-204 (1998).
201. 2 superfamily of signal transduction enzymes. Trends Biochem. Sci. 22, 1-2 (1997).
202. 2+. Biochem. J. 208, 845-850 (1982).
203. Ferretti, A., Podo, F., Carpinelli, G., Chen, L. L., Borghi, P. and Masella, R. Detection of neutral phosphatidylcholine-specific phospholipase C in Friend leukemia cells before and after erythroid differentiation. Anticancer Res. 13, 2309-2318 (1993).
204. Podo, F., Ferretti, A., Knijn, A., Zhang, P., Ramoni, C., Barletta, B., Pini, C., Baccarini, S., Pulciani, S. Detection of phosphatidylcholine-specific phospholipase C in NIH-3T3 fibroblasts and their H-ras transformants: NMR and immunochemical studies. Anticancer Res. 16, 1399-1412 (1996).
205. Wolf, R. A. and Gross, R. W. Identification of neutral active phospholipase C with hydrolyses choline glycerophospholipids and plasmalogen selective phospholipase A2 in canine myocardium. J. Biol. Chem. 260, 7295-7303 (1985).
206. Garcia de Herreros, A., Dominguez, I., Diaz-Meco, M. T., Graziani, G., Cornet, M. E., Guddal, P. H., Johansen, T. and Moscat, J. Requirement of phospholipase C-catalyzed hydrolysis of phosphatidylcholine for maturation of Xenopus laevis oocytes in response to insulin and ras p21. J. Biol. Chem. 266, 6825-6829 (1991).
207. Exton, J. Phospholipase D. Biochim. Biophys. Acta 1436, 105-115 (1998).
208. George, T. P., Morash, S. C., Cook, H. W., Byers, D. M., St. Claire Palmer, F. B. and Spence, M. W. Phosphatidylcholine biosynthesis in cultured glioma cells: evidence for channeling of intermediates. Biochim. Biophys. Acta 1004, 283-291 (1989).
209. 2+. J. Biol. Chem. 266, 12419-12423 (1991).
210. Tijburg, L. B. M., Geelen, M. J. H. and van Golde, L. M. G. Regulation of the biosynthesis of triacylglycerol, phosphatidylcholine and phosphatidylethanolamine in the liver. Biochim. Biophys. Acta 1004, 1-19 (1989).
211. Dennis, E. A. and Kennedy, E. P. Intracellular site of lipid synthesis and the biogenesis of mitochondria. J. Lipid Res. 13, 263-267 (1972).
212. Hübscher, G., Dils, R. R. and Pover, W. F. R. Studies on the biosynthesis of phosphatidylserine. Biochim. Biophys. Acta 36, 518-528 (1959).
213. Jelsema, C. L. and Morré, D. J. Distribution of phospholipid biosythetic enzymes among cell components of rat liver. J. Biol. Chem. 253, 7960-7971 (1978).
214. Vance, J. E. and Shiao, Y.-J. Intracellular trafficking of phospholipids: import of phosphatidylserine into mitochondria. Anticancer Res. 16, 1333-1340 (1996).
215. Voelker, D. R. Phosphatidylserine functions as the major precursor of phosphatidylethanolamine in cultured BHK-21 cells. Proc. Natl Acad. Sci USA 81, 2669-2673 (1984).
216. Kuge, O., Nishijima, M. and Akamatsu, Y. Phosphatidylserine biosynthesis in cultured Chinese hamster ovary cells. J. Biol. Chem. 261, 5790-5794 (1986).
217. Miller, M. A. and Kent, C. Characterization of the pathways for phosphatidylethanolamine biosynthesis in Chinese hamster ovary mutant and parental cell lines. J. Biol. Chem. 261, 9753-9761 (1986).
218. Sundler, R., Åkesson, B. and Nilsson, Å. Quantitative role of base exchange in phosphatidylethanolamine synthesis in isolated rat hepatocytes. FEBS 43, 303-307 (1974).
219. Tijburg, L. B. M., Geelen, M. J. H. and van Golde, L. M. G. Biosynthesis of phosphatidylethanolamine via the CDP-ethanolamine route is an important pathway in isolated rat hepatocytes. Biochem. Biophys. Res. Commun. 160, 1275-1280 (1989).
220. Bell, R. M. and Coleman, R. A. Enzymes of glycerolipid synthesis in eukaryotes. A. Rev. Biochem. 49, 459-487 (1980).
221. Kuge, O., Nishijima, M. and Akamatsu, Y. A. Chinese hamster cDNA encoding a protein essential for phosphatidylsenine synthase I activity. J. Biol. Chem. 266, 24184-24189 (1991).
222. Voelker, D. R. Characterization of phosphatidylserine synthesis and translocation in permeabilized animal cells. J. Biol. Chem. 265, 14340-14346 (1990).
223. Sakai, K., Okuyama, H., Yura, J., Takeyama, H., Shinagawa, N., Tsuruga, N. Kato, K., Miura, K., Kawase, K., Tsujimura, T., Naruse, T. and Koike, A. Composition and turnover of phospholipids and neutral lipids in human breast cancer and reference tissues. Carcinogenesis 13, 579-584 (1992).
224. 31P NMR spectroscopy study. Magn. Reson. Med. 6, 296-299 (1988).
225. Hofman, K. and Dixit V. M. Ceramide in apoptosis - does it really matter? TIBS 23, 374-377 (1998).
226. Katz-Brull, R. and Degani, H. Kinetics of choline transport and phosphorylation in human breast cancer cells; NMR application of the zero trans method. Anticancer Res. 16, 1375-1380 (1996).
227. Chao, C. K., Pomfert, E. A. and Zeisel, S. H. Uptake of choline by rat mammary-gland epithelial cells. Biochem. J. 254, 33-38 (1988).
228. Lacal, J. C., Moscat, J. and Aaronson, S. A. Novel source of 1,2-diacylglycerol elevated in cells transformed by H-ras oncogene. Nature 330, 269-272, 1987.
229. Moscat, J. Cornet, M. E., Diaz-Meco, M. T., Larrodera, P., Lopez-Alanon, D. and Lopez-Barahona, M. Activation of phosphatidylcholine-specific phospholipase C in cell oncogene transformation. Biochem. Soc. Trans. 17, 988-991, 1989.
230. Price, B. D., Morris, J. D. H., Marshall, C. J. and Hall, A. Stimulation of phosphatidylcholine hydrolysis, diacylglycerol release and arachidonc acid production by oncogenic ras is a consequence of protein kinase C activation. J. Biol. Chem. 264, 16638-16643 (1989).
231. Lopez-Barahona, M., Kaplan, P. L., Cornet, M. E., Diaz-Meco, M. T., Larrodera, P., Laviada, I., Municio, A. M. and Moscat, J. Kinetic evidence of rapid activation of phosphatidylcholine hydrolysis by Ki-ras oncogene. J. Biol. Chem. 265, 9022-9026 (1990).
232. Carnero, A., Cuadrado, A., del Peso, L. and Lacal, J. C. Activation of type D phospholipase by serum stimulation and ras-induced transformation in NIH-3T3 cells. Oncogene 9, 1387-1395 (1994).
233. Kiss, Z. Regulation of phospholipase D by protein kinase C. Chem. Phys. Lipids 80, 81-102 (1996).
234. Cook, H. W., Ridgway, N. D., Byers, D. M. Involvement of phospholipase D and protein kinase C in phorbol ester and fatty acid stimulated turnover of phosphatidylcholine and phosphatidylethanolamine in neural cells. Biochim. Biophys. Acta 1390, 103-117 (1998).
235. Warden, C. H. and Friedkin, M. Regulation of choline kinase activity and phosphatidylcholine biosynthesis by mitogenic growth factors in 3T3 fibroblasts. J. Biol. Chem. 260, 6006-6011 (1985).
236. Clark, M. A., Shorr, R. G. L. and Bomalaski, J. S. Antibodies prepared to Bacillus cereus phospholipase C in mammalian cells. Biochem. Biophys. Res. Commun. 140, 11.4-119 (1986).
237. 31P NMR measurements of the effects of unsaturated fatty acids on cellular phospholipid metabolism. Magn. Reson. Med. 35, 481-188 (1996).
238. Siddiqui, R. A. and Exton, J. H. Oleate stimulation of diacylglycerol formation from phosphatidylcholine through effects on phospholipase D and phosphatidate phosphohydrolase. Eur. J. Biochem. 210, 601-607 (1992).
239. Franks, S., Negendank, W., Smith, M. R., Shaller, C., Stoyanova, R. and Brown, T. R. Investigations of the decrease in phosphoethanolamine associated with treatment response in a human non-Hodgkin's lymphoma cell line. 5th Meeting of the International Society for Magnetic Resonance in Medicine, Abstr., p. 1108 (1997).
240. 31P NMR studies of phosphonium metabolism. NMR Biomed. 7, 121-127 (1994).
241. Szwergold, B. S., Shaller, C., Kappler, F., Aiken, N. R., Stoyanova, R. and Brown, T. R. Effects of mitogenic stimulation on choline and phosphatidylcholine metabolism in mammalian cells. 4th Annual Meeting of the International Society for Magnetic Resonance in Medicine, Abstr., p. 268 (1996).
242. Jackowski, S. Coordination of membrane phospholipid synthesis with the cell cycle. J. Biol. Chem. 269, 3858-3867 (1994).