Do cytokines induce vascular calcification by the mere stimulation of TNAP activity?

Medical Hypotheses

Volumn 75, Issue 6, 2010, Pages 517-521

  Lencel, P ^a   Hardouin, P ^a   Magne, D ^a  

^a Physiopathologie des Maladies Osseuses Inflammatoires   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; COLLAGEN; COLLAGEN FIBRIL; CYTOKINE; FIBRILLAR COLLAGEN; INTERLEUKIN 1BETA; TRANSCRIPTION FACTOR RUNX2; TUMOR NECROSIS FACTOR ALPHA;

AGING; ARTICLE; ATHEROSCLEROSIS; BLOOD VESSEL CALCIFICATION; BLOOD VESSEL WALL; CELL DIFFERENTIATION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MESENCHYMAL STEM CELL; NON INSULIN DEPENDENT DIABETES MELLITUS; OSSIFICATION; OSTEOBLAST; PROTEIN EXPRESSION;

ALKALINE PHOSPHATASE; CALCINOSIS; COLLAGEN; CORE BINDING FACTOR ALPHA 1 SUBUNIT; CYTOKINES; HUMANS; INTERLEUKIN-1BETA; OSTEOBLASTS; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR DISEASES;

EID: 77958452855     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2010.07.011     Document Type: Article

References (59)

1. Franceschi C., Bonafe M., Valensin S., Olivieri F., De Luca M., Ottaviani E., et al. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci 2000, 908:244-254.
2. Franceschi C., Bonafe M. Centenarians as a model for healthy aging. Biochem Soc Trans 2003, 31:457-461.
3. Ballou S.P., Lozanski F.B., Hodder S., Rzewnicki D.L., Mion L.C., Sipe J.D., et al. Quantitative and qualitative alterations of acute-phase proteins in healthy elderly persons. Age Ageing 1996, 25:224-230.
4. Bruunsgaard H., Andersen-Ranberg K., Jeune B., Pedersen A.N., Skinhoj P., Pedersen B.K. A high plasma concentration of TNF-alpha is associated with dementia in centenarians. J Gerontol A Biol Sci Med Sci 1999, 54:M357-M364.
5. Bruunsgaard H., Pedersen B.K. Age-related inflammatory cytokines and disease. Immunol Allergy Clin North Am 2003, 23:15-39.
6. Krabbe K.S., Pedersen M., Bruunsgaard H. Inflammatory mediators in the elderly. Exp Gerontol 2004, 39:687-699.
7. Lusis A.J. Atherosclerosis. Nature 2000, 407:233-241.
8. Libby P. Inflammation and cardiovascular disease mechanisms. Am J Clin Nutr 2006, 83:456S-460S.
9. Moreno P.R., Fuster V. New aspects in the pathogenesis of diabetic atherothrombosis. J Am Coll Cardiol 2004, 44:2293-2300.
10. Donath M.Y., Boni-Schnetzler M., Ellingsgaard H., Halban P.A., Ehses J.A. Cytokine production by islets in health and diabetes: cellular origin, regulation and function. Trends Endocrinol Metab 2010, 21:261-267.
11. Clowes J.A., Riggs B.L., Khosla S. The role of the immune system in the pathophysiology of osteoporosis. Immunol Rev 2005, 208:207-227.
12. Burger H., de Laet C.E., van Daele P.L., Weel A.E., Witteman J.C., Hofman A., et al. Risk factors for increased bone loss in an elderly population: The rotterdam study. Am J Epidemiol 1998, 147:871-879.
13. Hannan M.T., Felson D.T., Dawson-Hughes B., Tucker K.L., Cupples L.A., Wilson P.W., et al. Risk factors for longitudinal bone loss in elderly men and women: The framingham osteoporosis study. J Bone Miner Res 2000, 15:710-720.
14. Wang T.J., Larson M.G., Levy D., Benjamin E.J., Kupka M.J., Manning W.J., et al. C-reactive protein is associated with subclinical epicardial coronary calcification in men and women: The framingham heart study. Circulation 2002, 106:1189-1191.
15. Doherty T.M., Fitzpatrick L.A., Inoue D., Qiao J.H., Fishbein M.C., Detrano R.C., et al. Molecular, endocrine, and genetic mechanisms of arterial calcification. Endocr Rev 2004, 25:629-672.
16. Magne D., Julien M., Vinatier C., Merhi-Soussi F., Weiss P., Guicheux J. Cartilage formation in growth plate and arteries: from physiology to pathology. Bioessays 2005, 27:708-716.
17. Shao J.S., Cai J., Towler D.A. Molecular mechanisms of vascular calcification: lessons learned from the aorta. Arterioscler Thromb Vasc Biol 2006, 26:1423-1430.
18. Speer M.Y., Yang H.Y., Brabb T., Leaf E., Look A., Lin W.L., et al. Smooth muscle cells give rise to osteochondrogenic precursors and chondrocytes in calcifying arteries. Circ Res 2009, 104:733-741.
19. Persy V., D'Haese P. Vascular calcification and bone disease: the calcification paradox. Trends Mol Med 2009, 15:405-416.
20. Mintz G.S., Popma J.J., Pichard A.D., Kent K.M., Satler L.F., Chuang Y.C., et al. Patterns of calcification in coronary artery disease. A statistical analysis of intravascular ultrasound and coronary angiography in 1155 lesions. Circulation 1995, 91:1959-1965.
21. Vengrenyuk Y., Carlier S., Xanthos S., Cardoso L., Ganatos P., Virmani R., et al. A hypothesis for vulnerable plaque rupture due to stress-induced debonding around cellular microcalcifications in thin fibrous caps. Proc Natl Acad Sci USA 2006, 103:14678-14683.
22. Aikawa E., Nahrendorf M., Sosnovik D., Lok V.M., Jaffer F.A., Aikawa M., et al. Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease. Circulation 2007, 115:377-386.
23. Tyson K.L., Reynolds J.L., McNair R., Zhang Q., Weissberg P.L., Shanahan C.M. Osteo/chondrocytic transcription factors and their target genes exhibit distinct patterns of expression in human arterial calcification. Arterioscler Thromb Vasc Biol 2003, 23:489-494.
24. Ishimura E., Okuno S., Kitatani K., Kim M., Shoji T., Nakatani T., et al. Different risk factors for peripheral vascular calcification between diabetic and non-diabetic haemodialysis patients-importance of glycaemic control. Diabetologia 2002, 45:1446-1448.
25. Vattikuti R., Towler D.A. Osteogenic regulation of vascular calcification: an early perspective. Am J Physiol Endocrinol Metab 2004, 286:E686-E696.
26. Shanahan C.M., Cary N.R., Salisbury J.R., Proudfoot D., Weissberg P.L., Edmonds M.E. Medial localization of mineralization-regulating proteins in association with Monckeberg's sclerosis: Evidence for smooth muscle cell-mediated vascular calcification. Circulation 1999, 100:2168-2176.
27. Li J.J., Zhu C.G., Yu B., Liu Y.X., Yu M.Y. The role of inflammation in coronary artery calcification. Ageing Res Rev 2007, 6:263-270.
28. Stompor T., Pasowicz M., Sullowicz W., Dembinska-Kiec A., Janda K., Wojcik K., et al. An association between coronary artery calcification score, lipid profile, and selected markers of chronic inflammation in ESRD patients treated with peritoneal dialysis. Am J Kidney Dis 2003, 41:203-211.
29. Aikawa E., Nahrendorf M., Figueiredo J.L., Swirski F.K., Shtatland T., Kohler R.H., et al. Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo. Circulation 2007, 116:2841-2850.
30. Tintut Y., Patel J., Parhami F., Demer L.L. Tumor necrosis factor-alpha promotes in vitro calcification of vascular cells via the cAMP pathway. Circulation 2000, 102:2636-2642.
31. Tintut Y., Patel J., Territo M., Saini T., Parhami F., Demer L.L. Monocyte/macrophage regulation of vascular calcification in vitro. Circulation 2002, 105:650-655.
32. Nadra I., Mason J.C., Philippidis P., Florey O., Smythe C.D., McCarthy G.M., et al. Proinflammatory activation of macrophages by basic calcium phosphate crystals via protein kinase C and MAP kinase pathways: A vicious cycle of inflammation and arterial calcification?. Circ Res 2005, 96:1248-1256.
33. Parhami F., Basseri B., Hwang J., Tintut Y., Demer L.L. High-density lipoprotein regulates calcification of vascular cells. Circ Res 2002, 91:570-576.
34. Al-Aly Z., Shao J.S., Lai C.F., Huang E., Cai J., Behrmann A., et al. Aortic Msx2-Wnt calcification cascade is regulated by TNF-alpha-dependent signals in diabetic Ldlr-/- mice. Arterioscler Thromb Vasc Biol 2007, 27:2589-2596.
35. Beresford J.N., Gallagher J.A., Gowen M., Couch M., Poser J., Wood D.D., et al. The effects of monocyte-conditioned medium and interleukin 1 on the synthesis of collagenous and non-collagenous proteins by mouse bone and human bone cells in vitro. Biochim Biophys Acta 1984, 801:58-65.
36. Nanes M.S., Rubin J., Titus L., Hendy G.N., Catherwood B. Tumor necrosis factor-alpha inhibits 1,25-dihydroxyvitamin D3-stimulated bone Gla protein synthesis in rat osteosarcoma cells (ROS 17/2.8) by a pretranslational mechanism. Endocrinology 1991, 128:2577-2582.
37. Ding J., Ghali O., Lencel P., Broux O., Chauveau C., Devedjian J.C., et al. TNF-alpha and IL-1beta inhibit RUNX2 and collagen expression but increase alkaline phosphatase activity and mineralization in human mesenchymal stem cells. Life Sci 2009, 84:499-504.
38. Gilbert L., He X., Farmer P., Rubin J., Drissi H., van Wijnen A.J., et al. Expression of the osteoblast differentiation factor RUNX2 (Cbfa1/AML3/Pebp2alpha A) is inhibited by tumor necrosis factor-alpha. J Biol Chem 2002, 277:2695-2701.
39. Abbas S., Zhang Y.H., Clohisy J.C., Abu-Amer Y. Tumor necrosis factor-alpha inhibits pre-osteoblast differentiation through its type 1 receptor. Cytokine 2003, 22:33-41.
40. Kaneki H., Guo R., Chen D., Yao Z., Schwarz E.M., Zhang Y.E., et al. Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts. J Biol Chem 2006, 281:4326-4333.
41. Guo R., Yamashita M., Zhang Q., Zhou Q., Chen D., Reynolds D.G., et al. Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins. J Biol Chem 2008, 283:23084-23092.
42. Murshed M., Harmey D., Millan J.L., McKee M.D., Karsenty G. Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone. Genes Dev 2005, 19:1093-1104.
43. Terkeltaub R.A. Inorganic pyrophosphate generation and disposition in pathophysiology. Am J Physiol Cell Physiol 2001, 281:C1-C11.
44. Price P.A., Toroian D., Chan W.S. Tissue-nonspecific alkaline phosphatase is required for the calcification of collagen in serum: a possible mechanism for biomineralization. J Biol Chem 2009, 284:4594-4604.
45. Rekhter M.D., Zhang K., Narayanan A.S., Phan S., Schork M.A., Gordon D. Type I collagen gene expression in human atherosclerosis. Localization to specific plaque regions. Am J Pathol 1993, 143:1634-1648.
46. Katsuda S., Kaji T. Atherosclerosis and extracellular matrix. J Atheroscler Thromb 2003, 10:267-274.
47. Stary H.C., Chandler A.B., Dinsmore R.E., Fuster V., Glagov S., Insull W., et al. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation 1995, 92:1355-1374.
48. Price P.A., Toroian D., Lim J.E. Mineralization by inhibitor exclusion: the calcification of collagen with fetuin. J Biol Chem 2009, 284:17092-17101.
49. Komori T., Yagi H., Nomura S., Yamaguchi A., Sasaki K., Deguchi K., et al. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 1997, 89:755-764.
50. Otto F., Thornell A.P., Crompton T., Denzel A., Gilmour K.C., Rosewell I.R., et al. Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 1997, 89:765-771.
51. Hoshi K., Komori T., Ozawa H. Morphological characterization of skeletal cells in Cbfa1-deficient mice. Bone 1999, 25:639-651.
52. Bell D.M., Leung K.K., Wheatley S.C., Ng L.J., Zhou S., Ling K.W., et al. SOX9 directly regulates the type II collagen gene. Nat Genet 1997, 16:174-178.
53. Lomashvili K.A., Cobbs S., Hennigar R.A., Hardcastle K.I., O'Neill W.C. Phosphate-induced vascular calcification: Role of pyrophosphate and osteopontin. J Am Soc Nephrol 2004, 15:1392-13401.
54. Anger T., Carson W., Weyand M., Daniel W.G., Hoeher M., Garlichs C.D. Atherosclerotic inflammation triggers osteogenic bone transformation in calcified and stenotic human aortic valves: Still a matter of debate. Exp Mol Pathol 2008.
55. Mathieu P., Voisine P., Pepin A., Shetty R., Savard N., Dagenais F. Calcification of human valve interstitial cells is dependent on alkaline phosphatase activity. J Heart Valve Dis 2005, 14:353-357.
56. Kotobuki N., Matsushima A., Kato Y., Kubo Y., Hirose M., Ohgushi H. Small interfering RNA of alkaline phosphatase inhibits matrix mineralization. Cell Tissue Res 2008, 332:279-288.
57. Yuan H., van Blitterswijk C.A., de Groot K., de Bruijn J.D. Cross-species comparison of ectopic bone formation in biphasic calcium phosphate (BCP) and hydroxyapatite (HA) scaffolds. Tissue Eng 2006, 12:1607-1615.
58. Isaac J., Hornez J.C., Jian D., Descamps M., Hardouin P., Magne D. Beta-TCP microporosity decreases the viability and osteoblast differentiation of human bone marrow stromal cells. J Biomed Mater Res A 2008, 86:386-393.
59. Hofbauer L.C., Brueck C.C., Shanahan C.M., Schoppet M., Dobnig H. Vascular calcification and osteoporosis -from clinical observation towards molecular understanding. Osteoporos Int 2007, 18:251-259.