Growth inhibition effect of β-catenin small interfering RNA-mediated gene silencing on human colon carcinoma HT-29 Cells

Cancer Biotherapy and Radiopharmaceuticals

Volumn 25, Issue 5, 2010, Pages 529-537

  Xu, Wei Li ^a   Wang, Qi ^b   Du, Ming ^a   Zhao, Yong Huan ^c   Sun, Xiang Rong ^b   Sun, Wen Guang ^b   Chen, Bing Qing ^b  

^a HARBIN INSTITUTE OF TECHNOLOGY   (China)

^b HARBIN MEDICAL UNIVERSITY   (China)

^c HEILONGJIANG AUGUST FIRST LAND RECLAMATION UNIVERSITY   (China)

Author keywords

colon cancer; gene therapy; HT 29; RNA interference; Wnt catenin

Indexed keywords

BETA CATENIN; CYCLIN D1; SMALL INTERFERING RNA; T CELL FACTOR PROTEIN;

APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN HT29; CELL STRUCTURE; CELL SURVIVAL; COLONY FORMATION; CONTROLLED STUDY; GENE EXPRESSION; GENE SILENCING; GENE TARGETING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RNA INTERFERENCE;

APOPTOSIS; BETA CATENIN; CELL CYCLE; CELL PROLIFERATION; COLONIC NEOPLASMS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, BCL-1; GENES, MYC; HT29 CELLS; HUMANS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSFECTION; WNT PROTEINS;

EID: 77958194583     PISSN: 10849785     EISSN: None     Source Type: Journal    
DOI: 10.1089/cbr.2010.0768     Document Type: Article

References (42)

1. Osias GL, Osias KB, Srinivasan R. Colorectal cancer in women: An equal opportunity disease. J Am Osteopath Assoc 2001;101(12 Suppl Pt 2): S7.
2. Polakis P. The oncogenic activation of beta-catenin. Curr Opin Genet Dev 1999;9:15.
3. Waltzer L, Bienz M. The control of beta-catenin and TCF during embryonic development and cancer. Cancer Metastasis Rev 1999;18:231.
4. Behrens J. Control of beta-catenin signaling in tumor development. Ann NY Acad Sci 2000;910:21.
5. Behrens J, vonKries JP, Kuhl M, et al. Functional interaction of β-catenin with the transcription factor LEF-1. Nature 1996;382:638.
6. Molenaar M, vandeWetering M, Oosterwegel M, et al. XTcf- 3 transcription factor mediates β-catenin-induced axis formation in Xenopus embryos. Cell 1996;6:391.
7. Fire A, Xu S, Montgomery MK, et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998;391:806.
8. Bass BL. Double-stranded RNA as a template for gene silencing. Cell 2000;101:235.
9. Caplen NJ, Parrish S, Imani F, et al. Specific inhibition of gene expression by small double-stranded RNAs In invertebrate and vertebrate systems. Proc Natl Acad Sci USA 2001;98:9742.
10. Elbashir SM, Harborth J, Lendeckel W, et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001;411:494.
11. Thatte HS, Rhee JH, Zagarins SE, et al. Acidosis-induced apoptosis in human and porcine heart. Ann Thorac Surg 2004;77:1376.
12. Orlandini M, Semboloni S, Oliviero S. Beta-catenin inversely regulates vascular endothelial growth factor-D mRNA stability. J Biol Chem 2003;278:44650.
13. Vinodhkumar R, Song YS, Devaki T. Romidepsin (depsipeptide) induced cell cycle arrest, apoptosis and histone hyperacetylation in lung carcinoma cells (A549) are associated with increase in p21 and hypophosphorylated retinoblastoma proteins expression. Biomed Pharmacother 2008;62:85.
14. Shi L, Keefe D, Durand E, et al. Granzyme B binds to target cells mostly by charge and must be added at the same time as perforin to trigger apoptosis. J Immunol 2005;174:5456.
15. Fevr T, Robine S, Louvard D, et al. Wnt/β-Catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells. Mol Cell Biol 2007;27:7551.
16. Sparks AB, Morin PJ, Vogelstein B, et al. Mutational analysis of the APC/β-catenin/Tcf pathway in colorectal cancer. Cancer Res 1998;58:1130.
17. Morin PJ, Sparks AB, Korinek V, et al. Activation of β- catenin-Tcf signaling in colon cancer by mutations in β- catenin or APC. Science 1997;275:1787.
18. He TC, Sparks AB, Rago C, et al. Identification of c-MYC as a target of the APC pathway. Science 1998;281:1509.
19. Shtutman M, Zhurinsky J, Simcha I, et al. The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway. Proc Natl Acad Sci USA 1999;96:5522.
20. Tetsu O, McCormick F. β-Catenin regulates expression of Cyclin D1 in colon carcinoma cells. Nature 1999;398:422.
21. Orford K, Orford C, Byers SW. Exogenous expression of β catenin regulates contact inhibition, anchorage-independent growth, Anoikis and radiation-induced cell-cycle arrest. J Cell Biol 1999;146:855.
22. Zhu AJ, Watt FM. β-Catenin signalling modulates prolif-Erative potential of human epidermal keratinocytes independently of intercellular adhesion. Development 1999;126:2285.
23. Morin PJ, Vogelstein B, Kinzler KW. Apoptosis and APC in colorectal tumorigenesis. Proc Natl Acad Sci USA 1996;93:7950.
24. Din FV, Dunlop MG, Stark LA. Evidence for colorectal cancer cell specificity of aspirin effects on NF kappa B signalling and apoptosis. Br J Cancer 2004;91:381.
25. Mariadason JM, Bordonaro M, Aslam F, et al. Down-regulation of beta-catenin TCF signaling is linked to colonic epithelial cell differentiation. Cancer Res 2001;61:3465.
26. Huang X, Guo B. Adenomatous polyposis coli determines sensitivity to histone deacetylase inhibitor-induced apoptosis in colon cancer cells. Cancer Res 2006;66:9245.
27. Verma UN, Surabhi RM, Schmaltieg A, et al. small interfering RNAs directed against β-catenin inhibit the in vitro and in vivo growth of colon cancer cells. Clin Cancer Res 2003;9:1291.
28. Huang WS, Wang JP, Wang T, et al. ShRNA-mediated gene silencing of beta-catenin inhibits growth of human colon cancer cells. World J Gastroenterol 2007;13:6581.
29. Zeng G, Apte U, Cieply B, et al. siRNA-mediated β-catenin knockdown in human hepatoma cells results in decreased growth and survival. Neoplasia 2007;9:951.
30. Wijnhoven BP, Dinjens WN, Pignatelli M. E-cadherincatenin cell-cell adhesion complex and human cancer. Br J Surg 2000;87:992.
31. Roh H, Green DW, Boswell CB, et al. Suppression of β- catenin inhibits the neoplastic growth of APC-mutant colon cancer cells. Cancer Res 2001;61:6563.
32. Thompson EB. The many roles of c-Myc in apoptosis. Annu Rev Physiol 1998;60:575.
33. Alarcon RM, Rupnow BA, Graeber TG, et al. Modulation of c-Myc activity and apoptosis in vivo. Cancer Res 1996;56:4315.
34. Pompetti F, Rizzo P, Simon RM, et al. Oncogene alterations in primary, recurrent, and metastatic human bone tumors. J Cell Biochem 1996;63:37.
35. Erisman MD, Rothberg PG, Diehl RE, et al. Deregulation of c-myc gene expression in human colon carcinoma is not accompanied by amplification or rearrangement of the gene. Mol Cell Biol 1985;5:1969.
36. Escot C, Theillet C, Lidereau R, et al. Genetic alteration of the c-myc protooncogene (MYC) in human primary breast carcinomas. Proc Natl Acad Sci USA 1986;83:4834.
37. Eilers M, Schirm S, Bishop JM. The MYC protein activates transcription of the alpha-prothymosin gene. EMBO J 1991;10:133.
38. Polakis P. The adenomatous polyposis coli (APC) tumor suppressor. Biochim Biophys Acta 1997;1332: F127.
39. Malumbres M, Barbacid M. To cycle or not to cycle: A critical decision in cancer. Nat Rev Cancer 2001;1:222.
40. Bartek J, Lukas J. Are all cancer genes equal? Nature 2001;411:1001.
41. Sherr CJ. The pezcoller lecture: Cancer cell cycle revisited. Cancer Res 2000;60:3689.
42. Shiina H, Igawa M, Shigeno K, et al. Beta-catenin mutations correlate with over expression of C-myc and cyclin D1 genes in bladder cancer. J Urol 2002;168:2220.