Heat increases MDMA-enhanced NAcc 5-HT and body temperature, but not MDMA self-administration

European Neuropsychopharmacology

Volumn 20, Issue 12, 2010, Pages 884-894

  Feduccia, Allison A ^a   Kongovi, Nundhun ^a   Duvauchelle, Christine L ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

3,4 Methylenedioxymethamphetamine; Ambient temperature; Heat; MDMA reinforcement

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; DOPAMINE; SEROTONIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; CORE TEMPERATURE; HEAT; INSTRUMENTAL CONDITIONING; LOCOMOTION; MALE; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT; ROOM TEMPERATURE;

ANIMALS; BODY TEMPERATURE; CONDITIONING, OPERANT; HOT TEMPERATURE; MALE; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; NUCLEUS ACCUMBENS; RATS; RATS, SPRAGUE-DAWLEY; SELF ADMINISTRATION; SEROTONIN;

EID: 77958177635     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2010.08.009     Document Type: Article

References (54)

1. Bankson M.G., Cunningham K.A. Pharmacological studies of the acute effects of (+)-3, 4-methylenedioxymethamphetamine on locomotor activity: role of 5-HT(1B/1D) and 5-HT(2) receptors. Neuropsychopharmacology 2002, 26(1):40-52.
2. Battaglia G., Yeh S.Y., De Souza E.B. MDMA-induced neurotoxicity: parameters of degeneration and recovery of brain serotonin neurons. Pharmacol. Biochem. Behav. 1988, 29(2):269-274.
3. Baumann M.H., Clark R.D., Rothman R.B. Locomotor stimulation produced by 3, 4-methylenedioxymethamphetamine (MDMA) is correlated with dialysate levels of serotonin and dopamine in rat brain. Pharmacol. Biochem. Behav. 2008, 90(2):208-217.
4. Bedi G., Redman J. Recreational ecstasy use: acute effects potentiated by ambient conditions. Neuropsychobiology 2006, 53(2):113. author reply 114.
5. Benamar K., Geller E.B., Adler M.W. A new brain area affected by 3,4-methylenedioxymethamphetamine: a microdialysis-biotelemetry study. Eur. J. Pharmacol. 2008, 84-88.
6. Bevins R.A., Besheer J., Palmatier M.I., Jensen H.C., Pickett K.S., Eurek S. Novel-object place conditioning: behavioral and dopaminergic processes in expression of novelty reward. Behav. Brain Res. 2002, 129(1-2):41-50.
7. Broening H.W., Bowyer J.F., Slikker W. Age-dependent sensitivity of rats to the long-term effects of the serotonergic neurotoxicant (+/-)-3, 4-methylenedioxymethamphetamine (MDMA) correlates with the magnitude of the MDMA-induced thermal response. J. Pharmacol. Exp. Ther. 1995, 275(1):325-333.
8. Cornish J.L., Shahnawaz Z., Thompson M.R., Wong S., Morley K.C., Hunt G.E., McGregor I.S. Heat increases 3, 4-methylenedioxymethamphetamine self-administration and social effects in rats. Eur. J. Pharmacol. 2003, 482(1-3):339-341.
9. Cowan R.L., Lyoo I.K., Sung S.M., Ahn K.H., Kim M.J., Hwang J., Haga E., Vimal R.L., Lukas S.E., Renshaw P.F. Reduced cortical gray matter density in human MDMA (Ecstasy) users: a voxel-based morphometry study. Drug Alcohol Depend. 2003, 72(3):225-235.
10. Curran H.V., Rees H., Hoare T., Hoshi R., Bond A. Empathy and aggression: two faces of ecstasy? A study of interpretative cognitive bias and mood change in ecstasy users. Psychopharmacology (Berl) 2004, 173(3-4):425-433.
11. Dafters R.I. Effect of ambient temperature on hyperthermia and hyperkinesis induced by 3, 4-methylenedioxymethamphetamine (MDMA or "Ecstasy") in rats. Psychopharmacology (Berl) 1994, 114(3):505-508.
12. Daniela E., Brennan K., Gittings D., Hely L., Schenk S. Effect of SCH 23390 on (+/-)-3, 4-methylenedioxymethamphetamine hyperactivity and self-administration in rats. Pharmacol. Biochem. Behav. 2004, 77(4):745-750.
13. Duvauchelle C.L., Ikegami A., Castaneda E. Conditioned increases in behavioral activity and accumbens dopamine levels produced by intravenous cocaine. Behav. Neurosci. 2000, 114(6):1156-1166.
14. Feduccia A.A., Duvauchelle C.L. Auditory stimuli enhances MDMA-conditioned reward and MDMA-induced nucleus accumbens dopamine, serotonin and locomotor responses. Brain Res. Bull. 2008, 189-196.
15. Gold L.H., Hubner C.B., Koob G.F. A role for the mesolimbic dopamine system in the psychostimulant actions of MDMA. Psychopharmacology (Berl) 1989, 99(1):40-47.
16. Gough B., Ali S.F., Slikker W., Holson R.R. Acute effects of 3, 4-methylenedioxymethamphetamine (MDMA) on monoamines in rat caudate. Pharmacol. Biochem. Behav. 1991, 39(3):619-623.
17. Green A.R., Sanchez V., O'Shea E., Saadat K.S., Elliott J.M., Colado M.I. Effect of ambient temperature and a prior neurotoxic dose of 3, 4-methylenedioxymethamphetamine (MDMA) on the hyperthermic response of rats to a single or repeated ('binge' ingestion) low dose of MDMA. Psychopharmacology (Berl) 2004, 173(3-4):264-269.
18. Gudelsky G.A., Nash J.F. Carrier-mediated release of serotonin by 3, 4-methylenedioxymethamphetamine: implications for serotonin-dopamine interactions. J. Neurochem. 1996, 66(1):243-249.
19. Gudelsky G.A., Yamamoto B.K. Actions of 3, 4-methylenedioxymethamphetamine (MDMA) on cerebral dopaminergic, serotonergic and cholinergic neurons. Pharmacol. Biochem. Behav. 2008, 90(2):198-207.
20. Hall A.P., Henry J.A. Acute toxic effects of 'Ecstasy' (MDMA) and related compounds: overview of pathophysiology and clinical management. Br. J. Anaesth. 2006, 96(6):678-685.
21. Hargreaves G.A., Hunt G.E., Cornish J.L., McGregor I.S. High ambient temperature increases 3, 4-methylenedioxymethamphetamine (MDMA, "Ecstasy")-induced Fos expression in a region-specific manner. Neuroscience 2007, 145(2):764-774.
22. Ikegami A., Olsen C.M., D'Souza M.S., Duvauchelle C.L. Experience-dependent effects of cocaine self-administration/conditioning on prefrontal and accumbens dopamine responses. Behav. Neurosci. 2007, 121(2):389-400.
23. Indlekofer F., Piechatzek M., Daamen M., Glasmacher C., Lieb R., Pfister H., Tucha O., Lange K.W., Wittchen H.U., Schutz C.G. Reduced memory and attention performance in a population-based sample of young adults with a moderate lifetime use of cannabis, ecstasy and alcohol. J. Psychopharmacol. 2009, 495-509.
24. Kalant H. The pharmacology and toxicology of "Ecstasy" (MDMA) and related drugs. Cmaj 2001, 165(7):917-928.
25. Kalivas P.W., Duffy P., White S.R. MDMA elicits behavioral and neurochemical sensitization in rats. Neuropsychopharmacology 1998, 18(6):469-479.
26. Kankaanpaa A., Meririnne E., Lillsunde P., Seppala T. The acute effects of amphetamine derivatives on extracellular serotonin and dopamine levels in rat nucleus accumbens. Pharmacol. Biochem. Behav. 1998, 59(4):1003-1009.
27. Koch S., Galloway M.P. MDMA induced dopamine release in vivo: role of endogenous serotonin. J. Neural Transm. 1997, 104(2-3):135-146.
28. Kurling S., Kankaanpaa A., Seppala T. Sub-chronic nandrolone treatment modifies neurochemical and behavioral effects of amphetamine and 3, 4-methylenedioxymethamphetamine (MDMA) in rats. Behav. Brain Res. 2008, 189(1):191-201.
29. Lile J.A., Ross J.T., Nader M.A. A comparison of the reinforcing efficacy of 3, 4-methylenedioxymethamphetamine (MDMA, "Ecstasy") with cocaine in rhesus monkeys. Drug Alcohol Depend. 2005, 78(2):135-140.
30. Malberg J.E., Seiden L.S. Small changes in ambient temperature cause large changes in 3, 4-methylenedioxymethamphetamine (MDMA)-induced serotonin neurotoxicity and core body temperature in the rat. J. Neurosci. 1998, 18(13):5086-5094.
31. McCreary A.C., Bankson M.G., Cunningham K.A. Pharmacological studies of the acute and chronic effects of (+)-3, 4-methylenedioxymethamphetamine on locomotor activity: role of 5-hydroxytryptamine(1A) and 5-hydroxytryptamine(1B/1D) receptors. J. Pharmacol. Exp. Ther. 1999, 290(3):965-973.
32. McElrath K., McEvoy K. Negative experiences on ecstasy: the role of drug, set and setting. J. Psychoactive Drugs 2002, 34(2):199-208.
33. Olds M.E., Christenson T. Effects of drive and training on extinction after self-stimulation and food reward. Am. J. Physiol. 1970, 219(1):208-213.
34. O'Shea E., Granados R., Esteban B., Colado M.I., Green A.R. The relationship between the degree of neurodegeneration of rat brain 5-HT nerve terminals and the dose and frequency of administration of MDMA ('Ecstasy'). Neuropharmacology 1998, 37(7):919-926.
35. O'Shea E., Escobedo I., Orio L., Sanchez V., Navarro M., Green A.R., Colado M.I. Elevation of ambient room temperature has differential effects on MDMA-induced 5-HT and dopamine release in striatum and nucleus accumbens of rats. Neuropsychopharmacology 2005, 30(7):1312-1323.
36. Parrott A.C. Recreational Ecstasy/MDMA, the serotonin syndrome, and serotonergic neurotoxicity. Pharmacol. Biochem. Behav. 2002, 71(4):837-844.
37. Parrott A.C. MDMA (3, 4-Methylenedioxymethamphetamine) or Ecstasy: the neuropsychobiological implications of taking it at dances and raves. Neuropsychobiology 2004, 50(4):329-335.
38. Parrott A.C. Chronic tolerance to recreational MDMA (3, 4-methylenedioxymethamphetamine) or Ecstasy. J. Psychopharmacol. 2005, 19(1):71-83.
39. Paxinos, G., Watson, C., 1997. The rat brain: in stereotaxic coordinates (Atlas & Computer Graphics Files), 3 ed. Academic Press, Inc., San Diego.
40. Quednow B.B., Jessen F., Kuhn K.U., Maier W., Daum I., Wagner M. Memory deficits in abstinent MDMA (Ecstasy) users: neuropsychological evidence of frontal dysfunction. J. Psychopharmacol. 2006, 20(3):373-384.
41. Ratzenboeck E., Saria A., Kriechbaum N., Zernig G. Reinforcing effects of MDMA ("Ecstasy") in drug-naive and cocaine-trained rats. Pharmacology 2001, 62(3):138-144.
42. Reneman L., Endert E., de Bruin K., Lavalaye J., Feenstra M.G., de Wolff F.A., Booij J. The acute and chronic effects of MDMA ("Ecstasy") on cortical 5-HT2A receptors in rat and human brain. Neuropsychopharmacology 2002, 26(3):387-396.
43. Reveron M.E., Maier E.Y., Duvauchelle C.L. Experience-dependent changes in temperature and behavioral activity induced by MDMA. Physiol. Behav. 2006, 358-363.
44. Reveron M.E., Maier E.Y., Duvauchelle C.L. Behavioral, thermal and neurochemical effects of acute and chronic 3, 4-methylenedioxymethamphetamine ("Ecstasy") self-administration. Behav. Brain Res. 2010, 207(2):500-507.
45. Rudnick G., Wall S.C. The molecular mechanism of "Ecstasy" [3, 4-methylenedioxy-methamphetamine (MDMA)]: serotonin transporters are targets for MDMA-induced serotonin release. Proc. Natl Acad. Sci. USA 1992, 89(5):1817-1821.
46. Sanchez V., O'Shea E., Saadat K.S., Elliott J.M., Colado M.I., Green A.R. Effect of repeated ('binge') dosing of MDMA to rats housed at normal and high temperature on neurotoxic damage to cerebral 5-HT and dopamine neurones. J. Psychopharmacol. 2004, 18(3):412-416.
47. Schenk S., Gittings D., Johnstone M., Daniela E. Development, maintenance and temporal pattern of self-administration maintained by Ecstasy (MDMA) in rats. Psychopharmacology (Berl) 2003, 169(1):21-27.
48. Schenk S., Hely L., Lake B., Daniela E., Gittings D., Mash D.C. MDMA self-administration in rats: acquisition, progressive ratio responding and serotonin transporter binding. Eur. J. Neurosci. 2007, 26(11):3229-3236.
49. Semple D.M., Ebmeier K.P., Glabus M.F., O'Carroll R.E., Johnstone E.C. Reduced in vivo binding to the serotonin transporter in the cerebral cortex of MDMA ('Ecstasy') users. Br. J. Psychiatry 1999, 175:63-69.
50. Shioda K., Nisijima K., Yoshino T., Kuboshima K., Iwamura T., Yui K., Kato S. Risperidone attenuates and reverses hyperthermia induced by 3, 4-methylenedioxymethamphetamine (MDMA) in rats. Neurotoxicology 2008, 29(6):1030-1036.
51. Spanos L.J., Yamamoto B.K. Acute and subchronic effects of methylenedioxymethamphetamine [(+/-)MDMA] on locomotion and serotonin syndrome behavior in the rat. Pharmacol. Biochem. Behav. 1989, 32(4):835-840.
52. Verkes R.J., Gijsman H.J., Pieters M.S., Schoemaker R.C., de Visser S., Kuijpers M., Pennings E.J., de Bruin D., Van de Wijngaart G., Van Gerven J.M., Cohen A.F. Cognitive performance and serotonergic function in users of ecstasy. Psychopharmacology (Berl) 2001, 153(2):196-202.
53. Verrico C.D., Miller G.M., Madras B.K. MDMA (Ecstasy) and human dopamine, norepinephrine, and serotonin transporters: implications for MDMA-induced neurotoxicity and treatment. Psychopharmacology (Berl) 2007, 189(4):489-503.
54. Zakzanis K.K., Campbell Z. Memory impairment in now abstinent MDMA users and continued users: a longitudinal follow-up. Neurology 2006, 66(5):740-741.